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Alpha Blockers | Mechanism of Action, Indications, Adverse Reactions, Contraindications
Official Ninja Nerd Website: https://ninjanerd.org
Ninja Nerds!
In this cardiovascular pharmacology lecture, Professor Zach Murphy presents a high-yield breakdown of Alpha Blockers, focusing on their mechanisms of action, therapeutic uses, and side effect profiles in the treatment of cardiovascular and genitourinary conditions.
We begin by reviewing the role of alpha-adrenergic receptors (α₁ and α₂) in regulating vascular tone and sympathetic outflow. From there, we explore how alpha-1 antagonists—such as prazosin, doxazosin, and terazosin—induce vasodilation by blocking α₁ receptors on vascular smooth muscle, leading to a reduction in systemic vascular resistance and blood pressure.
The lecture also highlights the use of alpha-1 blockers in benign prostatic hyperplasia (BPH) by relaxing smooth muscle in the bladder neck and prostate to improve urinary flow. We discuss uroselective agents like tamsulosin, which minimize systemic vascular effects.
We briefly cover nonselective alpha blockers like phenoxybenzamine and phentolamine, commonly used in the management of pheochromocytoma and hypertensive emergencies involving catecholamine excess.
Enjoy the lecture and support us below!
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