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What? A Cough Medicine for Depression? Side Effects 1 Views • 1 month ago

Serotonin antidepressants, step aside there’s a new kid in town. The FDA has just approved a new antidepressant that contains the active ingredient found in over-the-counter cough medicines. This new drug, which will be available soon, is said to work more rapidly than the current antidepressants. So if you're struggling with depression, this may be something to ask your doctor about in the coming months.

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References
Zorumski, Charles F et al. “Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.” Frontiers in psychiatry vol. 6 172. 9 Dec. 2015, doi:10.3389/fpsyt.2015.00172

Chandrasekar, Raman. “Alcohol and NMDA receptor: current research and future direction.” Frontiers in molecular neuroscience vol. 6 14. 28 May. 2013, doi:10.3389/fnmol.2013.00014

Bai G, Hoffman PW. Transcriptional Regulation of NMDA Receptor Expression. In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 5.

Mutschler, Jochen et al. “Dextromethorphan withdrawal and dependence syndrome.” Deutsches Arzteblatt international vol. 107,30 (2010): 537-40. doi:10.3238/arztebl.2010.0537

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Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor. mental health education mental health channel

Auvelity (Dextromethorphan and Bupropion) | A Fast Acting Antidepressant? Side Effects 1 Views • 1 month ago

Auvelity (Dextromethorphan and Bupropion) | A Fast Acting Antidepressant?
Content written by: Chris Aiken, MD
💡Auvelity Fact Sheet: https://www.thecarlatreport.com/auvelity
➡️Full Article: https://www.thecarlatreport.co....m/articles/4417-auve
📖Medication Fact Book: https://www.thecarlatreport.co....m/products/499-medic

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00:00 Carlat Intro
00:13 Auvelity
0:46 Mechanism of Action
2:33 Side-effects
2:49 Controversies
3:58 Unanswered Questions
4:18 Carlat Verdict
4:27 Fact Sheet
4:38 TheCarlatReport.com

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In today’s video, we’re taking a deep dive into Auvelity, a new antidepressant that combines Dextromethorphan and Bupropion. While Bupropion is well-established in the treatment of depression, Dextromethorphan is less familiar in psychiatric contexts. It’s primarily known as a cough suppressant in products like Robitussin DM. The combination in Auvelity aims to offer a new approach by leveraging both drugs’ unique benefits.

Auvelity’s primary claim to fame is its dual-action mechanism. Dextromethorphan enhances glutamate transmission through NMDA antagonism, a mechanism seen in other third-line treatments for depression such as ketamine and amantadine. This approach goes beyond traditional monoamines like serotonin and norepinephrine, which are targeted by most antidepressants. Dextromethorphan is also thought to have anti-convulsant and neuroprotective effects and can block serotonin and dopamine reuptake. This novel mechanism makes Auvelity the first oral antidepressant to incorporate this specific approach.

The combination of Dextromethorphan and Bupropion in Auvelity helps achieve a pharmacokinetic goal by extending the half-life of Dextromethorphan. Bupropion inhibits CYP2D6, the enzyme responsible for metabolizing Dextromethorphan, thus prolonging its effects from a few hours to over 20. This extended duration might contribute to Auvelity’s effectiveness.

Clinical trials provide promising results. Compared to Bupropion alone, Auvelity has shown quicker onset and greater efficacy in treating depression. One large trial, involving over 300 patients, demonstrated that Auvelity effectively improved depressive symptoms faster than other antidepressants. A smaller trial confirmed these findings, noting a significant remission rate of 47% after six weeks, compared to just 16% with Bupropion alone. However, the drug’s effectiveness for treatment-resistant depression is still uncertain, as a large trial in this area yielded negative results.

Regarding side effects, Dextromethorphan’s sedative properties can lead to issues such as somnolence, nausea, dizziness, headache, and dry mouth. There is also concern about potential misuse. While the clinical trials showed no inappropriate use, the combination with Bupropion could potentially push Dextromethorphan into higher, possibly abusable levels.

Auvelity is quite costly, with prices around $1,200 per month. For those looking for more affordable options, generic alternatives might be used, though these are not FDA-approved and come with their own set of considerations. Generic Bupropion and Dextromethorphan could be combined to mimic Auvelity’s effects, but this approach isn’t officially endorsed.

