Auvelity (Dextromethorphan and Bupropion) | A Fast Acting Antidepressant?
Content written by: Chris Aiken, MD
💡Auvelity Fact Sheet: https://www.thecarlatreport.com/auvelity
➡️Full Article: https://www.thecarlatreport.co....m/articles/4417-auve
📖Medication Fact Book: https://www.thecarlatreport.co....m/products/499-medic

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00:00 Carlat Intro
00:13 Auvelity
0:46 Mechanism of Action
2:33 Side-effects
2:49 Controversies
3:58 Unanswered Questions
4:18 Carlat Verdict
4:27 Fact Sheet
4:38 TheCarlatReport.com

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In today’s video, we’re taking a deep dive into Auvelity, a new antidepressant that combines Dextromethorphan and Bupropion. While Bupropion is well-established in the treatment of depression, Dextromethorphan is less familiar in psychiatric contexts. It’s primarily known as a cough suppressant in products like Robitussin DM. The combination in Auvelity aims to offer a new approach by leveraging both drugs’ unique benefits.

Auvelity’s primary claim to fame is its dual-action mechanism. Dextromethorphan enhances glutamate transmission through NMDA antagonism, a mechanism seen in other third-line treatments for depression such as ketamine and amantadine. This approach goes beyond traditional monoamines like serotonin and norepinephrine, which are targeted by most antidepressants. Dextromethorphan is also thought to have anti-convulsant and neuroprotective effects and can block serotonin and dopamine reuptake. This novel mechanism makes Auvelity the first oral antidepressant to incorporate this specific approach.

The combination of Dextromethorphan and Bupropion in Auvelity helps achieve a pharmacokinetic goal by extending the half-life of Dextromethorphan. Bupropion inhibits CYP2D6, the enzyme responsible for metabolizing Dextromethorphan, thus prolonging its effects from a few hours to over 20. This extended duration might contribute to Auvelity’s effectiveness.

Clinical trials provide promising results. Compared to Bupropion alone, Auvelity has shown quicker onset and greater efficacy in treating depression. One large trial, involving over 300 patients, demonstrated that Auvelity effectively improved depressive symptoms faster than other antidepressants. A smaller trial confirmed these findings, noting a significant remission rate of 47% after six weeks, compared to just 16% with Bupropion alone. However, the drug’s effectiveness for treatment-resistant depression is still uncertain, as a large trial in this area yielded negative results.

Regarding side effects, Dextromethorphan’s sedative properties can lead to issues such as somnolence, nausea, dizziness, headache, and dry mouth. There is also concern about potential misuse. While the clinical trials showed no inappropriate use, the combination with Bupropion could potentially push Dextromethorphan into higher, possibly abusable levels.

Auvelity is quite costly, with prices around $1,200 per month. For those looking for more affordable options, generic alternatives might be used, though these are not FDA-approved and come with their own set of considerations. Generic Bupropion and Dextromethorphan could be combined to mimic Auvelity’s effects, but this approach isn’t officially endorsed.

There are still many unanswered questions about Auvelity. For example, can Bupropion alone be used initially, with Dextromethorphan added if needed? What happens if doses are adjusted, or if Dextromethorphan is tapered off? These aspects remain under investigation.

In summary, Auvelity offers a new approach with its combination of Dextromethorphan and Bupropion, providing a faster therapeutic onset and novel mechanism of action. While it shows promise in treating depression, its high cost and potential for misuse are important considerations. For more detailed information and updates, check out our full article on the CARLAT website and consider subscribing to the Carlette Psychiatry Report for in-depth psychiatric news and clinical insights.

"Discussing Auvelity: The New Dextroantidepressant"

In this video, I read experience reports and talk about the new antidepresant that contains Bupropion and Dextreomethorphan...

MAIN CHANNEL: https://www.youtube.com/@talesfromthetrip

Auvelity (dextromethorphan/ buproprion) is an NMDA Antagonist and a newer type of medication used in the treatment of Depression (Major Depressive Disorder) at our Philadelphia office. This medication's primary effective agent is dextromethorphan (which is commonly used in cough medications / antitussives). The buproprion (also known as Wellbutrin) in this combination pill works to decrease the effectiveness of a liver enzyme that breaks down dextromethorphan (CYP2D6) thereby increasing the dextromethorphan blood concentration and allowing it to have a longer duration of action, than when it's used for colds (dextromethorphan breaks down relatively quickly). Wellbutrin is an antidepressant, but trials indicate that the dextromethorphan is the medication in this pill, the predominantly is resulting in improved mood. Dextromethorphan works as an N-Methyl-D-Aspartate (NMDA) antagonist increasing Glutamate levels (again, this is a relatively novel pathway to treat depression). If an individual has failed several anti-depressants, utilizing a different method of treatment (or pathway for treatment) may be a good option. Side effects can include dizziness, nausea and headache (among others). Severe side effects can include elevated blood pressure, severe rash or others. However, most tolerate it well, with per manufacturer, less than a 15% discontinuation rate, due to side effects.

