Fatal Side Effects

I was on Olanzapine (Zyprexa) 💊 for two years!
I was on Olanzapine (Zyprexa) 💊 for two years! Side Effects 3 Views • 5 months ago

In this video, I discuss my horrific experience with Olanzapine, an atypical antipsychotic drug I never should have been prescribed (I never presented with psychoses).

Hopefully, you won't have to endure what I endured.

**MEDICAL DISCLAIMER: This video documents my own personal experience with Olanzapine, so it's important to remember that everyone's situation is different, and that viewers should consult with their mental health professional before making any decisions about medication. Nothing in this video is intended to be taken as medical advice**.

0:19 - What is Olanzapine/Zyprexa?
0:22 - What is Olanzapine prescribed for?
0:35 - My dosage.
1:05 - I presented with mood disorders.
1:15 - Why was I prescribed Olanzapine?
1:26 - Damaging side effects.
2:34 - Weight gain.
3:04 - I have medical records documenting all of the side effects.
3:29 - My opinion of Olanzapine.
3:34 - Olanzapine posed some serious risks to my physical health.
4:46 - Have you been prescribed Olanzapine?
4:50 - The 'potential' side effects.
4:55 - My Consultant Psychiatrist.
5:10 - "This is your GP's problem".
5:17 - A mental health professional's role.
5:43 - Withdrawal from Olanzapine.
6:02 - Why did my mental health get worse?
6:14 - Antipsychotic drug withdrawal syndrome.
6:24 - Off Olanzapine for almost a year.
7:10 - Anxiety, depression and dissociation.

All of the metabolic side effects I experienced:
*[8-11 not mentioned in video]*.

1. Weight gain.
2. Bloating.
3. Elevated cholesterol (8.5 per mmol/L).
4. Fatty liver (steatosis).
5. Libido problems.
6. Acid reflux/heartburn.
7. Severe adverse reactions to alcohol.
8. Waking up with bile and choking.
9. Shortness of breath.
10. Difficulty swallowing.
11. Gagging, after eating too fast.

I also was terrible at managing my finances during my time on Olanzapine - I've never experienced that kind of carelessness otherwise.

{Also to note, after discontinuing Olanzapine, my mental health took a severe downturn, leading to a period of intense suicidality, which lasted for the initial three weeks that followed}.


Relevant articles:

Fitzgerald I, O'Dwyer S, Brooks M, Sahm L, Crowley (2021). Worth the Weight? Olanzapine Prescribing in Schizophrenia. A Review of Weight Gain and Other Cardiometabolic Side Effects of Olanzapine
https://www.frontiersin.org/ar....ticles/10.3389/fpsyt

Li R, Zhu W, Huang P, Yang Y, Luo F, Dai W, Shen L, Pei W, Huang X, (2021).
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway
https://www.sciencedirect.com/....science/article/pii/

Berenson, A (2007). Lilly Adds Strong Warning Label to Zyprexa, a Schizophrenia Drug
https://www.nytimes.com/2007/1....0/06/business/06zypr

Simons, P (2020). Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain
https://www.madinamerica.com/2....020/07/randomized-co

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2D structure of antipsychotic drug olanzapine (original brand name Zyprexa)—a thienobenzodiazepine derivative.
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Report: Lilly Hid Info On Zyprexa.
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Please like, comment and share - let's spread some awareness, and save someone else from suffering the same fate.

#olanzapine #zyprexa #antipsychoticdrugreview #mentalhealthawareness #mentalhealth #mentalhealthmatters

Thank you for watching this video.
John O'Rourke, June 22nd, 2023.

@JohnzyZombee

Copyright © 2023 John O'Rourke. All rights reserved.

Common Antipsychotic withdrawal symptoms! And how to Avoid!!
Common Antipsychotic withdrawal symptoms! And how to Avoid!! Side Effects 3 Views • 5 months ago

Thanks for watching Mental Health with Jeremy! I hope i have helped you in your Mental Health journey! Subscribe for more Mental Health and Disorder videos!

Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis, principally in schizophrenia but also in a range of other psychotic disorders

Common Side Effects: Drowsiness, weight gain, dry mouth, stomach upset, QTc interval prolongation, restlessness, dystonia (uncontrollable muscle contractions), tardive dyskinesia (repetitive, involuntary movements), parkinsonism (slowness, stiffness, and tremor), neuroleptic malignant syndrome (rare, but fatal), and seizures.

Huntington disease, Parkinson disease, Lesch-Nyhan syndrome, pervasive developmental disorder are some other conditions where antipsychotics are an option though it is not the primary drug of choice.

