चिंता तनाव से छुटकारा | Desvenlafaxine Tablet Uses, Dose & Side Effects In Hindi
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00:00 - what is Desvenlafaxine Khedezla - Pristiq / Desvenlafaxine Khedezla - Pristiq pharmacological category

00:05 - what is the USFDA approved indication for Desvenlafaxine Khedezla - Pristiq / labeled indication for Desvenlafaxine Khedezla - Pristiq

00:10 - what are off label uses of Desvenlafaxine Khedezla - Pristiq / off label uses of Desvenlafaxine Khedezla - Pristiq / can Desvenlafaxine Khedezla - Pristiq treat hot flashes

00:19 - what is US BOXED warning for Desvenlafaxine Khedezla - Pristiq / can Desvenlafaxine Khedezla - Pristiq cause suicidal deaths




Major depressive disorder
Vasomotor symptoms associated with menopause
Desvenlafaxine
Khedezla - Pristiq
Brand Names: Canada
AG-Desvenlafaxine; APO-Desvenlafaxine; APO-Desvenlafaxine ER; JAMP-Desvenlafaxine; Pristiq; PRO-Desvenlafaxine; TEVA-Desvenlafaxine

Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor

US Boxed Warning
​Suicidal thoughts and behavior:
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behaviors with antidepressant use in adults older than 24 years; there was a reduction in risk with antidepressant use in adults 65 years and older. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. Desvenlafaxine is not approved for use in pediatric patients.

Serotonin-noradrenaline reuptake inhibitors (SNRIs) are medications that are evidence-based in the treatment of depression, anxiety, panic disorder and some other mood disorders.
#antidepressants #venlafaxine #duloxetine #snris #milnacipran #pristiq #desvenlafaxine

They block the reuptake of serotonin and norepinephrine, two neurotransmitters released by the presynaptic neurons.

SNRIs are dual-action antidepressants as they increase NA and 5HT in the synapse. SSRIs only increase 5HT.
Although being a dual-action agent increasing 5HT & NA they have a 3rd action on DA in the prefrontal cortex (PFC) but NOWHERE else in the brain.

So they’re not FULL triple-action agents since they do not inhibit the DA transport DAT, but SNRIs can perhaps be considered to have 2.5 actions, rather than just two.
In the PFC, SERTs and NATs are abundant on 5HT & NA nerve terminals but there are very few DATs on dopamine nerve terminals in this part of the brain. NAT performs the role of DAT in the PFC.
Therefore, NAT inhibition also enhances DA levels and increases DA’s diffusion radius.
SNRIs:
Duloxetine
Venlafaxine
Desvenlafaxine
Milnacipran

Side effects:
GI side effects 10%-30%
Weight gain- less than 10%
Sexual dysfunction - less than 30%
Anticholinergic -10%-30%
CNS activation - 10%-30%

Serotonin-Norepinephrine Reuptake Inhibitors, or SNRIs, are a common treatment for depression and a variety of other ailments like anxiety disorders and chronic pain. In this video, I discuss how SNRIs work in the brain and how they are proposed to be able to treat the symptoms of depression.

TRANSCRIPT:

Serotonin-norepinephrine reuptake inhibitors, or SNRIs, first appeared on the market in 1993 with the introduction of venlafaxine. Several others, like duloxetine, would be introduced in the following decades. Most SNRIs were primarily developed for the treatment of depression, but some are now also used to treat a variety of other conditions like anxiety and chronic pain. The development of SNRIs was guided by research that suggests neurotransmitters like serotonin and norepinephrine play a role in depression. Specifically, this research suggests that low levels of these neurotransmitters might contribute to the symptoms of depression.

SNRIs work primarily by inhibiting a mechanism called reuptake. In reuptake, a protein called a transporter transports excess neurotransmitter molecules out of the synaptic cleft, typically back into the neuron that released them. SNRIs inhibit the reuptake of serotonin and norepinephrine. When the removal of serotonin and norepinephrine from the synaptic cleft is inhibited, this causes levels of these neurotransmitters in the synaptic cleft to rise. These increases in serotonin and norepinephrine levels have been hypothesized to be the mechanism by which SNRIs can treat the symptoms of depression. It should be noted, however, that research suggests the neurobiological mechanism of depression is more complex than a simple neurotransmitter deficiency. Thus, it may be that increasing serotonin and norepinephrine levels leads to other effects that can alleviate the symptoms of depression, or that the drugs have other mechanisms that contribute to their effectiveness.

Studies have found SNRIs to be comparable to other popular antidepressants, like SSRIs, in terms of effectiveness. SNRIS are also generally well-tolerated, with problems like nausea, sweating, and loss of appetite being some of the commonly reported side effects---although different snri drugs have different side effect profiles.

REFERENCES:

Brunello N, Mendlewicz J, Kasper S, Leonard B, Montgomery S, Nelson J, Paykel E, Versiani M, Racagni G. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol. 2002 Oct;12(5):461-75. doi: 10.1016/s0924-977x(02)00057-3. PMID: 12208564.

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018 Apr 7;391(10128):1357-1366. doi: 10.1016/S0140-6736(17)32802-7. Epub 2018 Feb 21. PMID: 29477251; PMCID: PMC5889788.

Hillhouse TM, Porter JH. A brief history of the development of antidepressant drugs: from monoamines to glutamate. Exp Clin Psychopharmacol. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. PMID: 25643025; PMCID: PMC4428540.

Lambert O, Bourin M. SNRIs: mechanism of action and clinical features. Expert Rev Neurother. 2002 Nov;2(6):849-58. doi: 10.1586/14737175.2.6.849. PMID: 19810918.
Sansone RA, Sansone LA. Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison. Innov Clin Neurosci. 2014 Mar;11(3-4):37-42. PMID: 24800132; PMCID: PMC4008300.

Here’s how to manage the tricky process... #Pristiq #lexapro #effexor #psychiatricmedications #medicationtaper #respondingtoquestions #askmequestions

Hello! My name is Bri and I, like many others, am trying to get my mental health in order.
I struggle with anxiety, depression, and PTSD.

What this video is about:
My introduction to YouTube and talking about my first four weeks on a new medication: Pristiq (desvenlafaxine).
This is a neutral review so far, as I have yet to feel the benefits. I talk about initial side effects and things I struggle with.

Intro: 0:00
Diagnosis: 0:32
Symptoms: 1:32
Let Me Be Honest: 2:30
Initial Side Effects: 3:00
How I Feel Right Now: 3:55
Why I am Making This Now: 4:30
You Are Not Alone: 4:57
Keep Fighting: 5:35
Thank You for Inspiration: 6:13
There is Hope: 6:56

I hope this is helpful to you an someway, and I hope you’ll join me as I check in with updates on how I’m feeling.

All of the things said are personal opinion, and you should always talk to your doctor with questions regards medication and mental health.

Thank you so much for watching!

#mentalhealthawarness #medication