Practitioners require an understanding of side effects for commonplace treatment options in colorectal cancer. Karon Martyn, MSN, ANP-BC, AOCNP, discusses bevacizumab/cetuximab and the associated side effects.

Welcome to our informative video on Beyfortus (nirsevimab-alip), a medication commonly prescribed to protect all infants through their first RSV season. In this comprehensive guide, we'll cover its various uses, recommended dosage, and potential side effects to help you make informed decisions about your health.

If your infant currently prescribed for Beyfortus, this video is a must-watch. Always consult your healthcare provider before making any changes to your medication regimen. Remember, your health is important, and being well-informed is the first step towards managing your condition effectively.

Don't forget to like, subscribe, and hit the notification bell to stay updated on our latest health-related content. Thank you for watching!

(Note: Always ensure accuracy by referring to up-to-date medical sources and consult a healthcare professional for personalized advice.)

#Beyfortus #RSV #respiratorydisease #Respiratory

Beyfortus is a new RSV vaccine being marketed to prevent RSV infections in children. This video will go over if it's really that good. It will go over everything you need to know. I'll review the research behind Beyfortus and see if it's worth getting your child vaccinated against RSV with Beyfortus. Is this drug really that good?

If you're wondering if Beyfortus is a good RSV vaccine for your child, this video is for you. We'll review the research behind Beyfortus and see if it's worth getting your child vaccinated against RSV. We'll also discuss the side effects of Beyfortus from the studies that were evaluated by the american academy of pediatrics (AAP) and the CDC.

Thanks for watching!

00:00 Video Content
00:27 What is Beyfortus
00:55 How does it work?
01:24 Who can get it?
02:18 How is it given?
02:38 Side effects?
02:51 Conclusion

Beyfortus (nirsevimab-alip) is a long-acting monoclonal antibody with activity against the respiratory syncytial virus (RSV) that may be used to protect neonates and infants against lower respiratory tract disease (LRTD) caused by RSV.

Video Content:
0:00 Beyfortus injection
0:18 Indications
0:39 How to use
1:17 Contraindications
1:31 Warnings
1:52 Side effects


Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#Beyfortus #RSV #medicine

RSV vaccination in pregnancy: risks, benefits, and alternatives #RSV #RSVvaccine #abrysvo #beyfortus #pregnancy

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The first vaccine targeting respiratory syncytial virus (RSV) was just approved for use in the United States. The vaccine is made by GSK, under the name Arexvy, and is for use in individuals 60 years of age+. Older adults are at particular risk for severe disease and death caused by RSV. This approval highlights a critical milestone in public health efforts to combat the prevention of lower respiratory tract disease.

Alex sits down the PCRI's Executive Director, Mark Scholz, MD, to discuss commonly asked questions from the PCRI Helpline on the topics of Casodex (bicalutamide), SpaceOAR, and questions related to pathology (e.g. biopsies, Gleason score).

1:01 Why is Casodex added to everything?

Originally Casodex was added to Lupron (or another hormonal agent) to counteract the testosterone flare that occurs in the first month of hormonal treatment. Additionally, studies showed a slight survival advantage—without significant additional side effects—in men who continued to use the Casodex and the Lupron together for the entire duration of the treatment. However, in the past, Casodex's high cost made it impractical to use for longer than the first month to suppress the Lupron flare.

3:01 Is Casodex Chemotherapy?

While Casodex is often designated at a chemotherapy for billing reasons, it is in a totally different class of medications than chemotherapies like Taxotere and Jevtana.

3:50 What are the side effects of Casodex?

The side effects of Casodex are similar to Lupron, except usually milder; when added to Lupron, some men will experience increased fatigue. In a small number of patients, Casodex can cause liver irritation, and so it is recommended that patients speak with their physician about checking their liver function with a hepatic panel about 4-6 weeks after starting Casodex. When used alone, Casodex can cause breast tenderness and enlargement. This can be counteracted by radiation to the nipples prior to treatment, the use of an aromatase inhibitor, or both.

6:18 What is SpaceOAR?

SpaceOAR is an injectible gel (administered through the perineum) that separates the prostate from the rectal wall to prevent radiation proctitis. Although increasingly rare as technology and practices improve, radiation proctitis can be disastrous if it occurs, and so the use of SpaceOAR is a wise choice.

10:16 Which doctors provide SpaceOAR? How do I find one?

You can find doctors that use SpaceOAR on the SpaceOAR website, or you can ask your radiation oncologist if they are familiar with the technology. If they are not, then that may be a good indication that this physician is not up to speed with the latest developments in the field.

