In patients with heart failure, both with and without diabetes, dapagliflozin was shown to provide identical efficacy and possibly beneficial effects on the heart, said John McMurray, MD, FRCP, FESC, professor of medical cardiology in the Institute of Cardiovascular and Medical Sciences at the University of Glasgow.

Dapagliflozin may be an ally in the treatment of type 2 diabetes and heart failure, helping to reduce blood sugar levels and improve heart function. Learn how this medication, part of the sodium-glucose cotransporter type 2 inhibitors, facilitates the elimination of glucose through urine. We explain the recommended dose of 5 mg per day, which can be increased to 10 mg depending on the patient's response, always under medical supervision. Like and share this video so others can also benefit from this essential information!

#Type2Diabetes #HeartFailure #Dapagliflozin #CardiacHealth #DiabetesControl #Health

In today's video I discuss Farxiga (dapagliflozin) including:
Farxiga side effects
Farxiga indications
Mechanisms of action for Farxiga
A special FDA warning concerning Farxiga and other SGLT2 inhibitors
Thank you for watching!

The sodium-glucose co-transporter 2 (SGLT2) is expressed in the proximal tubule and mediates reabsorption of approximately 90 percent of the filtered glucose load. SGLT2 inhibitors promote the renal excretion of glucose and thereby modestly lower elevated blood glucose levels in patients with type 2 diabetes. They do not usually cause hypoglycemia in the absence of therapies that otherwise cause hypoglycemia.

Video transcript :-

Dexamethasone belongs to the drug class of corticosteroids, which are potent anti-inflammatory and immunosuppressant medications.
It is used to treat a wide range of disease conditions, including the following.
Inflammatory disorders such as rheumatoid arthritis, systemic lupus erythematosus, dermatitis, inflammatory bowel disease, asthma, and chronic obstructive pulmonary disease.
Allergic reactions, including allergic rhinitis, allergic dermatitis, and drug reactions.
Autoimmune diseases like multiple sclerosis, and autoimmune hepatitis.
Certain types of cancers such as leukemia, lymphoma, and multiple myeloma, to reduce inflammation and suppress the immune response.
To reduce swelling in the brain caused by tumors, injury, or surgery.
Endocrine disorders such as adrenal insufficiency and congenital adrenal hyperplasia.
To prevent nausea and vomiting in patients who undergo chemotherapy.
To induce fetal lung maturation and reduce the risk of respiratory distress syndrome in premature infants.
Dexamethasone, like other corticosteroids, exerts its effects by binding to intracellular glucocorticoid receptors.
Once bound, the dexamethasone-receptor complex translocates into the cell nucleus, where it acts as a transcription factor.
This complex regulates gene expression by either enhancing or suppressing the transcription of specific target genes.
The net result is a wide range of physiological effects, including anti-inflammatory, immunosuppressive, anti-allergic, and metabolic actions.
Dexamethasone inhibits the production of inflammatory mediators, such as prostaglandins and leukotrienes, and suppresses the activity of various immune cells, such as T cells and macrophages.
Additionally, it alters the expression of proteins involved in glucose metabolism, leading to increased blood glucose levels.
Dexamethasone is well-absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
It can also be administered via intramuscular or intravenous routes for rapid onset of action.
Metabolism of dexamethasone primarily occurs in the liver, primarily via the enzyme cytochrome P450.
Metabolites are mostly inactive and undergo further conjugation before excretion.
Dexamethasone and its metabolites are primarily excreted via the kidneys.
Common adverse effects of dexamethasone include the following.
Immunosuppression, which increases the susceptibility to various infections.
Glucose Intolerance and Hyperglycemia.
Fluid and Electrolyte Imbalances.
Osteoporosis and Bone Fractures.
Gastrointestinal Effects, including gastric irritation, peptic ulcers, and pancreatitis.
Psychiatric Effects, including insomnia, mood swings, anxiety, depression, and cognitive changes such as memory impairment and confusion.
Ocular Effects such as increased intraocular pressure, leading to glaucoma or exacerbating pre-existing glaucoma.
It may also induce cataract formation with long-term use.
Skin Changes such as skin thinning, easy bruising, delayed wound healing, and exacerbation of existing skin conditions such as acne and rosacea.
Weight Gain.
Musculoskeletal Effects like muscle weakness, myopathy, and muscle wasting, particularly with prolonged use.
Endocrine Effects, including menstrual irregularities, hirsutism, and adrenal suppression.
In children, it can inhibit growth and development.
Cardiovascular Effects such as hypertension, myocardial infarction, and stroke.
Hematological effects such as leukopenia and thrombocytopenia.
Metabolic effects such as elevated blood cholesterol and triglycerides and hypokalemic metabolic alkalosis.
Contraindications for dexamethasone therapy include the following.
Systemic Fungal Infections.
Live Vaccines.
Hypersensitivity to dexamethasone
Systemic Viral Infections.
Active Peptic Ulcer Disease.