Please talk to your provider about all risks and benefits of this medication before starting, stopping or changing doses. This information is meant to educate providers and give patients more information to discuss with them about their options.

Dr. Pagnani is the Medical Director of Rittenhouse Psychiatric Associates in Philadelphia, PA and surrounding areas. Their practice has 25 Academically oriented provides and is now scheduling in-office and telemedicine visits.

For additional informative mental health videos:
youtube.com/@rittenhousepsych

www.RittenhousePA.com
www.ChrisPagnaniMD.com

Dextromethorphan is cough suppressant but still used to treat depression in combination with bupropion.


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__________

Sources:
- Stahl's Prescriber's Guide, 8th ed.
- Uptodate.com - prozac
- Uptodate.com - auvelity
- Stahl's Essential Psychopharmacology 5th edition.
- Drug bank: https://go.drugbank.com/drugs/DB01156.
- Current Diagnosis & Treatment: Psychiatry, 4th ed - ch. 26.
- 2022 Tabuteau; https://pubmed.ncbi.nlm.nih.gov/35582785/
- 2022 Losifscu: https://pubmed.ncbi.nlm.nih.gov/35649167/
- 2021 COMET trial: https://www.axsome.com/publica....tions/ASCP_2021_COME
- 2022 EVOLVE trial: https://www.axsome.com/publica....tions/ASCP_2022_EVOL

__________

Mattias Hartmann, Board-Certified Psychiatric Physician Assistant.
Mood Psych.
Not medical advice, for entertainment/education only.

__________

Chapters:
00:00 Introduction
00:16 1. Who can't take Auvelity?
00:42 2. How does it work?
02:51 3. Efficacy and dosing
10:19 4. How long until it works & monitoring
11:07 5. Side effects
12:52 6. Special considerations

Is Deutetrabenazine (Austedo) Addictive? In this informative video, we will discuss Deutetrabenazine, commonly known by its brand name Austedo, and its role in treating movement disorders associated with serious conditions. We will cover how this medication functions in the brain and its potential effects on mood and cognitive abilities. Understanding the difference between psychological and physical dependence is essential when considering the safety of any medication, including Deutetrabenazine.

We will also address the important side effects that can arise from its use, particularly in patients with Huntington's disease, and the significance of monitoring during treatment. Additionally, we will highlight the necessity of regular consultations with healthcare providers to ensure the medication is effective and safe.

If you or someone you know is considering Deutetrabenazine as a treatment option, this video will provide essential information to help navigate the potential risks and benefits. Remember, staying informed and communicating with healthcare professionals is key to managing treatment effectively.

Join us for this important discussion, and subscribe to our channel for more helpful content on mental health and treatment options.

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🔗Subscribe: https://www.youtube.com/@Schiz....ophreniaSupportNetwo

#Deutetrabenazine #Austedo #MentalHealth #Schizophrenia #HuntingtonsDisease #MovementDisorders #MentalHealthAwareness #MedicationSafety #PsychiatricMedications #PatientEducation #Healthcare #SideEffects #MentalHealthTreatment #MentalHealthSupport #MedicationManagement

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

How Does Deutetrabenazine (Austedo) Work? In this informative video, we will discuss Deutetrabenazine, also known by its brand name Austedo, and its role in managing movement disorders. While primarily used for conditions like Huntington's disease and tardive dyskinesia, understanding how this medication works can provide insight into its potential relevance for individuals experiencing movement issues related to their treatment. We’ll explain the mechanism behind Deutetrabenazine, focusing on its effects on neurotransmitter release and how it can help stabilize excessive movements.

Additionally, we will touch on the connection between Deutetrabenazine and schizophrenia, particularly in cases where patients develop movement disorders as a side effect of antipsychotic medications. It’s essential to be aware of the possible side effects of this treatment, especially for those with a history of mood disorders.

Join us for a comprehensive discussion about Deutetrabenazine and its implications for managing movement disorders. Don't forget to subscribe to our channel for more helpful information on mental health and treatment options.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Schiz....ophreniaSupportNetwo

#Deutetrabenazine #Austedo #MovementDisorders #HuntingtonsDisease #TardiveDyskinesia #Schizophrenia #MentalHealth #Neurotransmitters #Dopamine #Antipsychotics #MentalHealthTreatment #MoodDisorders #InvoluntaryMovements #PatientCare #MedicationManagement

