Dangerous Side Effects

Neosporin Ointment / Neosporin Ointment Uses / Neosporin Antibiotic Ointment
Neosporin Ointment / Neosporin Ointment Uses / Neosporin Antibiotic Ointment Side Effects 3 Views • 5 months ago

Neosporin Ointment / Neosporin Ointment Uses / Neosporin Antibiotic Ointment
#neosporin #neosporineyeointment #creativehealthcare


Neosporin ointment is a combination of three medicine namely:- neomycin polymyxin B and bacitracin.
It is used to treat bacterial infections of skin and eyes.
In this video we will discuss about:-
Neosporin ointment uses composition mode of action how to apply side effects and precautions.



#neosporin #neosporineyeointment #neosporinointment #skininfection #skincare #pharmacistdanish #creativehealthcare


Moxifloxacin eye drops:-
https://youtu.be/ysOzY8yKbGM?si=GU5w1fWG6b3VKGKv

Tobramycin and Fluorometholone eye drops:-
https://youtu.be/cuAI3wckNnA?si=ZISsp2e9Q3Zl8gra

Ciplox d eye drops:-
https://youtu.be/MKzoZ60Xs4Q?si=NNGFSJ8urwvqMy3F

Betadine ointment:-
https://youtu.be/AEYjnYINSE0?si=X9my18EGC8RtO-iM

Mupirocin ointment:-
https://youtu.be/CVCTx0nvooc?si=3F9E1yYPosDxzc_0

Soframycin skin cream:-
https://youtu.be/r5mP_UbEj90?si=3ZbWKM-OwDb80-6F

Medisalic cream:-
https://youtu.be/z2ObFmU318o?si=rmWXASpKug-TyWSa

Skinlite cream:-
https://youtu.be/3IazL8k-jRA?si=TQZXOoZnWbCgFgVN

ELOSONE-HT cream:-
https://youtu.be/J69cY38IZ2M?si=WFn_12NWwqYJtUUn


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Disclaimer :- We create videos for education and information purpose only.Please consult your doctor before taking any medicine.we are not promoting self medication.This channel doesn't take any responsibility for any harm,side effect or any health problem caused due to the use of our content.

Neomycin Tablet क्यों use नहीं होती? | side effects of Neomycin | Uses of antibiotic Neomycin
Neomycin Tablet क्यों use नहीं होती? | side effects of Neomycin | Uses of antibiotic Neomycin Side Effects 3 Views • 5 months ago

Neomycin Tablet क्यों use नहीं होती? | side effects of Neomycin | Uses of antibiotic Neomycin
In this video you'll know about Neomycin Tablet
It is active against most gram negative bacilli
and some gram positive cocci.
Neomycin is highly toxic to the internal ear (mainly auditory) and kidney, hence it is not preferred to be used systemically.
It is poorly absorbed from the G.I.T.
It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.

Indications:
Orally used for bacterial diarrhoeas and dysentery.
Preparation of bowel before surgery
Hepatic coma

Dosage:
0.25-1 gm four times

Contra indications:
Hypersensitivity to aminoglycosides
renal impairment
Prolonged use can induce malabsorption syndrome with diarrhoea and steatorrhoea.
It decreases absorption of digoxin, bile acid reabsorption and lowers plasma cholesterol levels.
Paediatrics: Use with caution
Pregnancy: Contraindicated
Lactation: Contraindicated
Elderly: Use with caution.