Uncontrolled Hypertension.
Diabetes.
Ocular Herpes Simplex.
Active Tuberculosis.
And Recent Myocardial Infarction.

#dexamethasone #dexa #medtoday #medicaleducation #pharmacology
#medicaleducation #medicalknowledge #health #healtheducation

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Dexamethasone is a potent corticosteroid medication used to treat a wide range of medical conditions, from asthma and arthritis to certain types of cancer. In this informative video, we'll dive into the various uses, dosage, and potential side effects of this powerful drug.

We'll cover how Dexamethasone works, the conditions it's commonly prescribed for, and the appropriate dosage guidelines. Importantly, we'll also explore the possible side effects, both short-term and long-term, so you can make an informed decision with your healthcare provider.

Understanding the risks and benefits of Dexamethasone is crucial for anyone considering or currently using this medication. Watch this video to learn more and share it with anyone who may find the information useful.

#Dexamethasone #Corticosteroid #MedicationSideEffects #HealthInformation

OUTLINE:

00:00:00 Introduction to Dexamethasone
00:00:35 Correct Usage of Dexamethasone
00:00:59 Side Effects of Dexamethasone
00:01:37 Recap and Conclusion

Dexamethasone is a synthetic glucocorticoid (adrenocortical hormone)
Corticosteroids are hormones that are found naturally in your body that help to keep you healthy and well.

Video Content:
0:00 Dexamethasone tablets
0:33 Indications
0:45 How to use
1:20 Contraindications
1:45 Precautions
2:23 Side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#dexamethasone #immunesystem #medicine

Dexamethasone is a steroid called glucocorticoid. Dexamethasone sodium phosphate injection ip is available in 2ml/4ml/8ml strength. Dexamethasone injection is long acting having half-life of 36 hours.
Dexamethasone injection brand names are
Dexona injection
Dexa injection
Decadron injection
Decdan injection etc…
Dexamethasone can be administered I.V / I.M.
Dexamethasone injection is used in the treatment of skin allergic reactions, breathing problems, asthma, vomiting, bee bitr, insect bite, minor poisoning etc…
Dexamethasone injection contraindications are
Cannot use in pregnancy and breastfeeding mother etc…
We also discuss about dexamethasone sodium phosphate ip injection
Brand name
Uses in details
Contraindications
Hoe to use
Side effects
Like/ share/ subscribe
LEARN ABOUT MEDICINE
#dexamethasone
#dexamethasoneinjection
#dexonainjection
#decadroninjection
#learnaboutmedicine

Many of my patients have come to me for rehabilitation after sustaining a fall and horrific fracture because their bones are so brittle that they shatter like a glass.
When they are put back together in the operating room, typically without my bone protocol, their healing times are significantly longer than normal.
This is a patient's story and a cautionary tale about why you shouldn't be on your bisphosphonates, or osteoporosis medications for too long.

Depakote or Divalproex sodium treats the mania of bipolar disorder, prevents attacks of migraine and reduces the frequency of epileptic seizures. For convenience two forms of Depakote exist with confusing names. The delayed release form must be taken two or three times a day while only one dose suffices of the extended release tablet.

Widespread unapproved prescriptions of Depakote treat schizophrenia and impulsivity associated with the borderline personality disorder or dementia. Other off-label use of Depakote includes treatment for aggression, agitation and alcohol dependence. None of these indications are approved by the FDA.

In the intestine Depakote dissolves into the active form valproic acid or valproate. In the body it appears to act on the neurotransmitter GABA. Nausea, tiredness and significant weight gain occur. Pregnant women must not receive Depakote; it regularly leads to birth defects and harms the developing fetal brain. Depakote causes both benign and malignant tumors in laboratory animals.

Overall Depakote provides some benefit but may not be as helpful as desired.

In this video, we reveal the shocking reality of using Depakote for epilepsy patients. Learn about the risks and benefits of this medication for managing generalized tonic clonic seizures and epilepsy.
Join Dr Caudill Miller to learn about this old, but very useful anticonvulsants.
Depakote is a very effective anticonvulsant for generalized seizure disorders, but has very significant "baggage" (i.e. side effects)
Still used in epilepsy and migraine headaches but learn about it use in epilepsy.