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

See Important Safety Information below; Prescribing Information including Boxed Warning: https://bit.ly/3YhB0s9. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.
INDICATIONS & USAGE
AUSTEDO XR is indicated in adults for the treatment of chorea associated with Huntington's disease (HD) & for the treatment of tardive dyskinesia (TD).
IMPORTANT SAFETY INFORMATION
Depression & Suicidality in HD Patients: AUSTEDO XR can increase the risk of depression & suicidal thoughts & behavior (suicidality) in HD Patients. Balance the risks of depression & suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior. Inform patients, their caregivers, & families of the risk of depression & suicidality & instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation. AUSTEDO XR is contraindicated in patients who are suicidal, & in patients with untreated or inadequately treated depression.
Contraindications: AUSTEDO XR is contraindicated in HD patients who are suicidal, or have untreated or inadequately treated depression. AUSTEDO XR is also contraindicated in: patients with hepatic impairment; patients taking reserpine or within 20 days of discontinuing reserpine; patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of discontinuing MAOI therapy; & patients taking tetrabenazine or valbenazine.
Clinical Worsening & Adverse Events in HD Patients: AUSTEDO XR may cause a worsening in mood, cognition, rigidity, & functional capacity. Prescribers should periodically re-evaluate the need for AUSTEDO XR in their patients by assessing the effect on chorea & possible adverse effects.
QTc Prolongation: AUSTEDO XR may prolong the QT interval, but the degree of QT prolongation is not clinically significant when AUSTEDO XR is administered within the recommended dosage range. AUSTEDO XR should be avoided in patients with congenital long QT syndrome & in patients with a history of cardiac arrhythmias.
Neuroleptic Malignant Syndrome (NMS), a potentially fatal symptom complex reported in association with drugs that reduce dopaminergic transmission, has been observed in patients receiving tetrabenazine. The risk may be increased by concomitant use of dopamine antagonists or antipsychotics. The management of NMS should include immediate discontinuation of AUSTEDO XR; intensive symptomatic treatment & medical monitoring; & treatment of any concomitant serious medical problems.
Akathisia, Agitation, & Restlessness: AUSTEDO XR may increase the risk of akathisia, agitation, & restlessness. The risk of akathisia may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops akathisia, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Parkinsonism: AUSTEDO XR may cause parkinsonism in TD or HD patients. The risk of parkinsonism may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops parkinsonism, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Sedation & Somnolence: Sedation is a common dose-limiting adverse reaction of AUSTEDO XR. Patients should not perform activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery, until they are on a maintenance dose of AUSTEDO XR & know how the drug affects them. Concomitant use of alcohol or other sedating drugs may have additive effects & worsen sedation & somnolence.
Hyperprolactinemia: Tetrabenazine elevates serum prolactin concentrations in humans. If there is a clinical suspicion of symptomatic hyperprolactinemia, appropriate laboratory testing should be done & consideration should be given to discontinuation of AUSTEDO XR.
Binding to Melanin-Containing Tissues: Deutetrabenazine or its metabolites bind to melanin-containing tissues & could accumulate in these tissues over time. Prescribers should be aware of the possibility of long-term ophthalmologic effects.
Common Adverse Reactions: The most common adverse reactions for AUSTEDO (greater than 8% & greater than placebo) in a controlled clinical study in HD patients were somnolence, diarrhea, dry mouth, & fatigue. The most common adverse reactions for AUSTEDO (4% & greater than placebo) in controlled clinical studies in TD patients were nasopharyngitis & insomnia. Adverse reactions with AUSTEDO XR are expected to be similar to AUSTEDO.

See Important Safety Information below; Prescribing Information including Boxed Warning: https://bit.ly/3YhB0s9. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.
INDICATIONS & USAGE
AUSTEDO XR is indicated in adults for the treatment of chorea associated with Huntington's disease (HD) & for the treatment of tardive dyskinesia (TD).
IMPORTANT SAFETY INFORMATION
Depression & Suicidality in HD Patients: AUSTEDO XR can increase the risk of depression & suicidal thoughts & behavior (suicidality) in HD Patients. Balance the risks of depression & suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior. Inform patients, their caregivers, & families of the risk of depression & suicidality & instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation. AUSTEDO XR is contraindicated in patients who are suicidal, & in patients with untreated or inadequately treated depression.
Contraindications: AUSTEDO XR is contraindicated in HD patients who are suicidal, or have untreated or inadequately treated depression. AUSTEDO XR is also contraindicated in: patients with hepatic impairment; patients taking reserpine or within 20 days of discontinuing reserpine; patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of discontinuing MAOI therapy; & patients taking tetrabenazine or valbenazine.
Clinical Worsening & Adverse Events in HD Patients: AUSTEDO XR may cause a worsening in mood, cognition, rigidity, & functional capacity. Prescribers should periodically re-evaluate the need for AUSTEDO XR in their patients by assessing the effect on chorea & possible adverse effects.
QTc Prolongation: AUSTEDO XR may prolong the QT interval, but the degree of QT prolongation is not clinically significant when AUSTEDO XR is administered within the recommended dosage range. AUSTEDO XR should be avoided in patients with congenital long QT syndrome & in patients with a history of cardiac arrhythmias.
Neuroleptic Malignant Syndrome (NMS), a potentially fatal symptom complex reported in association with drugs that reduce dopaminergic transmission, has been observed in patients receiving tetrabenazine. The risk may be increased by concomitant use of dopamine antagonists or antipsychotics. The management of NMS should include immediate discontinuation of AUSTEDO XR; intensive symptomatic treatment & medical monitoring; & treatment of any concomitant serious medical problems.
Akathisia, Agitation, & Restlessness: AUSTEDO XR may increase the risk of akathisia, agitation, & restlessness. The risk of akathisia may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops akathisia, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Parkinsonism: AUSTEDO XR may cause parkinsonism in TD or HD patients. The risk of parkinsonism may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops parkinsonism, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Sedation & Somnolence: Sedation is a common dose-limiting adverse reaction of AUSTEDO XR. Patients should not perform activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery, until they are on a maintenance dose of AUSTEDO XR & know how the drug affects them. Concomitant use of alcohol or other sedating drugs may have additive effects & worsen sedation & somnolence.
Hyperprolactinemia: Tetrabenazine elevates serum prolactin concentrations in humans. If there is a clinical suspicion of symptomatic hyperprolactinemia, appropriate laboratory testing should be done & consideration should be given to discontinuation of AUSTEDO XR.
Binding to Melanin-Containing Tissues: Deutetrabenazine or its metabolites bind to melanin-containing tissues & could accumulate in these tissues over time. Prescribers should be aware of the possibility of long-term ophthalmologic effects.
Common Adverse Reactions: The most common adverse reactions for AUSTEDO (greater than 8% & greater than placebo) in a controlled clinical study in HD patients were somnolence, diarrhea, dry mouth, & fatigue. The most common adverse reactions for AUSTEDO (4% & greater than placebo) in controlled clinical studies in TD patients were nasopharyngitis & insomnia. Adverse reactions with AUSTEDO XR are expected to be similar to AUSTEDO.