Side- effects:
Ototoxicity
Nephrotoxicity
Nausea
Vomiting
Diarrhoea

Drug interactions : Potentiates nephrotoxicity produced
by other aminoglycosides, neuromuscular blocking action of
tubocurarine and pancuronium. Potentiates ototoxic effect
of loop diuretics. Interferes with absorption of digoxin, phe-
noxymet-hylpenicilline, Vit. B12, Methotrexate, 5-flurouracil
and spironolactone. Cholestercl lowering

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Neomycin - Skin Infection की दवा | Uses & Side-effects | इसका इस्तेमाल कब किया जाता है ?
Neomycin - Skin Infection की दवा | Uses & Side-effects | इसका इस्तेमाल कब किया जाता है ? Side Effects 3 Views • 5 months ago

Skin Infection Medicine - Neomycin
Full Details In Hindi
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What Is Neomycin Sulfate? - Pharmaceutical Insights
What Is Neomycin Sulfate? - Pharmaceutical Insights Side Effects 3 Views • 5 months ago

What Is Neomycin Sulfate? In this informative video, we will explore Neomycin sulfate, a widely used antibiotic that effectively combats bacterial infections. We will discuss its origins, derived from the bacterium Streptomyces fradiae, and its composition, which includes active components that contribute to its antibacterial properties. You will learn how Neomycin sulfate functions at the cellular level by targeting bacterial ribosomes, disrupting protein production, and leading to bacterial death.

The video will cover the various applications of Neomycin sulfate in the medical field, including its use in oral treatments for intestinal conditions and its topical formulations for skin, eye, and ear infections. We will also highlight the importance of understanding dosage measurements in pharmaceutical products, as well as the potential side effects associated with its use.

Join us as we provide a comprehensive overview of Neomycin sulfate, its role in treating infections, and its significance in modern medicine. Don't forget to subscribe to our channel for more informative content on medications and health topics.

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#Neomycin #Antibiotics #InfectionTreatment #Aminoglycoside #MedicalEducation #Pharmaceuticals #BacterialInfections #TopicalAntibiotics #OralMedications #HealthCare #Medicine #DrugInformation #PatientCare #Pharmacy #HealthTopics

About Us: Welcome to Pharmaceutical Insights! Our channel is dedicated to providing clear and informative content on a variety of topics related to pharmaceutical drugs, prescription medications, over-the-counter medicines, drug side effects, and medication safety. We also discuss medical treatments, alternative medicine, and pain management drugs, ensuring you have access to the information you need to make informed health decisions. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Nebivolol, vale a pena?
Nebivolol, vale a pena? Side Effects 3 Views • 5 months ago

Nebivolol, vale a pena?

Aqui neste vídeo voce vai saber 05 pontos positivos sobre o nebivolol que podem mudar a sua vida!

O conhecimento é algo que muda a sua vida!
Vamos aprender sobre esta medicação?


👨🏻‍⚕️ BEM VINDO AO MINUTO CARDIOLOGIA

Quer saber mais sobre assuntos médicos na área de cardiologia?
✔✔ Bom, sou médico, especialista em medicina interna, cardiologia e ecocardiografia.

Você pode conferir meu currículo em
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💊Neste canal teremos vídeos com frequência, trocaremos informações, tira dúvidas e diversas formas de te ajudar a desmistificar tudo sobre o assunto de forma bem intuitiva, com linguagem fácil e esclarecedora e o melhor de tudo, sem delongas, sem informações sensacionalistas!

Serei sempre honroso com a ética médica e aqui tudo será colocado de acordo com a literatura médica, baseada em estudos científicos e apenas veracidade.

Naloxone (Narcan) and Opioid Overdose
Naloxone (Narcan) and Opioid Overdose Side Effects 3 Views • 5 months ago

In this episode we bring attention to a potentially life saving drug. The FDA recently approved the opioid reversal agent Naloxone (Narcan) nasal spray to be made available over the counter without a prescription. In this podcast we talk with Dr. Daniel Colby, an emergency and addiction medicine physician, about the dangers of opioid misuse, what opioids are, how to recognize an overdose and how and when to administer this life saving medication.

This episode was written by Dr. Lena van der List, Dr. Dean Blumberg & Daniel Colby, and was originally published on 5/8/2023. For information purposes only. Consult your local medical authority for advice.

