Question answered this week:
I have had insomnia for at least three to four years. What do I need to consider when taking over-the-counter sleep medications, specifically Unisom? I know that one should not take this medication long-term, and I have discussed it with my primary care [physician] but if I don't take the Unisom I am literally up all night.

This BJC Help for Your Health video is intended as a reference and information source only. If you suspect you have a health problem, you should seek immediate care with the appropriate health care professionals. The information in this video is not a substitute for professional care, and must not be used for self-diagnosis or treatment. Do not start, stop or change medications; or any health, nutritional or exercise program without first consulting your personal physician. BJC HealthCare assumes no liability for the information contained in this video or for its use.

Diphenhydramine, commonly known as Unisom, is an antihistamine that can be used to relieve symptoms of allergies, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, runny nose, and sneezing. It can also help prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Additionally, it can help you relax and fall asleep.

This medication works by blocking certain natural substances in your body that cause allergic reactions, such as histamine and acetylcholine. It is important to note that cough-and-cold products containing diphenhydramine are not recommended for children under 6 years old, and some long-acting forms are not recommended for children under 12 years old. It's important to talk to your doctor or pharmacist for more details on safely using these products.

It's also important to note that these products do not cure or shorten the length of a common cold and may cause serious side effects, so it's important to carefully follow the dosage directions. Do not use this product to make a child sleepy, and be cautious of giving other cough-and-cold medications that contain similar ingredients. Talk to your doctor or pharmacist about other ways to relieve cough and cold symptoms, such as staying hydrated and using a humidifier or saline nose drops/spray.

As for the optimal timing and dosage, it's best to follow the instructions provided by your healthcare professional.
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General information regarding Unisom Sleep Gels (diphenhydramine). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Tramadol tablet use/ultracet tablet use/Acuvin tablet use/ tramadol dose,side effects/pain killer


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side effects of tramadol

Tramadol side effects are a concern for many users. Tramadol is a prescription medication used to treat moderate to severe pain, and it is also used for short-term relief of chronic pain. This drug belongs to the opioid family of drugs, which means that it has similar properties to opium or morphine.

Tramadol and paracetamol. Also named tramadol and acetaminophen tablet.
Tramadol and Paracetamol tablet is used to treat moderate to severe pain. Caused by many reason. Strength of this tablet is tramadol 37.5 mg and paracetamol 325 mg.
Popular brand name are
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Tramadol and Paracetamol tablets side effects are
Gastritis/ Bloating / Nausea / Vomiting / Diarrhoea/ Breathing problem / Seizure / Abdominal pain / Slow heart rate / Chest pain / Loss of appetite / Dark urine.
We also discuss about Tramadol and Paracetamol tablets | ultracet tablet Strength / brand name / uses in detail / dosage/ side effects/ warnings and precautions and many more in hindi

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General information regarding Ultracet (acetaminophen and tramadol). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

Ultracet Tablet Review In Hindi | Ultracet Tab Uses,How Works & Side Effects In Hindi

Hi Friends Is Video Me Maine Apko Ultracet tablet ke bare me bataya hai ye bahut famous or har doctor ki choice hoti hai gambhir dard me ise use karte hai is video me ap janenge ki ultracet tab kis kis bimari me diya ja sakta hai kitna dose rhta hai or kya side effects ho sakta hai puri jankari ke liye video dekhen
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Ultracet Tablet Use Dose Side Effects and Price explained here in Hindi | Tramadol Plus Acetaminophen combination tablet for pain fever and inflammation

Ultracet Tablet is a combination of two medicines that are used for short term relief of pain inflammation and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.

