E. David Crawford, MD, professor, Urologic and Radiation Oncology, head, Section of Urologic Oncology, University of Colorado at Denver, discusses a study presented at the 2014 AUA Annual Meeting that analyzed intermittent androgen deprivation with degarelix.

Philip J. Buffington, MD, chief medical officer at The Urology Group, discusses administering Firmagon (degarelix) and determining which patients to treat with the hormonal therapy.

Steven Joniau, MD, PhD, University Hospitals Leuven, Leuven, The Netherlands, discusses data from the Phase II ARNEO trial (NCT03080116) of neoadjuvant degarelix with or without apalutamide in patients with high-risk prostate cancer. 89 patients were randomized to either receive degarelix with apalutamide or a placebo and the difference in minimal residual disease was the primary endpoint. The cohort receiving degarelix and apalutamide achieved superior outcomes and loss of PTEN was additionally found to predict negative outcomes. This interview took place at the European Association of Urology (EAU) Meeting 2022.

Alec S. Koo, MD, FACS, managing partner, Skyline Urology, board of directors, Large Urology Group Practice Association (LUGPA), discusses degarelix (Firmagon) for the treatment of patients with prostate cancer.

Learn about the advantages and disadvantages of a new treatment for lowering testosterone that results in an immediate decline to castrate levels more rapidly than other medications previously available.

Judd W. Moul, MD, director, Duke Prostate Center, James H. Semans, MD, Professor of Surgery, Duke University Medical Center, discusses the 5-year results from a phase III extension trial with a 1-arm crossover from leuprolide to degarelix.

Discover degarelix, a GnRH antagonist utilized for advanced prostate cancer to rapidly suppress testosterone levels. Understand its unique mechanism, pharmacokinetics, and key side effects like injection-site reactions and hormonal changes. This video simplifies its role and advantages over traditional therapies.

What is it and how does it work?.
Dayvigo is a prescription medication specifically designed to treat insomnia. Its active ingredient, lemborexant, works by targeting the orexin receptors in the brain. Orexin is a neuropeptide that regulates wakefulness and arousal. By blocking the orexin receptors, Dayvigo helps promote sleep and reduce wakefulness.
Unlike other sleep medications that primarily focus on sedation, Dayvigo tackles the root cause of insomnia. It helps regulate the sleep-wake cycle, ensuring a more natural and restful night's sleep. This innovative approach sets Dayvigo apart from other treatments and makes it a game-changer for those struggling with insomnia.
The benefits of using Dayvigo for insomnia.
Dayvigo offers a multitude of benefits for individuals suffering from insomnia. Firstly, it helps you fall asleep faster, reducing the time spent tossing and turning in bed. This means you can spend more time in deep, restorative sleep, allowing your body and mind to fully recharge.
Secondly, Dayvigo promotes uninterrupted sleep by regulating the sleep-wake cycle. This means you're less likely to wake up throughout the night, leading to a more refreshing and rejuvenating sleep experience. No more waking up feeling groggy and unrested – Dayvigo ensures you wake up ready to conquer the day.
Another significant benefit of Dayvigo is its ability to improve sleep quality. It not only helps you fall asleep faster and stay asleep longer but also enhances the overall depth and restfulness of your sleep. This means you'll wake up feeling more refreshed, energized, and mentally sharp.
Who can benefit from Dayvigo?.
Dayvigo is suitable for adults who experience difficulty falling asleep, staying asleep, or both. It can be a game-changer for individuals suffering from chronic insomnia or those who occasionally struggle with sleep disturbances. If you find yourself lying awake at night, unable to quiet your mind and drift off into a peaceful slumber, Dayvigo may be the solution you've been searching for.
It's important to consult with a healthcare professional before starting Dayvigo or any other sleep medication. They can evaluate your specific situation, assess potential underlying causes of your insomnia, and determine if Dayvigo is the right choice for you.
How to use Dayvigo effectively for optimal results.
To get the most out of Dayvigo, it's crucial to use it as directed by your healthcare professional. Typically, the recommended starting dose is 5 mg, taken orally once daily, within 30 minutes of going to bed. However, the dosage may vary depending on individual needs and tolerability.
It's important to take Dayvigo only when you have a full 7-8 hours available for sleep. This ensures that you get the most out of the medication and avoid potential grogginess or impaired cognitive function upon waking. Taking Dayvigo with or immediately after a high-fat meal should be avoided, as it may delay its effects.
Consistency is key when using Dayvigo. It's important to establish a regular sleep routine and prioritize good sleep hygiene. This includes creating a relaxing environment, limiting exposure to screens before bed, and avoiding caffeine and stimulating activities close to bedtime. By combining Dayvigo with healthy sleep habits, you can maximize its effectiveness and reap the benefits of a restful night's sleep.
Common side effects and precautions of using Dayvigo.
As with any medication, Dayvigo may have potential side effects. The most common side effects reported in clinical trials include headache, somnolence (excessive sleepiness), and dry mouth. These side effects are generally mild to moderate and typically subside over time.
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



