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Buspar (Buspirone) - Can it Treat ADHD? Side Effects 1 Views • 7 months ago

Main Chapters:
00:00 Intro - Buspirone for ADHD?
00:13 Take home message
01:24 What is Buspar? (Buspirone)
10:12 Buspirone Treatment Uses
12:13 Buspirone for Treating ADHD?
16:11 Gepirone (Exxua)

The FDA approved Buspar for anxiety in 1986, and it has been available as a generic busprione since 2001. Pharmacologists classify buspirone as a serotonin 1A partial agonist, as its primary action appears to be the activation of pre-synaptic serotonin receptors, which gradually decreases firing of serotonin neurons.

For years, buspirone has been considered a third or fourth tier option for treating ADHD. In addition to effectively treating anxiety associated with ADHD, it may also provide direct benefit for ADHD. 1-2-pyrimidinylpiperazine (1-PP), a major metabolite of buspirone, is an alpha-2 antagonist, which boosts levels of norepinephrine, dopamine and serotonin. Limited research indicates buspirone does reduce ADHD symptoms in humans.

A handful of studies, almost all in rodents, indicate that buspirone can successfully treat several side effects associated with Ritalin, including teeth grinding (bruxism), liver toxicity, and growth inhibition. Buspirone also appears to reduce the potential for substance abuse and cognitive dulling that are associated with long term Ritalin use in rodents.

In September 2023, the FDA approved gepirone, (Exxua) which is chemically similar to buspirone, for the treatment of depression. Gepirone is also metabolized to 1-PP, so you may well be hearing more about this class of drugs for depression, anxiety, and ADHD.

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References:
Buspirone in ADHD (1998)
https://www.jaacap.org/article..../S0890-8567(09)63043

Azapirones for Attention Deficit Hyperactivity Disorder: A Systematic Review (2016)
https://www.thieme-connect.com..../products/ejournals/

Buspirone versus Methylphenidate in the Treatment of Children with Attention- Deficit/ Hyperactivity Disorder: Randomized Double-Blind Study
https://acta.tums.ac.ir/index.....php/acta/article/vie

Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial (2010)
https://link.springer.com/arti....cle/10.1007/s10578-0

Co-treatment with low doses of buspirone prevents rewarding effects of methylphenidate and upregulates expression of 5-HT1A receptor mRNA in the nucleus accumbens (2021)
https://www.sciencedirect.com/....science/article/abs/

Full Chapter list:
00:00 Intro - Buspirone for ADHD?
00:13 Take home message
01:24 What is Buspar? (Buspirone)
03:12 Approval and Usage of Buspar
04:12 Potential Side Effects of Buspar
04:53 Buspirone Half-life and Dosage
06:36 Buspirone and Metabolites
06:54 1-(2-Pyrimidinyl) Piperazine (1-PP)
07:51 6-Hydroxybuspirone
08:17 Buspirone and Dopamine
09:25 Buspirone and Liver Enzymes
10:12 Buspirone Treatment Uses
12:13 Buspirone for Treating ADHD?
13:21 Buspirone and Stimulants
16:11 Gepirone (Exxua)
17:05 Outro

Streamed live January 17, 2024

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world.

Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background.

You're welcome to email him with topics you want discussed or people you think he should interview.

[email protected]

#health #mentalhealth #adhd #buspirone

Why Does Candesartan Cause Dizziness? - Hypertension Help Hub Side Effects 1 Views • 7 months ago

Why Does Candesartan Cause Dizziness? In this informative video, we will discuss Candesartan, a medication commonly prescribed for managing hypertension. Understanding how this drug works and its potential side effects is essential for anyone taking it. We will explain the mechanism of action of Candesartan and how it affects blood pressure levels. Additionally, we will address the common side effect of dizziness associated with Candesartan and what causes it.

It's important to be aware of how to manage this side effect effectively. We will provide practical tips on how to minimize dizziness while taking this medication, including methods to adjust your body position safely and the importance of staying hydrated. If dizziness becomes severe or persistent, we will also highlight the importance of consulting with a healthcare provider for potential adjustments to your treatment plan.

Join us for this informative discussion about Candesartan and its effects on blood pressure. Don't forget to subscribe to our channel for more helpful information on hypertension and related topics. Your health is important, and we're here to support you on your journey to better management of high blood pressure.

⬇️ Subscribe to our channel for more valuable insights.

