In this video we discuss what is melatonin, how our body uses it in different ways, and melatonin as a supplement. We also cover how it affects sleep.

Transcript/notes
What is melatonin? Well, melatonin is actually a hormone that is increased by the brain in response to darkness, and decreases in the morning as it gets lighter outside.

Melatonin works with the body’s natural circadian rhythm. The circadian rhythm is the body’s internal clock, which signals when it is time to sleep, time to wake, and time to eat.

In some people, low melatonin levels can be caused by alcohol or caffeine consumption, smoking, aging, some medications and exposure to high levels of light at night from certain electronic devices.

Taking a melatonin supplement on a short term basis, 30 minutes to an hour before bedtime can help some people fall asleep and can also help increase sleep duration. 1 to 5 milligrams generally appears to be effective but varies greatly from person to person and it is typically smarter to start out with a lower dosage, but it is always best to consult your doctor before taking any type of sleep aide.

Melatonin also plays a role in body temperature regulation, blood pressure regulation, and blood glucose regulation.

Some of the reported side effects of melatonin include headache, dizziness, nausea and sleepiness. And many sources recommend not taking a melatonin supplement if you are pregnant or breastfeeding, have an autoimmune disorder, have diabetes or high blood pressure and if you are taking a medication, check with your pharmacist.

The bottom line is that for some people, taking a low dose of melatonin, over a short period of time to help with sleep may be beneficial.

Chapters/Timestamps
0:00 What is melatonin?
0:19 Some causes of low melatonin
0:32 Melatonin as a supplement
0:55 Other roles of melatonin in the body
1:05 Some side effects of melatonin
1:24 Bottom line

Venlafaxine is used to treat depression, anxiety, panic attacks, and social anxiety disorder (social phobia). It may improve your mood and energy level and may help restore your interest in daily living. It may also decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. Venlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

Aspirin, also known as Ecotrin Tablet, Delayed Release (Enteric Coated), is commonly used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling. It is important to consult your doctor before giving aspirin to a child younger than 12 years old.

Your doctor may recommend a low dose of aspirin to prevent blood clots, reducing the risk of stroke and heart attack. If you have recently had surgery on clogged arteries, such as bypass surgery, carotid endarterectomy, or coronary stent, your doctor may direct you to use aspirin in low doses as a "blood thinner" to prevent blood clots. When taking Ecotrin Tablet, Delayed Release (Enteric Coated), it is best to follow your doctor's instructions on the dosage and timing for optimal benefits.
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Stephanie Stahl reports.

Your Medication Aggrenox

Dipyridamole/aspirin is also known as the brand name: Aggrenox

Dipyridamole/aspirin comes in 200 mg dipyridamole/25 mg aspirin combination capsule

Dipyridamole/aspirin is most commonly used to prevent strokes in patients who have had a stroke or are risk of having a stroke. Dipyridamole/aspirin may also be used as an alternative therapy for intolerable headaches. No matter what your doctor has you taking it for, dipyr-idamole/aspirin is usually taken by mouth and is safe to take with food or on an empty stomach.

Usual dose of dipyridamole/aspirin is 200/25 mg twice daily

Some common side effects of dipyridamole/aspirin are headache, nausea, and diarrhea.
Some less common side effects of dipyridamole/aspirin are tiredness, nose bleeds, back pain, and vomiting.

Do not take dipyridamole/aspirin if you are allergy to non-steroidal anti-inflammatory drugs (NSAIDs).

While taking dipyridamole/aspirin, remember it is important to tell your doctor or pharmacist if you have:
• Signs of an allergic reaction, like rash, hives or itching
• Signs of bleeding, like throwing up blood or bleeding while brushing teeth
• Chest pain or pressure
• Changes in color of skin
• A heartbeat that does not feel normal
• Ringing in the ears

Ecotrin, also known as aspirin, is commonly used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. It works by blocking certain natural substances in your body to reduce pain and swelling.

Your doctor may also direct you to take a low dose of Ecotrin to prevent blood clots, reducing the risk of stroke and heart attack. If you have recently had surgery on clogged arteries, your doctor may also direct you to use Ecotrin in low doses as a "blood thinner" to prevent blood clots.
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When I started taking Dupixent I couldn't find much info on how to take it, so I wanted to show others how I take a dose in my leg.

What is Ebglyss (Lebrikizumab)? What is Ebglyss used for?

## What is Ebglyss?
- Introduction to Ebglyss: Ebglyss lerazumab, a biologic treatment for moderate-to-severe atopic dermatitis aimed at relieving itch and clearing skin.
- Mechanism of Action: Ebglyss targets the cause of atopic eczema inflammation by blocking IL-13, thereby improving symptoms.