What Are The Reviews Of Deutetrabenazine (Austedo)? In this informative video, we will discuss Deutetrabenazine, also known as Austedo, a medication used to treat movement disorders. Specifically, we'll focus on its role in managing tardive dyskinesia and involuntary movements associated with Huntington's disease. Understanding the experiences of those who have used Deutetrabenazine can provide valuable information regarding its effectiveness and potential side effects.

We will examine user reviews, highlighting both positive and negative experiences. While some individuals report a reduction in involuntary movements, others have faced concerning side effects. The importance of monitoring mood changes and other reactions when starting or adjusting this medication cannot be overstated.

Additionally, we will cover how Deutetrabenazine fits into the treatment plan for individuals with schizophrenia, particularly when tardive dyskinesia arises due to antipsychotic medications. It's vital for patients and healthcare providers to carefully consider the benefits and risks associated with this treatment.

Join us as we navigate through the experiences of users and the clinical perspective on Deutetrabenazine. Don't forget to subscribe to our channel for more informative discussions about mental health and treatment options.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Schiz....ophreniaSupportNetwo

#Deutetrabenazine #Austedo #TardiveDyskinesia #MovementDisorders #MentalHealth #Schizophrenia #HuntingtonsDisease #MedicationReview #PatientExperience #SideEffects #MentalHealthTreatment #HealthcareProviders #UserReviews #MentalHealthAwareness #PsychiatricMedications

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

See Important Safety Information below, & Medication Guide here: https://bit.ly/4ivEe2k. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.

Hear experts discuss the impact of tardive dyskinesia (TD) and why talking to your doctor about symptoms of TD is so important.

APPROVED USES
AUSTEDO XR is a prescription medicine that is used to treat:
• the involuntary movements (chorea) of Huntington’s disease (HD). AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements, & it does not treat other symptoms of HD, such as problems with thinking or emotions.
• movements in the face, tongue, or other body parts that cannot be controlled TD (tardive dyskinesia).
It is not known if AUSTEDO XR/AUSTEDO is safe & effective in children.
IMPORTANT SAFETY INFORMATION
AUSTEDO XR/AUSTEDO can cause serious side effects in people with HD, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR/AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR/AUSTEDO is started & when the dose is changed. Call your doctor right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.
Do not take AUSTEDO XR/AUSTEDO if you:
• have HD & are depressed or have thoughts of suicide.
• have liver problems.
• are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR/AUSTEDO. If your doctor plans to switch you from taking reserpine to AUSTEDO XR/AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR/AUSTEDO.
• are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR/ AUSTEDO. Do not start AUSTEDO XR/AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your doctor or pharmacist if you are not sure.
• are taking tetrabenazine. If your doctor plans to switch you from tetrabenazine to AUSTEDO XR/AUSTEDO, take your first dose of AUSTEDO XR/AUSTEDO on the day after your last dose of tetrabenazine.
• are taking valbenazine.
Other possible serious side effects include:
• Irregular heartbeat (QT prolongation). AUSTEDO XR/AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR/AUSTEDO with certain medicines may increase this chance.
• Neuroleptic Malignant Syndrome. Call your doctor right away & go to the nearest emergency room if you develop these signs & symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
• Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
• Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.
Sleepiness (sedation) is a common side effect of AUSTEDO XR/AUSTEDO. While taking AUSTEDO XR/AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR/AUSTEDO affects you. Drinking alcohol & taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR/AUSTEDO may increase any sleepiness caused by AUSTEDO XR/AUSTEDO.
The most common side effects of AUSTEDO in people with HD include sleepiness (sedation), diarrhea, tiredness, & dry mouth.
The most common side effects of AUSTEDO in people with TD include inflammation of the nose & throat (nasopharyngitis) & problems sleeping (insomnia).
The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with HD or TD. These are not all the possible side effects of AUSTEDO XR/AUSTEDO. Call your doctor for advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

In a significant advancement for those suffering from tardive dyskinesia (TD), the U.S. Food and Drug Administration (FDA) recently approved Austedo XR (extended-release deutetrabenazine). This approval brings a new, convenient treatment option for patients grappling with this often debilitating condition.