First-Generation Antipsychotics:

All dopamine receptor antagonists are available and can be administered in oral form. Except for thioridazine, pimozide, and molindone, all other first-generation antipsychotics can also be given parenterally. Haloperidol and fluphenazine can be delivered in long-acting depot parenteral form.

Second-Generation Antipsychotics:

These can be administered in oral or parenteral forms. Risperidone, olanzapine, aripiprazole, and paliperidone are available as extended-release or long-acting injectable forms. Clozapine, asenapine, and olanzapine are available in the sublingual formulation.




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Olanzapine Pamoate [Olanzapine Long-Acting Injectable] Olanzapine Depot
Olanzapine Pamoate [Olanzapine Long-Acting Injectable] Olanzapine Depot Side Effects 3 Views • 5 months ago

Olanzapine Pamoate [Olanzapine Long-Acting Injectable] Olanzapine Depot

Long-acting Olanzapine pamoate is a significant advancement in the treatment of psychotic disorders, offering the benefits of extended therapeutic effects and improved patient adherence. This essay provides an in-depth exploration of the pharmacological properties of Olanzapine pamoate, its administration methods, recommended dosing frequency, and its clinical application in the context of psychotic disorders.

Pharmacological Properties

Olanzapine pamoate is a long-acting injectable antipsychotic medication, which provides a depot formulation of Olanzapine. Olanzapine is a second-generation (atypical) antipsychotic medication known for its effectiveness in treating schizophrenia and bipolar disorder. The pharmacological properties of Olanzapine pamoate include:

Extended Half-Life: The depot formulation of Olanzapine pamoate provides an extended half-life, ranging from 21 to 30 days. This prolonged duration of action reduces the frequency of administration and allows for a more stable pharmacokinetic profile.

Mechanism of Action: Olanzapine, the active component released from Olanzapine pamoate, exerts its antipsychotic effects by antagonizing multiple receptors, including dopamine D2, serotonin 5-HT2A, histamine H1, and alpha-1 adrenergic receptors. This broad receptor profile contributes to its efficacy in managing positive and negative symptoms of psychosis.

Administration and Frequency

Olanzapine pamoate is administered through intramuscular injection, typically into the gluteal muscle. The frequency of administration is determined by several factors, including the patient's clinical condition, response to treatment, and the specific indication. Common dosing schedules for Olanzapine pamoate include:

Initial Dosing Phase: The treatment typically begins with a loading dose, given to achieve a therapeutic level of Olanzapine quickly. This initial loading dose generally ranges from 150 mg to 405 mg, divided into two separate injections on the first day. Subsequent injections during this phase may occur every two to four weeks.

Maintenance Dosing: Following the initial dosing phase, patients receive maintenance injections every two to four weeks, depending on the patient's clinical response and side effect profile. These injections can range from 150 mg to 300 mg, with a typical starting dose of 150 mg per month.

Response Assessment: Regular monitoring of the patient's clinical response and side effects is vital. Dosing adjustments can be made to optimize the therapeutic effect while minimizing side effects. The flexibility in dosing frequency allows for a personalized approach to treatment.

Dosing and Titration

The determination of the appropriate dosage of Olanzapine pamoate involves careful consideration of several factors:

Symptom Severity: Patients with severe or acute psychotic symptoms may require a higher initial loading dose to achieve a rapid therapeutic effect. The maintenance dose can be adjusted as needed once symptoms are controlled.

Individual Response: Patient-specific factors, including metabolism, drug sensitivity, and the presence of comorbid conditions, can influence the optimal dosage. Some individuals may respond well to lower doses, while others may require higher doses to achieve therapeutic benefit.

Clinical Application

Olanzapine pamoate has been clinically proven as an effective treatment for schizophrenia and related psychotic disorders. Its extended therapeutic effect, combined with the reduced frequency of administration, can lead to improved treatment adherence and enhanced symptom control. Some of the clinical applications of Olanzapine pamoate include:

Relapse Prevention: Olanzapine pamoate is valuable in preventing relapse in patients of schizophrenia, bipolar, and psychotic patients who have previously responded well to Olanzapine or other antipsychotic medications. It is especially useful for patients at risk of discontinuing oral antipsychotics due to non-adherence..

Long-acting Olanzapine pamoate is a significant advancement in the treatment of psychotic disorders, offering the advantages of extended therapeutic effects, reduced reliance on daily medication regimens, and improved patient adherence. Its pharmacological properties, including a gradual and steady release of Olanzapine and an extended half-life, contribute to its clinical efficacy.

The dosing frequency can be individualized to meet the specific clinical requirements of each patient, allowing for a personalized approach to treatment. Regular monitoring of the patient's clinical response and side effects is essential to optimize treatment outcomes. While Olanzapine pamoate is not without potential side effects, its advantages in terms of extended therapeutic effect make it a valuable addition to contemporary psychiatric practice.