Do you suffer from allergies? Meet desloratadine, a powerful antihistamine used to treat allergic rhinitis and hives. Find out how it works by blocking histamine in your body to prevent annoying allergic reactions. Learn about the recommended dosage: one five-milligram pill a day for adults and children over twelve years old, always at the same time for best results.

#Desloratadine #Allergies #Antihistamine #Health #Wellness

Loratadine D is a combination of an antihistamine and a decongestant. The antihistamine provides relief of seasonal allergy symptoms such as watery and itching eyes, runny nose, and sneezing. The decongestant helps relieve a stuffy nose, promotes sinus draining, and improves breathing. It is important to note that this medication is not recommended for use in children under 12 years of age due to the high amount of pseudoephedrine. The recommended daily dosage and the best time to take this medication should be determined by consulting a healthcare professional.
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✅AERIUS (Desloratadine) 5 mg :
Famille du médicament : ANTIALLERGIQUE
DANS QUEL CAS LE MÉDICAMENT AERIUS EST-IL PRESCRIT ?
Ce médicament est un antihistaminique antiallergique d'action prolongée. Dans la majorité des cas, il n'a pas d'effet sédatif, contrairement aux
antihistaminiques plus anciens.

Il est utilisé dans le traitement des symptômes de la rhinite allergique et de l'urticaire.

MODE D'EMPLOI ET POSOLOGIE DU MÉDICAMENT AERIUS
Ce médicament peut être pris indifféremment au cours ou au dehors du repas.

POSOLOGIE USUELLE :
Adulte et enfant de plus de 12 ans : 1 comprimé ou 10 ml de solution buvable par jour, en une prise.

Enfant de 6 à 11 ans : 5 ml de solution buvable par jour, en une prise.

Enfant de 1 à 5 ans : 2,5 ml de solution buvable par jour, en une prise.

La durée du traitement est fixée par le médecin en fonction des symptômes.

Hello! My name is Bri and I, like many others, am trying to get my mental health in order.
I struggle with anxiety, depression, and PTSD.

What this video is about:
My introduction to YouTube and talking about my first four weeks on a new medication: Pristiq (desvenlafaxine).
This is a neutral review so far, as I have yet to feel the benefits. I talk about initial side effects and things I struggle with.

Intro: 0:00
Diagnosis: 0:32
Symptoms: 1:32
Let Me Be Honest: 2:30
Initial Side Effects: 3:00
How I Feel Right Now: 3:55
Why I am Making This Now: 4:30
You Are Not Alone: 4:57
Keep Fighting: 5:35
Thank You for Inspiration: 6:13
There is Hope: 6:56

I hope this is helpful to you an someway, and I hope you’ll join me as I check in with updates on how I’m feeling.

All of the things said are personal opinion, and you should always talk to your doctor with questions regards medication and mental health.

Thank you so much for watching!

#mentalhealthawarness #medication

Serotonin-Norepinephrine Reuptake Inhibitors, or SNRIs, are a common treatment for depression and a variety of other ailments like anxiety disorders and chronic pain. In this video, I discuss how SNRIs work in the brain and how they are proposed to be able to treat the symptoms of depression.

TRANSCRIPT:

Serotonin-norepinephrine reuptake inhibitors, or SNRIs, first appeared on the market in 1993 with the introduction of venlafaxine. Several others, like duloxetine, would be introduced in the following decades. Most SNRIs were primarily developed for the treatment of depression, but some are now also used to treat a variety of other conditions like anxiety and chronic pain. The development of SNRIs was guided by research that suggests neurotransmitters like serotonin and norepinephrine play a role in depression. Specifically, this research suggests that low levels of these neurotransmitters might contribute to the symptoms of depression.

SNRIs work primarily by inhibiting a mechanism called reuptake. In reuptake, a protein called a transporter transports excess neurotransmitter molecules out of the synaptic cleft, typically back into the neuron that released them. SNRIs inhibit the reuptake of serotonin and norepinephrine. When the removal of serotonin and norepinephrine from the synaptic cleft is inhibited, this causes levels of these neurotransmitters in the synaptic cleft to rise. These increases in serotonin and norepinephrine levels have been hypothesized to be the mechanism by which SNRIs can treat the symptoms of depression. It should be noted, however, that research suggests the neurobiological mechanism of depression is more complex than a simple neurotransmitter deficiency. Thus, it may be that increasing serotonin and norepinephrine levels leads to other effects that can alleviate the symptoms of depression, or that the drugs have other mechanisms that contribute to their effectiveness.

Studies have found SNRIs to be comparable to other popular antidepressants, like SSRIs, in terms of effectiveness. SNRIS are also generally well-tolerated, with problems like nausea, sweating, and loss of appetite being some of the commonly reported side effects---although different snri drugs have different side effect profiles.

