Fatal Side Effects
Myrbetriq, which is one of the best medications to help prevent the symptoms of a neurogenic bladder has been unaffordable since it came to market. However, now there is an affordable option called Mirabegron, the generic version of Myrbetriq. Mirabegron relaxes the muscles of the urinary bladder, reducing bladder spasms. It is used to treat overactive bladder, which has symptoms of urgency, urinary incontinence, and urinary frequency. Have you taken Myrbetriq or Mirabegron, and did it help you with bladder issues? 🤔
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Read the article: http://onlinelibrary.wiley.com..../doi/10.1111/bju.130
Osamu Yamaguchi, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Akira Okitsu, Takuya Hamada, Akiko Kobayashi and Kentarou Kuroishi
Safety and efficacy of mirabegron as ‘add-on’ therapy in patients with overactive bladder treated with solifenacin: a post-marketing, open-label study in Japan (MILAI study)
BJU International DOI: 10.1111/bju.13068
Welcome to The Therapeutics Chronicles! In this episode, we dive deep into Mirabegron (Myrbetriq)—a game-changer in the management of overactive bladder (OAB), especially for patients who can't tolerate anticholinergic side effects.
🎯 Learning Objectives:
Understand mirabegron’s beta-3 agonist mechanism and how it improves bladder compliance
Learn Canadian dosing strategies, including titration and renal/hepatic adjustments
Discover key differences between mirabegron and anticholinergic OAB therapies
Recognize safety issues like hypertension and CYP2D6 drug interactions
Apply pharmacist interventions through real-world case scenarios
Simulate DREAM-style patient counseling
Reinforce knowledge with board-level rapid-fire Q&A
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In this video you will find quick review of drug MIRABEGRON including:
What is mirabegron
Indications of mirabegron
Mechanism of action
Pharmacokinetics of mirabegron
Adverse effects of mirabegron
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Treatment for overactive bladder (OAB) includes many medications like vibegron, darifenacin, solifenacin and fesoterodine etc.
Medications used to control urge to urinate and urinary frequency can be classified into 5 categories. Anticholinergics, beta-3 adrenergic agonists, Tricyclic antidepressants, Hormones and neurotoxins. Tolterodine, fesoterodine, darifenacin, solifenacin, oxybutynin and trospium belong to first group. Mirabegron and vibegron fall into second category. Imipramine and duloxetine are also used to control enuresis. Estrogen topical cream can be used in women with estrogen deficiency. Botulinum toxin A can be used to treat urinary incontinence.
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Overactive Bladder Medication Yearly Prescribing and Expenditure Trends
Chua K1, Patel H1, Tabakin A1, Doppalapudi S1, Hyams E2, Tunuguntla H1
1. Rutgers Robert Wood Johnson Medical School, 2. Columbia University Medical Center
KEYWORDS: Detrusor Overactivity, Incontinence, Overactive Bladder
Anticholinergics have a high discontinuation rate and many associated unfavorable adverse effects such as dry mouth, constipation and cognitive changes. [1] Mirabegron was approved by the FDA in 2012 as the first beta-3 agonist to treat overactive bladder and has been shown to have an increased persistence of use with less anticholinergic side effects. [2] This study aims to examine how prescribing patterns have changed since the approval of mirabegron.
Read the full abstract text here: https://www.ics.org/2020/abstract/489
What Are The Long-term Effects Of Mirabegron? In this informative video, we will discuss the long-term effects of mirabegron, a medication commonly used to manage overactive bladder symptoms in seniors. Understanding the potential outcomes of long-term use is essential for both patients and caregivers. We will cover how mirabegron works, its safety profile, and the importance of regular monitoring by healthcare providers.
As we address the common side effects that may arise during extended use, we will highlight the significance of keeping track of blood pressure and kidney function, especially in older adults who may have pre-existing conditions. It’s also vital to recognize serious side effects that could necessitate immediate medical attention.
For caregivers and family members, this video will provide key information on how to support elderly patients taking mirabegron and when to seek help from healthcare professionals. With proper guidance and supervision, mirabegron can be a beneficial option for managing bladder health in seniors.
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Some drugs prescribed for overactive bladder and other diseases may increase your risk of dementia, according to a recent JAMA study. Urogynecologist Dr. Cheryl Iglesia says it’s a “public health issue.” Watch as she explains what patients need to know with Lisa Fletcher in this WJLA-TV “7 On Your Side” report.
