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Clopidogrel/Plavix: where does it fit between coumadin and the NOACs? Side Effects 3 Views • 5 months ago

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Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

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In a previous video, we covered the importance of clot prevention in heart attack and stroke prevention. Plavix was the first option to coumadin. It is on the WHO list of Essential Medications. This means it's been found safe, effective and necessary. It costs about $25/month is the US.
The major side effects are the same as all the other anti-clotting or anti-platelet drugs: bleeding or hemorrhage.
There were other issues mentioned but not covered in depth:
relatively higher benefit for smokers;
dipyridamole;
CHAD2VAS2.
Here's the thing, the big issue - less than 1/3 of people needing this medication are actually taking it. Why? Patients blame docs, docs blame Pharma, ... Let's forget blame and get proper protection for people with atrial fibrillation, post-stroke, and other indications.

Clopidogrel ( Plavix 75 mg ): What is Clopidogrel Used For, Dosage, Side Effects & Precautions? Side Effects 1 Views • 5 months ago

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- This is lesson n# 64 in "A DRUG IN BRIEF" Series. In this video I'm gonna discuss almost all you need to know about Clopidogrel ( Plavix 75 mg ): What is Clopidogrel Used For, Dosage, Side Effects, Precautions and mechanism of action

- In 3 minutes you'll learn:

- What is Clopidogrel ( Plavix 75 mg )?

- Clopidogrel is an antiplatelet agent. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.

- It is available as 75 mg tablets.

- Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).

- The usual dosage of Clopidogrel
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: PO 75 mg once daily with or without food. Acute Coronary Syndrome (Unstable Angina/Non-Q-Wave MI): ADULTS: PO Start with a 300 mg loading dose, then continue at 75 mg once daily, initiating and continuing aspirin (75 to 325 mg/day) in combination with clopidogrel.

- Learn more about Clopidogrel ( Plavix 75 mg ) mechanism of action, uses, dosage, side effects, and precautions in this video...

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THE TRUTH ABOUT PLAVIX SIDE-EFFECTS AND THE LATEST LAWSUIT VICTORY Side Effects 2 Views • 5 months ago

In this video, we take a closer look at Clopidogrel, commonly known as Plavix. Whether you've been prescribed this medication or are simply looking to learn more, we'll cover everything you need to know including side-effects.

https://youtu.be/VZKcKTfVods
https://youtu.be/yCSf7VknE4E
https://youtu.be/0v4iXLvupfY

Topics Covered:
How Clopidogrel (Plavix) works
Potential side effects and what to watch out for
Important interaction warnings, including with indigestion medicines
The rare but serious risk of acquired haemophilia
The FDA black box warning and what it means
Recent legal developments and lawsuit victories against the makers of Plavix
If you have any questions or experiences you'd like to share, leave a comment below—I’d love to hear from you. Don’t forget to like, subscribe, and hit the notification bell to stay informed on future content.

TIMELINE:
00:00 Introduction
00:42 What exactly is Clopidogrel?
01:26 How does it work?
01:57 Who can and cannot take it?
02:36 How do you take it?
02:48 Whats the Dose?
03:00 How quickly does it work?
03:10 Is there any food or drink to avoid?
03:21 Can I drink alcohol?
03:39 What are the common side-effects?
04:23 What are the serious side-effects?
05:08 What are the cautions with other medicines?
06:06 What about taking Clopidogrel with everyday painkillers?
06:46 Are there any similar medicines?
07:20 What is the interaction warning between Clopidogrel and Proton Pump inhibitors such as Omeprazole?
08:01 What is the the risk of acquired haemophilia in association with Clopidogrel?
09:22 what is the latest lawsuit victory against the makers of Clopidogrel?

CLINICAL DATA:

MHRA DRUG SAFETY UPDATE: Clopidogrel and proton pump inhibitors: interaction—updated advice
https://www.gov.uk/drug-safety....-update/clopidogrel-

MHRA DRUG SAFETY UPDATE: Clopidogrel: risk of acquired haemophilia:
https://www.gov.uk/drug-safety....-update/clopidogrel-

Sanofi, Bristol Myers on the hook for $916M in do-over of Plavix marketing case in Hawaii
https://www.fiercepharma.com/p....harma/sanofi-bristol

#sideeffects #medicine #heartdisease
Disclaimer: The videos posted will be for general informational purposes only. They should not be used to self-diagnose or a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. You should not make any changes to your health regimen or diet before first consulting a doctor.

Clopidogrel - How to take | Side Effects | Things to be aware Side Effects 3 Views • 5 months ago

Clopidogrel is an anti platelet. It is prescribed by your doctor usually after you have suffered an acute coronary syndrome like an unstable angina where you have severe chest pain, heart attack, stroke, or have a condition called peripheral arterial disease where your leg is painful on walking or at rest.