## How Ebglyss Works
- Medication Details: From a class called interleukin 13 antagonists, administered via subcutaneous injection.
- Dosage Schedule: Initial dosing every two weeks up to week 16, then monthly for maintenance.

## FDA Approval
- Approval Information: FDA-approved on September 13, 2024 for use in patients 12 years and older, weighing at least 88 pounds.

## Egblyss Effectiveness
- Clinical Trial Results: Advocate trials showed significant improvement in skin clearance and itch relief.
- Timeline of Efficacy: Early clearing results seen as soon as four weeks, with notable relief by week 16.

## Side Effects
- Common Side Effects: Pain at injection site, shingles, eye inflammation.
- Serious Side Effects: Severe allergic reactions, breathing issues, significant eye problems.

## Warnings
- Contraindications: Not for those allergic to its components.
- Hypersensitivity Reactions: Watch for swelling, eye issues, infections, and stop use if severe reactions occur.

## Injection Instructions
- Administration: Steps for proper injection, such as warming the pen, injection sites, and visually inspecting the medication.
- Self-Injection Guidance: Patients and caregivers should be trained; pediatric use under caregiver’s administration.

## Conclusion
- Summarizes key points about Ebglyss usage, safety information, and encourages proper medical guidance.

00:00 What is Ebglyss?
00:49 Usage Guidelines
01:59 Efficacy Results
03:00 Side Effects
04:44 Precautions
06:05 Administration Instructions
08:09 Dosage Information

#Ebglyss #WhatIsEbglyss #WhatIsEbglyssUsedFor #AtopicDermatitis #BiologicTreatmentEczema #SkinInflammationTreatment #Interleukin13Antagonist #Lebrikizumab #WhatIsLebrikizumab #WhatIsLebrikizumabUsedFor #EbglyssInjection #EbglyssSideEffects #EbglyssWarnings #EbglyssDosing #EliLillyAndCompany #EbglyssUses #EbglyssTreatment #HowEbglyssWorks #FDAApprovedEbglyss #EbglyssForItchRelief #EbglyssUsageGuide #Ebglyssprecautions

On this episode, we review GLP-1 receptor agonists. We discuss their mechanism of action, adverse effects, and head-to-head comparison clinical trials. We also review the newly approved semaglutide (brand name Ozempic).

Social media is buzzing with its latest weight loss trend. People are turning to diabetes medication to shed pounds, which is causing a shortage.

Dr Paul Ryan
Dr Ryan Paul is an Executive Member of the New Zealand Society for the Study of Diabetes (NZSSD) and recently led the development of the NZSSD guidance on the management of type 2 diabetes in New Zealand. Dr Paul is heavily involved in teaching primary care clinicians, diabetes nurse prescribers and endocrinology trainees.
THE TOPIC WILL INCLUDE:
• When + how to use dulaglutide for type 2 diabetes
• Advice on whether to choose funded dulaglutide or empagliflozin and when to switch between the two
• When to advise to self-fund dulaglutide
• The potential for dulaglutide to get patients o insulin
• The role of dulaglutide in primary + secondary prevention of CVD

Ryan Paul will present a practical guide around experiences with dulaglutide, the newly funded subcutaneous once weekly GLP1 receptor agonist for type 2 diabetes.

Key topics include:

-Identifying which of your patients will benefit from dulaglutide.
-Which patients meet the special authority criteria for dulaglutide and who should consider self-funding.
-When to choose dulaglutide or empagliflozin or both.
-How to discuss starting dulaglutide with patients and how to manage any adverse effects.
-Recommended follow up for patients on dulaglutide.

CHAPTERS:
00:00 intro
00:43 Ryan Paul Presentation
57:53 Audience Q&A
01:24:15 Close

