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7. Anti anginal Drugs: Ivabradine & Fasudil: CVS Pharmacology
๐๐๐ผ๐ถ๐ป ๐ข๐๐ฟ ๐ง๐ฒ๐น๐ฒ๐ด๐ฟ๐ฎ๐บ ๐๐ต๐ฎ๐ป๐ป๐ฒ๐น ๐๐ฒ๐ฟ๐ฒ:- https://t.me/bhanuprakashdr
๐ ๐
๐จ๐ฅ๐ฅ๐จ๐ฐ ๐จ๐ง ๐๐ง๐ฌ๐ญ๐๐ ๐ซ๐๐ฆ:- https://www.instagram.com/drgbhanuprakash
๐๐ฆ๐๐ฏ๐๐ฐ๐ฟ๐ถ๐ฏ๐ฒ ๐ง๐ผ ๐ ๐ ๐ ๐ฎ๐ถ๐น๐ถ๐ป๐ด ๐๐ถ๐๐:- https://linktr.ee/DrGBhanuprakash
Anti anginal Drugs: Ivabradine & Fasudil: CVS Pharmacology
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Ivabradine and Fasudil are unique anti-anginal drugs that provide symptomatic relief in ischemic heart disease through distinct mechanisms, making them valuable alternatives to traditional agents like nitrates, beta-blockers, and calcium channel blockers ๐๐. Ivabradine, a selective If (funny current) channel inhibitor, acts on the sinoatrial (SA) node, reducing heart rate (negative chronotropy) without affecting myocardial contractility or blood pressure, thus lowering oxygen demand while preserving cardiac output ๐ซโก.
This makes it especially useful in chronic stable angina and heart failure patients who cannot tolerate beta-blockers due to hypotension or bradycardia โณ๐. It is contraindicated in severe bradycardia, acute decompensated heart failure, and pregnancy โ ๏ธ๐ซ.
Fasudil, on the other hand, is a Rho-kinase inhibitor that works by inhibiting vascular smooth muscle contraction, promoting vasodilation, and preventing coronary artery spasm, making it highly effective in vasospastic (Prinzmetalโs) angina ๐๐ฉธ.
Additionally, Fasudil has neuroprotective effects and is being explored for conditions like stroke, pulmonary hypertension, and Alzheimer's disease ๐ง ๐ฌ. Side effects of Ivabradine include visual disturbances (phosphenes), bradycardia, and atrial fibrillation, while Fasudil may cause hypotension and dizziness ๐จ๐.
Unlike nitrates, both Ivabradine and Fasudil do not cause tolerance, making them suitable for long-term angina management ๐๐ก. These drugs are often used as adjuncts alongside traditional therapies, providing better symptom control and improving exercise tolerance in chronic stable and vasospastic angina ๐โค๏ธ. #Ivabradine #Fasudil
#AntiAnginalDrugs #CVSPharmacology #HeartHealth #AnginaRelief #Cardiology #SinoatrialNode #CoronaryArteryDisease #MedicalScience #USMLE #NEETPG #ChronicStableAngina #VasospasticAngina #PrinzmetalsAngina #SaveHearts #GlobalHealth #CardiacCare #RationalDrugUse #medicalanimations #fmge #fmgevideos #rapidrevisionfmge #fmge2024 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2025 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #usmlestep2videos
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