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How well does Qulipta work for migraine Qulipta an oral prescription medicine used to prevent migraine headaches has been shown in studies to lead to a reduction in monthly migraine days in patients with episodic migraine a day reduction and a reduction in patients with chronic migraine headaches day reductionQulipta atogepant from AbbVie was first approved by the FDA in September of for the prevention of episodic migraine and then in April for prevention of chronic migraine headachesHow well does Qulipta work for episodic migraineThe ADVANCE trial was a week long doubleblind placebo controlled study with adult patients who received Qulipta mg mg or mg once daily or a placebo inactive pill for weeksDuring the study patients were allowed to use acute headache treatments ie triptans ergotamine derivatives NSAIDs acetaminophen and opioids as neededPatients who normally had an average of days of migraine headaches per month experienced a day reduction when treated with mg of Qulipta a reduction in monthly migraine days Similar reductions in monthly migraine days were seen with the mg and mg dosesIn addition a secondary goal of the study was to determine the percent of patients who reduced their monthly migraine migraine days by onehalf or more Over the week period to of patients across all Qulipta dose groups mg mg or mg achieved a to reduction in migraine days compared to of patients in the placebo arm all dose groups vs placebo pThe percent of patients who achieved a response rate equal to no monthly migraine days over the week period was an average of in the Qulipta mg group compared to taking a placeboOverall patients who received Qulipta met all the goals of the study and on average had significantly fewer migraine days over a month compared to the group that received a placebo an inactive agentHow well does Qulipta work for chronic migraineIn the Phase PROGRESS trial in participants with chronic migraine or more migraine days per month the average monthly migraine days MMDs at baseline beginning of the study was days Patients were treated with Qulipa mg per day or a placebo for weeksDuring the study patients were allowed to use acute headache treatments ie triptans ergotamine derivatives NSAIDs acetaminophen and opioids as neededThe effectiveness of Qulipta was determined by looking at the change from baseline the start of study in the average number of monthly migraine days across the week treatment periodPatients experienced a day reduction in monthly migraine days when treated with mg of Qulipta per day a reduction This result was significant when compared to a reduction of days a reduction in the placebo groupThe trial also demonstrated that treatment with Qulipta resulted in significant improvements in all secondary endpoints including the proportion of patients that achieved at least a reduction in mean monthly migraine days across the week treatment periodResults from studies also showed that Qulipta can help you maintain or improve your function related to daily activities as a whole which includework concentration and productivityleisure activitiesrelationshipsenergy levelsThe most common side effects across all doses with Qulipta include constipation nausea to and feeling sleepy fatigue to Learn more How does Qulipta work What is its mechanism of action MOAThis is not all the information you need to know about Qulipta atogepant for safe and effective use and does not take the place of your doctors directions Review the full product information and discuss this information and any questions you have with your doctor or other health care providerRelated questions How do Ubrelvy Qulipta and Nurtec compare for migraines What are the new drugs for the treatment of migraines Does Qulipta cause weight loss

Información general sobre Ubrogepant (Ubrelvy). Contenido creado utilizando inteligencia artificial con el objetivo de conectar el acceso entre comunidades. Por favor, señale cualquier sugerencia o error en la sección de comentarios. ¡Gracias!

This week, Neurology News Network covered the FDA approval of sodium oxybate (Xyrem) oral solution to include pediatric narcolepsy patients aged 7 years and older with cataplexy or excessive daytime sleepiness, the findings from a phase 2a clinical trial of ANAVEX 2-73, an investigational therapy for Alzheimer disease, a conversation with Dr. Richard Lipton about ubrogepant, and an interview with Dr. George Koshy Vilanilam to discuss the findings of a study he conducted to assess the trends and identify the risk factors for patients with migraine of developing ischemic stroke.

Chia-Chun Chiang, MD, Mayo Clinic, Rochester, MN, discusses the real-world use of calcitonin gene-related peptide (CGRP) monoclonal antibodies and gepants as preventive and acute treatments for migraine. Four CGRP monoclonal antibodies are currently available for the prevention of migraine, including erenumab, fremanezumab, ocrelizumab, and eptinezumab. More recently, the FDA has approved two gepants for the acute treatment of migraine: ubrogepant and atogepant; and rimegepant approved for both the acute and preventive treatment of migraine. Dr Chiang discusses how the CGRP monoclonal antibodies performed in a real-world setting – stating that many patients with previous unsuccessful treatment trials reported a reduction in frequency and severity of headaches. The efficacy was reported to be similar to that reported in the Phase III clinical trials – inferring success in the real world. However, the real-world studies with the CGRP monoclonal antibodies demonstrated a significantly higher rate of adverse side effects than the clinical trials. In terms of gepants, a real-world study demonstrated similar results to that of the CGRP monoclonal antibodies – whereby gepants had high efficacy levels like in the clinical trials. Yet, a higher percentage of patients also reported adverse side effects in the real-world study. This interview took place at the AAN 2022 Congress in Seattle, WA.

New movie comin' out all about a Woman - addicted to Ubrelvy.

