Ezetimibe blocks cholesterol absorption and decreases serum LDL-cholesterol. The detailed mechanism of action, indications, and adverse effects are discussed in this video.

0:00 Introduction
1:41 Mechanism of action of fibrates
2:45 Indications
3:16 Adverse effects

#thingyansane #ezemitibe #pharmacology #hyperlipidemia

We explore statin side effects like myopathy and elevated LFTs, and when to consider alternatives like ezetimibe or PCSK9 inhibitors. We also discuss how to manage statin side effects while keeping patients within the statin family. #Statins #Cholesterol #Myopathy #Ezetimibe #PCSK9 #Cardiology #LDL #LiverFunction #Diabetes #MedicationManagement

Ezetimibe is a medicine used to lower cholesterol in people who have high blood cholesterol. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your intestines.

Video Content:
0:00 Ezetimibe tablets
0:39 How to use
1:11 Contraindications
1:42 Warnings
2:27 Side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#Ezetimibe #cholesterol #medicine

Ezetimibe is chemically a beta lactam having azetidin-2-one ring system. It inhibits the absorption of cholesterol from the brush border of the intestine by inhibiting NPC1L1 receptors. It is given at a dose of 10 mg once daily and it can be given as monotherapy as well as combined with statins. Normally it has mild side effects like diarrhea and dizziness but when combined with statins it may enhance liver damage and rhabdomyolysis.

0:00 Introduction
2:02 How it acts?
4:00 Actions of Ezetimibe
5:56 Dose of ezetimibe
6:18 Side effects
7:07 Clinical uses
8:10 Advantages

What side effects and risks are associated with medications for lowering LDL cholesterol? Can those risks be avoided?

Dr. Pradeep Natarajan, MD, MMSc, identifies the side effects for major LDL-C-lowering strategies as well as strategies to mitigate the risks. First-line therapies including statins and ezetimibe are discussed as well as considerations for pursuing non-statin medications such as bempodoic acid, PCSK9 mAbs, and PCSK9 siRNAs to lower LDL-C.

00:00 | Introduction
00:27 | Side effects of statin
02:50 | Minimizing statin-associated side effects
04:16 | The relationship between statins and diabetes
05:03 | Key considerations for novel non-statin agents

This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content.

References:
Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat Rev Drug Discov. 2008;7(1):84-99. doi:10.1038/nrd2353

Preiss D, Tobert JA, Hovingh GK, Reith C. Lipid-Modifying Agents, From Statins to PCSK9 Inhibitors: JACC Focus Seminar. J Am Coll Cardiol. 2020;75(16):1945-1955. doi:10.1016/j.jacc.2019.11.072

Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, et al. Major lipids, apolipoproteins and risk of vascular disease. JAMA. 2009;302(18):1993-2000. doi:10.1001/jama.2009.1619

Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017;38(32):2459-2472. doi:10.1093/eurheartj/ehx144

Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med. 2015;372(25):2387-2397. doi:10.1056/NEJMoa1410489

Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-1722. doi:10.1056/NEJMoa1615664

Schwartz GG, Steg PG, Szarek M, et al. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018;379(22):2097-2107. doi:10.1056/NEJMoa1801174

Goldberg AC, Leiter LA, Stroes ESG, et al. Effect of Bempedoic Acid vs. Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial [published correction appears in JAMA. 2020 Jan 21;323(3):282]. JAMA. 2019;322(18):1780-1788. doi:10.1001/jama.2019.16585

Ray KK, Wright RS, Kallend D, et al. Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020;382(16):1507-1519. doi:10.1056/NEJMoa1912387

Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation. 2006;114(25):2788-2797. doi:10.1161/CIRCULATIONAHA.106.624890

Riaz H, Khan AR, Khan MS, et al. Meta-analysis of Placebo-Controlled Randomized Controlled Trials on the Prevalence of Statin Intolerance. Am J Cardiol. 2017;120(5):774-781. doi:10.1016/j.amjcard.2017.05.046

Gupta A, Thompson D, Whitehouse A, et al. Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomized, double-blind placebo-controlled trial and its non-randomized non-blind extension phase. Lancet. 2017;389(10088):2473-2481. doi:10.1016/S0140-6736(17)31075-9

Björnsson E, Jacobsen EI, Kalaitzakis E. Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. J Hepatol. 2012;56(2):374-380. doi:10.1016/j.jhep.2011.07.023

Swerdlow DI, Preiss D, Kuchenbaecker KB, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomized trials. Lancet. 2015;385(9965):351-361. doi:10.1016/S0140-6736(14)61183-1

Notice: At this time, the content in this video is not accredited.

