Breztri vs Trelegy Ellipta – Don’t Get Them Mixed Up

Breztri Aerosphere
• Ingredients: Budesonide (ICS) + Glycopyrrolate (LAMA) + Formoterol (LABA)
• Device: Pressurized metered-dose inhaler (pMDI) — shake before use
• Indication: COPD (not FDA-approved for asthma in the U.S.)
• Dose: 2 puffs twice daily

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Trelegy Ellipta
• Ingredients: Fluticasone furoate (ICS) + Umeclidinium (LAMA) + Vilanterol (LABA)
• Device: Dry powder inhaler (DPI) — breath-activated, no shaking
• Indication: COPD and asthma (some strengths for asthma)
• Dose: 1 inhalation once daily

⸻

Key Differences to Prevent Mix-Ups
• Device type: Breztri = MDI (press and inhale), Trelegy = DPI (inhale fast and deep)
• Frequency: Breztri = 2× daily, Trelegy = 1× daily
• Approved use: Trelegy has asthma approval; Breztri doesn’t (in U.S.)
• Appearance: Breztri = canister in inhaler body, Trelegy = flat rectangular device with cover

⸻

⚠️ Why it matters:
📌Mixing them up can cause wrong dosing, under-treatment, or overdosing. Always check the name and directions on your prescription before use.

📌 Gargle 💦 water after both Breztri and Trelegy.

Not medical advice. For educational purposes only.

#pharmacisteducationcorner
#breztri
#inhaler
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#asthma

How Breztri Aerosphere Works.
Breztri Aerosphere offers a breakthrough solution to the challenges faced in treating asthma and COPD. Its unique formulation combines three active ingredients – budesonide, glycopyrronium, and formoterol fumarate – in a single inhaler device. This triple-combination therapy targets the key components of both diseases, providing comprehensive symptom relief and improving lung function.
Budesonide, a corticosteroid, acts as an anti-inflammatory agent, reducing airway inflammation and preventing exacerbations. Glycopyrronium is an anticholinergic that helps relax the airway muscles, reducing bronchoconstriction and improving airflow. Formoterol fumarate, a long-acting beta-agonist, further enhances bronchodilation and supports long-term symptom control.
The unique formulation of Breztri Aerosphere ensures that each active ingredient is delivered directly to the lungs where it is needed most. The inhaler device utilizes advanced technology to optimize drug deposition and increase lung penetration, maximizing the therapeutic effects of the medication.
Key Benefits of Breztri Aerosphere.
Breztri Aerosphere offers several key benefits that set it apart from traditional asthma and COPD treatments. Firstly, its triple-combination therapy provides a comprehensive approach to managing symptoms, addressing inflammation, bronchoconstriction, and airflow obstruction simultaneously. This holistic approach leads to improved symptom control and better overall disease management.
In addition to symptom relief, Breztri Aerosphere also improves lung function. Clinical studies have shown that patients using the medication experience increased forced expiratory volume in one second (FEV1) – a measure of lung function – compared to those using other asthma and COPD treatments. This improvement in lung function translates to better exercise tolerance and increased overall respiratory health.
Furthermore, Breztri Aerosphere's convenient inhaler device simplifies treatment regimens and enhances patient adherence. The single inhaler design eliminates the need for multiple devices, reducing the risk of confusion and medication errors. Its easy-to-use mechanism allows patients to incorporate the medication seamlessly into their daily routines, ensuring consistent and effective treatment.
Clinical Studies and Efficacy of Breztri Aerosphere.
Clinical studies have demonstrated the efficacy and safety of Breztri Aerosphere in treating both asthma and COPD. In a randomized, double-blind trial involving patients with moderate to severe COPD, Breztri Aerosphere was found to significantly improve lung function and reduce exacerbations compared to other inhaler treatments. The study also showed that the medication was well-tolerated, with a similar safety profile to other commonly used inhalers.
Similarly, studies involving patients with asthma have shown promising results. Breztri Aerosphere was found to effectively control symptoms and improve lung function compared to other asthma treatments. Its triple-combination therapy demonstrated superior efficacy in reducing exacerbations and improving overall disease control.
The positive outcomes observed in these studies highlight the potential of Breztri Aerosphere as a game-changing treatment option for both asthma and COPD patients. Its comprehensive approach and proven efficacy make it a promising choice for healthcare providers and patients seeking optimal symptom control and improved quality of life.
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

Secrets of the side effects of Breztri Aerosphere
**Common Side Effects (occurring in more than 1% of patients)**

* Upper respiratory tract infections (e.g., sore throat, sinus infection)
* Cough
* Headache
* Diarrhea
* Nausea
* Blurred vision
* Increased heart rate
* Dry mouth
* Throat irritation
* Abdominal pain
* Muscle aches
* Vomiting
* Fatigue
* Rash
* Dry cough