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Prof Joseph Mikhael talks to ecancer following his MyKE Myeloma 2021 presentation.

He begins by stating that over the past several years we have become quite familiar with new forms of immunotherapy in multiple myeloma, primarily with monoclonal antibodies. Daratumumab being the first, which has been used as a single agent and in combination for many years.

Prof Mikhael then goes on to talk about the use of a more recent monoclonal antibody, Isatuximab. And brings up common questions such as should one be used over the other, what are the pragmatic differences between them and how do you sequence them.

He concludes by answering a question that comes up a lot with CD38 antibodies, which is, can they be reused or can you switch from one to another. He says he learned, based on his recent publishings looking at this exact question, you can't really rescue one with the other. Meaning that you can't expect one to overcome the resistance of another.

Sign up to ecancer for free to receive tailored email alerts for more videos like this.
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Niels van de Donk, MD, PhD from the University Medical Center, Amsterdam, Netherlands discusses three trials of daratumumab in multiple myeloma (MM). First, Dr van de Donk outlines the results of the Phase III POLLUX trial of daratumumab combined with lenalidomide and dexamethasone (DRd) vs lenalidomide and dexamethasone (Rd) (NCT02076009). The trial was perfomed in the relapsed/refractory setting. There was an increase in response rate, complete response rate and further progression-free survival (PFS) was improved in the DRd vs the Rd arm. According to Dr van de Donk, this is the best triplet combination tested so far. He also discusses the side effect profile of daratumumab. The main toxicity, experienced by 50% of patients, was an infusion-related reaction, which is easily managed according to Dr van de Donk. Overall, the triplet combination was well-tolerated. He also discusses the MAIA trial of daratumumab plus lenalidomide and dexamethaonse vs lenalidomide and dexamethaonse in the upfront setting (NCT02252172), which is enrolling patients. Finally, Dr van de Donk outlines the results of the CASTOR trial of daratumumab plus bortezomib and dexamethasone vs bortezomib and dexamethasone (NCT02136134).
Recorded at the European Hematology Association (EHA) 2016 Annual Congress in Copenhagen, Denmark.

Paul Richardson, MD, Dana-Farber Cancer Institute, Boston, MA, tells about the side effects that have been seen in the use of melflufen for the treatment of multiple myeloma at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands.

C. Ola Landgren, MD, PhD, chief of Myeloma Service at Memorial Sloan Kettering Cancer Center, discusses using daratumumab (Darzalex) for the treatment of patients with multiple myeloma.

Shaji Kumar, MD, and Peter Voorhees, MD, discuss the safety and efficacy of using daratumumab to treat multiple myeloma.

Charise Gleason, MSN, NP-BC, AOCNP; Kathleen Colson, RN, BSN, BS; and Wendy Vogel, MSN, FNP, AOCNP, provide insight on the adverse effects of daratumumab and elotuzumab, as well as the precautions surrounding serologic testing with daratumumab in patients with multiple myeloma.