To learn more about Dr. Iglesia, visit http://bit.ly/2skzNEv.
Mirabegron extended release tablets 50 mg | Mirabegron tablet uses in hindi
Mirabegron belongs to the group of medications called ‘urinary antagonists' or 'antispasmodics' primarily used to treat overactive bladder (OAB) symptoms. Overactive bladder is a condition in which the urinary bladder muscles constrict uncontrollably, thereby causing an urgent need to urinate, frequent urination, and an inability to control urination.
Mirabegron contains ‘mirabegron’ that relaxes the urinary bladder muscles, which in turn decreases the activity of the overactive bladder. In an overactive bladder, muscle contractions occur before the full expansion of the bladder, causing the patient to have frequent urges to urinate. Mirabegron stops these sudden contractions of urinary bladder muscles, thereby enabling control over urination. Thus, it increases the amount and volume of urine that can be held by the bladder.
In some cases, Mirabegron may cause common side effects of Mirabegron, which are nausea, constipation, diarrhoea, headache, dizziness, and increased heart rate. Most of these side effects do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult a doctor.
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Struggling with incontinence and wondering if medications really work? This video breaks down the most effective medications available for managing urinary incontinence, including how they work, who they’re best suited for, and what side effects to watch out for. Whether you're considering anticholinergic drugs like oxybutynin and tolterodine, or newer options like beta-3 agonists (Mirabegron and Vibegron), we cover the key differences to help you make an informed choice.
We also look at how age plays a role in selecting the right treatment—especially for older adults who want relief without the risk of cognitive side effects. Learn about the latest FDA-approved medications like Vibegron (Gemtesa) and how they compare to traditional options.
In addition to pharmaceutical treatments, we cover non-drug alternatives like bladder training, timed voiding, and Kegel exercises that complement medical management. Plus, discover how modern technology like mobile apps and wearable devices can support daily incontinence tracking and care.
If you or a loved one are exploring new solutions or seeking better results from current treatments, this video gives you a comprehensive starting point.
🔗 Dive deeper into the full blog post here for more insights and expert guidance: https://nevadasurgical.com/blo....g/do-incontinence-me
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Mirabegron is a sympathomimetic that acts on beta-3 adrenergic receptors as agonist. This drug is indicated for the treatment of overactive bladder leading to urinary incontinence.
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Mirabegron extended release tablets are used to treat overactive bladder.
How it affects blood pressure and what is its effect on eye?
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Mirabegron is a beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity.
In this video, let’s find found:
What is mirabegron?
What is mirabegron used for?
Contraindication
What are the side effects of taking mirabegron?
How does mirabegron work?
How to use mirabegron?
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Midorise 10 Tablet | Uses, Side Effects, Dosage, Review
Midorise 10 Tablet is a medication that contains midodrine, an alpha-1 selective adrenergic receptor agonist, primarily used for managing low blood pressure, also known as hypotension, in adults. Symptoms of low blood pressure may include blurred vision, dizziness, fainting, and difficulty concentrating. This medication works by acting on the blood vessels through the sympathetic nervous system, helping to prevent blood pooling in the legs, thus correcting blood distribution imbalances. It is crucial for patients to be monitored regularly, especially when transitioning from lying down to standing, as there is a risk of blood pressure fluctuations. While effective, common side effects include increased blood pressure when lying down, headache, nausea, and vomiting. Caution is advised for individuals with severe kidney or liver issues and for pregnant or breastfeeding women. Not suitable for those under 18 years or with severe heart disease, this medication should only be taken under physician guidance. Always consult your doctor to discuss potential side effects, the management of symptoms, and any other concerns.
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---
🔹 Video Chapters 🔹
⚠️ 0:00 – Disclaimer
⏳ 0:15 – Midorise 10 Tablet Introduction
💊 00:23 – Uses and Medical Indications
🧪 00:38 – How Midorise 10 Tablet Works
📏 00:49 – Dosage & Directions
⚠️ 01:08 – Common Side Effects
🛑 01:19 – Precautions, Warnings, and Safety Tips
❓ 01:35 – FAQs
🎯 02:03 – Final Thoughts
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🔹 What is Midorise 10 Tablet used for?
