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Sumatriptan pharmacology, triptans pharmacology, pharmacology made easy Side Effects 1 Views • 2 months ago

sumatriptan pharmacology, triptans for migraine pharmacology, antimigraine drugs pharmacology, pharmacology lecture nursing,

💊 Sumatriptan belongs to the class of anti-migraine medications known as triptans. Sumatriptan is a selective serotonin receptor agonist that is used to treat symptoms of migraine headaches. Triptans should be taken at the first sign of a migraine for best efficacy. Sumatriptan is the prototype drug of triptan class.

🧩 Sumatriptan is a 5-HT1B/1D receptor agonist used for acute migraine and cluster headache treatment. It causes cranial vasoconstriction and reduces inflammatory neuropeptide release. Administered orally (50-100 mg), subcutaneously (6 mg), or nasally (5-20 mg), it acts rapidly. Common side effects include dizziness and chest discomfort; rare risks are coronary vasospasm and serotonin syndrome. Contraindicated in ischemic heart disease, uncontrolled hypertension, and with MAO inhibitors or ergot derivatives.
#triptans #pharmacologylectures #migraineheadache #medicinelectures

Chapters:
0:00 - sumatriptan pharmacology
0:24 - sumatriptan mechanism of action
0:49 - sumatriptan pharmacokinetics
1:30 - sumatriptan side effects
2:11 - sumatriptan contraindications

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𝗗𝗶𝘀𝗰𝗹𝗮𝗶𝗺𝗲𝗿:
"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."

Sumatriptan pharmacology, triptans pharmacology, pharmacology made easy Side Effects 1 Views • 2 months ago

Effective Migraine Relief | Sumatriptan (2025) Side Effects 1 Views • 2 months ago

Suffering from migraines and searching for effective relief? In this video, we’ll explore everything you need to know about Sumatriptan, a powerful migraine medication that can help treat acute migraine attacks. Discover how Sumatriptan works, when to take Sumatriptan, and what you should be aware of to manage your migraines effectively.

What is Sumatriptan?
Sumatriptan is a medication used to treat acute migraine headaches. It helps relieve symptoms like severe headache pain, nausea, and sensitivity to light and sound, allowing sufferers to return to their normal activities more quickly.

Buy Sumatriptan online: https://www.pharmica.co.uk/migraine/sumatriptan/

If you have any questions or experiences with Sumatriptan, please share them in the comments below. Don't forget to give this video a thumbs up if you found it useful and subscribe to our channel for more health tips and medication guides. Hit the bell icon so you never miss an update. Thanks for watching!

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ABOUT PHARMICA

Pharmica is an award-winning and fully-regulated online pharmacy that has provided popular prescription and OTC treatments for a range of health conditions to more than 1.5 million customers and patients across the UK.

With a 4.9/5 rating from over 200,000 verified reviews, and as the number 1 ranked pharmacy in Trustpilot’s Online Prescription Medication and Medicine Supply Store categories as well as a Feefo Platinum Service Award Winner (2024), we're the top choice for those seeking an online pharmacy a cut above in the UK.

All treatments are dispensed from our Central London dispensary in plain and discreet packaging, and we only prescribe medication that has been approved by the MHRA. In addition, we offer a wealth of information on medications and health conditions through our free email newsletter and comprehensive articles posted on our Health Hub.

Visit www.pharmica.co.uk/ to browse our range of treatments or to learn more about improving your health.

Mechanism of Action of Aminosalicylates Side Effects 1 Views • 2 months ago

Developed and produced for http://www.MDPracticeGuide.com, a CME resource for physicians and healthcare providers.

Animation Description: This animation explains the mechanism of action of aminosalicylates used for the treatment of inflammatory bowel disease (IBD).

Aminosalicylates include sulfasalazine and 5-aminosalicylic acid (5-ASA).

Sulfasalazine, a sulfa drug, inhibits folic acid synthesis. As such, folic acid supplements should be taken with sulfasalazine to reduce the risk of neural tube defects.

Sulfasalazine exhibits anti-inflammatory properties when split by gut bacterium into its metabolites: sulfapyridine and 5-ASA (mesalamine).

The anti-inflammatory benefits of sulfasalazine, are chiefly derived from 5-ASA, which has fewer side effects than sulfapyridine. As such, administration of 5-ASA alone may be preferred over sulfasalazine.

5-ASA is poorly absorbed by the intestines and systemic circulation, thus most remains in the terminal ileum and colon or is passed in the stool. 5-ASA within the lumen primarily exhibits a topical effect on the colonic epithelium.

Absorbed 5-ASA is extensively metabolized to N-acetyl-5-ASA by N-acetyltransferase 1 (NAT1). N-acetyl-5-ASA then binds PPAR-gamma (peroxisome proliferator-activated receptor gamma) a nuclear hormone receptor.

Binding of N-acetyl-5-ASA induces the translocation of PPAR-gamma from the cytoplasm to the cell nucleus and a conformational change in PPAR-gamma.

This modification permits the recruitment of the co-activator, vitamin D3 receptor-interacting protein (DRIP), which interacts directly with PPAR-gamma.

Heterodimerization with the retinoid X receptor (RXR) occurs, resulting in formation of the PPAR-RXR complex, a transcriptional regulator.

The PPAR-RXR heterodimer controls transcription by binding a regulatory PPAR-gamma response element (PPRE) and modulating the expression of genes involved in the inflammation process.

PPAR-RXR downregulates the nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) to reduce production of pro-inflammatory cytokines.

This complex also reduces COX-2 activity, leading to a reduction in prostaglandins involved in inflammation.

Novel agents with similar mechanisms to 5-ASA, but which target PPAR-gamma more efficiently and report a reduction of adverse events, are currently under investigation.

For example the compound, GED-0507-34, exhibits a 100- to 150-fold greater anti-inflammatory effect than 5-ASA.

A new generation of 5-ASA, balsalazide, is able to bypass the small intestine and release a high concentration of 5-ASA in the colon.

Is Sulfasalazine Used To Treat Rheumatoid Arthritis? - Orthopedic Support Network Side Effects 1 Views • 2 months ago

Is Sulfasalazine Used To Treat Rheumatoid Arthritis? In this informative video, we'll discuss the role of sulfasalazine in managing rheumatoid arthritis. Sulfasalazine is a disease-modifying anti-rheumatic drug that helps address the underlying factors of this condition rather than just alleviating the symptoms. We will cover how this medication reduces inflammation, pain, and swelling in the joints, which is essential for preserving joint function over time.

You'll learn about the typical process for starting sulfasalazine, including the initial dosing and how doctors gradually adjust it to ensure patient tolerance. We’ll also touch on the importance of monitoring during treatment, including the necessary blood tests to check for potential side effects. This medication can be used alone or in combination with others, such as methotrexate or hydroxychloroquine, to achieve better control of symptoms.

Understanding the use of sulfasalazine is important for anyone affected by rheumatoid arthritis, whether you are a patient, caregiver, or simply interested in orthopedics. Join us in this discussion, and don't forget to subscribe for more helpful information on managing orthopedic conditions and medications.

⬇️ Subscribe to our channel for more valuable insights.

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#RheumatoidArthritis #Sulfasalazine #Orthopedics #JointHealth #AntiRheumaticDrugs #Inflammation #PainManagement #MedicationManagement #PatientCare #HealthMonitoring #ChronicIllness #AutoimmuneDisease #JointFunction #DiseaseModification #OrthopedicCare

About Us: Welcome to the Orthopedic Support Network, your go-to resource for all things orthopedic! Our channel is dedicated to empowering individuals with information about orthopedic health, treatments, and innovations. Whether you're dealing with joint pain, recovering from surgery, or simply looking to enhance your physical well-being, we cover a range of topics including injury prevention, rehabilitation exercises, and expert interviews with leading orthopedic specialists. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

What Are Sulfasalazine's Side Effects? - Sensitive Stomach Guide Side Effects 1 Views • 2 months ago

What Are Sulfasalazine's Side Effects? In this informative video, we will discuss the side effects associated with Sulfasalazine, a medication commonly prescribed for inflammatory bowel diseases like ulcerative colitis. Understanding these side effects is important for anyone dealing with conditions such as irritable bowel syndrome or colitis. We will cover the common digestive issues that may arise, including symptoms like indigestion, heartburn, nausea, and diarrhea, which can complicate managing your condition. Additionally, we will touch on other potential side effects that could affect your overall health, including headaches and dizziness.