Warfarin is very useful to prevent stroke in patients with atrial fibrillation and maintenance of function of a mechanical prosthetic valve. At the same time, it has several limitations.

How to prescribe Warfarin in secondary care

Coreg is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
Coreg is used to treat heart failure and hypertension (high blood pressure).

Video Content:
0:00 Coreg tablets
0:23 Indications
0:53 How to use
2:54 Contraindications
3:42 Precautions
4:11 Side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#Coreg #hypertension #medicine

COREG (Carvedilol) Uses, Dosage, Warnnigs, Side Effects #health #drug
0:19 COREG What is it and why is it used?
0:34 COREG How Does Work?
0:48 COREG How to use ?
1:17 COREG Precautions
1:47 COREG Who should not use
2:03 COREG Side Effects

If this video was useful to you, please like the video and subscribe to the channel for support. Thanks...

Drug promotional videos have been prepared based on the drug package inserts to provide general information about the use of drugs. The channel owner cannot be held responsible for any damage that may occur due to the incomplete, incorrect or not updated information provided on this channel and its application. The leaflets included in the medicine box contain more comprehensive and updated information. Please do not use any medication without consulting your doctor!

If any producer/label or photographer has an issue with this upload, please contact us ([email protected]) and we will delete it immediately.
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The BEST Beta-Blocker for a Diabetic & Hypertensive Patient with Palpitations! 🩺
You have a patient with diabetes, hypertension, and occasional palpitations. You decide on a beta-blocker, but which one offers the most comprehensive benefits?
In this video, Dr. Saurabh breaks down why Carvedilol is the superior choice.
Here's the 3-in-1 advantage:
1️⃣ Alpha-1 Blockade: Effectively lowers blood pressure through vasodilation.
2️⃣ Beta Blockade: Controls heart rate to manage palpitations.
3️⃣ Antioxidant Properties: Reduces atherogenic oxidized LDL, offering crucial cardiovascular protection—a huge plus for diabetic patients!
With one drug, you manage three critical issues. That's a clinical win!
Did you know about Carvedilol's triple mechanism? Let us know in the comments! 👇
Save this high-yield info & share it with a fellow medico!
#Carvedilol #BetaBlocker #Hypertension #Diabetes #Palpitations #Pharmacology #Cardiology #ClinicalCase #MedicalStudent #MBBS #DoctorLife #FMGE #USMLE #InternalMedicine #DrugOfChoice #MedicalEducation #clinicalguruji

#clobetasol #rinkeshpariyani #pathopharma #eczema #autoimmunedisease #

In this video, Doctor is explaining details on CLOBEVATE CREAM, We are going to discuss what is CLOBEVATE CREAM, its benefits, side effects, dosage & more.

00:00 Intro
00:26 What is CLOBEVATE CREAM?
00:44 Uses of CLOBEVATE CREAM?
01:33 How to apply CLOBEVATE CREAM?
02:09 Side effects of CLOBEVATE CREAM?
02:51 Precautions of CLOBEVATE CREAM?
04:04 Outro

What is CLOBEVATE CREAM
Clobevate cream is a steroidal cream which is used for inflammation and many skin conditions, It's active ingredient is clobetasol.

Uses of CLOBEVATE CREAM?
Clobevate Cream is used to treat a variety of skin conditions (such as eczema, psoriasis, dermatitis, allergies, rash). Clobetasol reduces the swelling, itching, and redness that can occur in these types of conditions.

How to apply CLOBEVATE CREAM?
Apply a thin film of medication to the affected area and gently rub in, usually 2 times daily or as directed by your doctor.

Side effects of CLOBEVATE CREAM?
Burning, stinging, itching, dryness, or redness at the application site may occur when first applied to the skin. This should disappear in a few days as your body adjusts to the medication. If any of these effects last or get worse, notify your doctor or pharmacist promptly.

Precautions of CLOBEVATE CREAM?
When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water. Use this medication only for the condition prescribed.

#clobevate #clobevatecream #clobetasol

Clobeta GM skin Cream Use Composition how to Apply over skin its Side Effects and Price explained here in Hindi.