11:37 How do I interpret my biopsy report?

Biopsy reports are given for 12-core random biopsies. Each core ought to be labeled with the location within the prostate from which it was taken. This is not universal, unfortunately, but it is good practice. Physicians are looking for the number of cores that contain cancer cells. If a core has cancer cells, then the biopsy report will say what percentage of the core involved cancer cells. The Gleason score is the final significant component of the biopsy report. Essentially, your doctor wants to know "How big is the tumor?" and "What grade is the tumor?"

15:03 How accurate are biopsy reports? Should I get a second opinion?

There is oftentimes disagreement among pathologists as to the exact grade of a given sample. It's a good idea, then, to get a second opinion on a pathology report. There are many good options. Jonathan Epstein of John Hopkins, for example, has a good reputation and a convenient system for sending in reports for a second opinion.

16:53 What can I do with my Gleason score?

Gleason score, among other factors, determines the best treatment (or non-treatment) for a man to balance achieving a cure (if necessary) and avoiding the side effects of overtreatment.

Who we are:

The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.

#ProstateCancer #Prostate #MarkScholzMD

Bi-calutamide and feminizing hormone therapy

Bicalutamide is an anti-androgen drug which means that it blocks the effect of androgenic hormones such as testosterone and DHT. The important thing to understand is that bicalutamide does not lower testosterone levels, it simply blocks the effect of testosterone on tissues.

In many cases, Testosterone levels initially increase after starting this medication however, that is nothing to be concerned about. Testosterone levels start declining over time, this change happens much more rapidly if you're also taking estrogen and progesterone in addition to bicalutamide.

Bicalutamide is most commonly used for treating men with prostate cancer

Off-label uses:
Puberty blocker
Feminization therapy
Androgenic Alopecia in females
Acne Reduction

Today primarily will be focusing on bicalutamide use in transgender females
Other anti-androgen medications often prescribed are spironolactone and cyproterone acetate. However, these drugs are much weaker than bicalutamide. Cyproterone is also not available in the US.

Bicalutamide also helps the aromatization of testosterone to estrogen which is why it is especially helpful for breast development when compared to other anti-androgen medications. Some small studies have shown better breast growth when compared to Aldactone and cyproterone. A possible mechanism is that Aldactone causes early maturation of the breast bud when compared with bicalutamide.

Bicalutamide is known to cause a reduction in vitamin C levels and glutathione levels in animal studies. Taking glutathione and vitamin C may reduce the risk of liver toxicity however I have no data to support this strategy.
Key Benefits:
better Breast development when compared to spironolactone and Cyproterone.
Reduced acne
Reduce facial hair
Half-life is 6 days so the drug stays in the body for several days so only twice a weekly dose is adequate. Compare that to spironolactone which has a half-life of only 2 hours
Do not use or use caution if you
Have Liver problems
If you drink heavily
Over the age of 35
Get a liver panel done 2-4 weeks after starting the medication. For any sign of liver failure such as jaundice, the medication must be immediately stopped.
Dosing:
Bicalutamide stays in the body for several days and has a half-life of 6 days which means half of the drug is broken down and removed by the body in 6 days. Twice a weekly dose of 50 mg is adequate. Higher doses increase the risk of liver toxicity and should be avoided
In summary, this is a very good medication for feminization therapy especially if high breast growth is strongly desired. Liver toxicity is a major concern and can be life-threatening so do not consume alcohol, and avoid hepatotoxic medications such as Tylenol.

Anna C. Ferrari, MD, professor, co-director, GU Research Program,
Departments of Medicine (Cancer Center) and Medicine (Residency Program), discusses a study that examined the efficacy of LBH589 and bicalutamide in patients with castration-resistant prostate cancer (CRPC).

Bismuth subsalicylate is a medication commonly used to treat various gastrointestinal issues, including diarrhea, indigestion, and upset stomach. It is an active ingredient in several over-the-counter (OTC) products, most notably in the brand Pepto-Bismol. Bismuth subsalicylate is a compound that combines bismuth and salicylate, which are responsible for its therapeutic effects.

Here are some key points about bismuth subsalicylate:

1. Mechanism of Action: Bismuth subsalicylate works through several mechanisms. It has mild antibacterial properties and can inhibit the growth of certain bacteria that can contribute to gastrointestinal infections and diarrhea. Additionally, it forms a protective coating over the lining of the stomach and intestines, which helps soothe irritation and reduce inflammation. The salicylate component also provides some anti-inflammatory effects.