There are still many unanswered questions about Auvelity. For example, can Bupropion alone be used initially, with Dextromethorphan added if needed? What happens if doses are adjusted, or if Dextromethorphan is tapered off? These aspects remain under investigation.

In summary, Auvelity offers a new approach with its combination of Dextromethorphan and Bupropion, providing a faster therapeutic onset and novel mechanism of action. While it shows promise in treating depression, its high cost and potential for misuse are important considerations. For more detailed information and updates, check out our full article on the CARLAT website and consider subscribing to the Carlette Psychiatry Report for in-depth psychiatric news and clinical insights.

Is Deutetrabenazine (Austedo) Addictive? - Schizophrenia Support Network Side Effects 1 Views • 1 month ago

Is Deutetrabenazine (Austedo) Addictive? In this informative video, we will discuss Deutetrabenazine, commonly known by its brand name Austedo, and its role in treating movement disorders associated with serious conditions. We will cover how this medication functions in the brain and its potential effects on mood and cognitive abilities. Understanding the difference between psychological and physical dependence is essential when considering the safety of any medication, including Deutetrabenazine.

We will also address the important side effects that can arise from its use, particularly in patients with Huntington's disease, and the significance of monitoring during treatment. Additionally, we will highlight the necessity of regular consultations with healthcare providers to ensure the medication is effective and safe.

If you or someone you know is considering Deutetrabenazine as a treatment option, this video will provide essential information to help navigate the potential risks and benefits. Remember, staying informed and communicating with healthcare professionals is key to managing treatment effectively.

Join us for this important discussion, and subscribe to our channel for more helpful content on mental health and treatment options.

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About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Hear From a Doctor: The Impact of TD Side Effects 1 Views • 1 month ago

See Important Safety Information below, & Medication Guide here: https://bit.ly/4ivEe2k. AUSTEDO XR®/AUSTEDO® can cause depression, suicidal thoughts, or actions in patients with HD. Don’t use if you have liver problems; are taking reserpine, tetrabenazine, or valbenazine.

Hear experts discuss the impact of tardive dyskinesia (TD) and why talking to your doctor about symptoms of TD is so important.

APPROVED USES
AUSTEDO XR is a prescription medicine that is used to treat:
• the involuntary movements (chorea) of Huntington’s disease (HD). AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements, & it does not treat other symptoms of HD, such as problems with thinking or emotions.
• movements in the face, tongue, or other body parts that cannot be controlled TD (tardive dyskinesia).
It is not known if AUSTEDO XR/AUSTEDO is safe & effective in children.
IMPORTANT SAFETY INFORMATION
AUSTEDO XR/AUSTEDO can cause serious side effects in people with HD, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR/AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR/AUSTEDO is started & when the dose is changed. Call your doctor right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.
Do not take AUSTEDO XR/AUSTEDO if you:
• have HD & are depressed or have thoughts of suicide.
• have liver problems.
• are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR/AUSTEDO. If your doctor plans to switch you from taking reserpine to AUSTEDO XR/AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR/AUSTEDO.
• are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR/ AUSTEDO. Do not start AUSTEDO XR/AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your doctor or pharmacist if you are not sure.
• are taking tetrabenazine. If your doctor plans to switch you from tetrabenazine to AUSTEDO XR/AUSTEDO, take your first dose of AUSTEDO XR/AUSTEDO on the day after your last dose of tetrabenazine.
• are taking valbenazine.
Other possible serious side effects include:
• Irregular heartbeat (QT prolongation). AUSTEDO XR/AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR/AUSTEDO with certain medicines may increase this chance.
• Neuroleptic Malignant Syndrome. Call your doctor right away & go to the nearest emergency room if you develop these signs & symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
• Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
• Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.
Sleepiness (sedation) is a common side effect of AUSTEDO XR/AUSTEDO. While taking AUSTEDO XR/AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR/AUSTEDO affects you. Drinking alcohol & taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR/AUSTEDO may increase any sleepiness caused by AUSTEDO XR/AUSTEDO.
The most common side effects of AUSTEDO in people with HD include sleepiness (sedation), diarrhea, tiredness, & dry mouth.
The most common side effects of AUSTEDO in people with TD include inflammation of the nose & throat (nasopharyngitis) & problems sleeping (insomnia).
The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with HD or TD. These are not all the possible side effects of AUSTEDO XR/AUSTEDO. Call your doctor for advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.