Clobeta GM Cream is a combination of Five medicines: Clobetasol
Neomycin
Miconazole
Zinc Oxide and Borax. Clobetasol is a steroid medicine. It blocks the production of certain chemical messengers (prostaglandins) that make the skin red swollen and itchy. Neomycin is an antibiotic. It stops bacterial growth by preventing the synthesis of essential proteins required by the bacteria to carry out vital functions. Miconazole is an antifungal which stops the growth of fungi by preventing them from forming their own protective covering. Borax and zinc provide essential nutrients to the body.


#clobetagmcream #skinallergycream #clobetacream #skinitchingcream

Clobex Spray Lotion Shampoo Which one do I use Key PointsClobex Spray and Clobex Shampoo are both topical corticosteroid medicines used to treat psoriasisClobex Lotion is also approved to treat psoriasis as well as the swelling and itching due to other skin conditions such as eczemaClobex topical treatments are used only in patients years of age or olderClobex clobetasol propionate is a superhigh potent topical corticosteroid available as a prescription spray lotion and shampoo Clobex Spray is used to treat plaque psoriasis on the skin and Clobex Shampoo treats scalp psoriasis Clobex Lotion is approved to treat the swelling and itching due to certain skin conditions such as atopic dermatitis eczema and plaque psoriasisLotions and sprays are often more acceptable for use on the skin and hardtoreach areas while shampoos work well on the scalpHow do I use ClobexAlways follow your doctors directions for dosing and length of time to treat your skin or scalp condition Do not exceed the prescribed dose as it may increase the risk for severe side effects Read the patient medication guide each time you get a prescription If you have questions ask your doctor or pharmacistClobex Spray is approved to treat moderate to severe plaque psoriasis affecting up to of your body surface area BSAThe total dosage should not exceed g mL or fl oz per week Do not use more than sprays per application or sprays per dayTreatment should be limited to consecutive weeks Use Clobex Spray for the shortest amount of time needed to clear your skin conditionDo not use Clobex Spray on the face axillae underarm area or groin area or if there is atrophy skin thinning at the treatment site Do not use Clobex Spray to treat rosacea or perioral dermatitisClobex Lotion is used for certain skin conditions such as atopic dermatitis and psoriasis known as corticosteroidresponsive dermatosesYou should not apply more than mL fluid ounces of Clobex Lotion to your skin per weekClobex Lotion should not be used for more than weeks in a row unless your doctor tells you to use it for a longer time Clobex Lotion should only be used for the shortest amount of time needed to treat your skin conditionDo not use Clobex Lotion on the face axillae underarm area or groin area or if there is atrophy skin thinning at the treatment site Do not use Clobex Spray to treat rosacea or perioral dermatitisClobex Shampoo is used to treat moderate to severe forms of scalp psoriasisYou should not apply more than mL fluid ounces of Clobex Shampoo to your scalp per weekDo not use Clobex Shampoo for longer than weeks unless directed by your doctor Clobex Shampoo should only be used for the shortest period of time needed to treat your scalp psoriasisClobex Shampoo should not be used on your face groin or axillae underarms Do not get the medicine into your eyes or on your lips In case of contact rinse thoroughly with water all parts of the body that came in contact with the shampooRelated questions Does Clobex help hair growth How often can I use Clobex Does clobetasol cause hair loss or growth Bottom LineClobex Spray is used to treat psoriasis on the skin and Clobex Shampoo treats scalp psoriasis Clobex Lotion is also approved to treat psoriasis in addition to other skin conditions such as eczema Clobex topical treatments are used only in patients years of age or olderAlways follow your doctors directions for dosing and length of time to treat your skin or scalp condition Do not exceed the prescribed dose as it may increase the risk for severe side effectsThis is not all the information you need to know about Clobex clobetasol propionate Topical Spray lotion or shampoo for safe and effective use Review the full Clobex information and discuss this information and any questions you have with your doctor or other health care provider

Cloxacillin is indicated for the treatment of infections caused by Grampositive organisms including infections caused by β-lactamase producing Staphylococci such as : Skin and soft tissue infections : Boils, Abscesses, Carbuncles, Furunculosis, Cellulitis, Infected wounds, Infected burns, Otitis media and externa, Protection of skin graft and Skin infections like ulcer, eczema, acne, etc.
Respiratory tract infections : Pneumonia, Lung abscess, Empyema, Sinusitis, Pharyngitis and Tonsillitis.
Other infections caused by sensitive organisms : Osteomyelitis, Enteritis, Endocarditis, Urinary tract infection, Meningitis and Septicaemia.