What is the mechanism of action for Ubrelvy The mechanism of action for Ubrelvy generic name ubrogepant involves the blockade of a nerve protein called calcitonin generelated peptide CGRP that contributes to migraine headache pain Ubrelvy is used to treat an acute migraine with or without auras once it starts It is not used to prevent a migraineAn aura occurs in about of people with a migraine headache An aura involves sensory changes such as bright lights blurred vision an unusual smell an unusual sensation or feeling trouble speaking and numbness or weakness in your body It can let a patient know that a migraine is startingIs Ubrelvy a CGRP inhibitorYes Ubrelvy is a CGRP inhibitor There are two types of calcitonin generelated peptide CGRP inhibitors monoclonal antibodies and CGRP receptor antagonists also called gepantsUbrelvy ubrogepant is classified as a CGRP receptor antagonist gepant a small molecule drug which blocks the CGRP receptor It works by directly blocking the CGRP protein from attaching to sensory nerve endings that lead to blood vessel dilation pain and inflammation in a migraine attackMonoclonal antibodies target either the CGRP protein itself or the CGRP receptor A monoclonal antibody is a group of identical proteins that only target one substance in the bodyWhich CGRP inhibitors are used to both treat and prevent migrainesSome CGRP inhibitors are approved for the treatment of migraine headaches some are approved for the prevention of migraine headaches and others are approved for both treatment and preventionCGRP inhibitors gepants approved by the FDA includeNurtec ODT rimegepant sulfate oral pill used for migraine treatment and preventionQulipta atogepant oral pill used for migraine preventionUbrelvy ubrogepant oral pill used for migraine treatmentZavzpret zavegepant intranasal spray nasal spray used for migraine treatmentCGRP inhibitors monoclonal antibodies approved by the FDA includeAimovig erenumabaooe subcutaneous under the skin injection used for migraine preventionAjovy fremanezumab subcutaneous under the skin injection used for migraine preventionEmgality galcanezumabgnlm subcutaneous under the skin injection used for migraine prevention and acute treatment of episodic cluster headachesVyepti eptinezumabjjmr intravenous IV infusion injection used for migraine preventionWhat does Ubrelvy do for migraine painIn clinical studies patients took Ubrelvy within hours from the start of their migraine headache Both the Ubrelvy mg and mg dose led to more relief from pain and the most bothersome symptoms like light sensitivity sound sensitivity or nausea at two hours compared with the group using a placebo an inactive treatmentPain relief was defined as a reduction in migraine pain from a moderate or severe level before treatment to mild or no pain after taking the Ubrelvy doseRelated questions Ubrelvy vs Imitrex sumatriptan How do they compare How often can you take Maxalt How long does it take for Maxalt to work How fast does it workIn Ubrelvy studies about to of patients experienced migraine pain relief within one hour compared to taking an inactive treatment called a placebo Over of patients had complete relief within hours of treatment compared to of those taking a placeboIf needed your healthcare provider may combine Ubrelvy with other migraine treatments such as NSAIDs triptans or preventive agents like betablockers antidepressants or BotoxRelated Is Ubrelvy better than triptansHow do I take Ubrelvy to stop my migraine painUbrelvy comes as an oral tablet The recommended dose of Ubrelvy is mg or mg taken by mouth with or without food If needed a second dose may be taken at least hours after the first dose You may need a dose adjustment if you have liver or kidney diseaseDo not take more than mg of Ubrelvy per day every hours It is not known if it is safe to treat more than migraines in a day period with Ubrelvy If your migraine headaches are not relieved call your healthcare provider for further advice and always follow their instructionsAre side effects common with UbrelvyThe most common side effects with Ubrelvy that occur in about to of patients to out of people are nausea and drowsinessSerious allergic reactions have also occurred and may cause lifethreatening anaphylaxis shortness of breath and dangerous swelling of your face mouth tongue or throat Get emergency medical help right away or call if you experience these side effectsUbrelvy also has important drug interactions Do not take this medicine if you are taking medicines known as strong CYPA inhibitors such as ketoconazole clarithromycin or itraconazole Ask your pharmacist if you are not sureHave your healthcare provider or pharmacist check all of your m

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Jessica Ailani, MD, FAAN, Medstar Georgetown University Hospital, Washington, DC, discusses the findings of a post-hoc analysis of ubrogepant safety and tolerability across various demographic and clinical subpopulations. Ubrogepant is an oral calcitonin gene–related peptide (CGRP) receptor antagonist, known as a gepant, FDA approved for acute migraine treatment in adults. The pooled population of over 1900 patients from the ACHIEVE I and II trials (NCT02828020; NCT02867709) showed that the safety and tolerability of ubrogepant were consistent across all subgroups. Rates of adverse events were independent of age group, race, gender, BMI, and anxiety/depression medication use. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.

Does Nurtec Really Work for Migraine?

