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How to use Ibandronate Sodium Syringe - Explain Uses,Side Effects,Interactions
How to use Ibandronate Sodium Syringe - Explain Uses,Side Effects,Interactions Side Effects 2 Views • 1 month ago

Ibandronate is a medication used to prevent and treat certain types of bone loss, known as osteoporosis. Osteoporosis causes bones to become thinner and break more easily, especially after menopause, as you age, or if you take corticosteroid medications for long periods. This medication works by slowing down bone loss to help maintain strong bones and reduce the risk of broken bones. Ibandronate belongs to a class of medications called bisphosphonates.
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Cuáles son los efectos secundarios más comunes de los inhaladores?
Cuáles son los efectos secundarios más comunes de los inhaladores? Side Effects 2 Views • 1 month ago

Este es uno de los videos que ofrece información creíble, gratuita e integral sobre prevención y detección de enfermedades, diagnóstico, tratamiento e investigación. Nuestros videos contienen información de expertos y personas reales sobre diversos problemas de salud, respondiendo la mayoría de sus preguntas, incluyendo cómo sucedió, cómo se siente, qué puede hacer al respecto y por qué es importante
10 Things you need to know about Cabenuva and HIV Treatments
10 Things you need to know about Cabenuva and HIV Treatments Side Effects 2 Views • 1 month ago

In this video, we'll cover the 10 things you need to know about Cabenuva and HIV treatments. Stay informed and educated about this important topic!

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Mavacamten (Camzyos) for Hypertrophic cardiomyopathy
Mavacamten (Camzyos) for Hypertrophic cardiomyopathy Side Effects 2 Views • 1 month ago

Mavacamten, marketed under the brand name Camzyos, is a medication specifically approved for the treatment of hypertrophic cardiomyopathy (HCM), particularly obstructive HCM. This is a genetic condition characterized by the thickening of the heart muscle, which can lead to obstruction of blood flow and various symptoms such as shortness of breath, chest pain, and fatigue.

How Mavacamten Works
Mavacamten is a first-in-class cardiac myosin inhibitor.

Targeting Myosin: Myosin is a motor protein in heart muscle cells responsible for contraction. In HCM, there is an excessive interaction between myosin and actin (another protein), leading to hypercontractility and thickening of the heart muscle.

Mechanism of Action: Mavacamten works by selectively inhibiting cardiac myosin. This reduces the excessive contractility of the heart muscle, helps relax the muscle, and reduces the obstruction in the left ventricular outflow tract (LVOT). As a result, blood flow from the heart is improved, and symptoms are alleviated.

Indication and Use
Mavacamten is approved for the treatment of symptomatic obstructive hypertrophic cardiomyopathy in adults.

Symptomatic Obstructive HCM: This form of HCM involves a thickened heart muscle that obstructs blood flow out of the heart, leading to symptoms like shortness of breath, chest pain, and fainting. Mavacamten is particularly beneficial for patients who remain symptomatic despite other treatments, such as beta-blockers or calcium channel blockers.

Benefits
Mavacamten offers several important benefits for patients with obstructive HCM:

Reduction in Symptoms: Clinical trials have shown that mavacamten significantly reduces symptoms associated with obstructive HCM, such as shortness of breath, chest pain, and exercise intolerance.

Improved Exercise Capacity: Patients treated with mavacamten have demonstrated improved exercise capacity, as measured by cardiopulmonary exercise testing (CPET). This improvement in exercise tolerance is a significant benefit for patients with HCM, who often experience limitations in physical activity.

Reduction in LVOT Gradient: Mavacamten effectively reduces the LVOT gradient, which is the pressure difference caused by the obstruction in blood flow. Lowering this gradient helps to alleviate symptoms and improve heart function.

Potential to Avoid Surgery: For some patients, mavacamten may reduce the need for invasive procedures, such as septal myectomy (surgical removal of part of the thickened heart muscle) or alcohol septal ablation.

Side Effects
While mavacamten is generally well-tolerated, it can cause side effects, particularly related to its impact on heart function:

Heart Failure: Because mavacamten reduces heart contractility, there is a risk of heart failure if the dose is too high. This necessitates careful monitoring of heart function, particularly ejection fraction (a measure of how well the heart is pumping blood).

Arrhythmias: There is a potential risk for arrhythmias (irregular heartbeats), which also requires monitoring.

Other Side Effects: Some patients may experience symptoms like dizziness, fainting, and fatigue.

Drug Interactions: Mavacamten can interact with other medications, especially those metabolized by the liver enzyme CYP2C19. This necessitates caution when prescribing mavacamten alongside other drugs.