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#Candesartan #Hypertension #BloodPressure #Dizziness #OrthostaticHypotension #MedicationSideEffects #HealthManagement #StayHydrated #BloodFlow #HealthcareProvider #PatientEducation #HighBloodPressure #HeartHealth #WellnessTips #MedicationAwareness

About Us: Welcome to Hypertension Help Hub, your go-to channel for everything related to high blood pressure. Here, we provide clear and concise information on High Blood Pressure Basics, Causes of Hypertension, Symptoms, Blood Pressure Monitoring, and Lifestyle Changes for Hypertension. We cover essential topics such as the DASH Diet, Medications for High Blood Pressure, and effective strategies for managing stress to support heart health. Our goal is to equip you with practical tips for Hypertension Prevention and ways to take control of your well-being. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

What Are The Side Effects Of Candesartan/Hydrochlorothiazide? - Hypertension Help Hub Side Effects 1 Views • 7 months ago

What Are The Side Effects Of Candesartan/Hydrochlorothiazide? In this informative video, we will discuss the side effects associated with the combination medication of candesartan and hydrochlorothiazide, commonly prescribed for managing high blood pressure. Understanding the potential side effects is essential for anyone considering this treatment option. We will cover various aspects of how these medications work together to lower blood pressure and what to expect while taking them.

We will highlight common side effects such as dizziness and headaches, as well as more serious concerns like kidney issues and electrolyte imbalances. Additionally, we will touch on gastrointestinal symptoms and respiratory effects that some individuals may experience. It's critical to be aware of these possibilities to manage your health effectively while on this medication.

We will also emphasize the importance of regular monitoring and communication with your healthcare provider, especially if you notice severe symptoms or changes in your health. If you're currently using or considering this medication, this video will provide you with essential information to help you navigate your treatment plan safely.

Join us for this informative discussion, and subscribe to our channel for more helpful information on managing hypertension and related health topics.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Hyper....tensionHelpHub/?sub_

#Hypertension #BloodPressure #Candesartan #Hydrochlorothiazide #MedicationSideEffects #HealthAwareness #KidneyHealth #ElectrolyteBalance #HeartHealth #Dizziness #Headaches #GastrointestinalHealth #RespiratoryHealth #MedicationManagement #HealthcareAdvice

About Us: Welcome to Hypertension Help Hub, your go-to channel for everything related to high blood pressure. Here, we provide clear and concise information on High Blood Pressure Basics, Causes of Hypertension, Symptoms, Blood Pressure Monitoring, and Lifestyle Changes for Hypertension. We cover essential topics such as the DASH Diet, Medications for High Blood Pressure, and effective strategies for managing stress to support heart health. Our goal is to equip you with practical tips for Hypertension Prevention and ways to take control of your well-being. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

chlorpheniramine maleate tablets ip| chlorpheniramine |chlorpheniramine maleate |chlorpheniramine Side Effects 1 Views • 7 months ago

Fluoxetina, sertralina, paroxetina, citalopram e escitalopram: quais as diferenças? Side Effects 1 Views • 7 months ago

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Qual a diferença entre sertralina e fluoxetina? O que é melhor sertralina ou fluoxetina? Qual a diferença entre paroxetina e fluoxetina? Qual o melhor antidepressivo: fluoxetina ou paroxetina? Qual a diferença de citalopram e escitalopram?

Esses cinco medicamentos que eu citei, fluoxetina, sertralina, paroxetina, citalopram e escitalopram são antidepressivos da classe dos inibidores da recaptação da serotonina.

Link para o vídeos sobre a FLUOXETINA: https://youtu.be/OqaEAgN64_U .

A fluoxetina você já sabe - tem um vídeo aqui do canal somente sobre ela (o link está aqui na descrição). Ela é a representante mais antiga da família - a irmã mais velha - nasceu nos Estados Unidos em 1987. E seus efeitos colaterais mais comuns são náusea, alterações no sono com insônia, redução da libido (eu falei sobre isso no outro vídeo), um retardo na ejaculação para os homens. Mas em geral são efeitos que aparecem no início do tratamento e vão embora com o tempo.

Em 1989, dois anos depois da fluoxetina, um laboratório dinamarquês lançou no mercado o citalopram. E a principal diferença do citalopram é que em princípio ele tem menos efeitos colaterais nessa questão dos sintomas sexuais.

A sertralina foi o terceiro medicamento dessa classe e apareceu lá em 1992. O perfil é muito parecido com o da fluoxetina. Mas a queixa de náusea é mais frequente e alguns estudos também mostraram melhores resultados no tratamento da depressão quando comparada com a fluoxetina.