The most notable advantage of Austedo XR is its once-daily dosing regimen. This is a significant improvement over the immediate-release form, which requires twice-daily dosing. A once-daily pill is easier for patients to adhere to, improving overall treatment compliance.

Read blog post here: https://psychiatryeducationforum.com/Austedo-XR

See Important Safety Information below, & Medication Guide here: https://bit.ly/4ivEe2k. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.

APPROVED USES
AUSTEDO XR is a prescription medicine that is used to treat:
• the involuntary movements (chorea) of Huntington’s disease (HD). AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements, & it does not treat other symptoms of HD, such as problems with thinking or emotions.
• movements in the face, tongue, or other body parts that cannot be controlled TD (tardive dyskinesia).
It is not known if AUSTEDO XR/AUSTEDO is safe & effective in children.
IMPORTANT SAFETY INFORMATION
AUSTEDO XR/AUSTEDO can cause serious side effects in people with HD, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR/AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR/AUSTEDO is started & when the dose is changed. Call your doctor right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.
Do not take AUSTEDO XR/AUSTEDO if you:
• have HD & are depressed or have thoughts of suicide.
• have liver problems.
• are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR/AUSTEDO. If your doctor plans to switch you from taking reserpine to AUSTEDO XR/AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR/AUSTEDO.
• are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR/ AUSTEDO. Do not start AUSTEDO XR/AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your doctor or pharmacist if you are not sure.
• are taking tetrabenazine. If your doctor plans to switch you from tetrabenazine to AUSTEDO XR/AUSTEDO, take your first dose of AUSTEDO XR/AUSTEDO on the day after your last dose of tetrabenazine.
• are taking valbenazine.
Other possible serious side effects include:
• Irregular heartbeat (QT prolongation). AUSTEDO XR/AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR/AUSTEDO with certain medicines may increase this chance.
• Neuroleptic Malignant Syndrome. Call your doctor right away & go to the nearest emergency room if you develop these signs & symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
• Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
• Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.
Sleepiness (sedation) is a common side effect of AUSTEDO XR/AUSTEDO. While taking AUSTEDO XR/AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR/AUSTEDO affects you. Drinking alcohol & taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR/AUSTEDO may increase any sleepiness caused by AUSTEDO XR/AUSTEDO.
The most common side effects of AUSTEDO in people with HD include sleepiness (sedation), diarrhea, tiredness, & dry mouth.
The most common side effects of AUSTEDO in people with TD include inflammation of the nose & throat (nasopharyngitis) & problems sleeping (insomnia).
The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with HD or TD. These are not all the possible side effects of AUSTEDO XR/AUSTEDO. Call your doctor for advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

See Important Safety Information below, & Medication Guide here: https://bit.ly/4ivEe2k. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.

Hear experts discuss the impact of tardive dyskinesia (TD) and why talking to your doctor about symptoms of TD is so important.

APPROVED USES
AUSTEDO XR is a prescription medicine that is used to treat:
• the involuntary movements (chorea) of Huntington’s disease (HD). AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements, & it does not treat other symptoms of HD, such as problems with thinking or emotions.
• movements in the face, tongue, or other body parts that cannot be controlled TD (tardive dyskinesia).
It is not known if AUSTEDO XR/AUSTEDO is safe & effective in children.
IMPORTANT SAFETY INFORMATION
AUSTEDO XR/AUSTEDO can cause serious side effects in people with HD, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR/AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR/AUSTEDO is started & when the dose is changed. Call your doctor right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.
Do not take AUSTEDO XR/AUSTEDO if you:
• have HD & are depressed or have thoughts of suicide.
• have liver problems.
• are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR/AUSTEDO. If your doctor plans to switch you from taking reserpine to AUSTEDO XR/AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR/AUSTEDO.
• are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR/ AUSTEDO. Do not start AUSTEDO XR/AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your doctor or pharmacist if you are not sure.
• are taking tetrabenazine. If your doctor plans to switch you from tetrabenazine to AUSTEDO XR/AUSTEDO, take your first dose of AUSTEDO XR/AUSTEDO on the day after your last dose of tetrabenazine.
• are taking valbenazine.
Other possible serious side effects include:
• Irregular heartbeat (QT prolongation). AUSTEDO XR/AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR/AUSTEDO with certain medicines may increase this chance.
• Neuroleptic Malignant Syndrome. Call your doctor right away & go to the nearest emergency room if you develop these signs & symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
• Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
• Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.
Sleepiness (sedation) is a common side effect of AUSTEDO XR/AUSTEDO. While taking AUSTEDO XR/AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR/AUSTEDO affects you. Drinking alcohol & taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR/AUSTEDO may increase any sleepiness caused by AUSTEDO XR/AUSTEDO.
The most common side effects of AUSTEDO in people with HD include sleepiness (sedation), diarrhea, tiredness, & dry mouth.
The most common side effects of AUSTEDO in people with TD include inflammation of the nose & throat (nasopharyngitis) & problems sleeping (insomnia).
The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with HD or TD. These are not all the possible side effects of AUSTEDO XR/AUSTEDO. Call your doctor for advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

