A drug recommended to use to treat and prevent only life-threatening ventricular arrhythmias due to potentially serious side effects (generally not recommended for less severe arrhythmias). It is taken by mouth or intravenously.

It is a non-selective beta-adrenergic receptor blocker with class II (beta-blocker) and III (potassium channel blocker) antiarrhythmic properties. It is a "pure" potassium channel blockers which produces little or no other cardiac ion channel electrophysiologic effect, as well as dofetilide and possibly ibutilide.

It can cause life-threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug-induced arrhythmia, give it by oral administration in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring.
Do not use it if baseline corrected QT is 450 msec or greater. If the QT interval prolongs to 500 msec or greater, reduce the dose, lengthen the dosing interval, or discontinue the drug.

It is nearly completely absorbed after oral administration and undergoes essentially no first-pass hepatic metabolism, resulting in its absolute bioavailability at 90-100%.
It is primarily eliminated by renal excretion, with approximately 80-90% of a dose being excreted unchanged in the urine, and a small amount is excreted unchanged in the feces.
Calculate creatinine clearance to determine appropriate dosing.

(Common side effects)
• bradycardia
• hypotension
• chest pain
• shortness of breath
• dizziness
• weakness
• blurred vision
• nausea, vomiting
• edema

(Serious side effects)
• QT prolongation
• heart failure
• bronchospasm

Welcome to Dr. Jawwad Afzal Kayani's channel, your go-to destination for all things related to public health awareness!
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Breast Cancer Index patient, Denise, shares how the side effects from anti-estrogen therapy affected her daily life.

Hi, I am Dan Reznicek from Pacific Northwest Urology, today we are going to be talking about aromatase inhibitors drugs sometimes referred to as estrogen blockers. We are going to discuss their use in men who are on Testosterone replacement therapy. There is a lot of mis-information online and in other youtube videos online out there claiming the benefits of these drugs. Often the muscle building “bros” talk about “balancing your estrogen”or optimizing the level. But it isn’t just misinformation online. I have also been getting a lot of men coming to my practice that I see from testosterone clinics who are on the drug. Doctors are prescribing them these medications that we are going to find out later, cause men erectile dysfunction and decreased libido. I ask them why they are on the medication. They say they want to normalize or balance their estrogen levels. They want me to check their estrogen levels if the are o testosterone replacement therapy even if they are doing well overall to make sure they aren’t getting too much estrogen. So unlike other videos that just give opinions on these medications, I am going to review the science and clinical trials that actually tested these drugs. I am going to show studies on how we are learning more every year about the physiology of estrogen in men and find that the hormone is essential to many tissues in the body. We are then going to review studies on the use of aromatase inhibitors. These will demonstrate clearly that taking these medications while on testosterone therapy has been shown to cause a host of medical problems from decreased bone mineral density to low libido and erectile dysfunction. That is right, it sounds crazy but the hormone estrogen is essential for male libido and erectile function. Even just a slightly lower level of estrogen can cause a problem.

Medications can be an incredibly effective tool for people, but can also have severe negative side effects for some, such as in the case of the anti-inflammatory medication, Singulair (Montelukast). Some individuals might experience severe suicidal depression while on this medication. Fortunately, this side effect resolves once Singulair has been discontinued. It's important to think about the medications you take whenever you have new symptoms.

Our videos are not medical advice. If you have questions about this content or about your health, please consult your medical provider.

ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE generic medicine: USES, DOSAGE & SIDE EFFECTS.

Uses:
What Is Acetaminophen Pheniramine Phenylephrine Used For and How Does it Work?.

Dosage:
What Are the Dosages of Acetaminophen Pheniramine Phenylephrine?.

Side Effects:
What Are Side Effects Associated with Using Acetaminophen Pheniramine Phenylephrine?.

Drugs Interactions:
What Other Drugs Interact with Acetaminophen Pheniramine Phenylephrine?.

Warning and Precautions:
What Are Warnings and Precautions for Acetaminophen Pheniramine Phenylephrine?.

WHAT IS ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE AND HOW DOES IT WORK?

Acetaminophen pheniramine phenylephrine is an over-the-counter (OTC) product used to treat allergy symptoms and common cold symptoms.

Acetaminophen pheniramine phenylephrine is available under the following different brand names: Theraflu Cold & Sore Throat and Theraflu Flu & Sore Throat.


WHAT ARE THE DOSAGES OF ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Dosages of Acetaminophen Pheniramine Phenylephrine:

Dosage Forms and Strengths:

Powder:

325mg per packet.
20mg per packet.
10mg per packet.