2. Indications: Bismuth subsalicylate is primarily used to alleviate symptoms associated with gastrointestinal disturbances, such as diarrhea, upset stomach, nausea, heartburn, and indigestion. It is not recommended for long-term use, and if symptoms persist, medical attention should be sought.

3. Dosage and Administration: The dosage of bismuth subsalicylate varies depending on the specific product and the condition being treated. It is generally available in liquid form (suspension) or chewable tablets. It's important to follow the dosing instructions provided on the product's packaging or as directed by a healthcare professional.

4. Precautions and Side Effects: Bismuth subsalicylate contains salicylate, which is related to aspirin. As a result, individuals who are sensitive to aspirin, have bleeding disorders, are taking blood-thinning medications, or have certain medical conditions should consult their healthcare provider before using products containing bismuth subsalicylate. Side effects are generally mild and can include temporary darkening of the tongue and stool, constipation, and ringing in the ears (tinnitus).

5. Interactions: Bismuth subsalicylate can interact with other medications, including anticoagulants (blood thinners), nonsteroidal anti-inflammatory drugs (NSAIDs), and some antibiotics. It's important to discuss any potential interactions with a healthcare professional before using products containing this compound.

6. Special Populations: Pregnant and breastfeeding individuals should consult their healthcare provider before using bismuth subsalicylate, as there might be potential risks associated with its use during these periods.

7. Overuse and Reye's Syndrome: Excessive or prolonged use of products containing bismuth subsalicylate can lead to a rare but serious condition called Reye's syndrome, particularly in children and teenagers recovering from viral infections. Reye's syndrome affects the brain and liver and can lead to severe complications. It's important to adhere to recommended dosages and usage guidelines.

As with any medication, it's recommended to consult a healthcare professional before using bismuth subsalicylate, especially if you have underlying medical conditions, are taking other medications, or have concerns about its use. This information is accurate as of my last knowledge update in September 2021, and there may have been developments or changes since that time.

Are you having a bad case of upset stomach , and looking for a way to relieve your symptoms? This video could be of use for you because in it, I’ll be discussing the medication bismuth subsalicylate, which is commonly sold under the brand name Pepto-Bismol.

Pepto-Bismol can be used to relieve diarrhea and upset stomach in adults and children 12 years and older. In children, 2 years to 12 years old, an alternative product can be used to help with heartburn and stomach upset, called Children’s Pepto Antacid. Pepto-Bismol is effective at relieving common symptoms of upset stomach, such as heartburn, nausea, gas, or indigestion.

You should talk to your doctor or pharmacist before taking this medication if you are pregnant or if you drink alcohol. Pepto Bismol is available as a liquid, caplet, and chewable tablet form. Take as recommended by the product packaging, unless your doctor or pharmacist said otherwise.

Typical Dosing:
Oral: ~524 mg every 30 to 60 minutes or 1,050 mg every 60 minutes as needed for up to 2 days (maximum: ~4,200 mg [8 doses (regular strength); 4 doses (maximum strength)]/24 hours)

Some common side effects are a temporary darkening of the stool, black tongue, or constipation. When taking Pepto-Bismol you should not drink alcohol as this can contribute to digestive tract imbalance. Contact a healthcare provider before use if you have fever or mucus in your stool. Discontinue use and contact your doctor if diarrhea lasts for more than 2 days or if other symptoms last more than 14 days, if you have diarrhea with a fever, or if you develop hearing loss or ringing in the ears. Children or adolescents who are recovering from chickenpox or flu-like symptoms should not use this medication, as it can put them at risk for a syndrome known as Reye’s syndrome.

In summary, Pepto-Bismol, called bismuth subsalicylate, is a medication used to treat episodes of diarrhea and upset stomach. When taking this, always take it as your doctor instructs you to, or follow the directions provided through the manufacturer. Make sure to avoid alcohol and speak to a doctor or pharmacist if symptoms progress beyond the blackening of the tongue, stool, or developing constipation.

