Laurence Albiges, MD, PhD, from the Gustave Roussy Institute, Villejuif, France discusses the safety of cabozantinib treatment in metastatic renal cell carcinoma at the European Cancer Congress of the European Cancer Organisation (ECCO) 2017 in Amsterdam, Netherlands. Cabozantinib is a potent VEGFR tyrosine kinase inhibitor (TKI), and is used for second-line or later treatment in patients in whom prior VEGFR inhibitor treatment failed. Dr Albiges describes common side effects of cabozantinib treatment, which can include hypertension, hand-foot syndrome (acral erythema), diarrhea, and fatigue. Management of these will often require a dose reduction, with 2 out of 3 patients in the Phase III METEOR trial of cabozantinib needing a dose reduction (NCT01865747). However, she argues that the positive effect of cabozantinib on overall survival (OS) and progression-free survival (PFS) speak for its use as a second-line treatment in metastatic renal cell carcinoma.

Nicholas J. Vogelzang, MD, from the Comprehensive Cancer Centers of Nevada describes cabozantinib's side effects.

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In this video I provide an update on my journey with Cabenuva ,which is a long-acting injectable for HIV treatment.

One of the commonest drug addictions that we encounter in hospitals is opiates. Opiate addiction needs to be treated in an emergency room and we use bupiniorphione and naloxone as some of the drugs that are available in our armamentarium for treatment of severe opiate withdrawal in patients.

So many of our patients have been to other clinics but have never been taught how to properly take Suboxone (Buprenorphine / Naloxone).

The problem is that most pharmacies don't carry it or know about it.

Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, shares the results of a trial which investigated the tolerability and efficacy of zanubrutinib in patients with B-cell malignancies who were intolerant to acalabrutinib. Overall, it was shown that zanubrutinib was well tolerated by the patient population, with majority of patients not experiencing the side effects that they experienced with acalabrutinib. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

In this video, Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, comments on BGB-3111-215, a Phase II trial (NCT04116437) evaluating zanubrutinib in patients with B-cell malignancies who have previously exhibited intolerance to ibrutinib and/or acalabrutinib, which has resulted in discontinuation of treatment. Dr Shadman focuses on patients with chronic lymphocytic leukemia (CLL) and elucidates that based on current data from the trial, most patients do not have recurrence of prior adverse events (AEs) experienced on ibrutinib and/or acalabrutinib when taking zanubrutinib. In those where AEs do reoccur, they are of a lower or equal grade. This interview took place at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Peter Hillmen, MBChB, PhD from St. James' University Hospital, Leeds, UK, explains how Bruton's tyrosine kinase inhibitors, like ibrutinib and acalabrutinib (ACP-196), target chronic lymphocytic leukemia (CLL) cells and the common side-effects experienced by these drugs.
Recorded at the American Society of Hematology (ASH) 2015 Annual Meeting, held in Orlando, FL.

Keppra has a cousin medication called briviact with less side effects.

In this informative video, we delve into the various aspects of Brivaracetam tablets, a medication commonly prescribed for epilepsy treatment. We cover its uses, dosage guidelines, mechanism of action, potential side effects, and important advice to keep in mind while taking this medication.

First, we discuss the uses of Brivaracetam tablets, focusing on their role as adjunctive therapy for partial-onset seizures in patients with epilepsy. We explain how Brivaracetam is utilized alongside other antiepileptic medications to control seizures effectively.

Next, we provide an overview of the dosage guidelines for Brivaracetam tablets. We explain the initial dose, maintenance dose, and the possibility of titration to achieve optimal therapeutic effects while minimizing side effects. We also mention that pediatric dosages may vary based on weight.

Moving on, we explore the mechanism of action of Brivaracetam tablets. We describe how this medication specifically binds to synaptic vesicle protein 2A (SV2A) in the brain, modulating neurotransmitter release, particularly gamma-aminobutyric acid (GABA). This modulation helps regulate abnormal electrical activity in the brain, reducing the likelihood and severity of seizures.

Additionally, we discuss the potential side effects of Brivaracetam tablets. We emphasize that while side effects vary from person to person, common ones include drowsiness, dizziness, headache, nausea, and irritability. We also mention rare but serious side effects that require immediate medical attention.