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See Important Safety Information below; Prescribing Information including Boxed Warning: https://bit.ly/3YhB0s9. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.
INDICATIONS & USAGE
AUSTEDO XR is indicated in adults for the treatment of chorea associated with Huntington's disease (HD) & for the treatment of tardive dyskinesia (TD).
IMPORTANT SAFETY INFORMATION
Depression & Suicidality in HD Patients: AUSTEDO XR can increase the risk of depression & suicidal thoughts & behavior (suicidality) in HD Patients. Balance the risks of depression & suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidality, or unusual changes in behavior. Inform patients, their caregivers, & families of the risk of depression & suicidality & instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation. AUSTEDO XR is contraindicated in patients who are suicidal, & in patients with untreated or inadequately treated depression.
Contraindications: AUSTEDO XR is contraindicated in HD patients who are suicidal, or have untreated or inadequately treated depression. AUSTEDO XR is also contraindicated in: patients with hepatic impairment; patients taking reserpine or within 20 days of discontinuing reserpine; patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of discontinuing MAOI therapy; & patients taking tetrabenazine or valbenazine.
Clinical Worsening & Adverse Events in HD Patients: AUSTEDO XR may cause a worsening in mood, cognition, rigidity, & functional capacity. Prescribers should periodically re-evaluate the need for AUSTEDO XR in their patients by assessing the effect on chorea & possible adverse effects.
QTc Prolongation: AUSTEDO XR may prolong the QT interval, but the degree of QT prolongation is not clinically significant when AUSTEDO XR is administered within the recommended dosage range. AUSTEDO XR should be avoided in patients with congenital long QT syndrome & in patients with a history of cardiac arrhythmias.
Neuroleptic Malignant Syndrome (NMS), a potentially fatal symptom complex reported in association with drugs that reduce dopaminergic transmission, has been observed in patients receiving tetrabenazine. The risk may be increased by concomitant use of dopamine antagonists or antipsychotics. The management of NMS should include immediate discontinuation of AUSTEDO XR; intensive symptomatic treatment & medical monitoring; & treatment of any concomitant serious medical problems.
Akathisia, Agitation, & Restlessness: AUSTEDO XR may increase the risk of akathisia, agitation, & restlessness. The risk of akathisia may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops akathisia, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Parkinsonism: AUSTEDO XR may cause parkinsonism in TD or HD patients. The risk of parkinsonism may be increased by concomitant use of dopamine antagonists or antipsychotics. If a patient develops parkinsonism, the AUSTEDO XR dose should be reduced; some patients may require discontinuation of therapy.
Sedation & Somnolence: Sedation is a common dose-limiting adverse reaction of AUSTEDO XR. Patients should not perform activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery, until they are on a maintenance dose of AUSTEDO XR & know how the drug affects them. Concomitant use of alcohol or other sedating drugs may have additive effects & worsen sedation & somnolence.
Hyperprolactinemia: Tetrabenazine elevates serum prolactin concentrations in humans. If there is a clinical suspicion of symptomatic hyperprolactinemia, appropriate laboratory testing should be done & consideration should be given to discontinuation of AUSTEDO XR.
Binding to Melanin-Containing Tissues: Deutetrabenazine or its metabolites bind to melanin-containing tissues & could accumulate in these tissues over time. Prescribers should be aware of the possibility of long-term ophthalmologic effects.
Common Adverse Reactions: The most common adverse reactions for AUSTEDO (greater than 8% & greater than placebo) in a controlled clinical study in HD patients were somnolence, diarrhea, dry mouth, & fatigue. The most common adverse reactions for AUSTEDO (4% & greater than placebo) in controlled clinical studies in TD patients were nasopharyngitis & insomnia. Adverse reactions with AUSTEDO XR are expected to be similar to AUSTEDO.

See Important Safety Information below, & Medication Guide here: https://bit.ly/4ivEe2k. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.