**Less Common Side Effects (occurring in less than 1% of patients)**

* Pneumonia
* Bronchitis
* Wheezing
* Chest tightness
* Shortness of breath
* Anxiety
* Dizziness
* Insomnia
* Taste changes
* Trembling
* Ear pain
* Dry eye

**Serious Side Effects**

* **Pneumonia:** A serious lung infection that can cause fever, chills, cough, and shortness of breath.
* **Bronchitis:** A lung infection that causes inflammation and swelling of the bronchial tubes, leading to cough, wheezing, and shortness of breath.
* **Anaphylaxis:** A severe allergic reaction that can cause difficulty breathing, swelling of the face and throat, hives, and low blood pressure.
* **Increased risk of serious cardiovascular events (e.g., heart attack, stroke):** Breztri contains formoterol, which can increase heart rate and blood pressure.
* **Hyperthyroidism:** This is a condition in which the thyroid gland produces too much thyroid hormone. Symptoms can include weight loss, increased appetite, rapid heart rate, and nervousness.

**Other Possible Side Effects**

* **GlaxoSmithKline has issued a warning about the potential for serious side effects with Breztri Aerosphere.** These include:
* Increased risk of death in patients with severe asthma exacerbations
* Increased risk of serious asthma-related events (e.g., intubation, hospitalization)
* **Breztri Aerosphere should only be used by patients who are 12 years or older.**
* **Patients who are taking Breztri Aerosphere should avoid smoking.** Smoking can worsen asthma symptoms.
* **Patients who are taking Breztri Aerosphere should tell their doctor about any other medications they are taking.** Some medications can interact with Breztri Aerosphere.
* **Patients who are taking Breztri Aerosphere should get regular check-ups with their doctor to monitor their progress.**

Breztri Aerosphere is a prescription inhaler used to treat chronic obstructive pulmonary disease (COPD) , a chronic lung disease that includes chronic bronchitis, emphysema, or both. It contains three active ingredients:
Budesonide – A corticosteroid that reduces inflammation in the lungs.
Glycopyrrolate – A long-acting muscarinic antagonist (LAMA) that helps relax airway muscles.
Formoterol fumarate – A long-acting beta agonist (LABA) that helps open the airways.
Breztri is used for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including:
Chronic bronchitis – Persistent inflammation of the airways.
Emphysema – Damage to the air sacs in the lungs.
It reduces inflammation in the airways (Budesonide).
Relaxes airway muscles to improve airflow (Glycopyrrolate).
Opens airways for easier breathing (Formoterol).
Mechanism of action
Each of the 3 ingredients in Breztri has a different mechanism of action. Budesonide helps to decrease inflammation in the lungs which can lead to breathing problems. Glycopyrrolate blocks the effects of acetylcholine (a neurotransmitter) in the lungs, which allows the airways to relax and widen, making breathing easier. Formoterol binds to and activates beta2-adrenergic receptors on the smooth muscle cells in the airways. This activation also allows the airways to relax and widen, making breathing easier. Formoterol has a long-lasting effect, typically lasting 12 hours or more, which provides sustained symptom relief throughout the day for COPD patients.

Breztri Aerosphere Dosage

Standard Dosage for COPD

Recommended dose: Two inhalations (puffs) twice daily

Time of use: Morning and evening (approximately 12 hours apart)

Inhaler strength: Each puff contains:

Budesonide 160 mcg.

Glycopyrrolate 9 mcg.

Formoterol fumarate 4.8 mcg.



Side Effects of Breztri Aerosphere

Like all medications, Breztri Aerosphere can cause side effects. These can be classified as common, serious, and rare.

Common Side Effects

These are usually mild but should be monitored:

Cough, Sore throat, Headache, Muscle cramps, Runny or stuffy nose, Nausea.

Serious Side Effects (Seek medical attention if these occur).

Pneumonia – Symptoms include fever, chills, chest pain, and increased phlegm.

Increased heart rate (tachycardia).

High blood sugar (hyperglycemia).

Low potassium levels – Can cause muscle weakness or irregular heartbeat.

Osteoporosis (bone thinning) with long-term use.

Eye problems – Glaucoma or cataracts may develop.

Paradoxical bronchospasm – Sudden breathing difficulty after inhaling.

VANNAIR (Formoterol, Budesonida): Tratamiento eficaz para el asma y la EPOC. Vannair, un medicamento combinado ideal para tratar afecciones respiratorias como el asma y la EPOC. Descubre cómo actúa en tu cuerpo y los beneficios que aporta al mejorar la función respiratoria.