Olanzapine (Zyprexa) : Meds Made Easy (MME)
Olanzapine (Zyprexa) : Meds Made Easy (MME) Side Effects 2 Views • 5 months ago

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Olanzapine tablet | Olanzapine | Olanzapine 10 mg | Olanzapine side effects | olanzapine dosage
Olanzapine tablet | Olanzapine | Olanzapine 10 mg | Olanzapine side effects | olanzapine dosage Side Effects 3 Views • 5 months ago

Olanzapine tablet Part - 1 :- https://youtu.be/7XrFrgsOwDY
Paroxetine capsule :- https://youtu.be/qTAqUFfO-Os

00:06 what is in this video?
01:26 olanzapine tablet side effects
02:28 olanzapine tablet dosage | Olanzapine dosage
03:40 Olanzapine overdose | Olanzapine tablet overdose
04:50 Olanzapine interaction | Olanzapine tablet drug interaction
05:25 Olanzapine withdrawal syndrome | Olanzapine withdrawal
06:15 how to discontinue Olanzapine tablet? | how to quit olanzapine tablet

Olanzapine is an antipsychotic medicine and belongs to atypical antipsychotic class. Olanzapine tablet is used to treat many mental disorders in adult and children above 13 years of age.

Olanzapine tablet side effects are

1. Dizziness
2. Weight gain
3. Feeling tired
4. Constipation
5. Dry mouth
6. High blood sugar
7. Change in walking
8. Difficulty with speaking
9. Difficulty to swallow
10. Seizure
11. Gyneacomestia
12. Erectile dysfunction

Olanzapine overdose symptoms

1. Increased heart rate
2. Agitation
3. Problem in speaking
4. Problem in hearing
5. Unconsciousness
6. Coma
7. Death

Olanzapine interaction | olanzapine drug interaction

1. Aripiprazole
2. Lorazepam
3. Citalopram
4. Codien
5. Duloxetin
6. Divalprox sodium
7. Diazepam
8. Fluoxetine
9. Clonazepam
10. Escitalopram
11. Pregabalin
12. Lithium
13. Metoprolol
14. Tramadol

Olanzapine tablet withdrawal syndrome are

1. Nausea
2. Vomiting
3. Loss of appetite
4. Restlessness
5. Increase sweating
6. Trouble in sleep
7. World spinning
8. Muscle pain
9. Numbness

We also discuss about olanzapine tablet | oleanz tablet
Olanzapine side effects
Olanzapine dosage
Olanzapine overdose
Olanzapine interaction
Olanzapine withdrawal syndrome and many more in hindi

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Related topic covered are: -
1. What is olanzapine tablets used for?
2. Is olanzapine a sleeping pill?
3. What does olanzapine do to the brain?
4. Olanzapine for sleep
5. Olanzapine dosage
6. Olanzapine overdose
7. Olanzapine interaction

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#oleanz
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ZYPREXA  -  - Generic Name , Brand Names, How to use, Precautions, Side Effects
ZYPREXA - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 5 Views • 5 months ago

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olanzapine review | Olanzapine side effects | Olanzapine uses in Hindi
olanzapine review | Olanzapine side effects | Olanzapine uses in Hindi Side Effects 3 Views • 5 months ago

olanzapine review | Olanzapine side effects | Olanzapine uses in Hindi - This lecture explains olanzapine review | Olanzapine side effects | Olanzapine uses in Hindi.
In this video, we'll review olanzapine, its side effects, and its uses in Hindi. We'll also discuss the common concern of weight gain associated with this medication.

If you or your loved one is taking olanzapine, it's important to be aware of potential side effects and how to manage them. We'll go over all the important information you need to know about this medication in a simple and easy-to-understand way. Don't forget to like and subscribe for more helpful videos on mental health!

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IM olanzapine for agitation associated with schizophrenia - video abstract [147124]
IM olanzapine for agitation associated with schizophrenia - video abstract [147124] Side Effects 3 Views • 5 months ago

Video abstract of original research paper "Safety and effectiveness of rapid-acting intramuscular olanzapine for agitation associated with schizophrenia – Japan postmarketing surveillance study" published in the open access journal Neuropsychiatric Disease and Treatment by Katagiri H, Taketsuna M, Kondo S, et al.

Objective: The objective of this study was to evaluate the safety and effectiveness of rapid-acting intramuscular (IM) olanzapine in the treatment of acute agitation associated with schizophrenia in real-world clinical settings in Japan.