APPROVED USES
AUSTEDO XR is a prescription medicine that is used to treat:
• the involuntary movements (chorea) of Huntington’s disease (HD). AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements, & it does not treat other symptoms of HD, such as problems with thinking or emotions.
• movements in the face, tongue, or other body parts that cannot be controlled TD (tardive dyskinesia).
It is not known if AUSTEDO XR/AUSTEDO is safe & effective in children.
IMPORTANT SAFETY INFORMATION
AUSTEDO XR/AUSTEDO can cause serious side effects in people with HD, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR/AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR/AUSTEDO is started & when the dose is changed. Call your doctor right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.
Do not take AUSTEDO XR/AUSTEDO if you:
• have HD & are depressed or have thoughts of suicide.
• have liver problems.
• are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR/AUSTEDO. If your doctor plans to switch you from taking reserpine to AUSTEDO XR/AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR/AUSTEDO.
• are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR/ AUSTEDO. Do not start AUSTEDO XR/AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your doctor or pharmacist if you are not sure.
• are taking tetrabenazine. If your doctor plans to switch you from tetrabenazine to AUSTEDO XR/AUSTEDO, take your first dose of AUSTEDO XR/AUSTEDO on the day after your last dose of tetrabenazine.
• are taking valbenazine.
Other possible serious side effects include:
• Irregular heartbeat (QT prolongation). AUSTEDO XR/AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR/AUSTEDO with certain medicines may increase this chance.
• Neuroleptic Malignant Syndrome. Call your doctor right away & go to the nearest emergency room if you develop these signs & symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
• Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
• Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.
Sleepiness (sedation) is a common side effect of AUSTEDO XR/AUSTEDO. While taking AUSTEDO XR/AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR/AUSTEDO affects you. Drinking alcohol & taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR/AUSTEDO may increase any sleepiness caused by AUSTEDO XR/AUSTEDO.
The most common side effects of AUSTEDO in people with HD include sleepiness (sedation), diarrhea, tiredness, & dry mouth.
The most common side effects of AUSTEDO in people with TD include inflammation of the nose & throat (nasopharyngitis) & problems sleeping (insomnia).
The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with HD or TD. These are not all the possible side effects of AUSTEDO XR/AUSTEDO. Call your doctor for advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

📌 Top 10 Must-Know Facts About Austedo | Uses, Benefits & Side Effects!

Thinking about Austedo (deutetrabenazine) or just want to learn more? In this video, we break down the top 10 key facts about Austedo, including its uses, benefits, side effects, and how it works for conditions like tardive dyskinesia (TD) and Huntington’s disease (HD)-related chorea.

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What Are The Side Effects Of Deutetrabenazine (Austedo)? Understanding the side effects of medications like Deutetrabenazine is vital for anyone managing movement disorders, especially in individuals dealing with schizophrenia. In this informative video, we’ll discuss the various side effects associated with Deutetrabenazine, also known as Austedo. We’ll cover both common and less common side effects, providing you with a comprehensive overview of what to expect when taking this medication.

We’ll highlight the importance of monitoring for symptoms that may arise and how they can impact daily life. Additionally, we’ll touch on the significance of communicating with healthcare providers to ensure that treatment is effective and safe. This video aims to equip you with the knowledge needed to manage potential side effects effectively.

If you or someone you know is considering or currently taking Deutetrabenazine, this video is a must-watch. Stay informed and proactive about your health. Don’t forget to subscribe to our channel for more helpful discussions and resources related to mental health and treatment options.

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#Deutetrabenazine #Austedo #MentalHealth #Schizophrenia #MovementDisorders #MedicationSideEffects #MentalHealthAwareness #PatientEducation #Healthcare #MentalWellness #SchizophreniaTreatment #PsychiatricMedications #MentalHealthSupport #MedicationManagement #SideEffects

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Austedo is an oral medication used to treat two movement disorders in adults: Huntington’s disease and tardive dyskinesia. It comes in immediate-release tablets that are taken twice per day, and once-daily extended-release tablets. Austedo was first approved by the FDA in 2017.

00:08 Dosage
00:26 How It Works
00:41 Side Effects

Learn more: https://www.drugs.com/austedo.html

Austedo belongs to a class of medications called vesicular monoamine transporter 2 (VMAT2) inhibitors. It works by changin g the activity of chemicals in the brain that affect nerves and muscles, which reduces the unwanted body movements. This medication isn’t a cure, but it can improve quality of life for those living with Huntington’s disease or tardive dyskinesia.

The most common side effects of Austedo may include drowsiness, tiredness, dry mouth, runny or stuffy nose, sore throat, sleep problems, and diarrhea.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Always consult with your healthcare provider.

To learn more about any medication, or medical treatment, visit https://www.drugs.com

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Aubagio (Teriflunomide) Safety Monitoring for Multiple Sclerosis [2018]

In this short video Dr. B reviews required safety screening before starting and while taking a bath you for multiple sclerosis. Your Provider will want to check several labs before starting including a TB test (skin or blood test), and liver enzyme test and blood counts. They may want to check a few others depending on your history.

During the 1st six months while taking Aubagio, we need to check ALT (a liver enzyme) once a month. After that we only need to check (liver enzymes and blood counts) every 3-6 months.