Struggling with migraines? Nurtec is one of the latest migraine medications designed for fast relief and prevention.

Migraines don’t have to control your life. Learn how Nurtec might help you find relief!

💬 Have you tried Nurtec? Share your experience in the comments!
📲 Hit LIKE & SUBSCRIBE for more migraine relief tips!

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Ubrelvy vs Imitrex sumatriptan How do they compare Ubrelvy and Imitrex are both oral tablets used to treat migraine but there are differences in the way they work Ubrelvy prevents a protein called CGRP thought to play a role in migraine attacks from binding to its receptor and Imitrex is thought to bind to serotonin HTBD receptors and inhibit proinflammatory substances Although no headtohead comparison trials compare Ubrelvy to Imitrex sumatriptan indirect evidence suggests that overall Ubrelvy is no more effective and may be inferior to Imitrex at relieving migraine in adults who are able to tolerate triptans For those adults with moderatetosevere migraine attacks that cannot tolerate triptans or who have found them ineffective Ubrelvy is beneficial for treating migraines compared to no treatment Ubrelvy is associated with fewer side effects than Imitrex but is more expensive costing almost twice as muchUbrelvy can be given together with Imitrex to treat the same migraine event and this combination is well tolerated Pharmacokinetic research shows slight alterations in pharmacokinetic parameters such as time to maximum concentration and mean maximum plasma concentration but these are not considered clinically relevantUbrelvy Vs Imitrex sumatriptan How do they workUbrelvy belongs to the class of medicines known as CGRP inhibitors CGRP stands for calcitonin generelated peptide CGRP receptor antagonists also known as gepants and Ubrelvy works by preventing CGRP from attaching to CGRP receptors on nerve endings CGRP is a protein that is thought to play a role in migraine attacks by causing pain dilation of blood vessels and inflammation By preventing CGRP from binding to its receptor Ubrelvy stops migraine pain and other symptomsImitrex sumatriptan belongs to the class of medicines known as Triptans and are thought to work by binding to serotonin HTBD receptors inhibiting proinflammatory substances and constricting cranial blood vessels Imitrex works in a different way to CGRP inhibitors such as UbrelvyRelated questions What are the new drugs for the treatment of migraines Can Imitrex sumatriptan cause rebound headaches How often can you take Imitrex sumatriptan Are there any trials that compare Ubrelvy with Imitrex sumatriptanHeadtohead trials comparing Ubrelvy with sumatriptan are lacking However indirect evidence suggestsThat triptans are similar or more effective than lasmiditan rimegepant and ubrogepant UbrelvyAll agents lasmiditan rimegepant and ubrogepant Ubrelvy showed lower odds of achieving pain freedom or pain relief at hours after dose compared with eletriptan or sumatriptanThere were no statistically significant differences on any measure of patient benefit between triptans and lasmiditan rimegepant or ubrogepant UbrelvyThese new agents provide an option for patients with absolute or relative contraindications to triptansUbrogepant Ubrelvy was twice more expensive than sumatriptanIn the analysis of triptaneligible patients sumatriptan and eletriptan produced higher quality of life scores at a lower total cost and dominated all novel agentsOverall rates of discontinuation were considerably lower in the ubrogepant and rimegepant group

With the recent approval of a number of highly effective preventive medications for patients with migraine, whether chronic or episodic, the ability of physicians to treat these individuals has become much easier. However, many challenges persist, and a number of treatments are still sorely needed.

One of the topics of conversation at the 2019 American Headache Society Annual Meeting, July 11-14, in Philadelphia, Pennsylvania, was a major area of unmet need in headache medicine: acute migraine treatments. Although new preventives can greatly reduce the number of migraines patients have, they still have a need for acute therapies for the attacks that they do. Data have shown that many patients fail these acute therapies or experience adverse effects, and perhaps even more fail to remain adherent.

Jessica Ailani, MD, director, MedStar Georgetown Headache Center, and associate professor, neurology, MedStar Georgetown University Hospital, is one of the migraine specialists involved in clinical trials of several potential new agents for this purpose. One of these, ubrogepant, has shown particularly exciting data in this area, and in March, a new drug application for the oral calcitonin gene-related peptide (CGRP) receptor antagonist was accepted for review by the FDA.

To find out more about ubrogepant’s long-term safety and efficacy, NeurologyLive sat with Ailani at the AHS meeting to discuss some of the study data that she and her colleagues presented at the meeting.