Ezetimibe is used to control elevated cholesterol levels. It inhibits absorption of cholesterol in intestine.

Disclaimer: The video is intended for educational purposes only, and all the information provided here is neither a substitute for medical advice nor is it recommended for diagnosis or treatment. All efforts are made to provide accurate and error-free information, but the content is variable from time to time due to advances in medical research. Always seek professional medical advice in case of any medical queries, and the videos on this platform do not provide any such suggestions or professional advice.

Ezetimibe is a cholesterol absorption inhibitor used in the treatment of hyperlipidemia. It can be used as alone or in combination therapy along with other drugs such as statins and fibrates.

In a viewpoint released today in The Journal of the American Medical Association Cardiovascular Special Issue, Mayo Clinic endocrinologists and researchers are warning against the “premature and widespread adoption” of a new type of drug that reduces cholesterol, PCSK-9 inhibitors. They argue that little is known about their long-term safety and efficacy on outcomes that matter to patients. Given the long track record of efficacy and safety and the low cost of statins, they think that it is premature to adopt PCSK-9 inhibitors as alternatives to statins.

The Food and Drug Administration has recently approved the new class of drugs for patients with high LDL-cholesterol who also have familial hypercholesterolemia or with clinical cardiovascular disease who are seeking secondary prevention or cannot tolerate statins. The Mayo experts are predicting four situations that will fuel abandoning statins in favor of the PCSK-9 inhibitors:

Patients who have muscle problems or other symptoms suggestive of statin intolerance.
Patients who have a heart attack or a stroke while using a statin.
Patients who may not to be taking statins every day.
Patients who have cholesterol levels that remain high despite statins.

A new study shows the two drugs in question may not work as well as advertised.

Katie Couric speaks to Dr. Steven Nissen of the Cleveland Clinic about a study that questions the benefits of the anti-cholesterol drug Zetia. (CBSNews.com)

Ezetimibe is a commonly used cholesterol medication. I talk about its uses and side effects.

Ezetimibe is a medication primarily used to lower blood cholesterol levels. It works by inhibiting the absorption of dietary cholesterol from the small intestine, which ultimately reduces the amount of cholesterol that enters the bloodstream. This makes it useful for managing high cholesterol levels, particularly when dietary and lifestyle changes alone are not sufficient to bring cholesterol levels under control.

Key points about Ezetimibe include:

1. **Mechanism of Action:** Ezetimibe works by inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) protein in the small intestine. This protein is responsible for the absorption of dietary cholesterol. By blocking this protein, Ezetimibe reduces the absorption of cholesterol from the diet, leading to decreased levels of cholesterol in the bloodstream.

2. **Combination Therapy:** Ezetimibe is often prescribed in combination with other cholesterol-lowering medications, such as statins. This combination can be more effective in reducing cholesterol levels compared to using either medication alone. Statins work by blocking an enzyme involved in cholesterol synthesis in the liver.

3. **Indications:** Ezetimibe is primarily used to treat hypercholesterolemia, a condition characterized by elevated levels of cholesterol in the blood. It can be used as a monotherapy or in combination with other medications to achieve better cholesterol control.

4. **Dosage and Administration:** Ezetimibe is typically taken orally in tablet form. The recommended dosage and frequency will depend on individual factors, including the patient's cholesterol levels and overall health. It can be taken with or without food.

5. **Side Effects:** Common side effects of Ezetimibe may include headache, diarrhea, abdominal pain, and fatigue. Serious side effects are rare but may include muscle pain or weakness (myopathy) and liver problems. It's important to monitor for any unusual symptoms and report them to a healthcare provider.

