Ampicillin is Broad Spectrum antibiotics which belongs to Penicillin Class of antibiotics. Penicillin is very effective in typhoid fever, pneumonia, Skin infection, bacterial meningitis and other infection. It is safe and well tolerated medicine. Know more about this please see the video.

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Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. It may also be used to prevent group B streptococcal infection in newborns. It is used by mouth, by injection into a muscle, or intravenously.Like all antibiotics, it is not useful for the treatment of viral infections.
Common side effects include rash, nausea, and diarrhea. It should not be used in people who are allergic to penicillin. Serious side effects may include Clostridium difficile colitis or anaphylaxis. While usable in those with kidney problems, the dose may need to be decreased.Its use during pregnancy and breastfeeding appears to be generally safe.

Ampicillin was discovered in 1958 and came into commercial use in 1961.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.Its wholesale cost in the developing world is between US$0.13 and 1.20 for a vial of the intravenous solution as of 2014.In the United States, it is available as a generic medication and 10 days of treatment cost about $13.
Ampicillin is used to treat infections by many Gram-positive and Gram-negative bacteria. Ampicillin was the first 'broad spectrum' penicillin with activity against Gram-positive bacteria including Streptococcus pneumoniae, Streptococcus pyogenes, some isolates of Staphylococcus aureus (but not penicillin-resistant or methicillin-resistant strains), and some Enterococcus. Activity against Gram-negative bacteria includes Neisseria meningitidis, some Haemophilus influenzae, and some of the Enterobacteriaceae. Its spectrum of activity is enhanced by co-administration of sulbactam, a drug that inhibits beta lactamase, an enzyme produced by bacteria to inactivate ampicillin and related antibiotics. It is sometimes used in combination with other antibiotics that have different mechanisms of action, like vancomycin, linezolid, daptomycin, and tigecycline.

Ampicillin can be administered by mouth, an intramuscular injection (shot) or by intravenous infusion.

Indications :
respiratory infections
sinusitis
bronchitis
pharyngitis
otitis media
bacterial meningitis
Salmonella, Shigella, and Listeria bacteria.
gastrointestinal infections caused by contaminated water or food.
healthcare-associated infections related to infection from urinary catheter use unresponsive to other medications.
Haemophilus influenzae, Streptococcus pneumoniae infections.
Genito-urinary tract infections
prevent infection (prophylaxis) in those who previously had rheumatic heart disease or are undergoing dental procedures.
Side effects:
Ampicillin is comparatively less toxic than other antibiotics. In very rare cases, it causes severe side effects such as angioedema, anaphylaxis, and C. difficile infection. Some develop black 'furry' tongue'. The most serious adverse effects are seizures, serum sickness, anaphylaxis, pseudomembranous colitis. The most common side effects to be expected in ten percent of users are diarrhea and rash. Less common side effects can be nausea, vomiting, itching, blood dyscrasias, and mild allergic reactions. Other conditions may develop up several weeks after treatment.

In this video, Dr Mike outlines the classes of antibiotics, examples of each, and their mechanism of action in 7 minutes!!

Instagram: @drmiketodorovic

The main types of penicillins are: penicillinase-resistant penicillins, antipseudomonal penicillins, beta-lactamase inhibitors, natural penicillins, aminopenicillins.

Narrow spectrum penicillins (beta-lactamase sensitive, beta-lactamase resistant) and broad spectrum penicillins (aminopenicillins, carboxypenicillins, ureidopenicillins) are known.

The main representatives of aminopenicillins are: amoxicillin, ampicillin, pivampicillin, getacillin, bacampicillin, metampicillin, talampicillin, epicillin.

Ampicillin is a white, crystalline powder. Molar mass: 349 g/mol (ampicillin trihydrate, C16H19N3O4S) and 371 g/mol (ampicillin sodium salt, C16H18N3NaO4S), melting point: 208 °C (with decomposition). Solubility in water: 10.1 g/l.