Lastly, we provide important advice for individuals taking Brivaracetam tablets. We emphasize the significance of following healthcare provider instructions, attending regular follow-up appointments, and reporting any concerning side effects promptly. We highlight the importance of not abruptly stopping the medication and mentioning the need for gradual tapering if discontinuation is required. We also touch upon considerations regarding pregnancy, breastfeeding, driving, and medication compliance.

Join us for this comprehensive exploration of Brivaracetam tablets, providing valuable insights into their uses, dosage, mechanism of action, potential side effects, and important advice to enhance understanding and ensure safe and effective medication management.

Remember, this video is for informational purposes only and should not replace medical advice. Always consult your healthcare provider for personalized guidance regarding Brivaracetam tablets.

General information regarding Ublituximab (Briumvi). Content created leveraging AI with the goal of bridging access across communities. Please flag any suggestions or errors in the comment section. Thank you!

See full Prescribing Information and Medication Guide at bit.ly/3Kjl6WW.

BRIUMVI® (ublituximab-xiiy) is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Don't take BRIUMVI if you’ve had a life-threatening allergic reaction to it or have hepatitis B. Your doctor should test for hepatitis B before treatment. If you've had it, it could come back which may cause serious liver problems or death.

BRIUMVI can cause serious side effects including infusion reactions; some may require hospitalization. BRIUMVI can increase your risk of infections and decrease some antibodies.
Some infections may be life-threatening. Signs of infection include fever, chills, a cough that does not go away, or painful urination. PML, a rare, serious brain infection that can be fatal or lead to severe disability, may happen.

Tell your doctor if you are or plan to become pregnant, as BRIUMVI may harm your unborn baby. Tell your doctor if you have symptoms of an infection and about all your medical conditions, medications and vaccines.

These are not all the possible side effects of BRIUMVI. Watch the video to see full Important Safety Information and call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or TG Therapeutics at 1-877-848-9462.

Briumvi injection belongs to a class of medications called monoclonal antibodies.
Active ingredient Ublituximab.

Video Content:
0:00 Briumvi injection
0:43 How to use
1:24 Contraindications
2:03 Warnings
2:40 Briumvi side effects

Disclaimer: this video and the comments are meant purely informational! This is not medical advice! If you are looking for medical advice always contact your own doctor.

#Briumvi #multiplesclerosis #medicine

Antonio Anzueto, MD; James F. Donohue, MD; Peter Salgo, MD; Byron Thomashow, MD; and Barbara P. Yawn, MD, MSc, FAAFP, review the various drug classes used in the treatment of chronic obstructive pulmonary disease (COPD).

Welcome to a comprehensive guide on Trelegy Ellipta, a powerful medication for managing respiratory conditions. In this guide, we will delve into various aspects of Trelegy Ellipta, including its mechanism of action, potential side effects, uses, and the optimal dose for effective treatment.

Trelegy Ellipta: A Brief Introduction

Trelegy Ellipta is a combination medication used for the long-term treatment of chronic obstructive pulmonary disease (COPD). It contains three active ingredients: fluticasone furoate, umeclidinium, and vilanterol. These components work synergistically to help manage COPD symptoms and improve lung function.

Understanding Its Uses

Chronic Obstructive Pulmonary Disease (COPD) Management:
Trelegy Ellipta is primarily used for the long-term maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema.
Mechanism of Action: How Trelegy Ellipta Works

Trelegy Ellipta combines three active components, each with a unique mechanism of action:

Fluticasone furoate: An inhaled corticosteroid that helps reduce inflammation in the airways.
Umeclidinium: An anticholinergic agent that relaxes the muscles in the airways, improving airflow.
Vilanterol: A long-acting beta2-adrenergic agonist that helps open the airways by relaxing the muscles in the air passages.
Together, these components work to provide comprehensive relief by reducing inflammation, relaxing the airway muscles, and improving airflow.

Balancing Benefits and Risks: Trelegy Ellipta Potential Side Effects

Common Side Effects:
Common side effects of Trelegy Ellipta may include throat irritation, headache, nausea, cough, and a fungal infection in the mouth. These side effects are typically mild and transient.

Serious Side Effects:
In rare cases, individuals may experience more severe side effects such as increased risk of pneumonia, bone thinning, high blood pressure, or a fast or irregular heartbeat. Immediate medical attention is necessary if any severe side effects occur.