Supplemental information:
How to use Narcan nasal spray -
https://youtu.be/Q8FjunfEUeg
Fentanyl Myths & Facts: https://youtu.be/DyNbZjg4bYY
The Opioid Epidemic: How to Protect Your Family - https://www.healthychildren.or....g/English/ages-stage

——

Kids Considered™ is a UC Davis Children’s Hospital podcast, featuring two pediatricians who discuss child health topics of interest to parents in plain, non-medical language. New subjects are considered in every episode, discussing issues that apply from healthy pregnancy to birth to teen years. We have different styles of practice and viewpoints, but our goals are the same: we want to optimize children’s health and development, and help parents understand current recommendations and why policies are the way they are. Hosted by Dr. Lena van der List and Dr. Dean Blumberg.

Kids Considered blog: https://health.ucdavis.edu/blog/kids-considered
UC Davis Children's Hospital: https://children.ucdavis.edu
See the latest news from UC Davis Health: https://health.ucdavis.edu/newsroom

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#kidsconsidered #podcast #narcan #fentanyl #opioids #overdose

How to: Narcan Nasal Spray - Step-by-step Instructions
How to: Narcan Nasal Spray - Step-by-step Instructions Side Effects 3 Views • 5 months ago

Narcan is used for the emergency treatment of opioid overdose, to reverse the life-threatening effects of the opioid. It’s available as a single-dose nasal spray. In this video, we will review step-by–step how to use Narcan.

00:00 Treatment
00:22 Check for a suspected overdose
00:32 How to use the device
00:52 What to do next

Learn more about Narcan:
https://www.drugs.com/narcan.html
Watch more Medication Basics: https://www.youtube.com/playli....st?list=PL93lxawed2h

Before using Narcan, review the instructions provided with the medication. Review the following steps on how to use Narcan nasal spray.

* Step 1: Check for a suspected overdose by yelling “wake up” and gently shaking the person. If the person does not wake up, proceed to step 2.
* Step 2: Hold the Narcan nasal spray device with your thumb on the bottom of the plunger, and insert the nozzle into either nostril of the person suspected to have overdosed. Press the plunger firmly to give the first dose. Remember, each Narcan device contains only one dose.
* Step 3: Call 911 immediately after giving the first dose of Narcan.
* Step 4: Wait 2-3 minutes. If the person wakes up, stay with them until medical help arrives. If they do not wake up or become sleepy again, give Narcan every 2-3 minutes until they wake up.

If you have any questions about how to use Narcan, contact your healthcare provider or the manufacturer, Emergent Devices Inc.

References:
Narcan [package insert]. Updated August 2023. Emergent Devices Inc. Accessed October 7, 2024 at https://dailymed.nlm.nih.gov/d....ailymed/drugInfo.cfm

What side effects can you get from LDN?- Dr Judy Tsafrir
What side effects can you get from LDN?- Dr Judy Tsafrir Side Effects 3 Views • 5 months ago

For further Q&A's visit https://ldnresearchtrust.org/questions-and-answers

Please visit our website https://www.ldnresearchtrust.org which is packed with information on LDN for Autoimmune Conditions, Cancers, Chronic Pain, Women's Health, Children's Health etc, plus we have a very active FB Closed Group https://www.facebook.com/groups/LDNRT/

How Low Dose Naltrexone for Fibromyalgia Can Change Your Life
How Low Dose Naltrexone for Fibromyalgia Can Change Your Life Side Effects 3 Views • 5 months ago

Low dose naltrexone for fibromyalgia: the four-year update.
It has changed my life!! I cannot wait to share the results of this long experiment with you.

get my LDN ebook
https://payhip.com/b/DNTL

Timestamps
What is LDN 1:30
How does LDN help fibromyalgia 2:10
Research 3:00
Side effects 4:10
Tips for starting 5:00
How I started and my experience 5:45
The benefits I have experienced 7:00
Pain 7:45
Emotional 9:44
Conclusion 11:00