Boniva, also known as ibandronate, is a prescription medication often used to treat osteoporosis in postmenopausal women. While it can be effective in increasing bone density and reducing the risk of fractures, like any medication, Boniva is not without its potential side effects.
Common side effects of Boniva.
When taking Boniva, it's important to be aware of the potential common side effects that you may experience. These side effects are usually mild and temporary, but it's still important to know what to expect.
One of the common side effects of Boniva is an upset stomach. Some individuals may experience nausea, vomiting, or abdominal discomfort after taking the medication. It's important to take Boniva with a full glass of water and remain upright for at least 30 minutes after taking it to reduce the risk of stomach-related side effects.
Diarrhea is another common side effect of Boniva. Some individuals may experience loose stools or increased frequency of bowel movements. If you experience severe or persistent diarrhea, it's important to contact your healthcare provider.
Headache is another potential side effect of Boniva. Some individuals may experience mild to moderate headaches after taking the medication. If you experience severe or persistent headaches, it's important to consult your healthcare provider for further evaluation.
Muscle or joint pain is another common side effect of Boniva. Some individuals may experience mild discomfort or achiness in their muscles or joints. This side effect is usually temporary and resolves on its own. If you experience severe or persistent muscle or joint pain, it's important to seek medical attention.
Rare but serious side effects of Boniva.
While rare, there are some serious side effects associated with Boniva that you should be aware of. It's important to understand these risks and discuss them with your healthcare provider before starting Boniva.
Difficulty swallowing is a rare but serious side effect of Boniva. Some individuals may experience pain or discomfort when swallowing food or liquids. If you have difficulty swallowing, it's important to contact your healthcare provider immediately.
Chest pain is another rare but serious side effect of Boniva. Some individuals may experience chest pain or tightness after taking the medication. If you experience chest pain, it's important to seek immediate medical attention as it could be a sign of a more serious underlying condition.
Severe heartburn is another potential serious side effect of Boniva. Some individuals may experience intense burning pain in the chest or throat. If you experience severe heartburn, it's important to contact your healthcare provider for further evaluation.
Boniva and gastrointestinal issues.
One of the common side effects of Boniva is gastrointestinal issues, such as upset stomach and diarrhea. These side effects can be bothersome but are usually mild and temporary.
If you experience an upset stomach after taking Boniva, try taking the medication with a full glass of water and remaining upright for at least 30 minutes after taking it. This can help reduce the risk of stomach-related side effects. If the upset stomach persists or becomes severe, it's important to consult your healthcare provider.
-----
"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

Anna Zuschnitt, Clinical pharmacist at Penn Bone Center, discusses the indications, risks and benefits of intravenous bisphosphonates in the treatment of osteoporosis.

Welcome to MediInsights, your go-to destination for unlocking the wonders of wellness. In today's video, we delve into the intricacies of a medication that plays a crucial role in bone health – Ibandronate Tablets.

Hello, MediInsights community! I'm Jagajjiban, and today, we'll explore the use, dosage, mechanism of action, potential side effects, and essential advice for taking Ibandronate Tablets.

Ibandronate Tablets are a pivotal medication in the management of osteoporosis, particularly in postmenopausal women. Osteoporosis weakens bones, making them susceptible to fractures. Let's unlock the first wonder – its use.

Dosage Ibandronate Tablets:
Understanding the proper dosage is key. Follow your healthcare provider's recommendations diligently. Ibandronate is often taken on a specific schedule, be it once monthly or weekly.

Mechanism of Action of Ibandronate Tablets
Now, let's dive into the science. Ibandronate works by inhibiting bone resorption. It zeroes in on osteoclasts, the cells responsible for breaking down bone tissue. This process helps maintain or increase bone density, reducing fracture risk.

Side Effects of Ibandronate Tablets:
Like any medication, Ibandronate can have side effects. Common ones include gastrointestinal symptoms, musculoskeletal pain, and joint pain. However, serious but rare effects like osteonecrosis of the jaw or atypical femur fractures may occur.

Important Advice for using Ibandronate Tablets
To maximize the benefits of Ibandronate, here are crucial tips: Take as prescribed, on an empty stomach, with plain water, and remain upright for at least 60 minutes after. Regular follow-ups with your healthcare provider are essential.

That concludes our journey into the world of Ibandronate Tablets. Remember, knowledge is the key to wellness. If you found this video insightful, don't forget to like, share, and subscribe to MediInsights for more health-related content. Until next time, stay informed, stay healthy!

INTRO: 0:00
USE OF IBANDRONATE TABLETS: 0:43
DOSAGE OF IBANDRONATE TABLETS: 1:10
MECHANISM OF ACTION OF IBANDRONATE TABLETS: 1:55
SIDE EFFECTS OF IBANDRONATE TABLETS: 2:25
IMPORTANT ADVICES FOR USING IBANDRONATE TABLETS: 3:03


#IbandronateTablets
#BoneHealth
#Osteoporosis
#MedicationGuide
#WellnessWednesday
#HealthEducation
#MediInsights
#WomenHealth
#HealthcareTips
#BoneDensity
#PostmenopausalHealth
#MedicalAdvice
#HealthAwareness
#WellnessJourney
#Pharmaceuticals
#HealthFacts
#MedicineExplained
#MedicationTips
#PatientEducation
#HealthEmpowerment

General information regarding Ibandronate (Boniva). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Dr. Lisa Lilienfield discusses natural ways to prevent osteoporosis and increase bone strength. Taking prescription medications can cause troublesome side effects in some patients, so Dr. Lisa recommends weight-bearing exercise, such as yoga, a "bone-healthy" diet and various nutritional supplements. Dr. Lisa Lilienfield specializes in women's health and sports medicine at the Kaplan Center for Integrative Medicine in McLean, VA.

