Cheryl Fitzer-Attas, PhD, ClinMed LLC, describes P2B001 – a potential therapy for Parkinson’s Disease (PD). P2B001 consists of low-dose, extended-release formulations of two known PD drugs – pramipexole and rasagiline. Rasagiline is an irreversible inhibitor of MAO-B, but recent research has shown additional mechanisms of action of rasagiline and its metabolites. Experts believe that exposure to both rasagiline and pramipexole throughout the day leads to additional clinical benefits for PD patients. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

The risk associated with Avonex

Dr. Richard Besser on medication that could help millions battling depression.

Dr. Kantor gives us more information about the recently FDA approved medication, Aubagio, for MS.

Daniel Kantor, M.D.
MS Treatments
Aubagio
September 2015

At AAN 2017, Aaron Miller, MD, Mount Sinai discussed results of the TOPIC trial that investigated the administration of (7 and 17mg) teriflunomide vs. placebo in multiple sclerosis patients with clinically isolated syndromes with a primary endpoint of the conversion to clinically definite multiple sclerosis, meaning a new relapse.

According to Miller, the pivotal portion of the double blind randomized trial demonstrated a 43% reduction in the conversion to clinically definite MS for the 14mg dose of teriflunomide. The TOPIC Extension trial then took patients who had been in the original, randomized trial and re-randomized the patients who completed that trial. The patients who were originally assigned to either 7 or 14mg of teriflunomide were continued on those doses and patients who had been originally assigned to placebo were re-randomized to either 7 or 14mg of teriflunomide.

This video explains some common side effects of teriflunomide tablets.

@ProfessorTushar

talk to your doctor if you're transitioning to new meds! .
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Mark Freedman, MSc, MD, CSPQ, FAAN, FRCPC, University of Ottawa & Ottawa Hospital Research Institute, Ottawa, Canada, shares the findings of a pooled analysis of four Phase III randomized clinical trials, assessing the impact of long-term teriflunomide treatment on lymphocyte counts and infection rates in patients with multiple sclerosis (MS). Over 1800 patients were analyzed from the TEMSO, TOWER, TENERE, and TOPIC trials. The results showed that long-term risk of lymphopenia and infections were low in patients receiving continued teriflunomide treatment. No late-stage problems were seen that were not identified early on. This interview took place during the ACTRIMS Forum 2021.

Qulipta (atogepant): A New Breakthrough in Migraine Treatment: Introducing Qulipta (atogepant), the latest prescription medication for the preventive treatment of migraines in adults. With its unique mechanism of action, Qulipta targets the root cause of migraines to help patients experience fewer migraine days.

QULIPTAis a calcitonin gene-related peptide receptor antagonist indicated for the preventive treatment of migraine in adults. This video provides information on pharmacological aspects of this drug including uses, mechanisms of actions, efficacy, dose, side effects and drug interactions.

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General information regarding Aricept (donepezil). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

This is a brief video aimed at doctors, summarising some of the salient points regarding cholinesterase-inhibitors (eg donepezil, rivastigmine).
It covers theoretical benefits, mode of action, potential side-effects and contraindications, and some ideas on duration of treatment.
The video is part of a teaching series on Geriatric Medicine given to medical students at University of Adelaide Rural Clinical School.

NCLEX EXAM ONLINE NURSING PREPARATORY COURSE FOR NURSING STUDENT

Andrew J. Armstrong, MD, MSc, Duke Cancer Institute, Durham, NC, discusses The Phase III PANTHER (NCT03098836) trial of apalutamide and abiraterone acetate plus prednisone (AAAP) in Black and White men with metastatic castrate-resistant prostate cancer. This multicenter study enrolled 43 Black and 50 White patients and assessed radiographic progression-free survival (rPFS), time to PSA progression (TTP), overall survival (OS), and best PSA response as primary and secondary endpoints. Baseline characteristics were largely similar between the two groups. Interim analysis revealed events in rPFS and deaths in both Black and White patients. The study suggests that AAAP combination therapy may hold clinical efficacy for Black men with mCRPC, but further investigation is needed to understand potential benefits in this understudied population. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Neal Shore, MD, FACS, highlights his recent research on the effects of apalutamide plus androgen deprivation therapy on the biochemical recurrence-free rate in patients with high-risk localized prostate cancer who underwent radical prostatectomy.

