Ceftriaxone pharmacology, cephalosporins pharmacology, pharmacology made easy

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antibiotics pharmacology, ceftriaxone pharmacology, cephalosporins pharmacology, cephalosporin antibiotics pharmacology, antibiotics clinical pharmacology,
📍 Ceftriaxone antibiotics, brand name, Rocephin, is a third generation cephalosporin, and beta lactam antibiotic. That inhibits cell wall synthesis, in susceptible bacteria. Ceftriaxone has activity versus Gram negatives, and Gram positives bacteria, but lacks any substantial activity against anaerobic bacteria.
📍 Ceftriaxone is used for infections, like community-acquired pneumonia, bacterial meningitis, and otitis media caused by certain bacteria. Commonly used in combination with azithromycin, for community acquired pneumonia, requiring hospitalization.
📍 Dosing of ceftriaxone. It has a long half-life, so typically dosed, once daily in adults. But in more severe infections. For example, meningitis, may require twice daily dosing. Usual adult’s doses are, 1gram daily. 2gram daily, or 2gram twice a day. No dose adjustments are needed for renal or hepatic dysfunction. But it is recommend, not to exceed 2 gram per day with concurrent renal and hepatic dysfunction.
📍 Adverse effects of ceftriaxone. Ceftriaxone is secreted in the bile, there’s a risk for pseudo cholithiasis, and pancreatitis. This drug also interferes, with vitamin K metabolism, leading to increased INR, and thus bleeding risk. Hypersensitivity reaction can also occur. Do not administer via I V line, along with calcium. Because this can cause potentially fatal precipitates, to form in lungs and kidneys, which ultimately leads to death.
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Chapters:
0:00 - ceftriaxone pharmacology
0:24 - ceftriaxone mechanism of action
0:48 - ceftriaxone clinical indications
1:14 - ceftriaxone daily dosing
2:03 - ceftriaxone side effects
2:37 - ceftriaxone contraindications

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"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."

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