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Anti epileptic Drugs / Anticonvulsants : Carbamazepine & Oxcarbamazepine : CNS Pharmacology

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Anticonvulsant drugs are classified as either classic or newer anticonvulsants. Newer anticonvulsants are usually better tolerated and have a broader therapeutic range than classic anticonvulsant drugs. The choice of drug is guided by the type of seizure. First-line treatment for focal seizures includes e.g., lamotrigine or levetiracetam, while valproate is used for generalized seizures. All anticonvulsants have dose-dependent side effects on the central nervous system such as somnolence and nausea, but some agents have more specific side effects (e.g., gingival hyperplasia caused by phenytoin).
Besides their importance in anti-epileptic therapy, anticonvulsants are also used for pain management (e.g., carbamazepine or gabapentin as coanalgesics) or as mood stabilizers in bipolar disorders (valproate).


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