6. **Precautions and Contraindications:** Ezetimibe should be used with caution in individuals with liver disease or a history of liver problems. Pregnant or breastfeeding women should also consult their healthcare provider before taking this medication. Additionally, it's important to let your doctor know about any other medications or supplements you're taking to avoid potential interactions.

7. **Effectiveness:** Clinical studies have shown that Ezetimibe can effectively lower LDL cholesterol levels, which is the "bad" type of cholesterol associated with an increased risk of heart disease. By reducing LDL cholesterol levels, Ezetimibe can contribute to the overall reduction of cardiovascular risk.

As with any medication, it's essential to take Ezetimibe as prescribed by a healthcare professional and to follow their recommendations for cholesterol management, which may also include lifestyle changes such as a healthy diet, regular exercise, and smoking cessation. Always consult a medical professional for personalized advice and guidance on managing your cholesterol levels and overall cardiovascular health.

What are the side effects of #Advil Migraine?

Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur.
Warnings:

Nonsteroidal anti-inflammatory drugs (including ibuprofen) may rarely increase the risk for a heart attack or stroke.
This effect can happen at any time while taking this drug but is more likely if you

Uses

#Ibuprofen is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis.

It is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).
It works by blocking your body's production of certain natural substances that cause inflammation.

This effect helps to decrease swelling, pain, or fever.
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your .

Check the ingredients on the label even if you have used the product before.
The manufacturer may have changed the ingredients.

Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.


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What's the best Over the Counter pain medication?
Which one works best? What's the one you like the most?
I recently hurt my back and wanted to know which one would work best. I looked at Advil, Aleve, Tylenol and Excedrin. They each work a little differently so it was interesting.
So which is the best pain reliever for you?
Lets compare and see. Pain Relief Showdown!
Depending on what kind of pain you're experiencing, the answer will be different.

How long does it take for Excedrin Migraine to work Key PointsExcedrin Migraine can work as quickly as minutes to relieve your migraine painIn clinical studies patients with moderate to severe migraines experienced pain relief with one dose and it lasted up to hoursExcedrin Migraine is taken as soon as your migraine headache begins It is not used to prevent migraine headachesWhats in Excedrin HeadacheEach caplet or geltab of Excedrin Migraine contains milligrams mg of caffeine mg of acetaminophen and mg of aspirin Caffeine increases the effects of pain medicines like aspirin and acetaminophen and can make these medicines more effectiveThe regular dosage for adults is caplets or geltabs with a full glass of waterDo not take more than two caplets or geltabs in any hour period unless directed by your doctorIf symptoms worsen or persist contact your doctorIf you are under years of age ask a doctor before useThe recommended dose of Excedrin Migraine contains roughly as much caffeine as a cup of coffee Limit caffeinecontaining medications foods or beverages while using Excedrin Migraine Excessive caffeine can cause nervousness irritability sleeplessness and rapid heart beatIf you have migraine headaches that are not responding to any overthecounter OTC medicines contact your doctor for further evaluation There are many prescription treatments available for migraine that may be helpful for youOverthecounter generic and storebrands of Excedrin Migraine are available in the USRelated Review of Migraine TreatmentHow long does Excedrin Migraine lastIn three placebocontrolled studies an acetaminophen aspirin and caffeine combination equivalent to Excedrin Migraine was shown to last up to hours when taken to relieve migraine headache painSignificant pain relief rated as mild or none began in minutes in the group receiving the acetaminophen aspirin and caffeine combination compared to placebo in a pooled analysis of all three studiesTwo hours after taking the dose the pain intensity was reduced to mild or none in of patients in the drugtreated group compared to of patients in the placebo groupAt six hours after taking the dose of those taking the active drug and of placebotreated patients rated pain as mild or none Also at six hours after the dose of drugtreated patients and of placebotreated patients reported being painfreeAt all time points results were found to be statistically significant when compared to placeboOther migraine headache symptoms such as nausea sensitivity to light and sound and inability to carry out usual daily activities functional disability were also significantly improved to hours after treatment with the acetaminophen aspirin and caffeine combination when compared with a placeboRead More Side effects and warnings for Excedrin MigraineThis is not all the information you need to know about Excedrin Migraine for safe and effective use and does not take the place of talking to your doctor about your treatment Review the full Excedrin Migraine information here and discuss this information and any questions you have with your doctor or other health care providerRelated questions Can you take Excedrin Migraine while pregnant How much caffeine is in Excedrin Migraine Staying Safe while taking Acetaminophen