REFERENCES:

Brunello N, Mendlewicz J, Kasper S, Leonard B, Montgomery S, Nelson J, Paykel E, Versiani M, Racagni G. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol. 2002 Oct;12(5):461-75. doi: 10.1016/s0924-977x(02)00057-3. PMID: 12208564.

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018 Apr 7;391(10128):1357-1366. doi: 10.1016/S0140-6736(17)32802-7. Epub 2018 Feb 21. PMID: 29477251; PMCID: PMC5889788.

Hillhouse TM, Porter JH. A brief history of the development of antidepressant drugs: from monoamines to glutamate. Exp Clin Psychopharmacol. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. PMID: 25643025; PMCID: PMC4428540.

Lambert O, Bourin M. SNRIs: mechanism of action and clinical features. Expert Rev Neurother. 2002 Nov;2(6):849-58. doi: 10.1586/14737175.2.6.849. PMID: 19810918.
Sansone RA, Sansone LA. Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison. Innov Clin Neurosci. 2014 Mar;11(3-4):37-42. PMID: 24800132; PMCID: PMC4008300.

In this informative video, our expert pediatric pharmacist, discusses the use of Dexamethasone as a treatment option for asthma in children. We'll cover its dosage guidelines, potential side effects, and benefits. Stay informed and empowered in managing your child's asthma with our trusted medical insights.

Dexamethasone is a corticosteroid medication that is commonly used to treat a wide range of medical conditions. It has anti-inflammatory and immunosuppressive properties, which make it effective in managing various conditions.

Some of the common uses of Dexamethasone include:

Inflammatory and autoimmune conditions: Dexamethasone is often prescribed to reduce inflammation and suppress the immune system in conditions such as rheumatoid arthritis, lupus, and multiple sclerosis.

Allergic reactions: It can be used to treat severe allergic reactions, including allergic rhinitis, asthma, and contact dermatitis.

Respiratory conditions: Dexamethasone is sometimes used to manage conditions like chronic obstructive pulmonary disease (COPD) and asthma exacerbations.

Cancer treatment: Dexamethasone can be prescribed alongside chemotherapy to reduce nausea and vomiting caused by chemotherapy drugs. It may also help reduce swelling and manage symptoms in certain types of cancer.

Cerebral edema: It is used to reduce brain swelling that can occur due to conditions like brain tumors or brain injuries.

Organ transplant: Dexamethasone may be given to transplant recipients to prevent organ rejection.

Benefits of using Dexamethasone include its ability to reduce inflammation, relieve pain, and improve symptoms associated with the aforementioned conditions. However, it is important to note that the use of Dexamethasone should always be under the supervision of a healthcare professional.

Like any medication, Dexamethasone can have side effects. These can vary depending on the dose and duration of treatment. Some common side effects include increased appetite, weight gain, mood changes, difficulty sleeping, increased blood sugar levels, and increased risk of infections. Long-term use or high doses may also lead to more serious side effects such as osteoporosis, muscle weakness, and adrenal suppression.

The dosage of Dexamethasone will depend on the condition being treated, the severity of the symptoms, and individual patient factors. It is crucial to follow the prescribed dosage and duration of treatment as directed by a healthcare professional.

As with any medication, there are certain risks associated with the use of Dexamethasone. These risks can include interactions with other medications, contraindications for certain medical conditions, and potential complications if the medication is misused or discontinued abruptly.

It is important to consult with a healthcare professional to assess the appropriateness and potential risks of using Dexamethasone for your specific condition. They can provide personalized guidance and monitor your progress throughout the treatment.
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately."

Your Medication Dexlansoprazole

Dexlansoprazole is also known as the brand names: Dexilant.
Dexlansoprazole comes in 30 and 60 mg tablets.
It is used to treat erosive esophagitis and heartburn associated with gastroesophageal reflux disease. If you are using it to treat erosive esophagitis, it is taken 60 mg once daily for up to 8 weeks. For heartburn, it is taken 30 mg once daily for 4 weeks. No matter what your doctor has you taking it for, it is taken orally with or without meals.
Some less common side effects of dexlansoprazole are headaches, diarrhea, abdominal pain, flatulence, vomiting, and upper respiratory tract infection.
Do not take dexlansoprazole if:
• You are taking products that contain rilpivirine
While taking dexlansoprazole, it is important to remember to tell your doctor or pharmacist if you experience any of the following:
• Signs of low magnesium (mood changes, muscle pain or weakness, muscle cramps, etc.)
• Signs of kidney problems (urinary retention, change in amount of urine passed or weight gain)
• Red or irritated eyes or sores in mouth, throat, nose or eyes
• Signs of an allergic reaction (wheezing, chest tightness, fever, itching, bad cough, blue skin color, etc.)
• If you start taking new medications, vitamins, or supplements
• Your condition does not improve or you develop new or worsening symptoms

DEXILANT (Dexlansoprazol): Medicamento esencial para tu salud digestiva. En este video, exploramos cómo Dexilant, un medicamento basado en Dexlansoprazol, puede ayudarte a tratar condiciones como el reflujo gastroesofágico y otros trastornos digestivos. Te explicamos cómo actúa en tu cuerpo para reducir la acidez estomacal y aliviar los síntomas relacionados.