Recommended Dosage: Tailoring Trelegy Ellipta Dose

Standard Dosage:
The standard dosage of Trelegy Ellipta is typically one inhalation once daily. The recommended dose contains 100 mcg of fluticasone furoate, 62.5 mcg of umeclidinium, and 25 mcg of vilanterol.

Dosage Administration:
Trelegy Ellipta comes in a pre-loaded inhaler device. It is crucial to follow the prescribed dosage and administration instructions provided by the healthcare provider to achieve optimal therapeutic effects.

Patient Perspectives: Trelegy Ellipta Reviews

Alex's Experience: Regaining Control Over COPD with Trelegy Ellipta
Alex, a COPD patient, shares his journey with Trelegy Ellipta and how it has positively impacted his quality of life. He discusses the improvements in his breathing and overall well-being.

Linda's Story: Supporting a Loved One Through Trelegy Ellipta Treatment
Linda, a caregiver to a COPD patient, narrates her perspective on Trelegy Ellipta and how it has influenced her loved one's battle against COPD. She emphasizes the importance of medication adherence and regular check-ups.

Conclusion: Trelegy Ellipta in COPD Management

In conclusion, Trelegy Ellipta stands as a crucial medication in the long-term management of chronic obstructive pulmonary disease (COPD), offering potential benefits in improving lung function and alleviating symptoms. Understanding its mechanism of action, potential side effects, uses, and recommended dosage equips both healthcare providers and patients with the knowledge needed to make informed decisions regarding its usage, ultimately contributing to improved COPD management and a better quality of life for those affected by this condition.

Thank you.
-----
"DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.



"

Your Guide to Breztri Aerosphere for COPD!

Breathe easier with our friendly guide to Breztri Aerosphere for COPD! Learn how it works, tips for proper use, side effects, and important safety info. Comment and share your experience!


00:00 Getting Started
01:26 Medicine Breakdown
03:06 Usage Tips
04:14 Side Effects
05:13 Safety & Risks
07:14 Medical History
08:49 Final Tips


## Getting Started
- Overview: The video introduces COPD and highlights Breztri Aerosphere as a powerful prescription inhaler designed for long-term COPD management.
- Triple Therapy: Emphasizes the unique combination of three medications and explains that Breztri Aerosphere is FDA approved for adults with COPD.

## Medicine Breakdown
- Ingredients Explained: Each of the three components—Budesonide, Glycopyrrolate, and Formoterol Fumarate—is discussed, including their distinct roles in opening airways and reducing inflammation.
- Mechanism & Maintenance: Details how the combination therapy works and stresses that Breztri Aerosphere is a maintenance medication, not for acute symptom relief.

## Usage Tips
- How to Use: Provides step-by-step advice for inhaler use, including dosage instructions and the importance of consistency.
- Rinsing & Rescue: Stresses other practical tips such as rinsing the mouth to prevent thrush and always carrying a rescue inhaler.

## Side Effects
- Common Side Effects: Describes possible mild side effects like respiratory infections, thrush, joint pain, headache, and more.
- Serious Side Effects: Outlines potentially severe reactions, including pneumonia, allergic responses, heart effects, and glaucoma symptoms.

## Safety & Risks
- Health Monitoring: Alerts viewers to watch for signs like increased mucus, fever, or breathing changes, as Breztri may weaken the immune system and affect steroid hormone production.
- Cautions & Contraindications: Warnings for potential risks like adrenal suppression, heart and nervous system concerns, bone thinning, and effects on blood chemistry.

## Medical History
- Disclosure Importance: Encourages discussing full medical history with healthcare providers before starting Breztri Aerosphere.
- Interactions: Highlights crucial medication interactions and stresses the importance of updating medication lists.

## Final Tips
- Pregnancy & Breastfeeding: Advises consulting healthcare providers about Breztri Aerosphere's safety for pregnancy and breastfeeding.
- Specialist Guidance: Underscores the need for regular communication with healthcare professionals and summarizes key recommendations for safe, effective use.