Te explicaremos la dosificación adecuada, tanto inicial como de mantenimiento, y cómo administrarlo correctamente. Además, abordaremos los posibles efectos secundarios y las precauciones que debes tener en cuenta para un uso seguro.

No olvides darle like y compartir este video si te ha sido útil. ¡Nos vemos en el siguiente!

#Vannair #Asma #EPOC #SaludRespiratoria

Este es uno de los videos que ofrece información creíble, gratuita e integral sobre prevención y detección de enfermedades, diagnóstico, tratamiento e investigación. Nuestros videos contienen información de expertos y personas reales sobre diversos problemas de salud, respondiendo la mayoría de sus preguntas, incluyendo cómo sucedió, cómo se siente, qué puede hacer al respecto y por qué es importante

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Learn how to use Dry Powder Inhaler (DPI) and Metered Dose Inhaler (MDI) for inhalation of steroids (Budesonide) in mild Covid-19

Anoro ellipta inhaler contains two active ingredients, umeclidinium and vilanterol. These work in different ways to relax and open the airways and make it easier to breathe. In chronic obstructive lung diseases (COPD), such as chronic bronchitis or emphysema, the airways are narrowed and this makes breathing difficult.

Make sure you're using your inhaler properly! Our team shows you how to use your Ellipta inhaler correctly.

This video was made by Randy Nguyen , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

Breo Ellipta combines an inhaled steroid with a long acting compound that dilates the airways. Marketed for both asthma and chronic obstructive pulmonary disease or COPD, it often fails to provide an ideal treatment for either. For most asthmatics preferred therapy includes inhaled steroids and short acting bronchodilators. The FDA recently linked long acting bronchodilators with increased hospitalization and death related to asthma. Optimal therapy for most individuals with COPD includes a long acting bronchodilator and a long acting anti-cholinergic but not an inhaled steroid. Breo often seems misused by patient and doctor alike.

What is Breo Ellipta inhaler used for?

BREO ELLIPTA is used to treat asthma and chronic obstructive pulmonary disease (COPD). To use BREO ELLIPTA, you breathe it into your lungs through your mouth using the ELLIPTA inhaler.
Asthma is when the muscles surrounding the smaller airways become tight (bronchoconstriction), swollen and irritated (inflammation). Symptoms come and go and include shortness of breath, wheezing, chest tightness and cough.

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This video was made by Yvonne Cunningham, 2023 Pharmacist Candidate. She will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

This video was made by Cafrey He Feng , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

Central Maine Pulmonary and Sleep Medicine provides this educational video to guide you on how to use of your inhaler. Each inhaler has two videos, the short video is a quick overview and the longer video goes over the use of the inhaler in more detail. If you have questions about your inhaler that aren’t addressed in the video be sure to contact your healthcare provider.

This demonstration is intended to complement the Patient information for BREO ELLIPTA. For full instructions on how to use BREO ELLIPTA, and other important information, please see the complete Prescribing Information and Patient Information for BREO ELLIPTA. You can also ask your healthcare provider or pharmacist for more information.

IMPORTANT SAFETY INFORMATION
BREO contains vilanterol. LABA medicines such as vilanterol when used alone increase the risk of hospitalizations and death from asthma problems. BREO contains an ICS and a LABA. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems.
Do not use BREO to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
Do not use BREO if you have a severe allergy to milk proteins or are allergic to any of the ingredients in BREO. Ask your healthcare provider if you are not sure.
Do not use BREO more often than prescribed.
Do not take BREO with other medicines that contain a LABA for any reason. Tell your healthcare provider about all the medicines you take and about all of your health conditions.
Call your healthcare provider or get medical care right away if your breathing problems get worse, if you need your rescue inhaler more often than usual or it does not work as well to relieve your symptoms.
BREO can cause serious side effects, including:
fungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using BREO to help reduce your chance of getting thrush.
pneumonia. People with COPD have a higher chance of getting pneumonia. BREO may increase the chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms: increase in mucus (sputum) production; change in mucus color; fever; chills; increased cough; increased breathing problems.
weakened immune system and increased chance of getting infections (immunosuppression). You should avoid exposure to chickenpox and measles, and, if exposed, consult your healthcare provider without delay. Worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or herpes infection of the eye may occur.
reduced adrenal function (adrenal insufficiency). This can happen when you stop taking an oral corticosteroid (such as prednisone) and start taking a medicine containing an inhaled corticosteroid (such as BREO). During this transition period, when your body is under stress such as from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death. Symptoms include: feeling tired; lack of energy; weakness; nausea and vomiting; low blood pressure (hypotension).
sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking BREO and call your healthcare provider right away.
serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction: rash; hives; swelling of your face, mouth, and tongue; breathing problems.
effects on heart: increased blood pressure; a fast or irregular heartbeat, awareness of heartbeat; chest pain.
effects on nervous system: tremor; nervousness.
bone thinning or weakness (osteoporosis).
eye problems including glaucoma and cataracts. You should have regular eye exams while using BREO.
changes in laboratory blood values, high blood sugar (hyperglycemia) and low potassium (hypokalemia).
Common side effects of BREO 100/25 for COPD include:
runny nose and sore throat
upper respiratory tract infection
headache
thrush in your mouth or throat. Rinse your mouth with water without swallowing after use to help prevent this
back pain
pneumonia
bronchitis
inflammation of the sinuses
cough
mouth and throat pain
joint pain
high blood pressure
flu
fever