Aubagio can cause GI upset that normal resolved in a couple months. About 13% of people have a transient hair thinning (alopecia) that occurs at month 2 and tends to resolve around month 6. Stopping Aubagio does not change that outcome.

Aubagio is not considered safe in pregnancy and appropriate birth control measures are important.

Aubagio has a long half life (Sticks around the body for a long time after you stop taking it). If you need to get it cleared quickly from the body for whatever reason, there is a rapid elimination process that can be used.

Rarely Aubagio can cause a peripheral neuropathy or elevated blood pressure.

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Start watching to learn about Aubagio for Multiple Sclerosis!

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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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Aubagio is a medication used to treat various types of Multiple Sclerosis (MS) including Relapse/Remitting, Clinically Isolated Syndrome and Secondary Progressive.

It's mechanism of action revolves around blocking pyrimidine synthesis which basically means it helps lower inflammation.

Interestingly, Aubagio is the active metabolite of the drug Arava (leflunomide). That means that Arava is broken down into Aubagio. So their side effect profiles are similar.

Speaking of which when you take Aubagio you'll want to watch out for side effects including low phosphate levels, headache, diarrhea and hair loss.

Your doctor will monitor your labs pretty closely as well. So you'll need to have a CBC (Complete Blood Count) and a TB (Tuberculosis) test. You'll also need to keep an eye on your immune system and liver function.

The manufacturer of Aubagio does offer various forms of financial assistance. You can learn more here: https://www.aubagio.com/cost

Are you or have you taken Aubagio? Know someone who has? I'd love to hear about it in the comments below.

Featuring Dr. Jim Bowen and Dr. Lily Jung Henson. Information in this video was accurate as of its creation in January 2013. Please visit www.nationalMSsociety.org/meds or www.aubagio.com for the most updated information. To learn more about Aubagio and other disease modifying therapy options, download the Consensus on Disease Modifying Therapies online at www.nationalmssociety.org/DMTconsensus.

Should we still use Aubagio?To learn my answer, start watching this video right now!

The Boster Center for Multiple Sclerosis accepts all major insurance carriers and accepts consults from around the globe, both in office and via telemedicine. www.BosterMS.com or call 614-304-3444 to schedule!
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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS to help education others. These videos do not provide medical advice and are for informational/educational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!

Welcome to my candid in-depth review of Qulipta! In this video, I'll be unveiling everything you need to know about this innovative product. If you've been curious about Qulipta and its effectiveness, you've come to the right place. Join me as I share my personal experience and insights on this remarkable solution. In this Qulipta review, I'll dive deep into its features, benefits, and potential side effects. I'll discuss how Qulipta can enhance your life and if it's the right choice for you.
Join me as I share some real-life testimonials from individuals who have already tried Qulipta. These personal stories will help you understand the impact Qulipta can have on your overall well-being. So, if you're curious to learn more about Qulipta and determine if it's the solution you've been searching for, make sure to watch the entire video. Don't forget to subscribe to my channel and hit the notification bell, so you don't miss any future reviews and insights.

don't forget to comment, like, and subscribe to my channel for more videos. follow me on my social media as well. thank you. :)

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Neurology Today At the American Academy of Neurology Annual Meeting: People with migraine who took atogepant, an orally administered calcitonin gene-related peptide receptor antagonist, had an average of three to four fewer migraines each month. Neurology Today Editor-in-Chief Joseph E. Safdieh interviews Jessica Ailani, MD, FAAN, director of MedStar Georgetown Headache Center and professor of clinical neurology in the department of neurology at Medstar Georgetown University in Washington, DC, about the clinical implications of the research.

Read the full report with Neurology Today At the Meetings:
https://journals.lww.com/neuro....todayonline/blog/Neu
Visit Neurology Today at http://www.NeurologyToday.com
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Episode 69: New data was revealed this month on the upcoming gepant indicated for migraine prevention called Atogepant. Dr. Lindsay Weitzel questions Dr. Tim Smith about its safety and effectiveness in Episode 69 of Heads UP. How will we take it and how often? Also, when will it be available?

#headache #migraine #podcast #wellness

Follow the National Headache Foundation's podcast HeadWise, as host Lindsay Weitzel, PhD, has informative discussions with headache experts on the latest treatment, research, lifestyle recommendations, and personal stories about living with migraine disease and headache disorders. HeadWise can be found on Apple Podcasts, Spotify, Stitcher, Overcast, or wherever you get your podcasts.

Subscribe for more episodes just like this: https://www.youtube.com/c/Nati....onalHeadacheFoundati

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#migraines #drugresearch

The drug atogepant may help prevent migraines for people who have had no success with
other preventive drugs, according to a preliminary study released April 20, 2023, which will be
presented at2 the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023. The study involved people with episodic migraine, which is defined as having up to 14 headache days per month with migraine
characteristics. Atogepant is a calcitonin gene-related peptide receptor antagonist or CGRP inhibitor. CGRP is
a protein that plays a key role in starting the migraine process.

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