This is a multi-dose DPI and it delivers the medications: Anoro (red cap), Arnuity (orange cap), Breo (blue cap), Incruse (green cap), and Trelegy (beige cap).

This demonstration is intended to complement the Patient information for BREO ELLIPTA. For full instructions on how to use BREO ELLIPTA, and other important information, please see the complete Prescribing Information and Patient Information for BREO ELLIPTA. You can also ask your healthcare provider or pharmacist for more information.

IMPORTANT SAFETY INFORMATION
BREO contains vilanterol. LABA medicines such as vilanterol when used alone increase the risk of hospitalizations and death from asthma problems. BREO contains an ICS and a LABA. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems.
Do not use BREO to relieve sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.
Do not use BREO if you have a severe allergy to milk proteins or are allergic to any of the ingredients in BREO. Ask your healthcare provider if you are not sure.
Do not use BREO more often than prescribed.
Do not take BREO with other medicines that contain a LABA for any reason. Tell your healthcare provider about all the medicines you take and about all of your health conditions.
Call your healthcare provider or get medical care right away if your breathing problems get worse, if you need your rescue inhaler more often than usual or it does not work as well to relieve your symptoms.
BREO can cause serious side effects, including:
fungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using BREO to help reduce your chance of getting thrush.
pneumonia. People with COPD have a higher chance of getting pneumonia. BREO may increase the chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms: increase in mucus (sputum) production; change in mucus color; fever; chills; increased cough; increased breathing problems.
weakened immune system and increased chance of getting infections (immunosuppression). You should avoid exposure to chickenpox and measles, and, if exposed, consult your healthcare provider without delay. Worsening of existing tuberculosis, fungal, bacterial, viral, or parasitic infections, or herpes infection of the eye may occur.
reduced adrenal function (adrenal insufficiency). This can happen when you stop taking an oral corticosteroid (such as prednisone) and start taking a medicine containing an inhaled corticosteroid (such as BREO). During this transition period, when your body is under stress such as from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death. Symptoms include: feeling tired; lack of energy; weakness; nausea and vomiting; low blood pressure (hypotension).
sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking BREO and call your healthcare provider right away.
serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction: rash; hives; swelling of your face, mouth, and tongue; breathing problems.
effects on heart: increased blood pressure; a fast or irregular heartbeat, awareness of heartbeat; chest pain.
effects on nervous system: tremor; nervousness.
bone thinning or weakness (osteoporosis).
eye problems including glaucoma and cataracts. You should have regular eye exams while using BREO.
changes in laboratory blood values, high blood sugar (hyperglycemia) and low potassium (hypokalemia).
Common side effects of BREO 100/25 for COPD include:
runny nose and sore throat
upper respiratory tract infection
headache
thrush in your mouth or throat. Rinse your mouth with water without swallowing after use to help prevent this
back pain
pneumonia
bronchitis
inflammation of the sinuses
cough
mouth and throat pain
joint pain
high blood pressure
flu
fever

This video was made by Cafrey He Feng , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

This video was made by Yvonne Cunningham, 2023 Pharmacist Candidate. She will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

This video was made by Randy Nguyen , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

Make sure you're using your inhaler properly! Our team shows you how to use your Ellipta inhaler correctly.

Anoro ellipta inhaler contains two active ingredients, umeclidinium and vilanterol. These work in different ways to relax and open the airways and make it easier to breathe. In chronic obstructive lung diseases (COPD), such as chronic bronchitis or emphysema, the airways are narrowed and this makes breathing difficult.