🔹 How should I take Midorise 10 Tablet?
🔹 What are the common side effects?
🔹 Who should avoid this medicine?
🔹 Can I take Midorise 10 Tablet during pregnancy?
🔹 Is Midorise 10 Tablet safe for long-term use?
🔹 Can I take this with other medications?
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Can we wean patients off of vasopressors faster by providing them with Midodrine? The MIDAS trial (Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit) published on September 3rd, 2020 is a randomized-controlled trial looking at this question.
Show Notes: https://eddyjoemd.com/midodrine/
The Vasopressor & Inotrope Handbook
I have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy.
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Citation: Santer, P., Anstey, M.H., Patrocínio, M.D. et al. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. Intensive Care Med (2020). https://doi.org/10.1007/s00134-020-06216-x
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Dr. Nemechek discusses how midodrine has been used for several decades for cerebral hypoperfusion (low brain blood pressure).
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In this high-yield pharmacology and critical care lecture, Professor Zach Murphy breaks down the spectrum of vasopressors and inotropes, focusing on their mechanisms of action, receptor profiles, clinical indications, and when to use them based on the type of shock and hemodynamic status.
We begin by classifying these agents into functional categories:
• Inopressors (e.g., Norepinephrine, Epinephrine, Dopamine): Drugs with both inotropic (↑ contractility) and vasopressor (↑ vascular tone) effects—ideal for distributive and cardiogenic shock
• Inodilators (e.g., Dobutamine, Milrinone): Drugs that increase cardiac output while promoting vasodilation—useful in low-output heart failure and cardiogenic shock with elevated afterload
• Pure Vasopressors (e.g., Phenylephrine, Vasopressin): Drugs that raise systemic vascular resistance without significant cardiac stimulation—used in neurogenic shock, septic shock adjuncts, or when tachyarrhythmias limit beta-agonist use
We also discuss:
• Methylene Blue: A rescue agent for refractory vasodilatory shock, working by inhibiting nitric oxide–mediated vasodilation
• Midodrine: An oral alpha-1 agonist used in chronic orthostatic hypotension and as a weaning agent from IV vasopressors in the ICU
The lecture emphasizes receptor pharmacology (α, β, DA, V1), dosing strategies, monitoring parameters, and how to individualize therapy based on preload, afterload, cardiac output, and MAP targets. We also address key side effects like arrhythmias, tachyphylaxis, ischemia, and extravasation injury.
Enjoy the lecture and support us below!
Table of Contents:
0:00 Lab
0:08 Vasopressors Introduction
0:36 Inodilators - Dobutamine, Milrinone, and Isoproterenol
23:02 Inopressors - Epinephrine, Norepinephrine, and Dopamine
43:10 Pure Vasopressors - Phenylephrine, Vasopressin, and Angiotensin-II
1:07:35 Methylene Blue
1:17:13 Methods to Administrate Vasopressors
1:22:07 Midodrine - Alternative Vasopressor
1:26:06 Comment, Like, SUBSCRIBE!
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tablet for blood pressure in hindi midodrine hydrochloride gutron 2.5 mg
Hi passi champ family 👋
Is video ke episode low blood pressure ko treat karne ke liye best tablet ka review diya hai. Is video main maine gutron 2.5 mg jis main midodrine hydrochloride 2.5 mg composition hai iske bare main btaya hai jaise iske price rate, company, uses, how to take, dosage or side effects ka ache se explain kiya hai. labialfarma iski manufacturer hai or gurmail brothers iski marketing krte hai. Yeh low blood pressure ko treat karne ke liye india main best medicines main se ek hai.
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Oral midodrine is an alpha-1 adrenergic agonist increasingly used as a vasopressor adjunct in clinical medicine. In this video, we break down the mechanism of action, indications, dosing, side effects, and evidence behind midodrine use — especially in the ICU and hospital setting. We will then end with practice questions!
Whether you’re a medical student, nurse, physician assistant, nurse practitioner, respiratory therapist, or practicing physician, this video will help you understand where midodrine fits into vasopressor and inotrope management.
