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Loperamide vs Diphenoxylate Mnemonic for USMLE

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Study this Loperamide vs Diphenoxylate mnemonic and other mnemonics with Pixorize.

Diphenoxylate and loperamide are opioid drugs that are used in the treatment of diarrhea. They act at mu-opioid receptors in the GI tract or enteric nervous system to reduce gut motility. This action helps these drugs treat diarrhea, from causes such as irritable bowel syndrome and traveler’s diarrhea. Notably, loperamide cannot cross the blood brain barrier, so it has low abuse potential. In contrast, Diphenoxylate can cross the blood brain barrier, so it is usually combined with atropine to prevent drug abuse. Adverse effects of these drugs to look out for include constipation, nausea and dry mouth. Loperamide can also lead to QT elongation and increase the risk of torsades de pointes.


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