Methods: In this multicenter, postmarketing surveillance (PMS) study, patients with acute agitation associated with schizophrenia were treated with IM olanzapine daily in a daily clinical setting. The observational period ranged from 1 to 7 days, including the day of initial administration. Safety was assessed by reporting treatment-emergent adverse events (TEAEs) and adverse drug reactions (ADRs). The Positive and Negative Syndrome Scale – Excited Component (PANSS-EC) score was used to evaluate effectiveness at baseline and at 2 hours (after each administration), 2 days, and 3 days (end of the observational period) from the last administration of the IM olanzapine injection.

Results: The safety analysis set included 999 patients, and the initial dose of 10 mg was administered to 955 patients. TEAEs were reported in 28 patients (36 events), the most common of which were dyslalia (5 patients), akathisia and somnolence (4 patients each), hepatic function abnormal (3 patients), and constipation and dehydration (2 patients each). One serious adverse event of akathisia occurred during the observation period. The PANSS-EC score (mean ± standard deviation) was 23.3±6.4 (n=625) at baseline, 16.9±7.0 (n=522) at 2 hours after initial injection, and 14.9±6.5 (n=650) at the last observation carried forward.

Conclusion: The results of this Japanese PMS study demonstrated that IM olanzapine is safe and has a favorable effectiveness profile in the treatment of schizophrenia patients with acute agitation.

Read the full paper here:
https://www.dovepress.com/safe....ty-and-effectiveness

Treating Antipsychotic Induced Weight Gain (3 BEST Medications Revealed)
Treating Antipsychotic Induced Weight Gain (3 BEST Medications Revealed) Side Effects 2 Views • 5 months ago

Dr. Aly (psychiatrist) discusses the most commonly used medications to combat antipsychotic-induced weight gain ***Link to Dr. Aly's FREE PDF on the medications discussed in this video ➡️ https://free.dralywood.com/antipsychoticweightgain

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New hope to cut weight gain side effect of anti-psychotic drugs | 7 News Australia
New hope to cut weight gain side effect of anti-psychotic drugs | 7 News Australia Side Effects 4 Views • 5 months ago

Medication to manage mental health often comes with an unwelcome side effect, weight gain.

Local scientists say they have found a way to solve that problem while also making the drugs more effective.

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FDA Panel Gives Qualified Okay to Depot Olanzapine (Zyprexa)
FDA Panel Gives Qualified Okay to Depot Olanzapine (Zyprexa) Side Effects 2 Views • 5 months ago

http://www.medpagetoday.com

SILVER SPRING, Md. -- Despite qualms over a rare but potentially serious side effect of a depot formulation of olanzapine (Zyprexa), FDA advisers today recommended approval of the new version for schizophrenia.

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Effects of switch from olanzapine to aripiprazole in schizophrenia – Video abstract [ID 80925]
Effects of switch from olanzapine to aripiprazole in schizophrenia – Video abstract [ID 80925] Side Effects 4 Views • 5 months ago

Video abstract of an original research paper “Effects of switching from olanzapine to aripiprazole on the metabolic profiles of patients with schizophrenia and metabolic syndrome: a randomized, open-label study” published in the open access Neuropsychiatric Disease and Treatment journal by Wani RA, Dar MA, Chandel RK, et al.

Background: Patients with schizophrenia suffer high rates of metabolic derangements on some antipsychotic medications that predispose them to cardiovascular diseases. Keeping this fact in mind, we planned this open-label study to see the effect on various metabolic parameters after switching stable schizophrenia subjects, who had developed metabolic syndrome on olanzapine, to aripiprazole.

Methods: Sixty-two patients with schizophrenia who were stable on olanzapine and were fulfilling modified National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III) criteria for the presence of metabolic syndrome were enrolled on the study. Patients were randomly assigned either to switch to aripiprazole or to stay on olanzapine, on a 1:1 basis. Cross-tapering over a period of 1 month was done while switching patients to aripiprazole. Laboratory assessment for metabolic parameters was done at baseline, 8 weeks, and 24 weeks after enrollment; efficacy assessment was done using the Positive and Negative Syndrome Scale (PANSS) at baseline and 24 weeks, the Clinical Global Impressions severity subscale (CGI-S) at baseline, and the Clinical Global Impressions improvement subscale (CGI-I) at 24 weeks.

Results: All parameters of metabolic syndrome (waist circumference, blood pressure, triglyceride level, fasting blood glucose, and high-density lipoprotein cholesterol) kept deteriorating in the stay group, compared with a continuous improvement in the switch group over time. At the end of the study, 26 patients (100%) from the stay group and 15 patients (42.8%) from switch group met the modified NCEP ATP-III criteria for presence of metabolic syndrome (P less than 0.001). There were no statistically significant differences between groups in psychopathology changes as measured by the PANSS total score and CGI-I scores.