For more information and plenty of links to classes check out this blog post:
https://www.melissavsfibromyalgia.com/?p=4891

For unlimited classes designed for people with fibromyalgia come and join Yoga for the Chronic Life virtual yoga studio https://melissavsfibromyalgia.....teachable.com/p/yoga

Donate https://www.patreon.com/MelissaReynolds

More videos for you
Gentle beginner yoga https://www.youtube.com/watch?v=Fkkfxgnr4Sw&t=0s
Yoga Nidra meditation https://www.youtube.com/watch?v=658qKNZLIYQ&t=0s
Gentle chair yoga for fibromyalgia https://www.youtube.com/watch?v=JW6aByjdkhU&t=0s
Ultimate guide to managing fibromyalgia https://www.youtube.com/watch?v=lgUA-67BdkM
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Disclaimer: Yoga includes physical movements as well as an opportunity for relaxation, stress re-education and relief of muscular tension. As is the case with any physical activity, the risk of injury, even serious or disabling, is always present and cannot be entirely eliminated. If you experience any pain or discomfort, listen to your body, discontinue the activity, and ask for support from your medical team. If you engage in this exercise or exercise program, you agree that you do so at your own risk, are voluntarily participating in these activities, assume all risk of injury to yourself, and agree to release and discharge
#lowdosenaltrexone #fibromyalgia #chronicpain #chronicfatigue #LDNforfibromyalgia

How long does Naltrexone last?
How long does Naltrexone last? Side Effects 3 Views • 5 months ago

Interested in learning more about us? Check us out at https://bit.ly/bicyclehealth2.

This video is for general education purposes only. The content here should not be take as medical advice. If you have questions about treatment for opioid use disorder speak to a licensed medical professional, or contact Bicycle Health at https://bit.ly/bicyclehealthhome.

0:00 How long does Naltrexone last?

Suboxone treatment is not for everyone. Review possible risks and side-effects at https://www.suboxone.com/.

Does naltrexone impact your mood or block healthy endorphins? | The Sinclair Method
Does naltrexone impact your mood or block healthy endorphins? | The Sinclair Method Side Effects 3 Views • 5 months ago

Dr. Mendelson discusses whether taking naltrexone as a treatment for alcohol addiction can block your bodies natural endorphins and affect your mood.
Learn more at
https://riahealth.com/youtube/
Subscribe: https://www.youtube.com/channe....l/UCHwYsKLJTk-K3mELJ

People often wonder if naltrexone blocks all the pleasure activities that produce endorphins - and not only alcohol related endorphins. In this video, Dr. Mendelson speaks about naltrexone and how it impacts endorphins, serotonin, and mood when someone is using the medication for alcohol addiction, or alcohol use disorder (AUD). Dr. Mendelson explains how endorphins from alcohol are different than endorphins from other activities.

Ria Health delivers evidence-based care that includes medications, one on one support, a digital app, and progress tools. We support people who want to either reduce or stop drinking with the care of an expert medical team and community support.

We use safe and FDA approved medications such as naltrexone, which is the cornerstone of the Sinclair Method. We also support not for profit advocates that promote awareness of options for people who want to change their relationship with alcohol. We are proud sponsors of Claudia Christian's CThree Foundation and Moderation Management.

Learn more about the Sinclair Method: https://riahealth.com/sinclair-method/
Ready to get started? Visit https://riahealth.com/begin-now/

Contact us at:
https://www.RiaHealth.com
800-504-5360
[email protected]

What Is the Dosing of Naltrexone for Alcohol Addiction? | Ria Health Psychiatrist Answers
What Is the Dosing of Naltrexone for Alcohol Addiction? | Ria Health Psychiatrist Answers Side Effects 3 Views • 5 months ago

Hear from Ria Health Psychiatrist Dr Paul Linde on how naltrexone is used to treat alcohol use disorder and the different doses used.