Ampicillin has a lot of names (more than 100).

The composition of ampicillin (sodium salt) includes the following chemical elements: carbon (51.8%), oxygen (17.3%), nitrogen (11.3%), sulfur (8.6%), sodium (6.2% ), hydrogen (4.9%).

This antibiotic was discovered in 1958 in the UK, in 1961 it began to be sold in pharmacies, and in 1970, along with co-trimoxazole, it replaced the more toxic chloramphenicol (levomycetin).

If ampicillin is considered a very cheap and affordable antibiotic, then for laboratory tests the used analogue can cost 15,000 times more!

This antibiotic is produced under the guise of trihydrate (for oral administration, slightly soluble in water) and sodium salt (for parenteral administration, highly soluble in water).

Solutions of this antibiotic are quickly inactivated. It does not cause noticeable irritation to tissues, does not accumulate in tissues, and is slightly toxic even at high doses.

It is acid-resistant and does not bind to blood proteins, but is destroyed by penicillin-resistant bacteria under the influence of penicillinase.

Introduced into the body ampicillin is rapidly absorbed in the intestine and rapidly distributed in the organs and tissues of the body, as well as in fluids. Partially destroyed in the stomach and intestines.

After administration, it reaches a therapeutic dose in 1-2 hours, and the effect lasts up to 6 hours. With parenteral administration, it is possible to obtain a higher concentration of the drug in the blood, but it is excreted faster.

With intramuscular injection, maximum concentrations are obtained after 30-60 minutes, but with intravenous administration - after 15-20 minutes.

The drug is well distributed in pleural, peritoneal and synovial fluids, while in sputum it is found in less small concentrations due to its destruction by enzymes.

In inflamed areas of the lungs, the content of ampicillin is higher compared to healthy areas.

In bone tissue, concentrations are found to be 50% lower than in the blood, but high concentrations are observed in the kidneys and liver. Found in the prostate gland.

In the blood of infants, ampicillin concentrations are 50% higher than in older children.

The antibiotic is excreted from the body mainly through the kidneys, in the urine observed in very high concentrations. With problems with the kidneys, it is partially excreted in the bile.

The antimicrobial effect of ampicillin is seen on gram-negative and gram-positive bacteria, including staphylococcus aureus (sensitive to penicillin), streptococcus, and pneumococcus.

Many microorganisms are sensitive to this medicine: gonococcus, meningococcus, enterococcus, listeria, gas gangrene clostridium, escherichia, salmonella, causative agents of typhoid fever, shigella, some Klebsiella and Proteus, hemophilic bacillus influenza, staphylococcus, streptococcus, pneumococcus.

Ampicillin-resistant microorganisms are: Pseudomonas aeruginosa, Mycobacterium tuberculosis, some strains of Klebsiella, many strains of Proteus, causative agents of tularemia.

Ampicillin is characterized by a similar spectrum of action as tetracyclines and levomycetin, but is less toxic. It acts mainly on multiplying bacteria and on bacteria located inside the cells.

Ampicillin should be used only if the pathogen is sufficiently sensitive. It is of low toxicity and can be used in doses higher than usual and for a long time (for chronic pyelonephritis and septic endocarditis).

Can be used by pregnant women and infants due to low toxicity.

It is used for septic infections and for various purulent-inflammatory surgical and gynecological infections, for listeriosis, endocarditis, for some forms of meningitis, for typhoid fever.

The main side effects are: rash, intestinal dysbacteriosis, headache, depression, arthralgia.

Contraindications for ampicillin are the same as for other pencillins. It is irrational to use ampicillin in staphylococcal infections and caution is required in case of impaired liver function.

Attention! This material is for informational purposes only. Before using any methods and means of treatment, it is recommended to consult a doctor!

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Amoxicillin belongs to the penicillin family and remains the most commonly prescribed antibiotic in America. This semisynthetic analog of ampicillin treats a wide variety of bacteria. Amoxicillin should not be prescribed for the typical sore throat associated with the common cold.