Neal Shore, MD, FACS, continues his discussion on the effects of apalutamide and ADT on patients with localized prostate cancer.

How does Erleada work?.
Erleada, also known by its generic name apalutamide, is a medication used in the treatment of prostate cancer. It belongs to a class of drugs called androgen receptor inhibitors, which work by blocking the effects of male hormones, such as testosterone, on prostate cancer cells. By interfering with the signaling pathways that promote cancer cell growth, Erleada helps to slow down the progression of the disease.
The mechanism of action of Erleada makes it a valuable treatment option for patients with non-metastatic castration-resistant prostate cancer (NM-CRPC). This type of prostate cancer is characterized by the cancer cells' ability to continue growing and spreading even in the absence of testosterone. Erleada helps to delay the time it takes for the cancer to spread to other parts of the body, providing patients with a potentially longer period of disease control.
While Erleada has shown great promise in clinical trials, it's essential to be aware of the potential side effects associated with its use. By understanding these side effects, patients can be better prepared and work closely with their healthcare team to manage them effectively.
Common side effects of Erleada.
Like many medications, Erleada can cause some common side effects. These side effects are generally mild to moderate in nature and tend to improve over time as the body adjusts to the medication. It's important to note that not all patients will experience these side effects, and the severity can vary from person to person.
One of the most common side effects of Erleada is fatigue. Patients may experience a general sense of tiredness and lack of energy, which can impact their daily activities. Other common side effects include nausea, decreased appetite, and weight loss. Some patients may also experience hot flashes, a sudden feeling of warmth and sweating, similar to menopause symptoms.
It's essential for patients to communicate any side effects they experience to their healthcare team. While these side effects may be bothersome, they are often manageable with appropriate interventions. Healthcare providers can provide guidance on lifestyle modifications and supportive medications to help alleviate these common side effects.
Rare but serious side effects of Erleada.
While rare, there are some potential serious side effects associated with the use of Erleada. These side effects require immediate medical attention and should not be ignored. It's crucial for patients to be aware of these risks and report any symptoms promptly to their healthcare provider.
One serious side effect to watch for is anemia, a condition characterized by a decrease in red blood cell count. Anemia can cause symptoms such as fatigue, shortness of breath, and pale skin. If left untreated, severe anemia can lead to complications and impact the overall well-being of the patient. Regular blood tests are typically conducted to monitor for any changes in blood cell counts.
Managing and reducing side effects.
While the potential side effects of Erleada may sound concerning, it's important to remember that not all patients will experience them, and the severity can vary. Additionally, there are various strategies available to manage and reduce these side effects, ensuring that patients can continue with their treatment regimen comfortably.
One of the key approaches to managing side effects is through open communication with the healthcare team. Patients should not hesitate to discuss any concerns or symptoms they are experiencing with their healthcare provider or nurse. By providing detailed information, healthcare professionals can tailor recommendations and interventions to address specific side effects.

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"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

Learn about apalutamide, a next-generation androgen receptor inhibitor used in non-metastatic and metastatic prostate cancer. This video highlights its mechanism of action, pharmacokinetics, and side effects, including fatigue and rash. Discover important drug interactions and considerations in its clinical use.

In this video, we provide a detailed overview of Apalutamide (Erleada), a medication used to treat advanced and metastatic prostate cancer. Learn how Apalutamide works by blocking testosterone’s effects on cancer cells, slowing down the progression of the disease. We also cover important information on how to take it, common side effects like fatigue, rash, and high blood pressure, and tips for managing them. Whether you're newly prescribed Apalutamide or looking for more information, this video will help you understand how the treatment fits into your prostate cancer journey. Always consult your healthcare provider for personalized medical advice.

