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Vortioxetine (Trintellix) The TOP 5 things you need to know Side Effects 2 Views • 1 month ago

In this video, we discuss the top 5 things you need to know about vortioxetine. Answering questions such as What is Vortioxetine? to What are the side effects of Vortioxetine?
Intro 0:00
1. What is vortioxetine? 0:31
Improves cognitive symptoms 1:10
Improves cognition in mild cognitive impairment 1:39
2. What is vortioxetine used for? 2:35
3. How long does it take for it to work? 3:25
4. Is vortioxetine (Trintellix) addicting? 3:43
5. What are the side effects and drug interactions? 4:15
- common side effects 4:42
- weight neutral 5:19
- drug interactions 6:15

🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suicide-hotlines/

Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own health care provider for proper diagnosis and treatment.

Resources:
Deprescribing Guide: https://amzn.to/4dZEUMk
Stahl's Prescribing Guide: https://amzn.to/3UXj8QL

References
Bennabi, D., Haffen, E., & Van Waes, V. (2019). Vortioxetine for Cognitive Enhancement in Major Depression: From Animal Models to Clinical Research. Frontiers in psychiatry, 10, 771. https://doi.org/10.3389/fpsyt.2019.00771

FDA Label (2018). Vortioxetine (Trintellix). Retrieved from https://www.accessdata.fda.gov..../drugsatfda_docs/lab

Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.

Stahl,S. (2017). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 6th Ed. Cambridge University Press.

Tan, S. N., & Tan, C. (2021). Vortioxetine improves cognition in mild cognitive impairment. International clinical psychopharmacology, 36(6), 279–287. https://doi.org/10.1097/YIC.0000000000000376

This video was made using
Doodly v2.7.4
Adobe Premiere- video editing software
Pixabay.com
Canva.com
Epidemic sounds

TRINTELLIX -- Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

Does Oxcarbazepine Affect Vision? - Pain Medicine Network Side Effects 2 Views • 1 month ago

Does Oxcarbazepine Affect Vision? In this informative video, we discuss the effects of oxcarbazepine, a medication commonly used for managing seizures and as an adjuvant in pain relief. While this drug is effective for many patients, it’s essential to understand the potential side effects, particularly those related to vision. We’ll cover the various visual disturbances that may arise, including double vision, blurred vision, and abnormal eye movements. Understanding these side effects is vital for patients and caregivers alike, as they can significantly impact daily life and overall safety.

We will also highlight the importance of maintaining open communication with healthcare providers regarding any vision changes experienced while on oxcarbazepine. Adjustments to medication should always be made under medical supervision to ensure patient safety and effective management of pain and seizures.

Join us as we unpack the complexities of oxcarbazepine and its effects on vision, providing you with the information you need to navigate your treatment options. Subscribe to our channel for more informative content on pain management and medication safety.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@PainM....edicineNetwork/?sub_

#Oxcarbazepine #VisionEffects #PainManagement #Anticonvulsants #DoubleVision #BlurredVision #EyeHealth #PatientSafety #MedicationSideEffects #HealthcareAdvice #Neuropharmacology #SeizureManagement #VisualDisturbances #Dizziness #HealthAwareness

About Us: Welcome to Pain Medicine Network, your trusted source for comprehensive information on pain management and treatment options. Our channel is dedicated to exploring the latest advancements in pain medicine, offering insights into innovative therapies, research breakthroughs, and expert interviews.
Please note that our content is purely informational and should not be considered medical advice. Always consult a healthcare professional for personalized guidance and do your own due diligence when it comes to your health and treatment options. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

OXTELLAR XR - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

Does Oxcarbazepine Treat Nerve Pain? - Pain Medicine Network Side Effects 2 Views • 1 month ago

Does Oxcarbazepine Treat Nerve Pain? In this informative video, we’ll discuss the role of oxcarbazepine in managing nerve pain, particularly conditions like painful diabetic neuropathy and trigeminal neuralgia. While primarily known as an anticonvulsant for epilepsy, oxcarbazepine is sometimes prescribed off-label for certain types of neuropathic pain. We’ll explain how this medication works by affecting electrical signals in the nervous system and how it may provide relief for some patients experiencing nerve pain.

We’ll also review the current evidence regarding the effectiveness of oxcarbazepine for pain management. While some studies indicate that it can lead to significant reductions in pain intensity for specific conditions, the overall quality of evidence varies. We will highlight the importance of understanding the potential side effects, including dizziness and low sodium levels, which require careful monitoring throughout treatment.

If you or someone you know is considering oxcarbazepine for nerve pain, it’s essential to consult with a healthcare professional to evaluate the best treatment options tailored to individual needs. Join us as we navigate this important topic in pain management and subscribe to our channel for more helpful information on pain medicine.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@PainM....edicineNetwork/?sub_

#Oxcarbazepine #NervePain #NeuropathicPain #PainManagement #DiabeticNeuropathy #TrigeminalNeuralgia #Anticonvulsant #PainRelief #Healthcare #MedicalAdvice #ChronicPain #PainTreatment #SideEffects #PatientCare #PainMedicine

About Us: Welcome to Pain Medicine Network, your trusted source for comprehensive information on pain management and treatment options. Our channel is dedicated to exploring the latest advancements in pain medicine, offering insights into innovative therapies, research breakthroughs, and expert interviews.
Please note that our content is purely informational and should not be considered medical advice. Always consult a healthcare professional for personalized guidance and do your own due diligence when it comes to your health and treatment options. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Oxcarbazepina (Trileptal): Para que serve e efeitos colaterais Side Effects 2 Views • 1 month ago

Mantenha-se informado e proteja sua saúde com o @NEUROCIRURGIABR ! Nosso objetivo é oferecer informações confiáveis sobre neurocirurgia, condições neurológicas e as principais notícias de saúde do momento. Explore conteúdos sobre:

- Neurocirurgia: Tumores cerebrais, aneurismas, doenças da coluna e muito mais.
Saúde em Foco: Dicas de prevenção, bem-estar e as últimas descobertas médicas.
- Vacinação: Atualizações sobre campanhas, importância da imunização e combate a doenças.
- Doenças da Atualidade: Informações sobre surtos, epidemias e prevenção de doenças prevalentes.

Autor: Julio Pereira - Neurocirugião - São Paulo 🇧🇷 CRM/SP 163.113
Consulta: http://drjuliopereira.com.br/ Consultório: (11)99503-8838 (WhatsApp) / (11)4200-2300
Atuando no Hospital Sírio-Libanês e na BP – A Beneficência Portuguesa de São Paulo.

A neurocirurgia é a especialidade médica que se dedica ao tratamento de doenças do sistema nervoso central e periférico, abrangendo desde recém-nascidos até adultos e, recentemente, fetos. Atuamos em uma ampla gama de condições, como:

Hidrocefalia
Tumores cerebrais e da coluna vertebral
Doenças vasculares (aneurismas, malformações arteriovenosas)
Doenças degenerativas (doença de Parkinson)
Traumatismos cranioencefálicos e lesões raquimedulares
Epilepsia
Dores crônicas
Distúrbios do movimento (distonias, síndrome de Tourette)
Alguns transtornos psiquiátricos (psicocirurgia)
Nosso objetivo é oferecer soluções cirúrgicas inovadoras e eficazes, visando melhorar a qualidade de vida dos pacientes.

http://weneuro.com/
http://radiocirurgia.com.br/

Nossas Mídias Sociais
Blog: http://www.neurocirurgiabr.com
Instagram: http://www.instagram.com/neurocirurgiabr
Twitter: http://www.twitter.com/neurocirurgiabr
Youtube: http://www.youtube.com/neurocirurgiabr
TikTok: https://www.tiktok.com/@neurocirurgiabr

Meus livros publicados:
1) Após um tumor cerebral
2) Escrito em letra de médico
3) Ultimas Cartas de um médico
4) Suturando Ideias
5) Neurocirurgia para o estudante de medicina

Quer ter acesso grátis aos livros? É só enviar um e-mail para [email protected] que mandamos em PDF.
Informações sobre alguma doença Neurológica ou sobre Neurocirurgia veja nos sites:

🤕 Tumor Cerebral https://tumor-cerebral.com/
😷 Radiocirurgia http://radiocirurgia.com.br/
🧠 Câncer https://www.neurocancer.com/
🫀 Aneurisma Cerebral https://aneurismacerebral.org/
👨🏽‍⚕️ Coluna e Dor https://cirurgianacoluna.com/
👨🏻‍🏫 Informações para Estudantes de Medicina http://weneuro.com/
👨‍🔬 Artigos Médicos: https://neurocirurgiabr.com/

⚠️ AVISO LEGAL:
As informações disponíveis neste vídeo são estritamente informativas, não substituindo o parecer médico/profissional. Sempre consulte o seu médico sobre qualquer assunto relativo à sua saúde e aos seus tratamentos e medicamentos.

TRILEPTAL - - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

Can Triamcinolone Injection Cause Hair Loss? - Orthopedic Support Network Side Effects 2 Views • 1 month ago

Can Triamcinolone Injection Cause Hair Loss? In this informative video, we will discuss the relationship between triamcinolone injections and hair loss. Triamcinolone is a corticosteroid commonly used in orthopedic practices to alleviate pain and inflammation in various conditions affecting joints, tendons, and soft tissues. We will explore how this medication works to relieve discomfort and the possible side effects associated with its use.

The focus will be on clarifying the misconceptions surrounding hair loss related to triamcinolone injections, particularly in orthopedic settings. While hair loss is a concern for many, we will explain why it is not typically linked to these injections. Additionally, we will touch upon the different contexts in which triamcinolone is used, including dermatological applications for hair loss treatment.

If you have received a triamcinolone injection and are worried about hair loss or any other unusual symptoms, it is essential to seek advice from a healthcare provider. Understanding the specific uses and effects of medications can help alleviate concerns and guide you toward the right solutions. Join us for this enlightening discussion, and don’t forget to subscribe to our channel for more helpful information on orthopedic health and treatments.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Ortho....pedicSupportNetwork/

#Triamcinolone #HairLoss #Orthopedics #Corticosteroids #JointPain #Inflammation #AlopeciaAreata #PainRelief #InjectionTherapy #HealthConcerns #MedicationSideEffects #Dermatology #HealthcareAdvice #PainManagement #OrthopedicHealth

About Us: Welcome to the Orthopedic Support Network, your go-to resource for all things orthopedic! Our channel is dedicated to empowering individuals with information about orthopedic health, treatments, and innovations. Whether you're dealing with joint pain, recovering from surgery, or simply looking to enhance your physical well-being, we cover a range of topics including injury prevention, rehabilitation exercises, and expert interviews with leading orthopedic specialists. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Does Triamcinolone Cause Weight Gain? - Pain Medicine Network Side Effects 2 Views • 1 month ago

Does Triamcinolone Cause Weight Gain? In this informative video, we will discuss the potential side effects of triamcinolone, particularly focusing on weight gain. Triamcinolone is a corticosteroid commonly used in pain management. While it can be effective in treating various conditions, it's essential to understand how it may impact your body. We will cover key factors that contribute to weight gain when using this medication, including fluid retention, increased appetite, and changes in metabolism.

Monitoring your weight and any changes while on triamcinolone is vital for maintaining your health. We will provide tips on how to manage these side effects effectively, including dietary adjustments and the importance of regular physical activity. Staying active can help you maintain a healthy weight and improve your overall well-being.

If you are currently using triamcinolone or considering it for pain management, this video will offer valuable information to help you make informed decisions. Always consult with your healthcare provider for personalized advice regarding your treatment and any side effects you may experience. Join us for this discussion, and don’t forget to subscribe to our channel for more helpful content on pain medicine and management.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@PainM....edicineNetwork/?sub_

#Triamcinolone #PainManagement #Corticosteroids #WeightGain #HealthTips #FluidRetention #IncreasedAppetite #Metabolism #HealthyLiving #DietaryAdjustments #Exercise #HealthcareProvider #PainRelief #MedicationSideEffects #Wellness #ChronicPain

About Us: Welcome to Pain Medicine Network, your trusted source for comprehensive information on pain management and treatment options. Our channel is dedicated to exploring the latest advancements in pain medicine, offering insights into innovative therapies, research breakthroughs, and expert interviews.
Please note that our content is purely informational and should not be considered medical advice. Always consult a healthcare professional for personalized guidance and do your own due diligence when it comes to your health and treatment options. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

स्टीरॉयड इंजेक्शन लेना चाहिए या नहीं ? Steroid injections for Pain Management….. by Dr Amod Manocha Side Effects 2 Views • 1 month ago

TRIAMCINOLONE - Generic Name , Brand Names, How to use, Precautions, Side Effects Side Effects 2 Views • 1 month ago

What Are The Side Effects Of Triamcinolone Cream? - Skin Savvy Dermatology Side Effects 2 Views • 1 month ago

What Are The Side Effects Of Triamcinolone Cream? In this informative video, we discuss the side effects associated with the use of triamcinolone cream, a topical corticosteroid commonly prescribed for various skin conditions. It’s crucial to understand the potential reactions that may occur while using this medication. We will highlight common side effects such as local skin irritation, skin changes, and other reactions that could arise from prolonged use. Additionally, we will cover less common side effects and the importance of monitoring your skin's response to the treatment.

Understanding how to use triamcinolone cream safely is essential for effective management of your skin condition. We will provide guidance on the proper application techniques and emphasize the importance of following your healthcare provider's instructions. Regular consultations with a dermatologist can help ensure that you are using the cream effectively and managing any side effects that may occur.

Stay informed about the potential risks and benefits of triamcinolone cream by watching this video. Don't forget to subscribe to our channel for more helpful information on dermatology and skin health.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@SkinS....avvyDermatology/?sub

#Triamcinolone #SkinCare #Dermatology #Corticosteroids #SkinHealth #EczemaTreatment #Psoriasis #SkinIrritation #CorticosteroidCream #TopicalMedication #Dermatitis #HealthySkin #SkinConditions #SkinTreatment #Dermatologist

About Us: Welcome to Skin Savvy Dermatology, your go-to source for all things skin! Our channel is dedicated to empowering you with the knowledge and tools to achieve healthy, glowing skin. From understanding common skin conditions to exploring the latest treatments and skincare routines, we cover a wide range of topics that cater to all skin types and concerns. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

What Are The Side Effects Of Tretinoin Cream? - Skin Savvy Dermatology Side Effects 2 Views • 1 month ago

What Are The Side Effects Of Tretinoin Cream? In this informative video, we will cover the side effects associated with Tretinoin cream, a commonly used treatment for acne. Tretinoin is well-known in dermatology for its effectiveness, but like any medication, it can lead to various skin reactions. We will discuss the common side effects you might encounter when starting this treatment, including skin irritation, dryness, and changes in skin color. Understanding these reactions is important for anyone considering Tretinoin as part of their skincare routine.

We will also explore ways to minimize discomfort while using Tretinoin, including tips on application frequency and the importance of moisturizing. Additionally, we will highlight when to consult a dermatologist if you experience persistent or severe side effects. This video aims to provide you with the necessary information to use Tretinoin effectively and safely, ensuring you can achieve clearer skin with minimal irritation. Join us for this essential discussion, and don’t forget to subscribe to our channel for more helpful tips and guidance on dermatological treatments.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@SkinS....avvyDermatology/?sub

#Tretinoin #AcneTreatment #Dermatology #Skincare #SkinHealth #TretinoinSideEffects #AcneCare #HealthySkin #Moisturizer #SunSensitivity #SkinIrritation #SkincareRoutine #Dermatologist #SkincareTips #AcneSolutions #SkinCareAdvice

About Us: Welcome to Skin Savvy Dermatology, your go-to source for all things skin! Our channel is dedicated to empowering you with the knowledge and tools to achieve healthy, glowing skin. From understanding common skin conditions to exploring the latest treatments and skincare routines, we cover a wide range of topics that cater to all skin types and concerns. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Tresiba® (insulin degludec) injection 100 U/mL, 200 U/mL Duration of Action With Dr Gavin Side Effects 2 Views • 1 month ago

Please click here https://bit.ly/3kWYNwG, or scroll below to see Important Safety Information. Please see the Prescribing Information for Tresiba® at https://bit.ly/3JEzfPg

Hear about the pharmacokinetics behind the duration of action of Tresiba® from past president of Morehouse College School of Medicine and renowned diabetes expert Dr James R Gavin, III.

For more information about the duration of action of Tresiba® visit the Tresiba® Pro website – https://bit.ly/3RyvOeH

Indications and Usage
Tresiba® (insulin degludec) injection is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus.

Limitations of Use
Tresiba® is not recommended for treating diabetic ketoacidosis.

Important Safety Information

Contraindications
• Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to insulin degludec or any of the excipients in Tresiba®