Um ano depois, em 1993 veio a quarta irmã dessa família - a paroxetina. E na nossa balança de diferenças entre elas em princípio a paroxetina é um pouco pior nos efeitos adversos - causa mais sonolência e a disfunção sexual é mais frequente também; mas a eficácia como antidepresssivo se mostrou ser um pouco melhor.

O irmão mais novo dessa família é o escitalopram, surgiu em 2001 - o escitalopram tem praticamente a mesma genética do citalopram. A diferença está na potência. Pra você entender melhor é assim: 10mg de escitalopram apresentam a mesma eficácia de 40mg de citalopram. Essa é a diferença - porque quanto tomados em doses equivalentes, ou seja, uma cápsula de 10mg de escitalopram ou duas cápsulas de 20mg de citalopram (que fecham 40mg), o perfil de efeitos colaterais e de eficiência das medicações são muito parecidos.

Eu espero ter te ajudado a esclarecer as principais diferençlas entre esses cinco medicamentos que como a gente viu são da mesma família. Se gostou desse vídeo deixa seu like aqui prá mim, se inscreve no canal se ainda não for inscrita ou inscrito, e ativa o sininho porque toda semana tem vídeo novo - assim você recebe o aviso quando o vídeo for postado.

E não esquece: esse vídeo tem objetivos de educação em saúde e de passar informações. Em hipótese nenhuma ele substitui um atendimento profissional individual. Nunca tome ou altere suas medicações sem antes conversar com seu médico. As pessoas, os amigos, os vizinhos, todo mundo gosta de dar opiniões dizendo o que é bom prá isso, o que é bom praquilo; toma esse remédio aqui; a questão é que quando dá algum problema, principalmente problemas raros mas graves como a síndrome serotoninérgica por exemplo, aí a gente precisa saber o que está fazendo; e se uma complicação dessas acontecer a pessoa terá que buscar tratamento médico de emergência. Portanto, não faça nada sem a avaliação com seu médico - principalmente nessa área e com relação ao uso de medicamentos dessa classe.

**As informações contidas nos vídeos deste canal não pretendem nem estão implícitas em substituir o aconselhamento, diagnóstico ou tratamento médico profissional. Todos os conteúdos, incluindo textos, gráficos, imagens e informações, contidos nestes vídeos servem apenas para fins de informação geral e não substituem uma consulta com seu próprio médico/profissional de saúde !**

Clonidine: The Best Medication no one talks about Side Effects 1 Views • 7 months ago

Welcome to our deep dive into Clonidine, a medication that has shaped the pharmacological landscape with its wide array of therapeutic applications. In this video, we're unpacking everything from Clonidine's pharmacodynamics and pharmacokinetics to its versatile uses in various medical conditions. Join us as we explore the science behind this multifaceted drug, shedding light on its mechanisms, benefits, potential side effects, and its pivotal role in modern medicine.

**What You'll Learn:**

- **Understanding Clonidine**: Get to grips with how Clonidine works in the body, including its classification as a centrally acting alpha-2 adrenergic agonist.

- **Therapeutic Uses**: Dive into the diverse uses of Clonidine, from managing hypertension to treating ADHD, withdrawal symptoms, and more.

- **Mechanism of Action**: Discover how Clonidine's effect on alpha-2 receptors leads to decreased sympathetic outflow, benefiting conditions like hypertension.

- **Side Effects and Considerations**: Familiarize yourself with the common side effects of Clonidine and crucial clinical considerations for its use.

**Why This Matters:**

Clonidine remains a cornerstone in the treatment of not just hypertension but also in addressing ADHD, withdrawal symptoms from various substances, and certain types of pain. Its broad therapeutic range and mechanism of action make it a subject of continuous interest in the medical community.

**For Healthcare Professionals and Patients Alike:**

Whether you're a healthcare professional seeking to broaden your pharmacological knowledge or a patient curious about the medications you're prescribed, this video offers valuable insights into one of the most widely used medications today.

**Subscribe for More Health Insights:**

Interested in more content like this? Subscribe to our channel for comprehensive videos on medications, health tips, and wellness strategies. Stay informed on the latest in healthcare and how it affects you.

**Engage with Us:**

Have questions about Clonidine or experiences you'd like to share? Comment below! We love hearing from our viewers and aim to foster a community where we can learn and grow together.

Remember, while Clonidine offers numerous benefits across a range of conditions, it's essential to approach any medication with an informed perspective, considering both its advantages and potential risks.