Conclusion: Clinically stable patients with schizophrenia who are taking olanzapine and who have evidence of metabolic syndrome can be successfully switched to aripiprazole, with improvement in various parameters of metabolic syndrome and without any significant change in efficacy measures.

Read the original research paper here:
http://www.dovepress.com/effec....ts-of-switching-from

Withdrawal from Psych Drugs —  UCLA Professor David Cohen, PhD
Withdrawal from Psych Drugs — UCLA Professor David Cohen, PhD Side Effects 1 Views • 5 months ago

For more information, including links to the scientific evidence base for the statements in this video, as well as further resources: http://medicatingnormal.com/

Biography of David Cohen, PhD: https://luskin.ucla.edu/person/david-cohen/

Your Drug May Be Your Problem: How and Why to Stop Taking Psychiatric Medications by Peter Breggin and David Cohen: https://amzn.to/2TpnuQr

“The Challenge of Going Off Psychiatric Drugs” in The New Yorker: https://bit.ly/2HYjEtT

“How to Quit Antidepressants: Very Slowly, Doctors Say” in the New York Times: https://nyti.ms/2SMXFYy

Mad in America has a number of resources regarding psychiatric drug withdrawal: https://www.madinamerica.com/d....rug-withdrawal-resou

Medicating Normal on Facebook: https://www.facebook.com/pg/medicatingnormalfilm/

Medicating Normal on Twitter: https://twitter.com/medicatingnorm1?lang=en

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Note: This video does not constitute medical advice. Stopping psychiatric drugs, especially abruptly, can be dangerous, as withdrawal effects may be severe, disabling or even life-threatening.

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Video edited by Daniel Mackler

Olanzapine (Zyprexa) Nursing Drug Card (Simplified) - Pharmacology
Olanzapine (Zyprexa) Nursing Drug Card (Simplified) - Pharmacology Side Effects 1 Views • 5 months ago

NCLEX Review: Olanzapine (Atypical Antipsychotic) - Mechanism of Action, Uses, Side effects, Contraindications, and Nursing considerations


Action: 0:18
Uses: 2:09
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Contraindications: 4:08
Nursing considerations: 5:09

To understand “off-label” uses, click here:
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Symptoms of schizophrenia image: cindydchung.com/verywell

Brain image: frontiersin.org - Cerebrovascular and Neurodegenerative Diseases - New Insights into Molecular Cell Biology and Therapeutic Targets

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6.14. An Antiviral Arms-Race: Acyclovir, Oseltamivir & More
6.14. An Antiviral Arms-Race: Acyclovir, Oseltamivir & More Side Effects 3 Views • 5 months ago

The timely choice of the right antiviral isn't just a treatment decision—it's a critical turning point for patient outcomes. In this clinical review, we provide a clear and concise guide to mastering the use of essential antiviral agents in your practice.

We cover the core principles of antiviral stewardship, emphasizing when to treat and, just as importantly, when to stop. Explore the key indications for our most common antiviral families, including Acyclovir/Valacyclovir for HSV and VZV, Oseltamivir for influenza, and Ganciclovir for CMV in immunocompromised patients.

Through practical clinical scenarios, we'll compare dosing strategies for conditions like shingles versus life-threatening HSV encephalitis. We also navigate the most important side effects to monitor, such as Acyclovir-induced neurotoxicity and renal toxicity, and discuss crucial considerations for special populations, including pregnancy. Finally, we'll break down the clinical pathway for managing antiviral resistance when first-line therapies like Acyclovir fail.

🕒 Timestamps:
00:00 - Intro: A Turning Point for Patient Outcomes
00:49 - Chapter 1: Principles of Use (Judicious Prescribing)
01:35 - Chapter 2: Key Indications (Agent to Pathogen)
02:12 - Chapter 3: Dosing & Clinical Cases
03:15 - Chapter 4: Side Effects & Complications
04:09 - Chapter 5: Special Populations (Pregnancy & High-Risk)
05:12 - Chapter 6: Resistance & Clinical Challenges

Sources:
This video was made with Gemini's deep research capabilities and NotebookLM.