Dosage Considerations – Should be Given as Follows:

Allergy Symptoms and Common Cold:

Adults and children 12 years of age and older: Dissolve contents of 1 packet in 8 oz of hot water; consume entire 8 oz within 10-15 minutes; not to exceed acetaminophen 1 g/dose or 4 g/day.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Side effects of acetaminophen pheniramine phenylephrine include:

Low blood pressure (hypotension).
Palpitations.
Reflex high blood pressure (hypertension).
Severe peripheral and visceral vasoconstriction.
Fast heart rate.
Confusion.
Dizziness.
Depression.
Distress.
Euphoria.
Fatigue.
Headache.
Insomnia.
Irritability.
Restlessness.
Sedation.
Tremors.
Dermatologic rash.
Loss of appetite.
Severe low white blood cell count (agranulocytosis).
Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia).
Hemolytic anemia.
Low blood platelets (thrombocytopenia).
Increased bilirubin and alkaline phosphatase.
Thickening of bronchial secretions.
Wheezing.

WHAT OTHER DRUGS INTERACT WITH ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Serious interactions of acetaminophen pheniramine phenylephrine include:
pexidartinib.
pitolisant.
pretomanid.

Moderate interactions of acetaminophen pheniramine phenylephrine include:
apalutamide.
avapritinib.
axitinib.
brexanolone.
busulfan.
cenobamate.
daclizumab.
dapsone topical.
eltrombopag.
exenatide injectable solution.
exenatide injectable suspension.
flibanserin.
imatinib.
isoniazid.
ivacaftor.
lasmiditan.
lemborexant.
levonorgestrel oral, ethinylestradiol/ferrous bisglycinate.
midazolam intranasal.
lixisenatide.
lomitapide.
midazolam intranasal.
mipomersen.
stiripentol.
tazemetostat.


WHAT ARE WARNINGS AND PRECAUTIONS FOR ACETAMINOPHEN PHENIRAMINE PHENYLEPHRINE?

Warnings:

This medication contains acetaminophen pheniramine phenylephrine. Do not take Theraflu Cold & Sore Throat or Theraflu Flu & Sore Throat if you are allergic to acetaminophen pheniramine phenylephrine or any ingredients contained in this drug.

Contraindications:

Hypersensitivity.
Asthma.
Children under 2 years old.
Narrow-angle glaucoma.
Symptomatic prostate hypertrophy.
Bladder-neck obstruction.
Stenosing peptic ulcer.
Use within 14 days of monoamine oxidase inhibitor (MAOI) therapy.
G-6-PD deficiency.
Severe hepatic impairment.

Cautions:

Pheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates.
Phenylephrine: Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe atherosclerosis.
Acetaminophen: Hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose.
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash.

Pregnancy and Lactation:

Use acetaminophen pheniramine phenylephrine with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
Acetaminophen pheniramine phenylephrine is excreted in breast milk. Use caution while breastfeeding.

Did you know that about 75% of sexually active Canadians will have at least one HPV infection in their lifetime?

The Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. It's highly contagious, but there are ways to reduce your risk. Dr. Nancy Durand explains.

Understanding Doxycycline Hyclate: How to Take It and Its Side Effects • Get the scoop on how to take Doxycycline Hyclate 100 mg and what side effects to look out for in this informative video! From respiratory tract infections to preventing malaria, we've got you covered on everything you need to know about this common antibiotic. Follow our tips on taking it properly and avoid any pesky side effects. Don't miss out on this must-watch video!

00:00 • How should I take Doxycycline hyclate 100 mg, and are there any side effects?
00:23 • What is Doxycycline Hyclate?
00:44 • How Should I Take Doxycycline Hyclate 100 mg?
01:22 • Are There Any Side Effects?

Side Effects of Neomycin and Polymyxin B Sulfate Ear Drops: What You Need to Know • Are you using neomycin and polymyxin B sulfate ear drops to treat an ear infection? It's important to know the possible side effects to ensure safe and effective medication use. In this informative video, we'll discuss common and serious side effects of these ear drops, so you can be aware of what to expect. Don't miss out on this essential information - watch now!

00:00 • What are the possible side effects of neomycin and polymyxin B sulfate ear drops?
00:30 • What are these Ear Drops?
00:48 • Common Side Effects
01:21 • Serious Side Effects
02:09 • What to Do If You Experience Side Effects?