Human Impact
Hypertrophic cardiomyopathy is a condition that can significantly impact a person's quality of life, leading to symptoms that interfere with daily activities and increase the risk of serious complications, including sudden cardiac death. Traditional treatments focus on managing symptoms and reducing the risk of complications, but they do not directly address the underlying hypercontractility of the heart muscle.

Mavacamten (Camzyos) represents a groundbreaking treatment for obstructive HCM because it directly targets the excessive contractility of the heart muscle, offering a novel mechanism of action compared to traditional therapies. For patients with symptomatic obstructive HCM, mavacamten provides a new option that can reduce symptoms, improve quality of life, and potentially decrease the need for surgical interventions.

The development of mavacamten is a significant milestone in the management of hypertrophic cardiomyopathy, providing hope for improved outcomes in a condition that has been difficult to manage with existing therapies. By addressing the root cause of the obstruction, mavacamten offers a targeted and effective treatment that can help patients with HCM live more active and comfortable lives.
Antipsychotic Plasma Levels and Adherence
Antipsychotic Plasma Levels and Adherence Side Effects 2 Views • 2 months ago

PDF of this video here (healthcare professionals only):

https://psychopharmacologyinstitute.com/antipsychotics/antipsychotic-plasma-levels-and-adherence/?utm_source=Youtube&utm_medium=Youtube&utm_campaign=0802

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Developing Hydroxyurea, the First FDA-Approved Therapy for Sickle Cell Disease
Developing Hydroxyurea, the First FDA-Approved Therapy for Sickle Cell Disease Side Effects 2 Views • 2 months ago

As NIDDK celebrates its 70th anniversary, we look back on decades of scientific advances. In this video, NIDDK Director Dr. Griffin P. Rodgers details the research, clinical trial, and results behind Hydroxyurea, the first FDA-approved therapy for sickle cell disease.


For more information, visit https://www.niddk.nih.gov/abou....t-niddk/70th-anniver


---


Transcript:


DR. RODGERS:

This drug Hydroxyurea – that was really the basis of our work in the late 80’s and early 90’s.



There was a group in the Heart, Lung, and Blood Institute who started working on this using a drug called 5-Azacytidine.


Just like all chemotherapy, it first causes some toxicity to the rapidly dividing cells, and then when you withdraw the drug and you give the cells a chance to recover maybe that’s what’s turning on the genes. And that led us to actually consider this drug Hydroxyurea because it’s a form of chemotherapy. It works on rapidly dividing cells. It doesn’t have the same toxicity profile that drugs like 5-Azacytidine does.

Using this drug Hydroxyurea in about 70 percent of hospitalized patients we could turn on their fetal hemoglobin to modest levels and the longer you gave it to them, the higher their values would go. Subsequently our work was replicated by groups in Seattle and Harvard and Johns Hopkins, and that led the NIH to fund this fairly large study, a cooperative randomized clinical trial, which tests whether the drug would in fact have a benefit.

And just to cut to the chase, the study was stopped early, a year early, because one group, which was blinded at the time, was doing much much, better than the other group, and that group was the Hydroxyurea group. In 1990, our paper came out. In 1995, this NIH-supported trial, this large randomized trial, showed that Hydroxyurea was quite beneficial. And in 1998, the FDA approved the drug as the first drug that was approved specifically to treat patients with sickle cell disease.

Lithium Kidney Damage (Learn lithium toxicity and lithiums effect on kidney)
Lithium Kidney Damage (Learn lithium toxicity and lithiums effect on kidney) Side Effects 2 Views • 2 months ago

Learn about lithium kidney damage and lithium toxicity through learning lithiums effect on kidney.
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The video discusses the effects of lithium on the kidneys, aiming to simplify complex nephrology concepts. Lithium primarily induces nephrogenic diabetes insipidus (NDI), resulting in excessive urination and thirst due to decreased response to antidiuretic hormone (ADH). This resistance occurs because lithium disrupts ADH signaling, hindering water reabsorption in the collecting ducts. The subsequent inability to concentrate urine leads to polyuria and polydipsia. Chronic use of lithium can progress to chronic kidney disease (CKD), marked by decreased glomerular filtration rate (GFR) and potential interstitial nephritis and fibrosis. Despite this, end-stage renal disease (ESRD) from lithium is rare, occurring in a small percentage of long-term users. Management includes monitoring kidney function, maintaining lower lithium levels, and considering discontinuation in severe cases. The video emphasizes simplifying renal physiology by breaking it down into three main components: glomerulus, renal tubules, and collecting ducts. It also addresses misconceptions and clarifies terminology related to kidney function assessment and pathology. Overall, while lithium poses renal risks, careful monitoring and management can mitigate adverse effects.