Disclaimer: This video is for educational and informational purposes only and is not intended as medical advice. The content is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Tags & Hashtags:
#Antiviral #Pharmacology #Acyclovir #Valacyclovir #Oseltamivir #Tamiflu #Influenza #Herpes #Shingles #InfectiousDisease #Virology #MedicalEducation #ClinicalPharmacy #MedStudent #AntiviralResistance

Acyclovir cream / Acivir cream uses, side effects LEARN ABOUT MEDICINE
Acyclovir cream / Acivir cream uses, side effects LEARN ABOUT MEDICINE Side Effects 4 Views • 5 months ago

Watch this video in English language: - https://youtu.be/A-RZLwOcNLk

Acyclovir cream / Aciclovir cream is an antiviral cream used in the treatment of herpes virus infection like herpes zoster, genetial herpes, cold sores, blister on lip, chickenpox etc..
Acyclovir cream brand names are
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ACYCLOVIR, What is acyclovir used for, Acyclovir (ZOVIRAX, SITAVIG) review
ACYCLOVIR, What is acyclovir used for, Acyclovir (ZOVIRAX, SITAVIG) review Side Effects 2 Views • 5 months ago

Acyclovir review, aciclovir: What is acyclovir, what is acyclovir used for, acyclovir uses, acyclovir dosage, acyclovir side effects,acyclovir moa, acyclovir brand names: Sitavig, Zovirax Capsules, Zovirax tablets.

What is acyclovir? and What is acyclovir used for?

Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time).
Acyclovir is also sometimes used to prevent outbreaks of genital herpes in people who are infected with the virus.
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body.
Acyclovir will not cure genital herpes and may not stop the spread of genital herpes to other people.


How to use acyclovir?

Acyclovir comes as a tablet, a capsule, and a suspension (liquid) to take by mouth. It also comes as a delayed-release buccal tablet to apply to the upper gum of the mouth.
The tablets, capsules, and suspension are usually taken with or without food two to five times a day for 5 to 10 days, starting as soon as possible after your symptoms begin.
When acyclovir is used to prevent outbreaks of genital herpes, it is usually taken two to five times a day for up to 12 months.
The delayed-release buccal tablet is usually applied with a dry finger as a one-time dose within 1 hour after itching, redness, burning or tingling cold sore symptoms begin but before the cold sore appears.
Take or use acyclovir at around the same time(s) every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take or use acyclovir exactly as directed.
Do not take or use more or less of it or take it more often or for a longer time than prescribed by your doctor.

Do not chew, crush, suck, or swallow the delayed-release buccal tablets. Drink plenty of liquids, if you have a dry mouth while using the delayed-release buccal tablets.

To use buccal acyclovir, follow these steps:

Find the area on the upper gum above your left and right incisor teeth (the teeth just to the left and right of your two front teeth).

With dry hands, remove one delayed-release tablet from the container.

Gently apply the tablet to the upper gum area as high as it will go on your gum above one of your incisor teeth on the side of your mouth with the cold sore. Do not apply it to the inside of the lip or cheek.

Hold the tablet in place for 30 seconds.

If the tablet does not stick to your gum or if it sticks to your cheek or the inside of your lip, reposition it to stick to your gum.
Leave the tablet in place until it dissolves.

Do not interfere with the placement of the tablet.
Check to see if the tablet is still in place after eating, drinking, or rinsing your mouth.

If the delayed-release buccal tablet comes off within the first 6 hours of application, reapply the same tablet.
If it still will not stick, then apply a new tablet. If you accidentally swallow the tablet within the first 6 hours of application, drink a glass of water and place a new tablet on your gum. If the tablet falls off or is swallowed 6 or more hours after application, do not apply a new tablet until your next regular time.

Avoid the following while you are using acyclovir buccal delayed-release tablet:

Do not chew gum, touch, or press the buccal tablet after it has been applied.
Do not wear upper dentures.
Do not brush your teeth until it dissolves. If your teeth need to be cleaned while the tablet is in place, rinse the mouth gently.

Shake the suspension well before each use to mix the medication evenly.

Your symptoms should improve during your treatment with acyclovir.
Call your doctor if your symptoms do not improve or if they get worse.

Take or use acyclovir until you finish the prescription, even if you feel better. If you stop taking acyclovir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat.
The delayed-release buccal tablet is applied as a one-time dose.


Acyclovir may cause side effects.
Tell your doctor if any of these symptoms are severe or do not go away:

upset stomach.
vomiting.
diarrhea.
dizziness.
tiredness.
agitation.

Anti-Herpetic Drugs - Side Effects and Resistance
Anti-Herpetic Drugs - Side Effects and Resistance Side Effects 2 Views • 5 months ago

Side effects of anti-herpetic drugs (acyclovir, ganciclovir, etc) include renal toxicity, neutropenia, anemia, and thrombocytopenia. If resistance develops, foscarnet or cidofovir can be used but they are more toxic. For more videos and questions, visit - https://www.macrophage.co. Subscribe - https://goo.gl/EMRlRa. Support us on Patreon - https://goo.gl/bhmrgJ.