Warnings and Precautions
• Never Share a Tresiba® FlexTouch® Pen, Needle, or Syringe Between Patients, even if the needle is changed. Patients using Tresiba® vials should never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
• Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen: Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, or injection site or method of administration) may affect glycemic control and predispose to hypoglycemia or hyperglycemia. Repeated insulin injections into areas of lipodystrophy or localized cutaneous amyloidosis have been reported to result in hyperglycemia; and a sudden change in the injection site (to an unaffected area) has been reported to result in hypoglycemia. Make any changes to a patient’s insulin regimen under close medical supervision with increased frequency of blood glucose monitoring. Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia. Adjustments in concomitant anti-diabetic treatment may be needed.
• Hypoglycemia: Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®. Severe hypoglycemia can cause seizures, may be life-threatening or cause death. Hypoglycemia can impair concentration ability and reaction time; this may place the patient and others at risk in situations where these abilities are important (e.g., driving or operating other machinery). Hypoglycemia can happen suddenly and symptoms may differ in each patient and change over time in the same patient. Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic neuropathy, using drugs that block the sympathetic nervous system (e.g., beta-blockers) or who experience recurrent hypoglycemia. The long-acting effect of Tresiba® may delay recovery from hypoglycemia compared to shorter-acting insulins.
Risk Factors for Hypoglycemia: The risk of hypoglycemia generally increases with intensity of glycemic control. The risk of hypoglycemia after an injection is related to the duration of action of the insulin and, in general, is highest when the glucose lowering effect of the insulin is maximal. As with all insulins, the glucose lowering effect time course of Tresiba® may vary among different patients or at different times in the same patients and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature. Other factors which may increase the risk of hypoglycemia include changes in meal pattern, changes in level of physical activity, or changes to concomitant drugs. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia. Patients and caregivers must be educated to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended.
• Hypoglycemia Due to Medication Errors: Accidental mix-ups between insulin products have been reported. To avoid medication errors between Tresiba® and other insulins, always instruct patients to always check the insulin label before each injection. To avoid dosing errors and potential overdose, never use a syringe to remove Tresiba® from the Tresiba® FlexTouch® disposable insulin prefilled pen.
• Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulins, including Tresiba®. If hypersensitivity reactions occur, discontinue Tresiba®; treat per standard of care and monitor until symptoms and signs resolve.

Click here: https://bit.ly/3kWYNwG, or see video above for additional Important Safety information.

Instructions For Using Tresiba® FlexTouch® U-100 (insulin degludec) injection Side Effects 2 Views • 1 month ago

Please click here https://bit.ly/3kWYNwG, or scroll below to see Important Safety Information. Please see the Prescribing Information for Tresiba® at https://bit.ly/3JEzfPg

Help your patients learn to use the Tresiba® U-100 Pen in this easy to follow video which shows detailed instructions on how to administer Tresiba® insulin.

For more information on Tresiba®, including cost and coverage, and resources for you and your patients, visit the Tresiba® Pro website – https://bit.ly/3XXs4pw

Indications and Usage
Tresiba® (insulin degludec) injection is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus.

Limitations of Use
Tresiba® is not recommended for treating diabetic ketoacidosis.

Important Safety Information

Contraindications
• Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to insulin degludec or any of the excipients in Tresiba®

Warnings and Precautions
• Never Share a Tresiba® FlexTouch® Pen, Needle, or Syringe Between Patients, even if the needle is changed. Patients using Tresiba® vials should never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
• Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen: Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, or injection site or method of administration) may affect glycemic control and predispose to hypoglycemia or hyperglycemia. Repeated insulin injections into areas of lipodystrophy or localized cutaneous amyloidosis have been reported to result in hyperglycemia; and a sudden change in the injection site (to an unaffected area) has been reported to result in hypoglycemia. Make any changes to a patient’s insulin regimen under close medical supervision with increased frequency of blood glucose monitoring. Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia. Adjustments in concomitant anti-diabetic treatment may be needed.
• Hypoglycemia: Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®. Severe hypoglycemia can cause seizures, may be life-threatening or cause death. Hypoglycemia can impair concentration ability and reaction time; this may place the patient and others at risk in situations where these abilities are important (e.g., driving or operating other machinery). Hypoglycemia can happen suddenly and symptoms may differ in each patient and change over time in the same patient. Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic neuropathy, using drugs that block the sympathetic nervous system (e.g., beta-blockers) or who experience recurrent hypoglycemia. The long-acting effect of Tresiba® may delay recovery from hypoglycemia compared to shorter-acting insulins.
Risk Factors for Hypoglycemia: The risk of hypoglycemia generally increases with intensity of glycemic control. The risk of hypoglycemia after an injection is related to the duration of action of the insulin and, in general, is highest when the glucose lowering effect of the insulin is maximal. As with all insulins, the glucose lowering effect time course of Tresiba® may vary among different patients or at different times in the same patients and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature. Other factors which may increase the risk of hypoglycemia include changes in meal pattern, changes in level of physical activity, or changes to concomitant drugs. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia. Patients and caregivers must be educated to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended.
• Hypoglycemia Due to Medication Errors: Accidental mix-ups between insulin products have been reported. To avoid medication errors between Tresiba® and other insulins, always instruct patients to always check the insulin label before each injection. To avoid dosing errors and potential overdose, never use a syringe to remove Tresiba® from the Tresiba® FlexTouch® disposable insulin prefilled pen.
• Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulins, including Tresiba®. If hypersensitivity reactions occur, discontinue Tresiba®; treat per standard of care and monitor until symptoms and signs resolve.

Click here: https://bit.ly/3kWYNwG, or see video above for additional Important Safety information.