Aimovig is a brand-name and the generic is Erenumab. In May 2018 it was the first CGRP which Works on receptor site. It blocks CGRP thereby blocks a migraine. It is given once a month at 70 to 140 mg subcutaneously that is under the skin. The half-life is 28 days. The side effects are Injection site reaction, constipation, some hypertension. Contraindications are hypersensitive reaction to the medicine or anaphylaxis and then you edema for me to discontinue the medicine and seek medical advice right away. Constipation is a major problem. You can keep it in the refrigerator but if you leave it outside the room temperature for seven days it’s OK beyond that you need to discard the medicine. It has excellent track record of preventing the migraine. It is a monoclonal antibody. It is for migraine prophylaxis or migraine prevention.
#aimoving #erenumab #migraine #migrainesymptoms #migrainetreatment #migrainerelief #prevention #migrainepain #monoclonalantibodies #antibody #CGRB #inhibitor #sideeffects #headice





Disclaimer

Views and opinions expressed on our site are not the views or pinions of anybody else but the author’s independent opinion & teaching point and will not constitute final word rather you need to read further on that subject. He or she including us are advising you that this is not a medical / legal advice. We are not giving you medical advice. The author is not implying any medical advice. The dosage and the material submitted should be confirm with the medical literature. We are not giving you any medical advice. We are not giving you any legal advice. We are not giving you any guarantees or promises of any of the products or services. The material presented in our blog and videosare to be used at the discretion of the reader in the viewer, Our site is provided for informational and educational purposes only. It does not, will not, should not, would not substitute medical advice and medical office /hospital/ER visits.

The Food and Drug Administration has approved the first new class of migraine drugs to stop headaches before they even start; KDKA's Dr. Maria Simbra reports.

Lawrence Robbins, MD, Robbins Headache Clinic, Riverwoods, IL, discusses the safety profile of CGRP-directed antibodies in migraine and how clinical studies can be improved. After 3 years, 50,000 adverse events in migraine patients receiving CGRP-directed antibodies have been reported by the FDA. Many side effects of CGRP therapy, such as constipation and hypertension, have emerged after initial studies predicted a much milder safety profile. This may be explained by clinical trials often lacking a checklist for adverse events, which has been associated with missed side effects in 67% of patients. Studies are also often underpowered by cohort size and time. Overall, clinical trials need to be improved to more accurately represent potential side effects. The short- and long-term side-effects of CGRP antibodies in migraine need to be uncovered. This interview was conducted during the virtual 2021 World Congress on Controversies in Neurology (CONy) meeting.

.

Chapters

0:00 Introduction
0:47 Uses of Aimovig
1:05 Potential side effects of Aimovig
2:08 Important considerations



Welcome to our comprehensive guide on Aimovig—a revolutionary migraine treatment that has been changing the lives of many migraine sufferers. In this video, we will delve into the uses, potential side effects, and important considerations you should keep in mind before considering Aimovig as a part of your migraine management plan.



Section 1: Understanding Aimovig
Aimovig is a novel medication specifically designed to prevent migraines in adults. It belongs to a class of drugs known as CGRP inhibitors, which target a protein linked to migraine attacks. By blocking CGRP, Aimovig aims to reduce the frequency and intensity of migraines.


Section 2: Benefits of Aimovig
Aimovig offers a ray of hope for chronic migraine sufferers. Its primary benefit lies in reducing the number of migraine days experienced each month, enabling individuals to resume normal activities and improve their overall quality of life. Many patients report fewer severe migraine attacks and a significant reduction in migraine-related symptoms.


Section 3: Potential Side Effects
While Aimovig has shown promising results, like any medication, it can come with potential side effects. Common side effects may include injection site reactions, constipation, and muscle pain. It's essential to be aware of these possibilities and discuss them with your healthcare provider before starting Aimovig.


Section 4: Considerations Before Using Aimovig
Before deciding on Aimovig as your migraine treatment, consider the following factors:


Medical History: Inform your doctor about any underlying health conditions or allergies you may have.
Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the risks and benefits of Aimovig with your doctor.
Drug Interactions: Inform your healthcare provider about any other medications or supplements you are taking to avoid potential interactions.
Cost and Insurance Coverage: Check with your insurance provider about the coverage of Aimovig to understand the financial implications.
Section 5: Dosage and Administration
Aimovig is administered through self-injection once a month. Your healthcare provider will guide you on the proper technique and dosage for optimal results.