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Breztri vs Trelegy Ellipta – Don’t Get Them Mixed Up

Breztri Aerosphere
• Ingredients: Budesonide (ICS) + Glycopyrrolate (LAMA) + Formoterol (LABA)
• Device: Pressurized metered-dose inhaler (pMDI) — shake before use
• Indication: COPD (not FDA-approved for asthma in the U.S.)
• Dose: 2 puffs twice daily

⸻

Trelegy Ellipta
• Ingredients: Fluticasone furoate (ICS) + Umeclidinium (LAMA) + Vilanterol (LABA)
• Device: Dry powder inhaler (DPI) — breath-activated, no shaking
• Indication: COPD and asthma (some strengths for asthma)
• Dose: 1 inhalation once daily

⸻

Key Differences to Prevent Mix-Ups
• Device type: Breztri = MDI (press and inhale), Trelegy = DPI (inhale fast and deep)
• Frequency: Breztri = 2× daily, Trelegy = 1× daily
• Approved use: Trelegy has asthma approval; Breztri doesn’t (in U.S.)
• Appearance: Breztri = canister in inhaler body, Trelegy = flat rectangular device with cover

⸻

⚠️ Why it matters:
📌Mixing them up can cause wrong dosing, under-treatment, or overdosing. Always check the name and directions on your prescription before use.

📌 Gargle 💦 water after both Breztri and Trelegy.

Not medical advice. For educational purposes only.

Secrets of the side effects of Breztri Aerosphere
**Common Side Effects (occurring in more than 1% of patients)**

* Upper respiratory tract infections (e.g., sore throat, sinus infection)
* Cough
* Headache
* Diarrhea
* Nausea
* Blurred vision
* Increased heart rate
* Dry mouth
* Throat irritation
* Abdominal pain
* Muscle aches
* Vomiting
* Fatigue
* Rash
* Dry cough

**Less Common Side Effects (occurring in less than 1% of patients)**

* Pneumonia
* Bronchitis
* Wheezing
* Chest tightness
* Shortness of breath
* Anxiety
* Dizziness
* Insomnia
* Taste changes
* Trembling
* Ear pain
* Dry eye

**Serious Side Effects**

* **Pneumonia:** A serious lung infection that can cause fever, chills, cough, and shortness of breath.
* **Bronchitis:** A lung infection that causes inflammation and swelling of the bronchial tubes, leading to cough, wheezing, and shortness of breath.
* **Anaphylaxis:** A severe allergic reaction that can cause difficulty breathing, swelling of the face and throat, hives, and low blood pressure.
* **Increased risk of serious cardiovascular events (e.g., heart attack, stroke):** Breztri contains formoterol, which can increase heart rate and blood pressure.
* **Hyperthyroidism:** This is a condition in which the thyroid gland produces too much thyroid hormone. Symptoms can include weight loss, increased appetite, rapid heart rate, and nervousness.

**Other Possible Side Effects**

* **GlaxoSmithKline has issued a warning about the potential for serious side effects with Breztri Aerosphere.** These include:
* Increased risk of death in patients with severe asthma exacerbations
* Increased risk of serious asthma-related events (e.g., intubation, hospitalization)
* **Breztri Aerosphere should only be used by patients who are 12 years or older.**
* **Patients who are taking Breztri Aerosphere should avoid smoking.** Smoking can worsen asthma symptoms.
* **Patients who are taking Breztri Aerosphere should tell their doctor about any other medications they are taking.** Some medications can interact with Breztri Aerosphere.
* **Patients who are taking Breztri Aerosphere should get regular check-ups with their doctor to monitor their progress.**

VANNAIR (Formoterol, Budesonida): Tratamiento eficaz para el asma y la EPOC. Vannair, un medicamento combinado ideal para tratar afecciones respiratorias como el asma y la EPOC. Descubre cómo actúa en tu cuerpo y los beneficios que aporta al mejorar la función respiratoria.

Te explicaremos la dosificación adecuada, tanto inicial como de mantenimiento, y cómo administrarlo correctamente. Además, abordaremos los posibles efectos secundarios y las precauciones que debes tener en cuenta para un uso seguro.

No olvides darle like y compartir este video si te ha sido útil. ¡Nos vemos en el siguiente!

#Vannair #Asma #EPOC #SaludRespiratoria

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Central Maine Pulmonary and Sleep Medicine provides this educational video to guide you on how to use of your inhaler. Each inhaler has two videos, the short video is a quick overview and the longer video goes over the use of the inhaler in more detail. If you have questions about your inhaler that aren’t addressed in the video be sure to contact your healthcare provider.

This video was made by Randy Nguyen , 2023 Pharmacist Candidate. He will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters