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DEGARELIX - - Generic ,Brand Names , Precautions , to use, Side Effects Side Effects 1 Views • 14 days ago

Orexin Blocking Sleep Medications - Belsomra - Dayvigo - Quviviq Side Effects 2 Views • 14 days ago

Main Chapters:
00:00 Intro - Orexin Blocking Sleep Medications - Belsomra - Dayvigo - Quviviq
00:11 Take home message
01:13 What is the Orexin System?
05:19 Medications Affecting the Orexin System
09:21 Other Types of Sleep Medications
14:32 Sleep and Mental Health Conditons
17:15 Conclusion and Outro

Belsomra - Suvorexant
Dayvigo - Lemborexant
Quviviq - Daridorexant

Belsomra (suvorexant) entered the US sleep-aid market almost a decade ago, and was recently joined by Dayvigo (lemborexant) and Quviviq (daridorexant).
All of these agents work to block orexin receptors in the brain, a distinctively different mechanism than other sleeping pills.

Despite several distinct advantages over other classes of sleeping agents, sales have not been spectacular. But recent discoveries, particularly a suggestion that suvorexant may reduce the amyloid Beta plaques and Tau fibrillary tangles that are hallmarks of Alzheimer's Dementia has driven up attention.

Experts think that these agents may also have a role in treating depression, anxiety and ADHD.

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Free link to my Medium Article on Orexin Blocking Sleep Medications:
https://medium.com/invisible-i....llness/our-best-inso

Follow https://dockruse.medium.com on Medium for hundreds of full length articles on this subject and more!
Access to other Medium articles requires paid membership.
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Full Chapter list:
00:00 Intro - Orexin Blocking Sleep Medications - Belsomra - Dayvigo - Quviviq
00:11 Take home message
01:13 What is the Orexin System?
02:41 What is Orexin?
05:19 Medications Affecting the Orexin System
05:35 Modafinil (Provigil) / Armodafinil (Nuvigil)
06:23 DORA Medications (Dual Orexin Receptor Antagonist)
09:21 Other Types of Sleep Medications
09:37 Benzodiazepines
11:33 NonBenzodiapzepines (Z-drugs)
13:04 Comparing with the DORA Medications
14:32 Sleep and Mental Health Conditons
17:15 Conclusion and Outro

Streamed live June 14, 2023

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world.

Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background.

You're welcome to email him with topics you want discussed or people you think he should interview.

[email protected]

#health #mentalhealth #sleep #orexin

Dayvigo (Lamborexant): The New Kid on the Insomnia Block Side Effects 1 Views • 14 days ago

Discover the latest breakthrough in insomnia treatment with Dayvigo! 🌙 In this video, we dive into the science behind Dayvigo (lemborexant), a revolutionary new medication that helps you fall asleep faster and stay asleep longer. Learn how this FDA-approved orexin receptor antagonist works, its benefits over traditional sleep aids, and what clinical trials reveal about its effectiveness. Say goodbye to sleepless nights and hello to restful sleep with Dayvigo! Don't forget to like, comment, and subscribe for more updates on cutting-edge treatments for insomnia and other mental health conditions.

Thank you for joining. Please like this video and subscribe to our channel
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DARZALEX ( Daratumumab Injection )- Generic ,Brand Names , Precautions , to use, Side Effects Side Effects 1 Views • 14 days ago

#21: warfarin (Coumadin) | Anticoagulant for MI and Thromboembolic Complications | Drug Cards Daily Side Effects 1 Views • 14 days ago

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Drug Cards Daily | Episode #21: warfarin (Coumadin) | Anticoagulant for Treatment of Myocardial Infarction and Thromboembolic Complications

Warfarin is an anticoagulant that is also known by the brand name Coumadin. It is used in the treatment of myocardial infarction and thromboembolic complications. There is a wide variety of tablet strengths from 1 mg to as high as 10 mg. When dosing warfarin it is very patient-specific. The therapeutic goal is based on various factors and treatment nomograms may vary from institution to institution. Prior to initiation it is wise to establish the patient’s genetic variant for CYP2C9 since this will play a large role in predicting their drug sensitivity. When attempting to reach a therapeutic target the healthcare professional uses INR readings to determine the level of anticoagulation. Generally a range between 2-3 is common with 2.5-3.5 when a high level of intensity is required. Other factors that may help determine patient response are age, race, and diet. The mechanism of action for warfarin lies in the antagonism of Vitamin K which leads toward the inhibition of coagulation factors 2, 7, 9, and 10. The rate-limiting factor can be seen as factor 2 due to it’s long half-life of 60-72 hours. Although INR elevation can be seen in 24-48 hours, therapeutic benefits are not achieved until around 5-7 days after initiation. There is a black box warning for bleeding risk so a patient's INR should be monitored regularly.

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Coumadin Side Effects 1 Views • 14 days ago

EmpoweRN.com
Hi Guys!
I really hope this video helps you out a ton! This medication is one of the major ones you will see in adult Med Surg & Critical care. Although it saves lives, we have to be very careful when taking care of patients with clotting tendencies.
Furthermore, we must also educate our patients about diet restrictions, safety precautions and the importance of their follow up appointments.
I hope this video simplifies at least a little bit of it ;)
Also, remember... you can access the audio of the video to download on your device, so that not matter where you are, you can always be learning.
If you prefer to watch the video without any music, you can go to my website... you will also find the audio there:
http://wp.me/s4CVjD-coumadin
I hope this & all of the videos help you tremendously.
Much love,
- Caroline

Warfarin aka Coumadin is the most used oral anticoagulant in the world and has been used for more than 50 years for therapy in prevention of thrombus formation and subsequent thromboembolic events. Anticoagulants are blood thinners which prevent formation of blood clots as well as prevent existent blood clots from increasing in size. Blood clots can hinder blood circulation and lead to serious medical conditions, like stroke, heart attack and pulmonary embolism. Thus warfarin is helpful in treating and preventing vein and artery blockage, stroke and heart attack.
Mechanism of Action
Warfarin slows down the formation of blood clots within 24 hours, but the complete effect takes place between 72 to 96 hours after taking the medication. Blood clot formation is a
complicated process which requires certain compounds known as coagulating factors to be present. These coagulating factors are produced by the liver. In the presence of sufficient vitamin K. Warfarin acts by inhibiting the presence of vitamin K and this inhibits the formation of coagulating factors. Substances that require vitamin K for their formation are: the anticoagulant proteins C and S and factors II, VII, IX, and X. Therefore, medications like warfarin block coagulating factors and disturb the process of clot formation. Thus slowing down blood clot formation. In the case of blood clots that are already formed, warfarin stops the clot from getting bigger. It also prevents breakage of the clot which can be otherwise dangerous if it travels in the bloodstream and blocks blood vessels. Warfarin cannot destroy or dissolve a blood clot that is already there. But the blood clot itself may slowly dissolve with time. Nor can Warfarin reverse ischemic tissue damage either, but, may help avoid secondary thromboembolic complications that can be dangerous and even fatal.

Indication
Warfarin (Coumadin) is indicated for/to:
• Prophylaxis, pulmonary embolism (PE), venous thrombosis and its extension, and to prevent blood clots from moving to other parts of the body.
• Reduce the risk of another stroke or heart attack in clients who already have had stroke or heart attack, and to reduce the risk of death.
• Prevent and treat blood clots associated with atrial fibrillation (irregular rapid heartbeat), heart-valve replacement and blood clots in lungs and legs.

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