Learn more at
https://riahealth.com/youtube/
Subscribe: https://www.youtube.com/channe....l/UCHwYsKLJTk-K3mELJ

Ria Health delivers evidence-based care that includes medications, one on one support, a digital app, and progress tools. We support people who want to either reduce or stop drinking with the care of an expert medical team and community support.

We use safe and FDA-approved medications such as naltrexone, which is the cornerstone of the Sinclair Method. We also support not-for-profit advocates that promote awareness of options for people who want to change their relationship with alcohol. We are proud sponsors of Claudia Christian's CThree Foundation and Moderation Management.

Learn more about the medications for alcohol use disorder: https://riahealth.com/medication-for-alcoholism/
Ready to get started? Visit https://riahealth.com/begin-now/

Contact us at:
https://www.RiaHealth.com
800-504-5360
[email protected]

#Telemedicine #RiaHealth #MedicationsforAlcoholism

Naltrexone for weight loss: Does it work?
Naltrexone for weight loss: Does it work? Side Effects 3 Views • 5 months ago

How to use Naltrexone for weight loss, how naltrexone helps curb appetite, and how to use it to burn fat.

Did you know that naltrexone, also referred to as low dose naltrexone, can help with weight loss?

It's actually an effective weight loss medication provided that it is used in the right way.

LDN or naltrexone or low dose naltrexone (all names for the same medicine) is typically used to treat alcohol dependence. But it was found that it can also be used to treat autoimmune conditions. Then later it was found that LDN also seems to have some weight loss properties.

LDN has very few side effects and it works through a different mechanism compared to other medications which makes it a great add-on for many people.

AS ALWAYS, make sure that you use LDN with OTHER weight loss therapies such as diet, exercise, and so on. Using it in this way is obviously the best.

We are going to discuss 6 ways that LDN (or low dose naltrexone) can help with weight loss:

#1. Naltrexone targets insulin resistance.

Insulin resistance is one of the primary drivers of weight gain and obesity in MANY people. Up to 50% of people in the US suffer from insulin resistance in some form.

LDN helps to drive down insulin levels which can help with weight loss.

#2. Naltrexone increases growth hormone.

Some studies show that naltrexone can also increase or normalize growth hormone levels. And because growth hormone helps maintain muscle mass and fat mass in balance, it will help manage weight.

#3. Naltrexone modulates your appetite.

Naltrexone also helps to MODULATE your appetite. Notice I said modulate and not suppress. It actually helps to reduce cravings for foods you shouldn't be eating and it helps you to eat the normal amount of calories you should be each day (instead of overeating).

#4. Naltrexone reduces inflammation.

Naltrexone ALSO helps to lower inflammation. Inflammation is a driver of fat cell dysfunction and weight gain by itself. So if you reduce inflammation you will help with weight loss indirectly.

This reduction in inflammation is also why LDN is often used to treat autoimmune conditions.

#5. Naltrexone improves your sleep.

Naltrexone has also been shown to regulate sleep cycles and to help improve sleeping patterns. Because a lack of sleep is associated with obesity, anything which improves your sleep may help with weight loss.

#6. Naltrexone improves and increases thyroid hormone.

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Want more from my blog? I have more than 400+ well-researched blog posts on thyroid management, hormone balancing, weight loss, and more. See all blog posts here:
https://www.restartmed.com/blog/

Prefer to listen via podcast? Download all of my podcast episodes here: https://apple.co/3kNYTCS

Disclaimer:
Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/wha....t-happened-to-my-med

This video is for general informational, educational, and entertainment purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Childs and you. You should not make any changes to your medications or health regimens without first consulting a physician. If you have any questions please consult with your current primary care provider. Restart Medical LLC and Dr. Westin Childs are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video.
#thyroid #hypothyroidism #hashimoto's

Critical Role of Naloxone in Opioid Poisoning   #usmle  #emergencydrugs #nursing
Critical Role of Naloxone in Opioid Poisoning #usmle #emergencydrugs #nursing Side Effects 3 Views • 5 months ago

Critical Role of Naloxone in Toxicological Emergencies
Welcome to Doc A T, your trusted source for high-yield medical lectures! In this detailed session, we dive deep into toxicological emergencies, focusing on the life-saving role of Naloxone in opioid overdoses. Whether you're a doctor, medical student, or preparing for exams like USMLE, PLAB, AMC, NEET PG, or FCPs, this lecture is packed with essential knowledge to boost your understanding and exam performance.