👉 Don't forget to like, share, and subscribe for more in-depth looks into the medications that impact our health and daily lives.

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This video cannot and does not contain medical/health advice. The medical/health information is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical health advice. THE USE OR RELIANCE OF ANY INFORMATION CONTAINED IN THIS VIDEO IS SOLELY AT YOUR OWN RISK.

Clopidogrel ( Plavix 75 mg ): What is Clopidogrel Used For, Dosage, Side Effects & Precautions? Side Effects 1 Views • 7 months ago

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- This is lesson n# 64 in "A DRUG IN BRIEF" Series. In this video I'm gonna discuss almost all you need to know about Clopidogrel ( Plavix 75 mg ): What is Clopidogrel Used For, Dosage, Side Effects, Precautions and mechanism of action

- In 3 minutes you'll learn:

- What is Clopidogrel ( Plavix 75 mg )?

- Clopidogrel is an antiplatelet agent. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.

- It is available as 75 mg tablets.

- Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease). It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).

- The usual dosage of Clopidogrel
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: PO 75 mg once daily with or without food. Acute Coronary Syndrome (Unstable Angina/Non-Q-Wave MI): ADULTS: PO Start with a 300 mg loading dose, then continue at 75 mg once daily, initiating and continuing aspirin (75 to 325 mg/day) in combination with clopidogrel.

- Learn more about Clopidogrel ( Plavix 75 mg ) mechanism of action, uses, dosage, side effects, and precautions in this video...

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#118 My System for Opioid Tapering: 10 tips and my tapering plan to avoid withdrawals Side Effects 1 Views • 7 months ago

Are you concerned about tapering off opioids? Learn how to reduce the dose without experiencing any withdrawal symptoms. In this video, we'll discuss different methods for tapering opioids safely and without experiencing any unpleasant side effects.

There are a lot of different ways to reduce the dose of opioids without having to go through the withdrawal process. In this video, we'll discuss the different options available to you and help you choose the method that best suits your needs. After watching this video, you'll be ready to reduce the dose of your opioids safely and without any unpleasant side effects!

In this video, Doctor Andrea Furlan explains why people who take opioids every day feel withdrawal symptoms when they try to reduce the dose. She talks about the withdrawal symptoms, and how to avoid these symptoms with a gradual and slow opioid taper plan.

To download the handout, visit this link: https://bit.ly/Opioid_Tapering_Tips

Dr. Furlan is a pain specialist in Toronto Canada. She is a physiatrist (specialist in Physical Medicine & Rehabilitation). She holds a medical degree from the University of Sao Paulo and a Ph.D. degree from the University of Toronto. She has 30 years of experience helping people with chronic pain to get better quality of life.

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ALERT: This video is not intended to replace medical advice. If you think you have a condition that is causing you pain, please consult with your doctor to get a diagnosis and a treatment plan for you. The intent of this video is only for educational purposes. If there is any emergency, go to the nearest emergency department or call an ambulance. CLOSED CAPTIONS in this video have not been professionally verified.
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CYCLOBENZAPRINE - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 1 Views • 7 months ago

Prolia Denosumab, The Long Term Answer for Osteoporosis or Recipe for Disaster? Side Effects 1 Views • 7 months ago

Prolia Denosumab, The Long Term Answer for Osteoporosis or Recipe for Disaster? In this video we will delve into the controversy surrounding Prolia, examining whether it is a calculated approach to managing osteoporosis or something to steer far away from .Watch this video to learn more on improving your bone health and lifespan.

Watch and Enjoy! Dr. Doug Lucas Key Moments in this Episode
========================
00:00 Intro and summary
0:44 Background
3:45 First Study
11:50 Masterclass Registration Link
12:00 Program Details Link
12:27 Can I take this drug forever? And what happens when I go off of it?
14:33 Fourth Study
16:38 Overview
20:18 Closing Summary
21:02 Masterclass Registration Link
21:20 Program Details Link

Study 1

https://pubmed.ncbi.nlm.nih.gov/19671655/

Study 2

https://pubmed.ncbi.nlm.nih.gov/28546097/

Study 3

https://pubmed.ncbi.nlm.nih.gov/28789921/

Study 4

https://pubmed.ncbi.nlm.nih.gov/36088628/

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The videos on this channel will be focused around helping women navigate healthspan and longevity through the lens of osteoporosis, perimenopause, and menopause. When it comes to osteoporosis and menopause providers and educators often get tunnel vision and your symptoms might get better, but if you don't keep longevity in mind, symptom improvement may come at the expense of heart and brain health.

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