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- Clotrimazole
- Diazepam
- Fentanyl
- Gabapentin
- Hydroxyzine
- Ibuprofen
- Ivermectin
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- Magnesium
- Meloxicam
- Metoprolol
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- Mirtazapine
- Naproxen
- Omega 3
- Omeprazole
- Ondansetron
- Paracetamol
- Propranolol
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- Tamsulosin
- Tirzepatide
- Tylenol
- Viagra
- Vitamin B12
- Vitamin C
- Vitamin D
- Xanax
- Acetaminophen
- Acyclovir
- Advil
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- Alfuzosin
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- Ambien
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- Amiodarone
- Ampicillin
- Anastrozole
- Apixaban
- Aripiprazole
- Ascorbic Acid
- Aspirin
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- Atenolol
- Ativan
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- Azelastine
- Bacitracin
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- Benadryl
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- Calcitriol
- Candesartan
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- Carbamazepine
- Carvedilol
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- Ceftriaxone
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- Celebrex
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- Cephalexin
- Chlorpheniramine
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- Cholecalciferol
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- Citalopram
- Claritin
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- Famotidine
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- Fenofibrate
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- Fish Oil
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- Flexeril
- Flomax
- Flonase
- Fluticasone
- Fluvoxamine
- Folic Acid
- Formoterol
- Fosamax
- Fosfomycin
- Furosemide
- Gardasil 9
- Garlic
- Gas X
- Gaviscon
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- Glimepiride
- Glipizide
- Glucagon
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- Pioglitazone
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- Rizatriptan
- Robaxin
- Rocephin
- Rosuvastatin
- Rybelsus
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- Scopolamine
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- Ticagrelor
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- Topamax
- Topiramate
- Toradol
- Torsemide
- Tranexamic Acid
- Tremfya
- Tresiba
- Tretinoin
- Triamcinolone
- Triamcinolone Acetonide
- Trileptal
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- Vitamin B6
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- Vraylar
- Vyvanse
- Warfarin
- Witch Hazel
- Wormwood
- Xarelto
- Xenical
- Xifaxan
- Xolair
- Xylitol
- Xyzal
- Yarrow
- Yasmin
- Yaz
- Yellow Fever Vaccine
- Zantac
- Zepbound
- Zetia
- Zinc
- Zithromax
- Zofran
- Zoladex
- Zolpidem
- Zopiclone
- Zovirax
- Zyprexa
- Zyrtec
- Hydroxytryptophan
- Serious
- Other
Why Are There So Many Antihistamines? 🤧💊
Antihistamine drugs are everywhere! While you’re used to the anti-allergy effects of commercially successful drugs like Benadryl and Claritin, popular drugs for motion sickness, peptic ulcers, and even antipsychotics started their lives as antihistamines. It also turns out that important concepts in pharmacology, like the receptor theory, and agonist and antagonist pharmacology, owe their development in part to the story of antihistamines.
☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️
🔗 L I N K S 🔗
📱Instagram: https://www.instagram.com/patkellyteaches/
🐦Twitter: https://twitter.com/PatKellyTeaches
💰Patreon: https://www.patreon.com/corporis
🔬Main channel: www.youtube.com/corporis/
📚My favorite books https://docs.google.com/docume....nt/d/1wuG-8EiF2lMbFd
🔑 P A T R O N S 🔑
Oxytocin Tier: Joanne K | Jim C Jr. | Sal F | Jody O | Ansel K | Paul B
Growth Hormone Tier: Dane M | Brendan P | Brandon K | Pia K | Joe B | Mindi F | Ansel K | Michael G | Brian B | Eileen H | Jonathan G | Waffles the Dog | Brian T | Brian H | Michael R | Karen S | Sarah B | Robin B | Jacob S | Hyeon-Seo | Drake W | Pranav M | Paul | Lucy F | Lucie C | Huynhy | elnombre91 | Alcedo | Magmania | Josef K | Kyle K | Dabrick B | Robert M | Kristal C | TierZoo | Unsalted Pecan | Marshall K | Eric L | Helena SB | Michelle J | Matthew B | Hailey H | Jack M | Jane G | Skasi | Jiggs
📜 S O U R C E S 📜
Full annotated script available for free on Patreon: https://www.patreon.com/posts/....antihistamines-10220
Blockbuster Drugs: the Rise and Decline of the Pharmaceutical Industry by Jie Jack Li https://amzn.to/3U4WnuM (affiliate link)
Ten Drugs by Thomas Hager https://amzn.to/4cFkZSj (affiliate link)
Histamine pharmacology: from Sir Henry Dale to the 21st century (2020) https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC70129
Histamine receptors and antihistamines: from discovery to clinical applications (2014) https://pubmed.ncbi.nlm.nih.gov/24925401/
Histamine and itch (2014) https://www.ncbi.nlm.nih.gov/books/NBK200934/
Frontiers in Clinical Drug Research - Anti-Allergy Agents (2018) https://www.google.com/books/edition/Frontiers_in_Clinical_Drug_Research_Anti/EIJoDwAAQBAJ?hl=en&gbpv=0
Allergy https://www.ncbi.nlm.nih.gov/books/NBK545237/
Allergic rhinitis https://www.nature.com/articles/s41572-020-00227-0
Inverse Agonism and Functional Selectivity (2018) https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC61659
Histamine H1 Receptor https://www.sciencedirect.com/....topics/neuroscience/
Histamine and the antiallergic antihistamines: a history of their discoveries (1999) https://pubmed.ncbi.nlm.nih.gov/10444205/
Dale and Laidlaw isolate histamine (1910) https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC15129
Dale and Richards experiment with histamine (1911) https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC14026
Halpern discovers Phenergan https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC15911
The Claritin Effect; Prescription for Profit (2001) https://www.nytimes.com/2001/0....3/11/magazine/the-cl
As Blockbuster Claritin Goes Generic, Schering-Plough Pushes a Close Sibling (2002) https://www.wsj.com/articles/SB1016748743581330920
💻 C O N T A C T 💻
Business inquiries only: patkellyteaches [at] gmail.com
⌛T I M E S T A M P S ⌛
0:00 intro
0:34 The Discovery of Histamine
5:46 The First Antihistamines
12:33 The Rise of Non-Drowsy (Second Generation) H1 Antihistamines
19:34 Tagamet: the first blockbuster
#historyofmedicine #medicalhistory
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