🔍 What You’ll Learn in This Video:
✅ Overview of toxicological emergencies and their clinical presentations
✅ Mechanism of action and pharmacology of Naloxone
✅ Indications, dosing, and administration routes for Naloxone
✅ Recognizing and managing opioid overdoses effectively
✅ Case-based discussions to enhance clinical decision-making

🎯 Perfect for:

Doctors refining their emergency medicine skills
Medical students seeking clarity on toxicology concepts
USMLE, PLAB, AMC, NEET PG, FCPs aspirants needing exam-relevant content
Anyone interested in emergency medicine and toxicology

DOC AT is your trusted source for medical and health education. Our mission is to educate the public about important medical concepts. We provide lectures on complex medical concepts in an easy-to-understand way to healthcare professionals, doctors, medical students, nurses, clinicians, and caregivers. Explore our library of video lectures, tutorials, and case studies covering various medical specialties.
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Disclaimer:
The prescriptions shared in this video are just for informational purposes. Everyone’s health journey is unique, so please check in with your doctor or a healthcare professional for advice that’s right for you.
We also do not claim ownership of any images, or clipart used in this content. All rights belong to their respective owners.
Take care, stay safe, and stay healthy! 😊


#ToxicologicalEmergencies #Naloxone #OpioidOverdose #medicallectures #usmleprep #plabprep #amcexams #neetpg #FCPsExam #emergencymedicine #docat #medicaleducation #toxicology #pharmacology #clinicalcases #medstudentlife #doctorlife

What is Naloxone?
What is Naloxone? Side Effects 3 Views • 5 months ago

Naloxone can rescue someone who might take too much-prescribed medication, too much heroin, or who accidentally takes a dangerous opioid combination.

#Naloxone #Overdose #MentalHealth

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Experts Explain Effects of Narcan on Opioids
Experts Explain Effects of Narcan on Opioids Side Effects 3 Views • 5 months ago

(29 Apr 2016) Prince's final days and unexpected death at age 57 raise questions among experts familiar with prescription painkiller overdoses.
It's possible the innovative musician's demise represents one of the most public tragedies in an overdose crisis now gripping America.
A law enforcement official told The Associated Press on Thursday that investigators are looking into whether Prince died from an overdose and whether a doctor was prescribing him drugs in the weeks before he was found dead at his home in suburban Minneapolis. The law enforcement official has been briefed on the investigation and spoke to the AP on condition of anonymity because he was not authorized to speak to the media.
Whether Prince was addicted to painkillers is uncertain, but some are wondering whether the stigma surrounding addiction may have prevented Prince — who built a reputation as a sober superstar — from seeking help if he was becoming dependent.
Questions about Prince's health surfaced April 15, when his private plane made an emergency stop in Moline, Illinois. He was found unconscious aboard the aircraft, according to a law enforcement official who was briefed on the investigation and spoke to The Associated Press.
The official spoke on condition of anonymity because he was not authorized to speak to the media.
While the plane was on the tarmac, the person said, first-responders gave Prince a shot of Narcan, an antidote that is used to reverse suspected opioid overdoses. Opioids include oxycodone, Percocet, morphine, codeine and heroin.