Breztri Aerosphere is a prescription inhaler used to treat chronic obstructive pulmonary disease (COPD) , a chronic lung disease that includes chronic bronchitis, emphysema, or both. It contains three active ingredients:
Budesonide – A corticosteroid that reduces inflammation in the lungs.
Glycopyrrolate – A long-acting muscarinic antagonist (LAMA) that helps relax airway muscles.
Formoterol fumarate – A long-acting beta agonist (LABA) that helps open the airways.
Breztri is used for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including:
Chronic bronchitis – Persistent inflammation of the airways.
Emphysema – Damage to the air sacs in the lungs.
It reduces inflammation in the airways (Budesonide).
Relaxes airway muscles to improve airflow (Glycopyrrolate).
Opens airways for easier breathing (Formoterol).
Mechanism of action
Each of the 3 ingredients in Breztri has a different mechanism of action. Budesonide helps to decrease inflammation in the lungs which can lead to breathing problems. Glycopyrrolate blocks the effects of acetylcholine (a neurotransmitter) in the lungs, which allows the airways to relax and widen, making breathing easier. Formoterol binds to and activates beta2-adrenergic receptors on the smooth muscle cells in the airways. This activation also allows the airways to relax and widen, making breathing easier. Formoterol has a long-lasting effect, typically lasting 12 hours or more, which provides sustained symptom relief throughout the day for COPD patients.

Breztri Aerosphere Dosage

Standard Dosage for COPD

Recommended dose: Two inhalations (puffs) twice daily

Time of use: Morning and evening (approximately 12 hours apart)

Inhaler strength: Each puff contains:

Budesonide 160 mcg.

Glycopyrrolate 9 mcg.

Formoterol fumarate 4.8 mcg.



Side Effects of Breztri Aerosphere

Like all medications, Breztri Aerosphere can cause side effects. These can be classified as common, serious, and rare.

Common Side Effects

These are usually mild but should be monitored:

Cough, Sore throat, Headache, Muscle cramps, Runny or stuffy nose, Nausea.

Serious Side Effects (Seek medical attention if these occur).

Pneumonia – Symptoms include fever, chills, chest pain, and increased phlegm.

Increased heart rate (tachycardia).

High blood sugar (hyperglycemia).

Low potassium levels – Can cause muscle weakness or irregular heartbeat.

Osteoporosis (bone thinning) with long-term use.

Eye problems – Glaucoma or cataracts may develop.

Paradoxical bronchospasm – Sudden breathing difficulty after inhaling.

How Breztri Aerosphere Works.
Breztri Aerosphere offers a breakthrough solution to the challenges faced in treating asthma and COPD. Its unique formulation combines three active ingredients – budesonide, glycopyrronium, and formoterol fumarate – in a single inhaler device. This triple-combination therapy targets the key components of both diseases, providing comprehensive symptom relief and improving lung function.
Budesonide, a corticosteroid, acts as an anti-inflammatory agent, reducing airway inflammation and preventing exacerbations. Glycopyrronium is an anticholinergic that helps relax the airway muscles, reducing bronchoconstriction and improving airflow. Formoterol fumarate, a long-acting beta-agonist, further enhances bronchodilation and supports long-term symptom control.
The unique formulation of Breztri Aerosphere ensures that each active ingredient is delivered directly to the lungs where it is needed most. The inhaler device utilizes advanced technology to optimize drug deposition and increase lung penetration, maximizing the therapeutic effects of the medication.
Key Benefits of Breztri Aerosphere.
Breztri Aerosphere offers several key benefits that set it apart from traditional asthma and COPD treatments. Firstly, its triple-combination therapy provides a comprehensive approach to managing symptoms, addressing inflammation, bronchoconstriction, and airflow obstruction simultaneously. This holistic approach leads to improved symptom control and better overall disease management.
In addition to symptom relief, Breztri Aerosphere also improves lung function. Clinical studies have shown that patients using the medication experience increased forced expiratory volume in one second (FEV1) – a measure of lung function – compared to those using other asthma and COPD treatments. This improvement in lung function translates to better exercise tolerance and increased overall respiratory health.
Furthermore, Breztri Aerosphere's convenient inhaler device simplifies treatment regimens and enhances patient adherence. The single inhaler design eliminates the need for multiple devices, reducing the risk of confusion and medication errors. Its easy-to-use mechanism allows patients to incorporate the medication seamlessly into their daily routines, ensuring consistent and effective treatment.
Clinical Studies and Efficacy of Breztri Aerosphere.
Clinical studies have demonstrated the efficacy and safety of Breztri Aerosphere in treating both asthma and COPD. In a randomized, double-blind trial involving patients with moderate to severe COPD, Breztri Aerosphere was found to significantly improve lung function and reduce exacerbations compared to other inhaler treatments. The study also showed that the medication was well-tolerated, with a similar safety profile to other commonly used inhalers.
Similarly, studies involving patients with asthma have shown promising results. Breztri Aerosphere was found to effectively control symptoms and improve lung function compared to other asthma treatments. Its triple-combination therapy demonstrated superior efficacy in reducing exacerbations and improving overall disease control.
The positive outcomes observed in these studies highlight the potential of Breztri Aerosphere as a game-changing treatment option for both asthma and COPD patients. Its comprehensive approach and proven efficacy make it a promising choice for healthcare providers and patients seeking optimal symptom control and improved quality of life.
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