This is a multi-dose DPI and it delivers the medications: Anoro (red cap), Arnuity (orange cap), Breo (blue cap), Incruse (green cap), and Trelegy (beige cap).

Dr. Lisa Lilienfield discusses natural ways to prevent osteoporosis and increase bone strength. Taking prescription medications can cause troublesome side effects in some patients, so Dr. Lisa recommends weight-bearing exercise, such as yoga, a "bone-healthy" diet and various nutritional supplements. Dr. Lisa Lilienfield specializes in women's health and sports medicine at the Kaplan Center for Integrative Medicine in McLean, VA.

Ibandronate is a medication used to prevent and treat certain types of bone loss, known as osteoporosis. Osteoporosis causes bones to become thinner and break more easily, especially after menopause, as you age, or if you take corticosteroid medications for long periods. This medication works by slowing down bone loss to help maintain strong bones and reduce the risk of broken bones. Ibandronate belongs to a class of medications called bisphosphonates.
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This video was made by Randy Nguyen , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

General information regarding Ibandronate (Boniva). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Welcome to MediInsights, your go-to destination for unlocking the wonders of wellness. In today's video, we delve into the intricacies of a medication that plays a crucial role in bone health – Ibandronate Tablets.

Hello, MediInsights community! I'm Jagajjiban, and today, we'll explore the use, dosage, mechanism of action, potential side effects, and essential advice for taking Ibandronate Tablets.

Ibandronate Tablets are a pivotal medication in the management of osteoporosis, particularly in postmenopausal women. Osteoporosis weakens bones, making them susceptible to fractures. Let's unlock the first wonder – its use.

Dosage Ibandronate Tablets:
Understanding the proper dosage is key. Follow your healthcare provider's recommendations diligently. Ibandronate is often taken on a specific schedule, be it once monthly or weekly.

Mechanism of Action of Ibandronate Tablets
Now, let's dive into the science. Ibandronate works by inhibiting bone resorption. It zeroes in on osteoclasts, the cells responsible for breaking down bone tissue. This process helps maintain or increase bone density, reducing fracture risk.

Side Effects of Ibandronate Tablets:
Like any medication, Ibandronate can have side effects. Common ones include gastrointestinal symptoms, musculoskeletal pain, and joint pain. However, serious but rare effects like osteonecrosis of the jaw or atypical femur fractures may occur.

Important Advice for using Ibandronate Tablets
To maximize the benefits of Ibandronate, here are crucial tips: Take as prescribed, on an empty stomach, with plain water, and remain upright for at least 60 minutes after. Regular follow-ups with your healthcare provider are essential.

That concludes our journey into the world of Ibandronate Tablets. Remember, knowledge is the key to wellness. If you found this video insightful, don't forget to like, share, and subscribe to MediInsights for more health-related content. Until next time, stay informed, stay healthy!

INTRO: 0:00
USE OF IBANDRONATE TABLETS: 0:43
DOSAGE OF IBANDRONATE TABLETS: 1:10
MECHANISM OF ACTION OF IBANDRONATE TABLETS: 1:55
SIDE EFFECTS OF IBANDRONATE TABLETS: 2:25
IMPORTANT ADVICES FOR USING IBANDRONATE TABLETS: 3:03


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FOSIMAX, BONIVA, ACTONEL

Prof Linn speaks with ecancertv at SABCS 2016 to discuss the impact of adjuvant bisphosphonate therapy on patients with early stage breast cancer, finding that there was no significant improvement through its addition after 3 years follow up.

Weighing the slight trends of gastrointestinal side effects against lowered risk of bone metastases, Prof Linn considers if 3 years is an adequate follow up to see the full effects of added bisphosphonate therapy, and notes patient concerns over osteonecrosis of the jaw as a side effect of treatment.

Boniva: Side Effects, Dosage & Uses


the Drugs is a chennel where we explain everything about drugs and side effects of drugs ans the using of it and also the doses.