Are LAMICTAL Users at Risk of this DEADLY Syndrome?

0 Views • 08/18/25

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Everything top expert Dr. Silva thinks you should know about Lamictal/lamotrigine, including a comprehensive look at the famous (because it is potentially life-threatening) Stevens-Johnson rash, essentially a mild form of Toxic Epidermal Necrolysis, which is also possible.

_Benign_ rashes are very common (10%) in patients treated with Lamictal, particularly children and those patients on concomitant Depakote therapy, or those for whom the titration schedule was too aggressive, but the more deadly variety is actually quite rare, akin to the incidence of the same syndromes in response to other medications, medications which clinicians frequently use instead of Lamictal, ironically due to a concern about Stevens-Johnson.

Lamictal may actually be the best-tolerated mood stabilizer and, while it is not particularly effective at stabilizing acute mania, it has been approved by the FDA for bipolar maintenance treatment, and is particularly helpful in bipolar I depression (it has not been shown to be especially effective for other forms of depression, including unipolar major depression).

00:00 Intro
01:18 FDA Indications
03:18 Off-Label Uses
04:50 Take-Home Message
05:23 Mechanism of Action
05:51 How Supplied, Dosing
06:35 Rashes
08:26 Stevens-Johnson v. T.E.N.
10:07 Depakote Combo
11:11 Lamictal Levels?
12:01 In Overdose
12:29 Side Effects
13:32 Dangerous Side Effects
13:54 Benign Rashes
14:59 Dangerous Rashes
15:47 Rash Risk Factors
16:07 Best Indications
16:35 Mechanism of Action DEEP DIVE

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