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What Are The Side Effects Of Naloxone? - Pain Medicine Network
What Are The Side Effects Of Naloxone? - Pain Medicine Network Side Effects 3 Views • 5 months ago

What Are The Side Effects Of Naloxone? In this informative video, we will discuss the side effects associated with naloxone, a medication that plays a vital role in reversing opioid overdoses. Understanding the potential side effects is essential for anyone involved in emergency situations or managing pain. We will cover common withdrawal symptoms that may occur in individuals who are dependent on opioids after naloxone administration. Additionally, we will touch on rare allergic reactions and other less frequent side effects that some individuals might experience.

Knowing how naloxone works and its implications in overdose scenarios is important for healthcare providers and pharmacists alike. We will highlight the significance of seeking medical assistance after administering naloxone, as its effects may not last long enough to prevent a subsequent overdose. Furthermore, we will discuss the accessibility of naloxone and its various forms, emphasizing the importance of having this lifesaving medication readily available.

Join us as we break down the essential information regarding naloxone and its side effects. Don't forget to subscribe to our channel for more helpful discussions on pain management and medication safety.

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#Naloxone #OpioidOverdose #PainManagement #WithdrawalSymptoms #EmergencyMedicine #HealthCare #MedicationSafety #AddictionRecovery #AllergicReactions #LifesavingMedication #OpioidCrisis #EmergencyResponse #Pharmacy #HealthEducation #MedicalAdvice

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2-Minute Neuroscience: Naloxone (Narcan)
2-Minute Neuroscience: Naloxone (Narcan) Side Effects 3 Views • 5 months ago

Naloxone, also known by the brand name Narcan, is a medication that can be used to treat opioid overdose and substantially reduce the risk of death associated with opioid toxicity. In this video, I discuss the pharmacology of naloxone.

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TRANSCRIPT

Naloxone, also known by the brand name Narcan, is a medication that can be used to treat opioid overdose and substantially reduce the risk of death associated with opioid toxicity. The drug is a competitive antagonist at opioid receptors, which means that it works by binding to the same receptors that opioid drugs bind to, but instead of activating those receptors like opioid drugs, naloxone blocks activity at them. Naloxone also causes opioid drugs that are already attached to the receptor to be displaced. This combination of receptor blockade and removal of active opioid drugs makes naloxone capable of reversing an opioid overdose and reducing the risk of complications associated with one.

Naloxone is commonly administered by injection or nasal spray, but intranasal administration has become a preferred method due to its ease of use and safety. The drug typically begins working within a few minutes, with the exact time to onset being dependent on the route of administration. The effectiveness of naloxone can vary due to a number of factors, including the potency of the opioid in the patient’s system and the dose of opioids they administered. Repeated doses of naloxone are sometimes used to keep the patient from re-experiencing effects of opioids still present in their system after naloxone begins to wear off.

When naloxone is administered to someone with opioids in their system it can cause acute withdrawal symptoms due to the sudden cessation of activity at opioid receptors. While there is some risk associated with complications of acute withdrawal, it is considered low especially compared to the risk of complications linked to opioid overdose. Naloxone administered to someone who has not used opioids recently typically has little to no effect.

REFERENCES

Aziz R, Nguyen L, Ruhani W, Nguyen A, Zachariah B. The Optimal Initial Dose and Route of Naloxone Administration for Successful Opioid Reversal: A Systematic Literature Review. Cureus. 2024 Jan 21;16(1):e52671. doi: 10.7759/cureus.52671. PMID: 38380203; PMCID: PMC10878679.

Rzasa Lynn R, Galinkin JL. Naloxone dosage for opioid reversal: current evidence and clinical implications. Ther Adv Drug Saf. 2018 Jan;9(1):63-88. doi: 10.1177/2042098617744161. Epub 2017 Dec 13. PMID: 29318006; PMCID: PMC5753997.

Saari TI, Strang J, Dale O. Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. Clin Pharmacokinet. 2024 Apr;63(4):397-422. doi: 10.1007/s40262-024-01355-6. Epub 2024 Mar 14. PMID: 38485851; PMCID: PMC11052794.


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