What you’ll learn:
How midodrine works as an oral vasopressor
Common clinical indications and patient selection
Dosing strategies and administration tips
Adverse effects and monitoring
Current evidence and clinical practice pearls
Practice questions
📚 Related Resources:
Download our midodrine study guide and practice questions: https://www.patreon.com/collection/1443765
Watch next: Playlist Vasopressors and Inotropes:
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Welcome to Talking with Docs! In this episode, our special guest Dr. Heffernan, a renowned cardiologist, sheds light on low blood pressure, or hypotension. Dr. Heffernan explains what is considered low blood pressure, its causes, symptoms, and potential health risks. Tune in to discover how low blood pressure is diagnosed and treated, and learn how to maintain healthy blood pressure levels.
Hypotension, commonly known as low blood pressure, is a condition in which the blood pressure in the arteries is lower than normal. Specifically, hypotension is defined as a systolic pressure (the higher number) of less than 90 millimeters of mercury (mm Hg) or a diastolic pressure (the lower number) of less than 60 mm Hg. Hypotension can cause symptoms such as dizziness, lightheadedness, and fainting, and can be caused by a variety of factors including dehydration, blood loss, certain medications, and underlying health conditions.
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Dr. Nemechek reviews how ADD (Attention Deficit Disorder) and MCI (Minor Cognitive Impairment) are both conditions involving low blood pressure in the brain and discusses how the use of Midodrine with or without Florinef are effective alternatives to Adderall and Ritalin-like medications especially when there are too many side effects.
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In Today’s video I am giving you an update about Midodrine for my POTS. Does Midodrine help my Postural Orthostatic Tachycardia Syndrome? I discuss with you what my status is with the drug.
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✅ Pharmacology review Midodrine (Proamatine): Side effects, uses, dosage (midodrine 5 mg), warnings, administration, precautions, indications, mechanism of action (moa), brand name (Proamatine 5 mg) and answers to questions like: what is Midodrine?, What is Midodrine used for?.❤️ Suscribe: https://www.youtube.com/c/Medi....cinesDiseases?sub_co
What is Midodrine?
Midodrine is a medicine used for the treatment of hypotension.
The brand name of Midodrine is ProAmatine, Orvaten.
More information about active ingredients here: https://activeingredients.online
In this video Doctor O'Donovan explains key facts you need to know about Metoprolol - also known by its brand name 'Lopressor' - a medication used to treat high blood pressure (hypertension), heart problems and migraine.
What is Metoprolol?
Metoprolol is a type of medicine called a beta blocker. Like other beta blockers, metoprolol works by changing the way your body responds to some nerve impulses, especially in the heart. It slows down your heart rate and makes it easier for your heart to pump blood around your body.
What doses of Metoprolol / Tablet Strengths and Uses are available?
Metoprolol is available in 50mg and 100mg strengths, used for treating high blood pressure, chest pain, irregular heartbeat, migraine prevention, and thyrotoxicosis, with varying dosages specific to each condition.
Administration Guidelines
Metoprolol an be taken with or without food, tablets should be swallowed whole with water, and some can be split in half if indicated. The first dose might be recommended at bedtime due to possible dizziness, otherwise taken in the morning, with evenly spaced doses if multiple are required daily.
Duration and Discontinuation
Metoprolol treatment is typically long-term, potentially lifelong. Stopping abruptly can worsen the condition, so a doctor's guidance is needed for cessation. The medicine takes 1 to 2 days to leave the body after stopping.
Overdose Risks and Actions
Overdose effects vary but can include slowed heart rate, breathing difficulties, dizziness, and trembling. Immediate medical advice is necessary if an overdose occurs. Bring medication packet and any remaining pills to the emergency services.
Are there any side effects of metoprolol?
According to the NHS UK website "Metoprolol is generally safe to take for a long time. In fact, it works best when taken for long periods of time."
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Content and timestamps:
00:00 - Introduction
01:03 - Who can and can't take metoprolol (lopressor)
01:57 - How and when to take metoprolol
05:04 - Side effects
06:50 - Interactions with other medications
08:33 - Common questions
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References and resources
NHS information: https://www.nhs.uk/medicines/metoprolol/
WebMD: https://www.webmd.com/drugs/2/....drug-8814-2372/metop
National Institute for Clinical Excellence (NICE UK): https://bnf.nice.org.uk/drugs/metoprolol-tartrate/
#doctor #health #medication #pharmacy #lopressor #metoprolol #betablocker #bloodpressure #highbloodpressure #hypertension
Video published: 1st April 2024. Next review: 2027.