#pharmacisteducationcorner
#breztri
#inhaler
#copd
#asthma

#breztri #budesonide #copd #pulmonaryrehabilitation #formoterol #astrazeneca

#bevespi #copd #pulmonaryrehabilitation #breathing #glycopyrrolate #formoterol #astrazeneca

Aclidinium Oral Inhalation review, aclidinio: What is aclidinium?, what is aclidinium used for, aclidinium uses, aclidinium dosage, aclidinium side effects, aclidinium brand names: Tudorza Pressair, Duaklir Pressair (containing Aclidinium, Formoterol).

What is aclidinium? and What is aclidinium used for?

Aclidinium is used as a long term treatment to prevent wheezing, shortness of breath, coughing, and chest tightness in patients with chronic obstructive pulmonary disease (COPD, a group of diseases that affect the lungs and airways) such as chronic bronchitis (swelling of the air passages that lead to the lungs) and emphysema (damage to air sacs in the lungs).
Aclidinium is in a class of medications called bronchodilators.
It works by relaxing and opening the air passages to the lungs to make breathing easier.


How to use aclidinium?

Aclidinium comes as a dry powder in an inhalation device to inhale by mouth. It is usually inhaled twice a day, once every 12 hours. Inhale aclidinium at around the same times every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Inhale aclidinium exactly as directed.
Do not inhale more or less of it or inhale it more often than prescribed by your doctor.

Do not use aclidinium to treat a sudden attack of wheezing or shortness of breath.
Your doctor will prescribe a rescue medication to treat sudden attacks of symptoms.
Keep this rescue medication with you at all times in case you have sudden difficulty breathing.

Your condition may worsen over time during your treatment with aclidinium. Do not take extra doses of aclidinium if this happens.
Call your doctor or get emergency medical help if your breathing problems worsen, you need to use your rescue medication to treat sudden attacks more often, or your rescue medication does not relieve your symptoms as well as it did in the past.

Aclidinium can help control your symptoms but does not cure COPD.
You may notice some improvement in your symptoms the first day that you use aclidinium, but it may take longer for you to feel the full benefit of the medication.
Continue to use aclidinium even if you feel well. Do not stop using aclidinium without talking to your doctor.

Before you use your aclidinium inhalation device for the first time, read the manufacturer's directions for use carefully.
Ask your doctor or pharmacist to show you how to use the device and practice using it while he or she watches.

Be careful not to get aclidinium powder in your eyes. If you get the powder in your eyes, you may experience blurred vision and sensitivity to light.

The aclidinium inhalation device does not need to be cleaned. If you want to clean the device, you may wipe the outside of the mouthpiece with a dry tissue or paper towel.
Never use water to clean the device because you might damage the medication.


When to use aclidinium?

Before using aclidinium:

tell your doctor and pharmacist if you are allergic to aclidinium, atropine (Atropen, in Lomotil, in Lonox, in Motofen), any other medications, any of the ingredients in aclidinium inhalation powder, or milk proteins.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
Be sure to mention any of the following: antihistamines; atropine (Atropen, in Lomotil, in Lonox, in Motofen); glycopyrrolate (Lonhala Magnair, Seebri, in Bevespi Aerosphere, in Utibron); ipratropium (Atrovent); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, and urinary problems; tiotropium (Spiriva); and umeclidinium (Incruse Ellipta, in Anoro Ellipta, in Trelegy Ellipta).
Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had glaucoma (increased pressure in the eye that may cause vision loss), benign prostatic hypertrophy (BPH; enlargement of a male reproductive gland), a bladder condition, or any other condition that makes it difficult for you to empty your bladder completely.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking aclidinium, call your doctor.


What should I do if I forget a dose?

Skip the missed dose and continue your regular dosing schedule.
Do not inhale a double dose to make up for a missed one.


What side effects can aclidinium cause?

Aclidinium may cause side effects.
Tell your doctor if any of these symptoms are severe or do not go away:

headache.
runny nose and other cold symptoms.
cough.
diarrhea.

Three things I like about my MS disease modifying drug, Briumvi

* Only two infusions a year (instead of daily oral
meds or weekly injections)

* I get my infusion at home.

* Few side effects.

Briumvi, a monoclonal antibody for treatment of MS, targets B cells to reduce relapses which cause inflammation and nerve damage in the brain and spinal cord. It helps slow disability progression and reduce relapse frequency in relapsing forms and primary progressive MS.