================

#lithium #bipolar #bipolardisorder

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00:00 Ready, Able to Learn Nephrology
00:10 Introduction, Lithium's Effect on the Kidney
01:12 Nephron's For Dummies
02:26 Etymology of Diabetes
03:13 Collecting Duct
03:40 Anti-diuretic Hormone (ADH) Review
04:33 How Lithium Causes Nephrogenic Diabetes Insipidus
07:29 Chronic Kidney Disease
08:15 Lithium's Overall Impact on Kidney
12:51 Outro

EL METOPROLOL Y SUS EFECTOS EN EL CORAZÓN
EL METOPROLOL Y SUS EFECTOS EN EL CORAZÓN Side Effects 2 Views • 1 month ago

El metoprolol es un medicamento de la familia de los beta bloqueadores que la mayoría de los colombianos ha escuchado o toma para la hipertensión arterial, arritmias cardiacas, insuficiencia cardiaca y pacientes que han tenido un infarto agudo al miocardio. Un medicamento que ha sido estudiado por un grupo de científicos liderados por el doctor Borja Ibáñez director del departamento de investigación clínica del Centro Nacional de Investigaciones Cardiovasculares Carlos III en España (CNIC) en el que han analizado por qué el metoprolol podría reducir el tamaño del infarto, un estudio que explica el doctor Andrés Buitrago cardiólogo Fundación Santa Fe de Bogotá.
#hipertensión #insuficienciacardiaca
#corazon
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#cardiologia
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Phenytoin overdose and poisoning: Not that bad!
Phenytoin overdose and poisoning: Not that bad! Side Effects 2 Views • 1 month ago

Please subscribe if you like these videos and let me know what topics you'd like me to cover!

Phenytoin overdose is surprisingly benign considering how many significant side effects you can get from therapeutic use.

The main effect is sedation, and this can usually be managed with good supportive care.

If phenytoin is given IV, you can get cardiotoxicity from the solvent, propylene glycol. This doesn't happen when taken orally.

References:

Chan BS, Sellors K, Chiew AL, Buckley NA. Use of multi-dose activated charcoal in phenytoin toxicity secondary to genetic polymorphism. Clin Toxicol (Phila) 2015;53(2):131–3

Craig S. Phenytoin poisoning. Neurocrit Care 2005;3(2):161–70

Wyte CD, Berk WA. Severe oral phenytoin overdose does not cause cardiovascular morbidity. Ann Emerg Med 1991;20(5):508–12.
USO DA DESVENLAFAXINA (Deller, Pristiq) - VANTAGENS, RISCOS E EFEITOS COLATERAIS
USO DA DESVENLAFAXINA (Deller, Pristiq) - VANTAGENS, RISCOS E EFEITOS COLATERAIS Side Effects 2 Views • 1 month ago

Dr Bruno Machado , médico psiquiatra pela USP , explica as vantagens e desvantagens do medicamento Succinato de Desvenlafaxina , também conhecido como Pristiq , Deller , Elifore , Desve , Zodel , Imense , Vellana e Vendexla , dentre outros nomes comerciais com este mesmo princípio ativo .

Entenda as indicações , efeitos colaterais , tolerabilidade , uso em adultos , bem como doses , mecanismo de ação , efeitos sobre o sono , insônia , apetite , ganho de peso e demais informações de grande relevância sobre a farmacologia deste medicamento usado para quadros como transtorno depressivo . Entenda a comparação com a Venlafaxina nos quadros de ansiedade social , ansiedade generalizada , depressão grave , TOC e Síndrome do Pânico .

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AVISO LEGAL:

As informações contidas nos vídeos não pretendem substituir a consulta ao profissional médico ou servir como recomendação para qualquer plano de tratamento.

De acordo com o Código de Ética Médica, os vídeos têm somente caráter educativo, assim como, não são divulgados endereços e telefone de consultório, clínica ou serviço de saúde.

Os vídeos são produzidos com base na literatura médica e na experiência clínica do Dr. Bruno, mas em assuntos médicos não capacitam qualquer indivíduo a diagnosticar ou medicar a si próprio ou a terceiros.

Em caso de dúvidas procure seu médico.

What Are Ramipril's Side Effects? - Cardiology Community
What Are Ramipril's Side Effects? - Cardiology Community Side Effects 2 Views • 1 month ago

What Are Ramipril's Side Effects? In this informative video, we will discuss the various side effects associated with Ramipril, a medication commonly prescribed for high blood pressure and heart failure. Understanding the potential side effects is essential for anyone taking this medication or considering it as part of their treatment plan. We will cover both common and serious side effects that may occur, providing you with the necessary information to recognize and address any issues that may arise.