Welcome to our channel! In this informative video, we will be diving deep into the topic of Methylprednisolone and its various applications, advantages, potential side effects, dosage recommendations, and risks. If you have ever wondered "What is Methylprednisolone used for?", then you have come to the right place.

Methylprednisolone is a powerful medication that belongs to the group of corticosteroids. It is commonly used to treat a wide range of medical conditions and is known for its anti-inflammatory and immunosuppressant properties.

Some of the usual applications of Methylprednisolone include the management of allergic reactions, asthma, arthritis, skin disorders, and certain types of cancer. It can also be prescribed to alleviate symptoms of various autoimmune diseases, such as lupus and multiple sclerosis.

One of the major advantages of Methylprednisolone is its ability to provide quick and effective relief from inflammation and pain. It can significantly reduce swelling and stiffness, helping patients regain their quality of life.

However, like any medication, Methylprednisolone does come with potential side effects. It is important to be aware of these risks and discuss them with your healthcare provider. Some of the common side effects may include increased appetite, weight gain, mood changes, insomnia, and fluid retention.

Dosage recommendations for Methylprednisolone can vary depending on the condition being treated and the individual patient. It is crucial to follow your doctor's instructions and never exceed the prescribed dosage.

As with any medication, Methylprednisolone does carry some risks. Long-term use or high dosages can lead to more serious side effects, such as osteoporosis, diabetes, and suppression of the immune system. It is essential to weigh the benefits against the risks and make an informed decision.

In conclusion, Methylprednisolone is a potent corticosteroid that is widely used for its anti-inflammatory and immunosuppressant properties. It has a range of applications and can provide relief for various medical conditions. However, it is crucial to use it under the guidance of a healthcare professional and be aware of the potential side effects and risks.

If you found this video helpful, don't forget to like, share, and subscribe to our channel for more informative content. Stay tuned for our upcoming videos on other essential medications and their uses. Thank you for watching!
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately."

Consumer Reports takes a look at common over-the-counter painkillers.

Headaches can be incredibly disruptive, affecting your ability to concentrate, work, and enjoy daily activities. Excedrin, a well-known over-the-counter medication, has been a go-to choice for many seeking relief from headaches. In this comprehensive guide, we'll explore Excedrin, its benefits, active ingredients, proper usage, potential side effects, and how it can provide faster relief and maximum comfort during those uncomfortable headache episodes.

1. Understanding Headaches
Headaches are a common ailment experienced by people of all ages. They can range from mild discomfort to severe pain and can be caused by various factors, including stress, tension, sinus issues, dehydration, or even certain medical conditions. Finding effective relief is crucial to restore your productivity and overall well-being.

2. Introduction to Excedrin
Excedrin is an over-the-counter medication specifically formulated to provide relief from headaches. It combines three active ingredients: acetaminophen (a pain reliever), aspirin (a pain reliever), and caffeine (a stimulant). This unique combination targets headache symptoms effectively.

3. Active Ingredients and Their Roles
Acetaminophen: Known for its pain-relieving and fever-reducing properties, acetaminophen helps alleviate headache pain.
Aspirin: An analgesic that also reduces inflammation and is effective in providing headache relief.
Caffeine: A stimulant that can enhance the effectiveness of pain relievers and provide a boost of energy.
4. Benefits of Excedrin for Headache Relief
Fast-Acting: The combination of ingredients in Excedrin allows for faster absorption and quicker relief, aiding in managing headache symptoms promptly.
Effective Pain Relief: The dual-action of acetaminophen and aspirin, coupled with the added benefit of caffeine, helps tackle even severe headache pain.
Improved Focus: The inclusion of caffeine enhances concentration and focus, making it easier to resume daily activities without the hindrance of a persistent headache.
5. Proper Usage and Dosage Guidelines
It's important to follow the recommended dosage instructions provided on the packaging or by a healthcare professional. Typically, for adults, the recommended dose is 2 caplets with a glass of water. It's advisable not to exceed the stated dose within a 24-hour period.