Platelets are blood cells that help blood clot. These are important when you have an injury. However, too much clotting in the blood can block blood vessels in your heart to cause a heart attack and block the blood vessels in your brain to cause a stroke, this is where low-dose aspirin as antiplatelet comes into play.

Dependent on your condition, your doctor may pair up clopidogrel with aspirin. Instead of taking clopidogrel and aspirin separately, to reduce the cost, there are formulations where manufacturers combine both clopidogrel and aspirin into one tablet. If you are being prescribed clopidogrel and aspirin separately, Speak to your doctor about the combination formula

Clopidogrel is a prodrug, which means it has to be converted into its active form by an enzyme in the body called CYP2C19 before it can work. For some people, they are CYP2C19 poor metabolizers, it is harder for their body to convert Clopidogrel to its active form, thus clopidogrel will not be working properly. In this situation, the doctor will change the dosing of clopidogrel or change clopidogrel into something else. Approximately 2% of Caucasians, 4% of African Americans, and 14% of Chinese are CYP2C19 poor metabolizers. Your doctor may perform a test to identify if you are CYP2C19 poor metabolizers.

Before you start taking clopidogrel, make sure your doctor knows all medical conditions that you have, this includes any kidney, liver problems, any bleeding disorder, more in the video...

You need to also tell your doctor all the medicines that you are currently taking, more in the video...

How much to take
The usual dose of clopidogrel is one 75 mg tablet daily.
If you have acute coronary syndrome, you may receive a single starting dose of 300 mg and then continue at one 75 mg tablet daily.

How to take it
It does not matter if you take this medicine before or after food.
Swallow the tablet with a glass of water. Do not crush or chew the tablets. more in the video

While you are on Clopidogrel
if you are seeing a new doctor or dentist or starting a new medication prescribed by a doctor or dentist, tell them that you are on Clopidogrel. if you plan to have surgery, tell your surgeon and anesthetist, that you are on clopidogrel. more in the video...

Side effects
- abnormal bruising or bleeding
- abnormal nose bleeds
more in the video

Lifestyle Changes:
Now, if you are put on aspirin, it's a wake-up call, you need to have some lifestyle changes.
What you eat and how much you eat are important. Reducing fat and salt intake. Salt is commonly known as, Sodium the symbol is Na+ increases blood pressure, and many foods in the supermarket contain sodium. this includes your daily bread. So read the labels while you purchasing your groceries, to control how much salt you take in. It's a good idea to remove table salt from your dining table. An adult body only needs around 1 – 2g of salt (460 – 920mg sodium) per day to function. Licorice is also something that increases blood pressure, so avoid it.

If you are a smoker, quit smoking. if you drink too much alcohol, stop it. If you need help stopping these. contact your doctor. Exercises are important as well. Now if you just have a heart attack or stroke, speak to your doctor or cardiac rehabilitation team for advice on types of suitable exercises to begin. Follow your doctor’s advice and slowly build up your activity. and Remember, never hold your breath when lifting weights.

Let me know in the comments down below, what lifestyle changes have you made or plan to make, and what other videos can I make to help you improve your health.

I hope this video is of value to you. Thank you for watching. Please do subscribe and hit the notification button for more Health and Medication-related videos!

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This video is for general information only and should not be used to diagnose or treat medical conditions. Pharmacist Soonkie has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Always consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions.

Clopidogrel (Plavix) uses and side effects | WATCH THIS before you take the drug!! Side Effects 1 Views • 5 months ago

This video examine Clopidogrel uses and side effects.Clopidogrel is also known as Plavix.This video looks at common side effects of Clopidogrel and Clopidogrel uses.

READ entire transcript here: https://drthinkyourhealth.com/....clopidogrel-plavix-u

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00:00 Intro
00:10 What is Clopidogrel?
00:47 How does Clopidogrel lower the RISK of heart attack or a stroke?( Clopidogrel uses)
01:10 What is Clopidogrel used for?
01:45 What are the doses of Clopidogrel?
02:04 Clopidogrel and grapefruit
04:52 Clopidogrel and bleeding
05:13 Clopidogrel and TTP ( Thrombotic Thrombocytic Purpura)
06:08 Clopidogrel side effects
08:05 Clopidogrel and drug drug interactions

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Sources:
1)https://www.uptodate.com/contents/clopidogrel-drug-information?search=plavix&source=panel_search_result&selectedTitle=1~148&usage_type=panel&kp_tab=drug_general&display_rank=1

2) https://www.accessdata.fda.gov..../drugsatfda_docs/lab

3) https://www.rxlist.com/plavix-drug.htm

4) https://www.goodrx.com/clopidogrel

Think Your Health provides general educational information on various topics on this YouTube video and channel as a public service, which should not be construed as medical, psychological or health advice. These are my personal opinions only.

