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Redefining tamoxifen for breast cancer
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• 08/26/25
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Dr Das speaks with ecancer at AACR 2017 about the effect of tamoxifen before surgery on the genome of breast cancer cells.
He reports that binding of oestrogen receptors deactivates p53, a tumour suppressor gene, based on sequencing after four weeks of tamoxifen therapy.
Dr Das describes these findings pointing towards p53 activation as a predictor of tamoxifen response, with further trials to confirm utility in stratifying patients with triple negative breast cancer.
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