Ibuprofen, Naproxen, Celecoxib: When Are NSAIDs Actually Appropriate

Ibuprofen, Naproxen, Celecoxib: When Are NSAIDs Actually Appropriate | Sean Mackey, M.D., Ph.D

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This clip is from episode #345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.
In this clip, they discuss:

- How NSAIDs Work – A clear explanation of COX enzymes, prostaglandins, and how NSAIDs reduce inflammation and pain
- NSAIDs vs. Steroids – Understanding the difference in mechanism and why it matters clinically
- Side Effects & Risk Management – Exploring GI bleeding, kidney function, cardiovascular events, and how to lower the risk
- Why Dose and Duration Matter – How even short courses of NSAIDs can carry significant risk depending on patient profile
-Choosing the Right Anti-Inflammatory – When to use (or avoid) NSAIDs and how to individualize treatment safely

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The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.

Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

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