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Disclaimer:
The video is intended as an educational resource only. The information within this video or on this channel isn't designed to replace professional input, so if you have any medical issues please consult a medical provider. No professional relationship is being created by watching this video. Dr. O'Donovan cannot give any individual medical advice. All information should be verified for accuracy by the individual user. Dr O'Donovan accepts no responsibility for individual interpretation of data, although it is always accurate to the best of his knowledge at the time of the video being published. This is an EDUCATIONAL video. Images are used in accordance with fair use guidelines.
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What is #Midodrine used for?
What are the side effects of midodrine?
What is similar to Midodrine?
Is Midodrine available in India?
#MIDODRIVE #MIDODRIVE_2.5 #MIDODRIVE2.5 #MIDODRIVE_2.5_mg #sunpharma
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Midodrine hydrochloride is used to prevent fainting associated with orthostatic hypotension and vasovagal syncope.
This medication activates alpha-1 adrenergic receptors on the blood vessels and increases supine and sitting blood pressure. It prevents the risk of fainting and injuries. It can produce urinary retention and increase urinary urgency. The actions of midodrine can be antagonized by medications like tamsulosin, prazosin, and doxazosin.
Disclaimer: The content in this video is intended for educational purposes only. Always seek professional medical advice in case of any medical queries, and the videos on this platform do not provide any such suggestions or professional advice. All the information provided here should not be treated as a substitute for medical advice. The content in this channel is intended to provide educational information to students and to educate the general public. However, it should never be taken as a recommendation for a specific diagnosis or treatment. All efforts are made to provide accurate and error-free information. Due to the advances in medical research, the content may be variable from time to time.
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Taking Midodrine for Postural Orthostatic Tachycardia Syndrome | POTS | Dysautonomia
In this video I update you all about my experience taking Midodrine for POTS. I am on day #4. I let you know how I've been feeling and what side effects I have been experiencing. I'll update again soon!
#POTS #Dysautonomia #Midodrine
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https://www.youtube.com/watch?v=PsLFT...
My POTS Story
https://www.youtube.com/watch?v=5xPds...
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My name is Whitney and I am here to bring awareness to Dysautonomia and POTS and chronic illnless in general. I want to help anyone on their diagnostic journey and share helpful information and my own journey with you all in the hopes of helping as many as I can.
Taking Midodrine For the FIRST Time | POTS Treatment
In this video I talk about my experience taking Midodrine for the first time for my POTS treatment. I let you know after a few hours how I was feeling and what side effects I experienced.
#POTS #Dysautonomia #Midodrine
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What is POTS?
https://www.youtube.com/watch?v=PsLFT...
My POTS Story
https://www.youtube.com/watch?v=5xPds...
About My Channel:
My name is Whitney and I am here to bring awareness to Dysautonomia and POTS and chronic illnless in general. I want to help anyone on their diagnostic journey and share helpful information and my own journey with you all in the hopes of helping as many as I can.
Ever have a patient who is on low dose norepinephrine or another vasopressor who you can't get out of the ICU solely for that reason? Have you tried to administer midodrine to increase their blood pressure? This podcast describes the FDA-approved as well as the off-label uses of midodrine, pharmacology data explained in english, dosing, side effects, and a little about the studies. I discuss the mechanism of action, midodrine uses, midodrine parameters, what's comparable to a midodrine IV drip or midodrine drip, the brand name, and more!
Show Notes: https://eddyjoemd.com/midodrine/
The Vasopressor & Inotrope Handbook
I have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy.
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#POTS #Dysautonomia #Midodrine
All About Midodrine | What is It? | POTS Treatment
In Today’s video I am talking about Midodrine. I discuss what the drug is, what it does and who it’s for.
Don’t Forget to Like and SUBSCRIBE for More Videos EVERY WEEK 😊
IF YOU’RE NEW TO MY CHANNEL, START HERE:
What is Dysautonomia?
https://www.youtube.com/watch?v=46j4U
What is POTS?
https://www.youtube.com/watch?v=PsLFT
My POTS Story
https://www.youtube.com/watch?v=5xPds
About My Channel:
My name is Whitney and I am here to bring awareness to Dysautonomia and POTS and chronic illnless in general. I want to help anyone on their diagnostic journey and share helpful information and my own journey with you all in the hopes of helping as many as I can.