Conclusion:
Aimovig has emerged as a game-changer in the world of migraine management, offering hope to those who have long suffered from chronic migraines. However, it's crucial to have an open conversation with your healthcare provider, weigh the benefits against the potential side effects, and consider your unique medical situation before deciding on Aimovig as part of your migraine treatment plan. Remember, your doctor is the best person to guide you through this decision-making process and ensure the best possible outcome for your migraine management journey.

Advair Diskus is used for long-term treatment of asthma and chronic obstructive pulmonary disease (COPD) in certain patients. It may also be used to treat other breathing conditions as determined by your doctor.
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What is Advair Diskus used for?


Advair Diskus, Advair HFA, AirDuo Respiclick is used to treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness caused by asthma. Advair Diskus is also used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema). Advair Diskus is used in adults and children 4 years of age and older. Advair HFA, AirDuo Respiclick are used in children 12 years of age and older.


How should this medicine be used?


Advair Diskus comes as a powder and as an inhalation solution to inhale by mouth using a specially designed inhaler. It is usually used twice a day, in the morning and evening, about 12 hours apart. Use Advair Diskus at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Advair Diskus exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Talk to your doctor about how you should take your other oral or inhaled medications for asthma during your treatment with salmeterol and fluticasone inhalation. If you were using a short-acting beta agonist inhaler such as albuterol (Proventil, Ventolin) on a regular basis, your doctor will probably tell you to stop using it regularly but to continue to use it to treat sudden attacks of asthma symptoms. Follow these directions carefully. Do not change the way you use any of your medications or stop taking any of your medications without talking to your doctor.

Do not use fluticasone and salmeterol during an attack of asthma or COPD. Your doctor will prescribe a short-acting inhaler to use during attacks.

Advair Diskus inhalation controls the symptoms of certain lung diseases but does not cure these conditions. It may take a week or longer before you feel the full benefit of Advair Diskus. Continue to use Advair Diskus even if you feel well. Do not stop using Advair Diskus without talking to your doctor. If you stop using Advair Diskus inhalation, your symptoms may return.

Before you use Advair Diskus, Advair HFA, or AirDuo Respiclick for the first time, read the written package instructions that come with it. Look at the diagrams and package instructions carefully and be sure that you recognize all the parts of the inhaler. Ask your doctor, pharmacist, or respiratory therapist to show you how to use the inhaler. Practice using your inhaler while they watch, so you are sure you are doing it the right way.

If your child will be using fluticasone and salmeterol inhalation, be sure that he or she knows how to use it. Watch your child each time they use the inhaler to be sure that they are using it correctly.

Never exhale into the inhaler, take the inhaler apart, or wash the mouthpiece or any part of the inhaler. Keep the inhaler dry. Do not use the inhaler with a spacer.


What special dietary instructions should I follow?


Talk to your doctor about eating grapefruit or drinking grapefruit juice while taking this medication.


What should I do if I forget a dose?


Skip the missed dose and continue your regular dosing schedule. Do not inhale a double dose to make up for a missed one.


What side effects can Advair Diskus cause?


Advair Diskus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

runny nose.
sneezing.
sore throat.
throat irritation.
sinus pain.
headache.
nausea.
vomiting.
diarrhea.
stomach pain.
muscle and bone pain.
dizziness.
weakness.
tiredness.
sweating.
tooth pain.
shaking of a part of your body that you cannot control.
sleep problems.

In this episode of Know Your Drug, Brothers Jake Messina and Matthew Gaeto discuss the prescription drug Advair Diskus (fluticasone/salmeterol). Advair is commonly prescribed to prevent chronic obstructive pulminary disease (COPD). This information is a general guideline and is not meant to replace physician orders. Patients using Advair should use this medication according to their prescriber!

Advair Diskus is used to control and prevent symptoms (wheezing and shortness of breath) caused by asthma or ongoing lung disease (chronic obstructive pulmonary disease-COPD, which includes chronic bronchitis and emphysema).

Video Content:
0:00 Advair Diskus
0:47 How to use
3:18 Precautions
3:59 Advair Diskus side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#AdvairDiskus #asthma #asthmatreatment

Please let me know if you experience any of these side effects!