Repasamos la dosis recomendada, tanto para el uso inicial como para el de mantenimiento, y los posibles efectos secundarios que debes conocer. También discutimos las precauciones necesarias para usarlo de manera segura y maximizar sus beneficios. ¡Infórmate y mejora tu calidad de vida con Dexilant de manera responsable!

#Dexilant #Dexlansoprazol #Salud #Medicina

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Dexlansoprazole is a proton pump inhibitor (PPI), a type of medication commonly used to reduce stomach acid production and alleviate symptoms of acid reflux. While dexlansoprazole is generally regarded as safe and effective, like any medication, it can cause adverse effects in some individuals.
Common side effects of dexlansoprazole may include headache, diarrhea, nausea, and abdominal pain. These side effects are usually mild and transient, resolving on their own without any intervention. However, if these symptoms persist or become severe, it is important to consult your healthcare provider.
It is worth noting that not everyone who takes dexlansoprazole will experience these common side effects. Each person's response to medication can vary, and some individuals may experience no side effects at all. It is essential to monitor your own body's response and communicate any concerns to your healthcare provider.
Rare but Serious Side Effects of Dexlansoprazole.
While uncommon, there are some rare but potentially serious side effects associated with dexlansoprazole. These side effects require prompt medical attention if they occur. It is crucial to be aware of these potential risks and inform your healthcare provider if you experience any unusual symptoms.
One such rare side effect is liver problems. Dexlansoprazole has been associated with an increased risk of liver injury, including inflammation and liver failure. Symptoms of liver problems may include jaundice (yellowing of the skin and eyes), dark urine, pale stools, abdominal pain, and fatigue. If you experience any of these symptoms, seek immediate medical attention.
Another potential serious side effect is kidney damage. In some cases, dexlansoprazole can cause acute interstitial nephritis, a condition characterized by inflammation of the kidneys. Signs of kidney damage may include changes in urinary frequency, blood in the urine, swelling of the legs or ankles, and fatigue. If you notice any of these symptoms, it is important to contact your healthcare provider right away.
Lastly, dexlansoprazole may lead to vitamin B12 deficiency. Prolonged use of PPIs can interfere with the absorption of vitamin B12, which plays a crucial role in nerve function and red blood cell production. Symptoms of vitamin B12 deficiency may include fatigue, weakness, numbness or tingling in the hands and feet, and difficulty with balance. If you experience any of these symptoms, discuss them with your healthcare provider.
Interactions and Precautions with Dexlansoprazole.
Before starting dexlansoprazole, it is essential to inform your healthcare provider about any other medications or supplements you are taking. Dexlansoprazole can interact with certain drugs, potentially affecting their effectiveness or increasing the risk of side effects. Your healthcare provider can help determine if any adjustments are necessary.
Additionally, there are certain precautions to consider when taking dexlansoprazole. It is important to take the medication exactly as prescribed and not exceed the recommended dosage. Dexlansoprazole is typically taken orally, usually once daily, with or without food. Swallow the capsule whole, and do not crush or chew it.
It is also important to avoid certain substances that can worsen acid reflux symptoms, such as alcohol, caffeine, fatty foods, and tobacco. Making lifestyle modifications, such as maintaining a healthy weight, elevating the head of the bed, and eating smaller, more frequent meals, can also help manage acid reflux and reduce the reliance on medication.
How to Minimize Side Effects of Dexlansoprazole.
While it is not possible to completely eliminate the risk of side effects, there are steps you can take to minimize the likelihood and severity of adverse reactions when using dexlansoprazole.
First, follow your healthcare provider's instructions carefully and take the medication as prescribed. Do not skip doses or stop taking dexlansoprazole without consulting your doctor. Abruptly discontinuing the medication can lead to rebound acid production and worsening of symptoms.
Second, be mindful of any changes in your body and report any new or worsening symptoms to your healthcare provider promptly. Keeping track of your symptoms and noting any patterns can help your doctor assess the effectiveness and safety of your treatment plan.
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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.