Ubrelvy is a medication that belongs to a class of drugs known as CGRP inhibitors. These drugs work by blocking the activity of calcitonin gene-related peptide (CGRP), a molecule that is believed to play a significant role in the development of migraines.
Unlike traditional migraine medications, which are often taken daily as a preventative measure, Ubrelvy is taken only when a migraine attack occurs. This allows for more targeted relief of symptoms, without the risk of side effects associated with long-term use.
In addition to its targeted relief of symptoms, Ubrelvy also offers a quick onset of action, with many patients experiencing relief within an hour of taking the medication. This means that individuals can quickly get back to their daily lives without the debilitating pain and other symptoms that come with migraines.
Clinical trials and studies supporting the effectiveness of Ubrelvy.
The effectiveness of Ubrelvy has been extensively studied in clinical trials, with promising results. In one study, over 1,400 patients were treated with Ubrelvy for a single migraine attack. The study found that a significantly higher percentage of patients experienced relief of pain and other symptoms compared to those who received a placebo.
Another study found that Ubrelvy was effective in treating migraines across multiple attacks, with many patients experiencing sustained relief of symptoms over time.
These studies and others like them have led to the approval of Ubrelvy by the US Food and Drug Administration (FDA) for the acute treatment of migraines in adults.
Key features and advantages of Ubrelvy over traditional migraine treatments.
One of the key advantages of Ubrelvy over traditional migraine medications is its targeted relief of symptoms. As mentioned earlier, Ubrelvy is taken only when a migraine attack occurs, allowing for more effective relief of pain and other symptoms without the need for daily medication.
Additionally, because Ubrelvy is a CGRP inhibitor, it does not come with the negative side effects associated with traditional migraine medications such as triptans. These side effects can include dizziness, fatigue, and chest discomfort.
Another advantage of Ubrelvy is its quick onset of action. Traditional migraine medications can take up to an hour or more to take effect, while Ubrelvy has been shown to provide relief within an hour of taking the medication.
Safety and side effects of Ubrelvy: What you need to know.
While Ubrelvy is generally well-tolerated by patients, like all medications, it does come with some potential side effects. These can include nausea, dizziness, and fatigue. However, these side effects are typically mild and short-lived.
It is important to note that Ubrelvy should not be taken by individuals with severe liver impairment, as it has not been studied in this population.
How to take Ubrelvy: Dosage instructions and precautions.
Ubrelvy is available in tablet form and is taken orally. The recommended dosage is one tablet (50 mg) taken as soon as possible after the onset of migraine symptoms. If symptoms persist or return after initial relief, a second dose may be taken after at least 2 hours have passed since the first dose.
It is important to follow the dosage instructions provided by your healthcare provider and to not exceed the recommended dosage. As with any medication, it is also important to let your healthcare provider know if you are taking any other medications or have any underlying health conditions.

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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



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This medication is the first one to truly help me and no side effects yet. It's all still early, and we're having to wrestle with our insurance to get more. But all things point to this medication actually helping me, maybe even get back to working again. We'll see.

#medication #ubrelvy #ubrogepant #migraine #migrainetreatment #Allergan

Find out the power of Ubrelvy in treating migraine headaches with Dr. Caudill Miller! Learn how this preventive treatment can help you find relief.
Find out the power of Ubrelvy in treating migraine headaches with Dr. Caudill Miller! Learn how this preventive treatment can help you find relief.Welcome to our latest video on Ubrelvy, a revolutionary migraine medication. This comprehensive guide breaks down what Ubrelvy is, how it works, its potential side effects, and more. We aim to provide accurate, easy-to-understand information intended to educate you about this FDA-approved migraine treatment. Make sure to hit the subscribe button for more insightful health and medication content. Remember, this video does not replace professional medical advice. Always consult with a healthcare provider before starting any new medication.

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Join Dr. Caudill Miller as he explains the power of Gepants for migraines, focusing on Nurtec and Ubrelvy. Learn about CGRP receptor antagonists and how these medications provide effective acute migraine treatment.
In this informative video, we delve into the world of Gepants, CGRP receptor antigonists, a new class of drugs that are transforming migraine treatment. We explain how Gepants work, discuss their benefits, and highlight potential side effects. Nurtec and Ubrelvy are the first new symptomatic medications to be released since triptans and are game changers in the treatment of an acute migraine. This video is perfect for anyone interested in health, medicine, or looking for innovative migraine solutions. Remember to click the subscribe button and turn on notifications to stay updated on the latest medical advancements. Remember, it's our aim to provide the most accurate and up-to-date health and wellness information.