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Aciclovir Side Effects
Aciclovir Side Effects Side Effects 3 Views • 5 months ago

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Zovirax -  - Generic Name , Brand Names, How to use, Precautions, Side Effects
Zovirax - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 5 months ago

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Generic Name, Brand Names, What is ?,
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Before taking this medicine (Precautions ), How to use ,
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Aciclovir - Pharmacology, Indication, Dosage and Uses, Contraindication and Precaution
Aciclovir - Pharmacology, Indication, Dosage and Uses, Contraindication and Precaution Side Effects 4 Views • 5 months ago

Aciclovir - Pharmacology, Indication, Dosage and Uses, Contraindication and Precaution.

Aciclovir.
Aciclovir (also known as acyclovir) is indeed an antiviral medication commonly used for the treatment of various viral infections. Its primary applications include the treatment of herpes simplex virus infections, chickenpox (varicella-zoster virus), and shingles (herpes zoster). This medication works by inhibiting the replication of the viruses, thereby helping to reduce the severity and duration of these infections.

Pharmacology:
• Aciclovir is a synthetic purine derivative, targeting Herpes simplex virus (HSV) and Varicella zoster virus by hindering DNA synthesis, thus inhibiting viral replication. Its antiviral action relies on intracellular conversion to Aciclovir Triphosphate, primarily facilitated by the virus-coded thymidine kinase. This conversion chain leads to the formation of the pharmacologically active triphosphate form. Percutaneous absorption of Aciclovir is minimal when topically applied to intact skin.

Indications:
• Aciclovir Cream is indicated for treating initial and recurrent labial and genital Herpes simplex infections, with early initiation recommended.
• Acyclovir tablets are indicated for viral infections involving herpes simplex virus (type I & II) and varicella-zoster virus, encompassing herpes zoster, chickenpox, and herpes simplex infections on the skin and mucous membranes, including both initial and recurrent genital herpes. It's also prescribed for prophylaxis in immunocompromised patients.

Dosage and Administration:
• Aciclovir Cream should be applied to affected lesions five times daily for 5-10 days, ensuring cleanliness and dryness. Patients are advised to wear loose-fitting clothing to prevent irritation.
• Acyclovir dosages vary, with oral administration for herpes simplex initial therapy (200mg, 5 times daily for 10 days), herpes simplex chronic suppressive therapy (200-400mg, 2-4 times daily for 12 months), herpes zoster (800mg, 5 times at 4-hour intervals for 7-10 days), and varicella-zoster (20mg/kg, not exceeding 800mg, 4 times daily for 5 days). Dosing is adjusted for children under 2 years and the elderly as required, or as directed by a physician.

Use in Pregnancy and Lactation:
• Both medications have specific considerations during pregnancy and lactation. Aciclovir is pregnancy category B, with caution exercised when used by nursing mothers. Acyclovir should be used during pregnancy when the potential benefit justifies potential fetal risk, and nursing mothers should use it with caution.

Contraindications:
• Aciclovir is contraindicated in patients hypersensitive to the drug, while Acyclovir should be avoided by those who develop hypersensitivity or intolerance to its components.


Precautions:
• Caution is needed when administering Acyclovir to patients with renal impairment, and dosages should be adjusted based on creatinine clearance.

Side Effects:
• Side effects for both medications may include fever, headache, pain, edema, anaphylaxis (rarely), dizziness, somnolence, gastrointestinal symptoms, and more.
• Transient burning or stinging may occur with Aciclovir Cream, and mild skin reactions such as erythema and flaking have been reported.

Storage:
• Store both medications below 25°C, protected from light, and out of the reach of children.

Acyclovir Eye Drops, Eye Ointment Side Effects (Ophthalmic Acyclovir)
Acyclovir Eye Drops, Eye Ointment Side Effects (Ophthalmic Acyclovir) Side Effects 3 Views • 5 months ago

What are the side effects of Acyclovir when it is applied to the eyes as eye drops, or as an eye ointment? The effects of taking ophthalmic Acyclovir are quite minimal, and this video will go through each one, and its incidence in the population.

Also see the side effects of Acyclovir when taken via other routes:

Side Effects of Acyclovir Tablets/Capsules/Suspension (Oral) -
https://www.youtube.com/watch?v=yfMfnyqmPBA
Side Effects of Acyclovir Cream – https://www.youtube.com/watch?v=QjpV4makh98
Side Effects of Acyclovir Injections (Intravenous) - https://www.youtube.com/watch?v=DuH2pCnvlF0

Introduction - 0:11
Common side effects - 0:26 (Over 1% of the population)
Uncommon side effects - 0:36
Final notes: 0:51

Read the full transcript: http://www.pharmacytrust.com/a....cyclovir-opthalmic-s

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This video is a medical not intended to replace professional medical advice. Please contact your healthcare provider with any questions regarding your medicine or condition. Do not disregard professional medical advice or delay seeking it based on information from this content. Relying on information provided in this content is done at your own risk.