Briumvi vs Ocrevus: How do they compare? - Key Points..Briumvi (ublituximab) and Ocrevus (ocrelizumab) are two injectable medications that may be used to treat multiple sclerosis in adults..Briumvi and Ocrevus are both B-cell therapies and work the same way..Head-to-head trials directly comparing the Briumvi and Ocrevus have not been conducted, making it difficult to definitively determine which is more effective..Both Briumvi and Ocrevus carry a risk of infusion reactions and infections...Briumvi (ublituximab) and Ocrevus (ocrelizumab) are prescription intravenous (IV) infusions given to treat relapsing forms of multiple sclerosis (MS). Ocrevus is also used to treat primary progressive MS..While there have not been head-to-head comparison studies in patients with MS, both medications work well and have similar side effects. In this article, we will review some similarities and differences between Briumvi and Ocrevus... . . . . . Briumvi. . Ocrevus. . . . Manufacturer. . TG Therapeutics, Inc.. . Genentech, Inc.. . . . FDA approval. . 2022. . 2017. . . . Active ingredient. . Ublituximab. . Ocrelizumab. . . . Approved uses. . . Relapsing forms of MS. . . . . Relapsing forms of MS. Primary progressive MS. . . . . . Drug class. . CD20 monoclonal antibody. . CD20 monoclonal antibody. . . . Route of administration. . Intravenous infusion. . Intravenous infusion. . ..Briumvi and Ocrevus have similar and different uses.Both Briumbi and Ocrevus are FDA approved for relapsing forms of multiple sclerosis. This includes clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. However, Ocrevus is additionally approved to treat primary progressive MS..Ocrevus was FDA approved in 2017, while Briumvi was approved in 2022. Both medications are currently only approved in adults, since there havent been enough studies in children to know if they are safe or effective..Briumvi and Ocrevus work the same way.Briumbi and Ocrevus are both monoclonal antibodies that target parts of the immune system that are believed to play a role in MS. Both medications attach to and decrease B cells expressing CD20 on their surface. These cells are thought to cause damage to nerve cell coverings in people with MS..Briumvi targets a different part of B cells than Ocrevus, but there havent been head-to-head studies comparing the two medications in terms of how well they work to treat MS..Related questions What are monoclonal antibodies? Is Kesimpta better than Ocrevus? How much does an Ocrevus infusion cost? How well does each medication work?.There have not been head-to-head trials comparing Ocrevus and Briumvi. However, separate studies evaluated how well these medications work to treat MS..Ocrevus.In studies of patients with RMS, up to 83% of patients taking Ocrevus were relapse free at year 2. In a 120-week clinical trial of patients with PPMS, those taking Ocrevus were less likely to have a 12-week confirmed disability progression compared to placebo..Briumvi.Briumvi was studied in two clinical trials that included more than 1,000 patients with RMS. Briumvi reduced relapses by up to 59% when compared to teriflunomide..Briumvi and Ocrevus have different dosages.A healthcare professional must administer Briumvi and Ocrevus. Both medications are given as an IV infusion. The dose is different depending on which medication you are taking..Briumvi is first given as a 150 mg IV infusion, followed by 450 mg 2 weeks later. Then, 450 mg is infused once every 6 months..Ocrevus is first given as a 300 mg IV infusion, followed by another 300 mg infusion 2 weeks later. Then, 600 mg is infused once every 6 months..One notable difference in dosing between the two medications is that Briumvi has shorter infusion times compared to Ocrevus. For the first infusion, it takes about 4 hours to infuse Briumvi. The remaining doses are infused over about 1 hour. This is compared to around 2.5 hours for the first two infusions of Ocrevus, and 3.5 hours or longer for any additional infusions..Briumvi and Ocrevus have similar side effects.The most common side effects of both Briumvi and Ocrevus include infections and infusion reactions. In clinical studies of Briumvi, 48% of patients taking it experienced infusion reactions. Additionally, 45% of patients taking Briumvi reported an upper respiratory tract infection. In comparison, 40% of patients taking Ocrevus for relapsing forms of MS in clinical studies reported an upper respiratory tract infection, and 34% had an infusion reaction..Other side effects reported by patients taking Briumvi or Ocrevus were lower respiratory tract infections and pain in arms or legs. These are not all side effects possible with these medications. Follow up with your healthcare provider to learn more..Ocrevus has a warning about cancer.During clinical trials, more people taking Ocrevus developed breast cancer. In females taking Ocrevus, 6 out of 781 developed breast cancer. This is compared to n...