It's essential to be aware of the serious reactions that can occur with Sulfasalazine. We will outline signs that require immediate medical attention, such as allergic reactions and liver damage. Recognizing these symptoms can help you take timely action and ensure your safety while using this medication.

If Sulfasalazine doesn't suit you, we will also mention alternative medications that may be more tolerable. Join us as we navigate through the important aspects of Sulfasalazine side effects, and remember to communicate with your healthcare provider about your experiences. Subscribe to our channel for more helpful information on managing digestive health.

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#Sulfasalazine #IBD #Colitis #IBS #DigestiveHealth #MedicationSideEffects #InflammatoryBowelDisease #HealthAwareness #PatientEducation #DigestiveDiscomfort #AllergicReactions #LiverHealth #MedicationManagement #ChronicIllness #HealthcareProvider

About Us: Welcome to Sensitive Stomach Guide! Our channel is dedicated to helping individuals navigate the challenges of digestive health. We cover a wide range of topics including Irritable Bowel Syndrome (IBS), IBS symptoms and triggers, the sensitive stomach diet, Inflammatory Bowel Disease (IBD), ulcerative colitis, Crohn’s disease, gut health tips, the low FODMAP diet, and managing bloating and gas, along with natural remedies for digestive issues. We aim to create a friendly and informative space where you can find support and practical advice tailored to your needs. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

SULFASALAZINE - - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 1 Views • 2 months ago

The Dangers of Long-Term Nasal Decongestant Spray Use Side Effects 1 Views • 2 months ago

Topical decongestants are typically used to relieve nasal congestion due to allergic rhinitis, acute or chronic rhinosinusitis, nasal polyps, or upper respiratory tract infections. However, long-term use of these nasal decongestants can cause rebound swelling of the nasal mucosa. This is called Rhinitis medicamentosa. And is classified as a subset of drug-induced rhinitis. The earliest nasal decongestants mainly derived from ephedrine showed rhinitis medicamentosa developing as early as 3 days after use and up to 4 to 6 weeks after use. All pharmacists therefore advise patients not to use decongestant sprays for more than 2 weeks.

Read the paper 'The Indispensable Nasal Decongestant: Patients’ Views and Perspectives on Nasal Decongestant Overuse' published in The Journal of Allergy and Clinical Immunology:
https://www.jaci-inpractice.or....g/article/S2213-2198

To better understand the dangers involving the overuse of nasal sprays, join Sophie Scheire, Pharmacist and PhD fellow at Ghent University in Belgium, and Prof. Philippe Gevaert, Professor of Rhinology & Allergy at Ghent University in Belgium and EUFOREA Rhinitis Panel Member.

Sophie Scheire Interview:
1:41 What did your study show?
2:33 Why do #patients keep using nasal decongestant sprays?
3:26 What are the dangers of nasal spray overuse?
4:31 What can be done to raise awareness on this?
6:03 What is the OTC status in other countries?
7:00 How should the collaboration between primary care, pharmacists, GPs and specialists be?

Prof. Philippe Gevaert Interview
8:13 What are the dangers of #nasalspray overuse?
9:23 How do you manage an addiction to a nasal decongestant spray?
10:42 What advice would you give to a patient on a nasal decongestant spray for more than 2 weeks?

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📌 EUFOREA is an international non-profit organisation aiming to implement optimal patient care for allergies and airway diseases (asthma, chronic rhinosinusitis, rhinitis) and comorbidities through education, research and advocacy. #euforea

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