What is Dulaglutide and how does it work?.
Dulaglutide belongs to a class of medications known as GLP-1 receptor agonists. It mimics the action of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is produced naturally in the intestines and plays a crucial role in regulating blood sugar levels.
When you inject dulaglutide, it activates GLP-1 receptors in the pancreas, leading to increased insulin release. Insulin is a hormone that helps regulate blood sugar levels by allowing glucose to enter cells and be used as energy. By stimulating the release of insulin, dulaglutide helps lower blood sugar levels.
In addition to its effects on insulin release, dulaglutide also reduces the production of glucose in the liver. This helps prevent excessive glucose buildup in the bloodstream and further contributes to improved glycemic control.
Furthermore, dulaglutide slows down the emptying of the stomach and reduces the absorption of sugar from the gut. By doing so, it helps prevent sudden spikes in blood sugar levels after meals, promoting more stable glucose control throughout the day.
Uses of Dulaglutide in diabetes management.
Dulaglutide is primarily used for the management of type 2 diabetes. It can be prescribed as a monotherapy, meaning it is used alone, or in combination with other diabetes medications such as metformin or insulin.
The goal of using dulaglutide is to achieve and maintain optimal blood sugar control. By keeping blood sugar levels within a target range, individuals with diabetes can reduce the risk of long-term complications such as heart disease, kidney damage, and nerve damage.
In addition to its blood sugar-lowering effects, dulaglutide has also been shown to promote weight loss in some individuals. This can be particularly beneficial for individuals with type 2 diabetes who are overweight or obese, as weight loss can further improve glycemic control and reduce the risk of complications.
It's important to note that dulaglutide is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis. It is specifically designed for individuals with type 2 diabetes who have not achieved adequate blood sugar control with diet and exercise alone.
Effectiveness of Dulaglutide in controlling blood sugar levels.
Numerous clinical trials have demonstrated the effectiveness of dulaglutide in controlling blood sugar levels in individuals with type 2 diabetes.
In a study published in the New England Journal of Medicine, researchers compared the effects of dulaglutide to placebo in over 9,000 patients with type 2 diabetes. The study found that dulaglutide significantly reduced hemoglobin A1c levels, a measure of average blood sugar control over a period of time, compared to placebo. Additionally, more patients in the dulaglutide group achieved the recommended target A1c levels compared to the placebo group.
Another study published in Diabetes Care compared dulaglutide to exenatide, another GLP-1 receptor agonist, in individuals with type 2 diabetes. The study found that dulaglutide was more effective at reducing A1c levels and promoting weight loss compared to exenatide.
Overall, these studies and others have consistently shown that dulaglutide is an effective treatment option for individuals with type 2 diabetes, providing significant improvements in blood sugar control and weight management.
Potential side effects of Dulaglutide.
Like any medication, dulaglutide can cause side effects in some individuals. It's important to be aware of these potential side effects and discuss them with your healthcare provider before starting treatment.
Common side effects of dulaglutide may include nausea, vomiting, diarrhea, and stomach pain. These side effects are usually mild and tend to improve over time as your body adjusts to the medication. If these side effects persist or worsen, it's important to contact your healthcare provider for further guidance.
In rare cases, dulaglutide can cause more serious side effects such as pancreatitis, a condition characterized by inflammation of the pancreas. Symptoms of pancreatitis may include severe abdominal pain, nausea, vomiting, and fever. If you experience these symptoms while taking dulaglutide, it's important to seek immediate medical attention.

"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

Common side effects of Depakote. Depakote, also known as divalproex sodium, is used to manage various medical conditions. While it can be an effective treatment, it is important to be aware of the potential side effects. Some of the most common side effects associated with Depakote include:.
Nausea and gastrointestinal discomfort:. Many individuals experience mild to moderate nausea when starting Depakote. This side effect typically subsides after a few weeks as the body adjusts to the medication. It is recommended to take Depakote with food to reduce the likelihood of stomach upset.
Dizziness and drowsiness:. Depakote can cause dizziness and drowsiness, especially in the initial stages of treatment. It is important to be cautious when engaging in activities that require mental alertness, such as driving or operating machinery. If these side effects persist or worsen, it is advisable to consult with your healthcare provider.
Weight gain:. Weight gain is another common side effect of Depakote. This can be particularly concerning for individuals who already struggle with weight management. It is important to maintain a healthy lifestyle and discuss any concerns about weight gain with your healthcare provider. They may be able to recommend strategies to mitigate this side effect.
It is essential to note that not everyone will experience these side effects, and their severity can vary from person to person. If you are starting Depakote and notice any side effects, it is crucial to inform your healthcare provider for proper guidance.
Serious side effects and risks of Depakote.
While most individuals tolerate Depakote well, there are some potential serious side effects and risks that need to be considered. It is important to be aware of these risks and discuss them thoroughly with your healthcare provider before starting treatment. Some of the more serious side effects and risks associated with Depakote include:.
Liver damage:. Depakote has the potential to cause liver damage, including liver failure. Symptoms of liver damage may include jaundice (yellowing of the skin and eyes), abdominal pain, dark urine, and unusual fatigue. Regular liver function tests are typically recommended while on Depakote to monitor liver health.
Pancreatitis:. Depakote usage has been associated with an increased risk of pancreatitis, which is inflammation of the pancreas. Symptoms of pancreatitis may include severe abdominal pain, nausea, vomiting, and fever. If you experience these symptoms, it is essential to seek immediate medical attention.
Birth defects:. Depakote has been linked to an increased risk of birth defects if taken during pregnancy. The risk of birth defects is highest when Depakote is taken during the first trimester. It is crucial for women of childbearing age to discuss the potential risks with their healthcare provider and explore alternative treatment options if planning to become pregnant.
These are just a few examples of the serious side effects and risks associated with Depakote. It is important to remember that the benefits of the medication may outweigh the risks for some individuals. However, it is crucial to have open and honest discussions with your healthcare provider to make an informed decision about treatment.
-----
"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately."