We’ll also highlight the importance of monitoring your health while on Ramipril, especially for those with underlying conditions. Regular check-ups and communication with your healthcare provider can help ensure that your treatment remains safe and effective. Knowing when to seek medical attention is key, and we will guide you through the symptoms that warrant immediate action.

If you or a loved one is currently taking Ramipril or is thinking about starting this medication, this video will provide essential information to help you manage your health effectively. Don’t forget to subscribe to our channel for more educational content on cardiology and heart health.

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#Ramipril #HeartHealth #BloodPressure #Cardiology #MedicationSideEffects #Hypertension #HeartFailure #PatientEducation #Healthcare #KidneyHealth #Cough #PotassiumLevels #Angioedema #MedicalAdvice #HealthMonitoring #WellnessTips

About Us: Welcome to Cardiology Community, your trusted source for all things related to cardiology and heart health. Our mission is to provide engaging, informative content that helps you understand the complexities of cardiovascular wellness.
Please note that our content is purely informational and should not be considered medical advice. Always consult with a healthcare professional for personal health concerns and do your own research to make informed decisions. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Evolocumab (Repatha) injection: Uses, Side effects and How to take?
Evolocumab (Repatha) injection: Uses, Side effects and How to take? Side Effects 2 Views • 1 month ago

Evolocumab injection works by unique mechanism increasing uptake of LDL cholesterol into live.


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Oral, Arthritis Drug RINVOQ Effective At Treating Moderate To Severe Eczema, Study Finds
Oral, Arthritis Drug RINVOQ Effective At Treating Moderate To Severe Eczema, Study Finds Side Effects 2 Views • 1 month ago

The itching and infections caused by eczema can be disabling. But a new study found a drug prescribed for arthritis may be the best treatment yet for eczema patients. CBS2's Dr. Max Gomez reports.
RINVOQ - -- Generic Name , Brand Names, Precautions , How to use, Side Effects
RINVOQ - -- Generic Name , Brand Names, Precautions , How to use, Side Effects Side Effects 2 Views • 1 month ago

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Ritalin Changes Boys' Brain Structure. That's Not Necessarily a Bad Thing.
Ritalin Changes Boys' Brain Structure. That's Not Necessarily a Bad Thing. Side Effects 2 Views • 1 month ago

As you're here on YouTube, you may want to watch "How Social Media Hacks Your Brain" https://www.youtube.com/watch?v=jzzjbSkrLCQ --~--
An MRI-based study shows that methylphenidate (ritalin) leads to white matter changes in the brain of boys with ADHD.

Get more medical news analysis at https://www.methodsman.com or https://www.medscape.com

ROBAXIN - - Generic Name , Brand Names, How to use, Precautions, Side Effects
ROBAXIN - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

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Rosuvastatin side effects | Common side effects of Rosuvastatin tablets
Rosuvastatin side effects | Common side effects of Rosuvastatin tablets Side Effects 2 Views • 1 month ago

Rosuvastatin Tablets Side effects | Common side effects of Rosuvastatin tablets

This video explains some common side effects of rosuvastatin tablets.

#professortushar
What Are The Long-term Effects Of Scopolamine? - Pharmaceutical Insights
What Are The Long-term Effects Of Scopolamine? - Pharmaceutical Insights Side Effects 2 Views • 1 month ago

What Are The Long-term Effects Of Scopolamine? In this informative video, we will discuss the long-term effects of scopolamine, a medication commonly used to treat motion sickness and postoperative nausea. Scopolamine is classified as an anticholinergic drug, which means it works by blocking the action of acetylcholine, a neurotransmitter involved in various bodily functions. While effective for its intended uses, scopolamine can lead to side effects, especially when used over extended periods.

We will cover both common and serious side effects associated with long-term use, including potential withdrawal symptoms and the impact on existing health conditions. Understanding these effects is vital for anyone considering or currently using this medication, particularly vulnerable populations like older adults. We will also emphasize the importance of monitoring for unusual symptoms and working closely with healthcare providers to manage any issues that may arise.

Join us as we dive into the details of scopolamine and its long-term implications for health. Don't forget to subscribe to our channel for more informative content about medications and their effects on health.

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Montelukast sodium uses dosage and side effects | montelukast | montelukast sodium tablet
Montelukast sodium uses dosage and side effects | montelukast | montelukast sodium tablet Side Effects 2 Views • 1 month ago

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VESIcare - - Generic Name, Brand Names, How to use, Precautions, Side Effects
VESIcare - - Generic Name, Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

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