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Zovirax (Aciclovir) Tablets/Liquid/Cream
Zovirax (Aciclovir) Tablets/Liquid/Cream Side Effects 2 Views • 5 months ago

Zovirax is used to treat viral infections such as genital herpes (a sexually transmitted infection), cold sores, shingles (sometimes called herpes zoster), and chickenpox. Shingles and chickenpox are caused by the varicella-zoster virus.

If you would like to find out more visit: 
http://www.lynchspharmacy.com/....medicine/zovirax-tab
http://www.lynchspharmacy.com

You can also visit Lynch's Pharmacy in Broadale, Maryborough Hill, Cork.

Please note that this video is meant for educational purposes only, and should not be used as a means to diagnose any health condition. You should always consult your doctor if you have any concerns regarding your health or medication.We are not selling or advertising any product our videos include.

Thank you for watching!

56# Acyclover Zovirax   Uses, Dose, Side effects, Precautions, Indications
56# Acyclover Zovirax Uses, Dose, Side effects, Precautions, Indications Side Effects 3 Views • 5 months ago

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Eszopiclone or Lunesta Medication Information (dosing, side effects, patient counseling)
Eszopiclone or Lunesta Medication Information (dosing, side effects, patient counseling) Side Effects 4 Views • 5 months ago

Your medication Eszopiclone

Eszopiclone is also known by the brand name: Lunesta.
Eszopiclone comes in 1, 2, and 3mg tablets.
Eszopiclone is most commonly used for treating sleep problems. This medication is taken by mouth right before you get into bed. Do not take with or right after a meal.
Standard dosing of eszopiclone ranges from 1mg to 3mg once nightly at bedtime.
The best way to store eszopiclone:
• Store at room temperature.
• Store in a dry place. Do not store in a bathroom or refrigerator.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

Some common side effects with eszopiclone include headache and a foul, salty, or metallic taste sensation that will persist in the mouth.
Some less common side effects include chest pain, drowsiness, dizziness, confusion, abnormal dreams, anxiety, and migraines.
Do not take eszopiclone if you have hypersensitivity to eszopiclone or any component of the formulation.
If you miss a dose of eszopiclone:
• This medication is taken on an as needed basis. Do not take more often than every 24 hours, unless told to do so by your doctor

When taking eszopiclone, remember it is important to tell your doctor or pharmacist if:
• You have signs of an allergic reaction, like rash; hives; itching; blistered, or peeling skin with or without fever
• You have signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life
• You have hallucinations (seeing or hearing things that are not there)
• You have memory problems or loss
• You have very bad dizziness
• You have a change in balance
• You are feeling confused
• You are feeling very tired or weak
• You have a very upset stomach or are throwing up

Using EEG to Evaluate the Behavioral Effects of Benzodiazepines in Rhesus Monkeys
Using EEG to Evaluate the Behavioral Effects of Benzodiazepines in Rhesus Monkeys Side Effects 4 Views • 5 months ago

In this webinar, Lais Berro, PhD presents recent research demonstrating the anxiolytic, sedative and abuse-related effects of benzodiazepine drugs, and how they correlate with telemetry-based EEG recordings in a translational non-human primate model.


Benzodiazepines are known to induce electroencephalography (EEG) changes in rodents and humans that are associated with distinct behavioral effects and have been proposed as quantitative biomarkers for GABAA receptor modulation. Specifically, central EEG beta and occipital EEG delta activity have been associated with anxiolysis and sedation, respectively. The extent to which nonhuman primates show the same dose- and topography-dependent effects remained unknown. Critically, rhesus macaques have been shown recently to share GABAA receptor subtype distributions in the brain that, unlike rodent species, align with human findings.


Lais Berro, PhD recently demonstrated that the benzodiazepine alprazolam induces dose- and topography-dependent EEG spectral power changes in rhesus monkeys. In this webinar, Dr. Berro reviews the main behavioral models used in her laboratory to investigate the anxiolytic, sedative and abuse-related effects of benzodiazepine drugs. She correlates her findings with recent data obtained using telemetry-based EEG recording, with the goal of promoting EEG evaluation in nonhuman primates as a valuable and translational model for studying benzodiazepine pharmacology.


Key Topics Include:
- Gain a conceptual understanding of benzodiazepine pharmacology and GABAA receptor modulation
- Become familiar with the main models used to investigate the behavioral effects of benzodiazepines in nonhuman primates
- Learn the dose- and topography-dependent EEG spectral power changes induced by benzodiazepine drugs across species
- Describe how benzodiazepine-induced EEG changes correlate with the different behavioral effects of these drugs

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