DEPAKOTE (divalproex ) Uses, Dosage, Warnnigs, Side Effects #divalproex
0:29 DEPAKOTE What is it and why is it used?
0:41 DEPAKOTE Why is it used?
0:58 DEPAKOTE Warnings
1:37 DEPAKOTE How to use ?
3:08 DEPAKOTE Precautions
4:08 DEPAKOTE Side Effects

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Sacubitril/valsartan is a medication that combines two active ingredients, sacubitril and valsartan, and is primarily used to treat heart failure. It's sold under the brand name Entresto and has been approved by various regulatory agencies, including the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), for the treatment of chronic heart failure in certain patients.

Here's some information about each of the components and how they work together:

1. **Sacubitril**: Sacubitril is an angiotensin receptor-neprilysin inhibitor (ARNI). Neprilysin is an enzyme responsible for breaking down certain hormones, including natriuretic peptides, which play a role in promoting vasodilation (relaxation of blood vessels) and reducing fluid retention. By inhibiting neprilysin, sacubitril helps increase the levels of these beneficial hormones, leading to improved cardiovascular function.

2. **Valsartan**: Valsartan is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that causes blood vessels to constrict and promotes the release of another hormone, aldosterone, which leads to fluid retention. Valsartan blocks the receptors that angiotensin II binds to, thus preventing its effects on blood vessels and reducing aldosterone release. This results in vasodilation and decreased fluid retention, which are beneficial for heart failure patients.

The combination of sacubitril and valsartan in a single medication like sacubitril/valsartan (Entresto) provides a dual mechanism of action. By simultaneously inhibiting neprilysin and blocking angiotensin II receptors, this medication helps improve the heart's pumping ability, reduce fluid accumulation, and alleviate the symptoms of heart failure.

Entresto is typically prescribed for patients with chronic heart failure with reduced ejection fraction (HFrEF). Ejection fraction is a measure of the heart's ability to pump blood. HFrEF indicates that the heart's pumping function is impaired, and this condition can lead to symptoms like shortness of breath, fatigue, and fluid retention.

It's important to note that sacubitril/valsartan can have side effects, including low blood pressure, elevated levels of potassium in the blood (hyperkalemia), and an increased risk of angioedema (a swelling of the deeper layers of the skin). Therefore, it's prescribed under the guidance of a healthcare professional who will monitor the patient's response and adjust the dosage as needed.

As with any medication, individuals should consult their healthcare provider before starting sacubitril/valsartan to ensure that it's appropriate for their specific condition and medical history.

Valsartan

This video was made by Ayeh Barekat, 2021 Pharmacist Candidate. She will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters.

The FDA says that patients who are taking the recalled valsartan-containing medicines should continue taking their medicine until they have a replacement product.

A brief video discussing MOA, PK, indications, dosing, side effects, contraindications and drug-drug interactions of Trazodone (Desyrel, Oleptro).

Welcome to AlphaNutritionTV, your ultimate YouTube channel for all things health and wellness! We are committed to providing you with science-backed nutrition advice, actionable wellness tips, and the support you need to lead a healthier lifestyle. Our content covers a wide range of topics, from balanced diets and exercise routines to stress management and sleep optimization. Subscribe now and join our growing community of health enthusiasts who strive for a better quality of life!

Join us as we dive into the truth about PrEP side effects in this informative video. Discover the facts, dispel the myths, and gain a clear understanding of what to expect when using PrEP (Pre-Exposure Prophylaxis) as an HIV prevention method. We explore common side effects, their frequency, and severity, as well as ways to manage and minimize them. Stay informed and make informed decisions about your sexual health with accurate information about PrEP side effects.


🔥 The Truth About Prep Side Effects
00:00 - Intro
00:


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🔖 Tags:
PrEP, HIV Prevention, PrEP Side Effects, Sexual Health, HIV Awareness, Medication Safety, Pre Exposure Prophylaxis, Health Education, Myth Busting, Medication Management, Sexual Wellness, HIV Risk Reduction, LGBTQ + Health, Preventive Care, Sexual Health Education

#PrEP #HIVPrevention #PrEPSideEffects #SexualHealth #HIVAwareness #MedicationSafety #PreExposureProphylaxis #HealthEducation #MythBusting #MedicationManagement #SexualWellness #HIVRiskReduction #LGBTQ+Health #PreventiveCare
#SexualHealthEducation

The video is designed for people who are considering PrEP. It contains important information on adherence, side effects and how to get started, and how to stop. It’s a good idea for people to check out the video before going to speak to a doctor, that way they will have a good baseline understanding of what’s involved.

Let’s talk pre-exposure prophylaxis, or PrEP! Truvada vs Descovy — what’s the real difference?

Email: [email protected]
IG: @OutLoudJB