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#Clopidogrel

Clonidine 0.1 mg (Catapres): What Is Clonidine Used For? Uses, Dosing and Side Effects of Clonidine Side Effects 3 Views • 5 months ago

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- This is lesson n# 149 in "A DRUG IN BRIEF" Series. In this video I'm gonna discuss almost all you need to know about Clonidine 0.1 mg (Catapres): What Is Clonidine Used For? Uses, Dosing, Side Effects of Clonidine, Precautions and Mechanism of Action

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- In 3 minutes you'll learn about:

- What is Clonidine 0.1 mg (Catapres)?

- Clonidine is a centrally acting antihypertensive, and antiadrenergic. It activates α2 receptors in the brain, resulting in an inhibitory effect on catecholamine release, and ultimately reduces peripheral vascular resistance, renal vascular resistance, heart rate, and blood pressure.

- It is available as tablets, transdermal patch, and solution for epidural injection.

- Learn more about Clonidine 0.1 mg (Catapres) mechanism of action, uses, dosage, side effects, and precautions in this video...

- Video Chapters:
00:12 - Clonidine Mechanism of Action
00:30 - Clonidine Dosage Forms
00:37 - Clonidine Uses
00:47 - Clonidine Dose
01:23 - Clonidine Side Effects
01:40 - Clonidine Patient Counseling

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What Are Clonidine's Side Effects? - Pain Medicine Network Side Effects 2 Views • 5 months ago

What Are Clonidine's Side Effects? In this informative video, we’ll discuss the side effects associated with clonidine, a medication commonly used for managing high blood pressure and certain types of pain. Understanding these side effects is essential for anyone considering or currently using clonidine, especially in the context of pain management. We will cover both common and less frequent side effects, helping you recognize what to look out for while on this medication.

Additionally, we will highlight the importance of monitoring for serious side effects that may require immediate medical attention. Knowing how to manage these potential issues can significantly impact your treatment experience and overall well-being. For those using clonidine in conjunction with other medications, we’ll address the considerations necessary to ensure safe usage.

Before making any changes to your medication regimen, it’s always best to consult with a healthcare provider. Join us for this informative discussion, and subscribe to our channel for more helpful content related to pain management and medication safety.

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Clonidine: The Best Medication no one talks about Side Effects 1 Views • 5 months ago

Welcome to our deep dive into Clonidine, a medication that has shaped the pharmacological landscape with its wide array of therapeutic applications. In this video, we're unpacking everything from Clonidine's pharmacodynamics and pharmacokinetics to its versatile uses in various medical conditions. Join us as we explore the science behind this multifaceted drug, shedding light on its mechanisms, benefits, potential side effects, and its pivotal role in modern medicine.

**What You'll Learn:**

- **Understanding Clonidine**: Get to grips with how Clonidine works in the body, including its classification as a centrally acting alpha-2 adrenergic agonist.

- **Therapeutic Uses**: Dive into the diverse uses of Clonidine, from managing hypertension to treating ADHD, withdrawal symptoms, and more.

- **Mechanism of Action**: Discover how Clonidine's effect on alpha-2 receptors leads to decreased sympathetic outflow, benefiting conditions like hypertension.

- **Side Effects and Considerations**: Familiarize yourself with the common side effects of Clonidine and crucial clinical considerations for its use.

**Why This Matters:**

Clonidine remains a cornerstone in the treatment of not just hypertension but also in addressing ADHD, withdrawal symptoms from various substances, and certain types of pain. Its broad therapeutic range and mechanism of action make it a subject of continuous interest in the medical community.

**For Healthcare Professionals and Patients Alike:**

Whether you're a healthcare professional seeking to broaden your pharmacological knowledge or a patient curious about the medications you're prescribed, this video offers valuable insights into one of the most widely used medications today.

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Have questions about Clonidine or experiences you'd like to share? Comment below! We love hearing from our viewers and aim to foster a community where we can learn and grow together.

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Clonidine Vs Guanfacine | Which ADHD Medication Is Best? Side Effects 3 Views • 5 months ago

Dr. Aly (psychiatrists) compares CLONIDINE and GUANFACINE, two commonly used non-stimulant ADHD medications ***Link to Dr. Aly's FREE "Antidepressants: A Beginner's Guide" ➡️ https://free.dralywood.com/antidepressants

⏰ TIMESTAMP ⏰
0:00 Intro
0:24 Brand Vs Generic Names
0:45 What Do Clonidine And Guanfacine Treat?
1:17 How Do Clonidine And Guanfacine Work?
2:27 How Are Clonidine And Guanfacine Prescribed?
3:35 Converting From Long-Acting To Short Acting Clonidine Or Guanfacine
4:31 How Long Until Clonidine And Guanfacine Work?
5:00 What Are The Side Effects Of Clonidine And Guanfacine?
6:08 How Do You Stop Taking Clonidine And Guanfacine?
6:57 What Is The Cost Of Clonidine And Guanfacine?
7:18 Clonidine Vs Guanfacine- Which Is Best?

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