Understanding the Effects of Clobetasol: From Application to Results • Get the Facts on Clobetasol: How Long Does it Take to Work?

00:00 • How long does it take for clobetasol to work?
00:28 • What is Clobetasol?
00:52 • How Does Clobetasol Work?
01:14 • How Long Does it Take for Clobetasol to Work?

My last loading dose for my new Cimzia injections for my rheumatoid arthritis.

From now on I will only have 1 shot every 2 weeks. I’m a lot more comfortable with the process now and I do feel like they are helping!

Cimzia injection contains the active ingredient certolizumab pegol, which is a type of medicine called a tumour necrosis factor alpha (TNF alpha) blocker. It works by suppressing the process of inflammation.

RA update
Side effects of Humira.
Cimzia update

I've tried a lot of med. for Crohn's Disease but had to go to injections. Cimzia didn't work very well for me and so now I'm on Humira which has really helped. Just a couple differences I noticed.

CIMZIA Explained in 60 Seconds 🩺💉
Struggling with rheumatoid arthritis, Crohn’s disease, or psoriasis? This quick guide breaks down everything you need to know about Cimzia, a unique biologic that helps calm your immune system and reduce chronic inflammation—especially during pregnancy.

🎯 In this video:
✔️ What Cimzia treats (RA, Crohn’s, psoriasis, and more)
✔️ How it works to block inflammation
✔️ Why it’s different from Humira or Enbrel
✔️ Risks, side effects, and safety in pregnancy
✔️ What to ask your doctor before starting it

Cimzia is not your average injection—it’s specially designed to last longer, lower infection risks, and minimize transfer to your baby if you’re pregnant or breastfeeding. Whether you’re researching treatment options or already on a biologic, this is must-know info 💡

👩‍⚕️ Hosted by Dr. Rezaian
🎨 Visuals: Low Poly 3D
🔗 Full video on YouTube for a deep dive

👇 Drop your questions in the comments
📲 Like & share to help others exploring biologics
#Autoimmune #Cimzia #ChronicIllness #BiologicTherapy #CrohnsDisease #PsoriasisRelief #RheumatoidArthritis #PregnancySafeMedications #Immunology #DoctorExplains #TikTokHealth #MedicalTikTok

Medication dosing details, proper storage techniques, administration procedures, side effects and more.

How long does it take Cequa to work Cequa cyclosporine ophthalmic solution and other cyclosporine eye drops will usually reach their full effect after to months of use Most dry eye patients will need to apply Cequa consistently for to months to experience significant symptom relief However a minority of people using Cequa especially those with a mild form of dry eye may begin to see their symptoms ease within the first monthThe usual dose is one drop of Cequa twice daily approximately hours apart into each eye It is sometimes used along with artificial tears with minute intervals between productsThere may be ways to accelerate Cequas effect for patients with more severe dry eye or those who are still experiencing symptoms after several months of treatment One option is to administer the drops more frequently to times per dayinstead of twice a day Studies have suggested that upping the dosage in this way may help alleviate symptoms more quickly without causing significant or adverse side effectsShortterm use of topical corticosteroids including loteprednol or methylprednisolone may also speed up the process Patients may be advised to administer a topical corticosteroid for to weeks before or during treatment with Cequa Briefly adding a topical corticosteroid to a longterm treatment protocol with Cequa may accelerate symptom relief and alleviate irritation or other potential side effects of cyclosporine eye dropsBe sure to ask your health care provider before making any changes to your dose or treatment plan