Glipizide / Glucotrol

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Side Effects

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Treatment for type 2 diabetes routinely defaults to oral or injectable therapies when a proper diet combined with exercise provide optimal results. Since most type 2 diabetics are overweight or obese, appropriate weight loss may reverse the disease without the need for any medication. Among the many preparations available for consideration, glipizide remains among the few cost effective oral agents.

Long off patent, glipizide is an inexpensive sulfonylurea drug approved by the FDA in 1984. With more than 17 million prescriptions each year in the United States, glipizide ranks among the 50 most frequently dispensed drugs. Due to glipizide's low price, pharmaceutical companies reserve their advertising dollars for more profitable products. As a result many doctors and patients alike simply overlook this reasonable option.

Most of the anti-diabetic drugs including glipizide reduce the glycosylated hemoglobin or A1c to a similar degree. Metformin generally should be the first therapeutic option beyond diet and exercise with many individuals ultimately requiring a second and even third drug. Glipizide may be purchased either separately or in combination with metformin.

Side effects associated with glipizide remain relatively few and easily managed. Glipizide appears less likely to result in hypoglycemia than other drugs in the same family. Glipizide should not be rank as a primary agent for consideration among those with pre-existing heart disease.

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