Amoxicillin with its superior absorption and slightly greater spectrum of activity has largely replaced ampicillin. The drug kills bacteria by interfering with synthesis of their cell wall and by forming free radicals. Most routinely prescribed antibiotics only inhibit growth of microorganisms and require the immune system to complete their removal.

Side effects associated with amoxicillin tend to be relatively mild and prominently include a skin rash and alteration of the intestinal flora which may lead to abdominal upset and diarrhea. Those allergic to penicillin will be allergic to amoxicillin. However a skin rash due to exposure to amoxicillin does not necessarily indicate a penicillin allergy.

Amoxicillin is one of several antibiotics on the American Heart Association list of antibiotics helpful in preventing heart problems due to dental manipulations in susceptible individuals. Amoxicillin also is included in a four drug combination meant to eradicate H. pylori, the bacterium associated with intestinal ulcers.

Ampicillin

Generic Name: ampicillin

Trade Name: Principen

Indication: skin infections, soft tissue infections, otitis media, sinusitis, respiratory infections, GU infections, meningitis, septicemia

Action: bactericidal, broader spectrum than penicillin, binds to cell wall leading to bacterial cell death

Therapeutic Class: anti-infective

Pharmacologic Class: aminopenicillin

Nursing Considerations
 contraindicated in penicillin allergy, use caution in renal insufficiency
 may lead to seizures, diarrhea, anaphylaxes, super infection
 assess for infection
 monitor liver function tests
 instruct patient on signs of super infection: fury over growth on tongue, vaginal itching, loose and foul smelling stool
 pt should not use with oral contraceptive use.

Ampicillin is an antibiotic medication belonging to the penicillin class. It works by inhibiting the growth of bacteria and is used to treat a variety of bacterial infections. Ampicillin is effective against many different types of bacteria and is commonly prescribed for various infections.

Video Content:
0:00 Ampicillin capsules
0:22 Indications
0:44 How to use
1:13 Contraindications
1:34 Warnings
1:57 Side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

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In this video, we'll be discussing the powerful antibiotic Ampicillin and all you need to know about it. We'll cover everything from the dosage to the mechanism of action, side effects, and expert tips for taking it safely and effectively.

First, we'll delve into the mechanism of action of Ampicillin. We'll explain how it works to inhibit the synthesis of bacterial cell walls and weaken the bacterial cell wall, making it more susceptible to damage and eventually death. We'll also cover the types of bacteria that Ampicillin is effective against, and the limitations of its effectiveness in certain cases.

Next, we'll talk about the dosage of Ampicillin. We'll go over the recommended dosage for different types of infections, and how to take it on an empty stomach to ensure optimal absorption. We'll also discuss the importance of finishing the full course of Ampicillin, even if you start feeling better.

After that, we'll cover the potential side effects of Ampicillin. We'll discuss the common side effects, such as nausea, vomiting, and diarrhea, as well as less common but more serious side effects, such as severe skin reactions and anaphylaxis. We'll also provide tips on how to manage these side effects and when to seek medical attention.

Lastly, we'll provide expert tips on taking Ampicillin safely and effectively. We'll discuss the importance of informing your healthcare provider of any allergies or medical conditions, using caution when driving or operating machinery, and staying hydrated while taking the medication.

In summary, this video is a comprehensive guide to Ampicillin, covering everything from its mechanism of action to its dosage, side effects, and expert tips. Whether you're currently taking Ampicillin or considering it as a treatment option, this video is a must-watch to ensure that you are taking the medication safely and effectively.

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Discover how ampicillin, a powerful antibiotic, can be your best ally against various bacterial infections. In this video, we explain how it works by preventing bacterial growth and damaging the cell walls of bacteria. In addition, we highlight the importance of following the dosage prescribed by the doctor and completing the treatment to ensure the complete eradication of bacteria. Don't miss this crucial information for your health.

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