6. Potential Side Effects and Precautions
While generally safe, Excedrin may cause side effects such as upset stomach, nausea, or allergic reactions. It's important to discontinue use and seek medical help if severe side effects occur. Additionally, individuals with certain medical conditions or allergies should consult a healthcare professional before using Excedrin.

7. How to Maximize the Benefits of Excedrin
To ensure maximum effectiveness and comfort, consider the following tips:

Early Intervention: Take Excedrin at the onset of a headache for faster relief.
Stay Hydrated: Drink plenty of water throughout the day to prevent dehydration, a common headache trigger.
Manage Stress: Practice relaxation techniques, exercise, or engage in hobbies to reduce stress and tension headaches.
Follow a Healthy Lifestyle: Maintain a balanced diet, regular sleep schedule, and avoid excessive caffeine intake to reduce the frequency of headaches.
8. Frequently Asked Questions (FAQs) about Excedrin
Can I take Excedrin on an empty stomach?

While you can take Excedrin on an empty stomach, it's advisable to have a light snack or meal before to prevent any potential stomach upset.

Can Excedrin be taken for migraines?

Yes, Excedrin Migraine is a specific formulation designed to provide relief for migraines. It contains the same active ingredients as regular Excedrin.

Can I use Excedrin for sinus headaches?

Excedrin Sinus contains specific ingredients to target sinus headaches. It can be an effective choice for relieving sinus-related headache symptoms.

Is Excedrin safe during pregnancy or breastfeeding?

It's recommended to consult a healthcare professional before using Excedrin during pregnancy or while breastfeeding to ensure safety and proper guidance.

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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

General information regarding Excedrin (acetaminophen, aspirin, and caffeine). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

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Producer can't say when Excedrin will return

There's bad news for migraine sufferers. Two popular pain medications have been temporally discontinued: Excedrin Extra Strength and Excedrin Migraine.

Two Excedrin products temporarily discontinued, company says

A GSK spokesperson said there were "inconsistencies in how we transfer and weigh ingredients" for Excedrin Extra Strength Caplets and Geltabs and Excedrin Migraine Caplets and Geltabs.

Excedrin Migraine is a combination of aspirin, acetaminophen, and caffeine. It is used for the temporary relief of pain from conditions such as muscle aches, toothaches, menstrual cramps, or headaches, including migraine. Aspirin and acetaminophen relieve pain by keeping your body from making certain natural substances. Caffeine helps increase the effects of aspirin and acetaminophen. It is recommended to take 2 caplets with a glass of water at the first sign of migraine symptoms. Do not take more than 2 caplets in 24 hours, unless directed by a doctor. The best time to take Excedrin Migraine is at the onset of migraine symptoms for the most effective relief.
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Excedrin Extra Strength is a combination of aspirin, acetaminophen, and caffeine, which helps to relieve pain from muscle aches, toothaches, menstrual cramps, and headaches, including migraines. Aspirin and acetaminophen work by preventing your body from producing certain natural substances that cause pain, while caffeine enhances the effects of aspirin and acetaminophen. The recommended dosage for adults is 2 caplets every 6 hours as needed, with a maximum of 8 caplets in 24 hours. It's best to take it with a full glass of water and with food to minimize stomach upset. Remember to read the label and follow the directions provided.
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Excedrin Migraine Caplets are an over-the-counter medication formulated specifically for the relief of migraine headaches. It combines three active ingredients: acetaminophen, aspirin, and caffeine, which work synergistically to alleviate migraine symptoms such as headache pain, nausea, and sensitivity to light and sound.

Video Content:
0:00 Excedrin Migraine caplets
0:24 Indications
0:35 How to use
1:11 Contraindications
1:36 Special Instructions
2:06 Side Effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#Excedrin #migraine #headache